{“_”：“感染期间巨噬细胞存活的调节。”，“i”：[“肺炎克雷伯菌”]}
{"_":"Modulation of macrophage survival during infections.","i":["Klebsiella pneumoniae"]}
摘要(中文译文)
作为一种兼性厌氧的革兰阴性杆菌，在公共卫生领域具有重要的临床意义。该菌以德国-瑞士微生物学家埃德温·克莱布斯的姓氏命名。卡尔·弗里德兰德首次从死于肺炎患者的肺组织中分离鉴定出该菌。该菌是肠杆菌科的重要成员，属于机会致病菌，也是在抗生素耐药大流行中席卷全球的病原体之一。该菌约占所有革兰阴性菌感染的1/3，包括肺炎、尿路感染、肝脓肿和菌血症。典型情况下，这些感染常见于住院患者或免疫功能低下者，通常使用β-内酰胺类及其他对该菌有效的抗生素进行治疗。然而，在重症监护病房（ICU）接受治疗的患者中出现多重耐药感染，已成为全球临床医生面临的严重问题。该菌近期被世界卫生组织（WHO）列入重点病原微生物清单，凸显了研发新型治疗手段以应对该菌的迫切需求。开发新的治疗干预措施需要全面了解宿主-病原体相互作用以及免疫细胞在清除该菌中的作用。为此，巨噬细胞在保护机体抵御感染性病原体方面发挥着关键作用，同时也参与病原体清除和组织稳态等过程。钙作为第二信使，可精细调控巨噬细胞的保护性反应并影响细胞存活。许多病原体已进化出多种策略来逃避巨噬细胞所介导的固有免疫清除机制。因此，本综述将聚焦于该菌感染时对巨噬细胞固有免疫应答及存活的调控。
Abstract
, a facultative anaerobe and Gram-negative bacterium, has high clinical significance in public health concerns. is given its name in recognition of the German-Swiss microbiologist Edwin Klebs. Carl Friedlander first identified as a bacterium isolated from the lungs of individuals who had died from pneumonia. is a prominent member of the family, an opportunistic pathogen, and one of the pathogens sweeping the world in the antibiotic resistance pandemic. This organism accounts for approximately one-third of all Gram-negative infections, including pneumonia, urinary tract infections, liver abscesses, and bacteremia. Classically, these infections commonly occur in individuals who are hospitalized or immunocompromised and regularly treated with -lactams along with other antibiotics effective against . Unfortunately, the emergence of multidrug-resistant infections in patients treated at intensive care units (ICUs) has been a serious problem faced by clinicians globally. has been recently added to the critical list of microorganisms by the World Health Organization (WHO), highlighting the urgent requirement for new therapeutic options to combat this bacterium. Developing new therapeutic interventions requires a comprehensive understanding of host-pathogen interactions and the role of immune cells in clearing the bacteria. To that end, macrophages play a crucial role in safeguarding our body against infectious agents, as well as contributing to processes such as pathogen clearance and tissue homeostasis. Calcium, a secondary messenger, refines the macrophage protective responses and influences cell survival. Many pathogens have evolved tactics to circumvent the innate immune clearance mechanisms exerted by macrophages. Therefore, this review will focus on the modulation of macrophage innate immune responses and survival upon infection.
如何引用
AMA
Nithya N, Anjoom Mohamed Ali, Sruthi K P, Subhash Mehto, Cecil Antony. {"_":"Modulation of macrophage survival during infections.","i":["Klebsiella pneumoniae"]}. Frontiers in cellular and infection microbiology. 2026; doi:10.3389/fcimb.2026.1757662.
APA
Nithya N, Anjoom Mohamed Ali, Sruthi K P, Subhash Mehto, Cecil Antony (2026). {"_":"Modulation of macrophage survival during infections.","i":["Klebsiella pneumoniae"]}. Frontiers in cellular and infection microbiology. https://doi.org/10.3389/fcimb.2026.1757662
GB/T 7714
Nithya N, Anjoom Mohamed Ali, Sruthi K P, Subhash Mehto, Cecil Antony. {"_":"Modulation of macrophage survival during infections.","i":["Klebsiella pneumoniae"]}[J]. Frontiers in cellular and infection microbiology, 2026 doi:10.3389/fcimb.2026.1757662.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出