槲皮素新型脂质体制剂的开发——体外研究
Development of new liposomal formulations of quercetin - in vitro study.
摘要(中文译文)
槲皮素是一种存在于许多水果和蔬菜中的化合物，以其抗氧化和抗炎作用而闻名。此外，这种生物活性黄酮类化合物能够诱导异常发育细胞的凋亡。本研究旨在开发一种将槲皮素包封于脂质体中的有效方法，并评估其药物包封率、制剂的稳定性以及对黑色素瘤细胞的抗癌效果。结果表明，通过将槲皮素与铜离子络合，可成功将其包封于脂质体的水相中。为评估脂质体槲皮素的细胞毒性，对两种黑色素瘤细胞系A-375和C32以及正常人角质形成细胞HaCaT进行了SRB试验。该制剂对黑色素性黑色素瘤细胞表现出细胞毒性作用，而对正常细胞无此作用，表明脂质体槲皮素可能用于抗癌治疗。
Abstract
Quercetin is a chemical compound present in many fruits and vegetables, known for its antioxidant and anti-inflammatory effects. Additionally, this bioactive flavonoid can induce apoptosis in abnormally developing cells. The aim of the study was to develop an effective method for encapsulating quercetin in liposomes and to evaluate the drug encapsulation efficiency, stability of the formulation and anticancer effects on melanoma cells. The results showed that quercetin can be successfully encapsulated in the aqueous phase of liposomes by complexing it with copper ions. To assess the cytotoxicity of the liposomal quercetin, SRB assays were performed on two melanoma cell lines, A-375 and C32, as well as on normal human keratinocytes, HaCaT. This formulation exhibited a cytotoxic effect on melanotic melanoma cells but not on normal cells, indicating the possible use of liposomal quercetin in anticancer treatment.
如何引用
AMA
Klaudia Krawczyńska, Agnieszka Rusak, Tomasz Górnicki, Monika Mrozowska, Piotr Dzięgiel, Jerzy Gubernator. Development of new liposomal formulations of quercetin - in vitro study.. Scientific reports. 2026; doi:10.1038/s41598-026-48068-3.
APA
Klaudia Krawczyńska, Agnieszka Rusak, Tomasz Górnicki, Monika Mrozowska, Piotr Dzięgiel, Jerzy Gubernator (2026). Development of new liposomal formulations of quercetin - in vitro study.. Scientific reports. https://doi.org/10.1038/s41598-026-48068-3
GB/T 7714
Klaudia Krawczyńska, Agnieszka Rusak, Tomasz Górnicki, Monika Mrozowska, Piotr Dzięgiel, Jerzy Gubernator. Development of new liposomal formulations of quercetin - in vitro study.[J]. Scientific reports, 2026 doi:10.1038/s41598-026-48068-3.
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