BMC Complementary Medicine and TherapiesBMC补充医学与治疗
BMC Complementary Medicine and Therapies(英文缩写 BMC COMPLEMENT MED),ISSN 2662-7671,eISSN 2662-7671,中文译名:BMC补充医学与治疗 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
BMC Complementary Medicine and Therapies 最新收录文献
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1. Treatment choices: insights into disease-specific use and self-perceived benefits of traditional, complementary and integrative medicine in Germany.
PMID:日期:2026-09-29Previous cross-sectional studies suggest that Traditional, Complementary and Integrative Medicine (TCIM) is used frequently in Germany. We assessed TCIM usage patterns across different disease categories in the German population. In this cross-sectional survey of an online-representative sample of the German population aged 18-75 years, participants were asked about their use and acceptance of TCIM. Participants were also queried about 15 illness categories. Health-related quality of life was assessed using the EQ-5D-5L questionnaire. Data were analyzed descriptively and inferentially. A total of 4,065 individuals (52% female) responded. 70% had used TCIM at some point in their lives, 32% in the last 12 months, and 18% were current users. Over half (52%) reported a mostly or very positive attitude towards TCIM. The highest rates of TCIM use were reported for acute respiratory illness (55.9%), chronic gastrointestinal illness (51.4%) and acute gastrointestinal illness (49.2%). The illness-specific, self-reported benefit from TCIM ranged from 61.4 to 86.2% (mean 70.8%) and remained high even among individuals of poorer health-related quality of life. No relation between TCIM use across different disease categories and the global research activity in those categories was apparent in the scatter plot. TCIM is widely used and perceived as beneficial for acute and chronic conditions in Germany. Individuals with poorer health status also reported substantial benefit. Stakeholders in the German healthcare system should critically examine the high level of TCIM use, promote rigorous scientific evaluation, integrate evidence-informed TCIM with conventional medicine, and ensure appropriate reimbursement for TCIM through statutory health insurance.
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2. Ethnopharmacological insights into type 2 diabetes management by traditional Moroccan herbal teas: HPLC-MS characterization of phenolic compounds and their related antioxidant and enzyme inhibitory activities.
PMID:日期:2026-09-26Traditional Moroccan herbal teas are widely consumed and have been traditionally used for managing chronic metabolic disorders, particularly type 2 diabetes mellitus (T2DM). Although these preparations have a long history of ethnomedicinal use, their phenolic composition and biological activities remain insufficiently characterized. Scientific validation is needed to support their traditional application and provide evidence for their potential relevance to T2DM management. This study aimed to characterize the phenolic profile, antioxidant potential, and carbohydrate-digestive enzyme inhibitory activity of 21 traditional Moroccan herbal teas used for glycaemic control. Phenolic constituents were identified and quantified using HPLC-MS. Antioxidant capacity was evaluated through DPPH, ABTS, and FRAP assays. Inhibitory effects on α-amylase and α-glucosidase were assessed in vitro. Correlation analyses were conducted to explore associations between phenolic constituents and biological activities. Marked variability in total phenolic content (TPC) was observed, with Mentha × piperita and Thymus broussonetii exhibiting the highest levels at 883.2 ± 13.0 and 746.8 ± 22.4 mg GAE/g dry weight, respectively. Antioxidant activity varied substantially among the investigated teas, with T. broussonetii (FRAP reducing power: 423.6 ± 9.8 µg/mL) and Mentha rotundifolia (162.6 ± 0.6 µg/mL) showing significant reducing capacities. TPC exhibited strong positive correlations with antioxidant indices (r = 0.93-0.96). Pelargonium graveolens presented potent α-amylase inhibition (IC = 2.98 ± 1.7 µg/mL), whereas Mentha viridis and Calamintha officinalis were among the most active α-glucosidase inhibitors (IC = 1.9 ± 0.4 and 1.2 ± 0.1 µg/mL, respectively). Negative correlations were found between rutin (r = - 0.49) and gallic acid (r = - 0.44) contents and α-amylase IC values. The investigated Moroccan herbal teas exhibited variable antioxidant and digestive-enzyme inhibitory activities that were associated with their phenolic composition. Variability among samples may reflect differences in plant species and environmental or agronomic factors. These findings provide comparative in vitro evidence supporting the traditional use of Moroccan herbal teas and highlight several species as promising sources of bioactive phenolics. However, the present findings do not establish therapeutic efficacy, and further in vivo, mechanistic, pharmacokinetic, and clinical studies are required to confirm their efficacy, safety, and clinical relevance.
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3. Harvest-Time-Dependent variations in phytochemistry and in vitro bioactivities of Vitis vinifera Leaves.
PMID:日期:2026-09-26Vitis vinifera L. leaves are rich in bioactive phytochemicals, but their composition and biological activities may vary considerably with harvest time. This study investigated harvest-dependent changes in the phytochemical profile and in vitro biological activities of grape leaves. Methanolic extracts of V. vinifera leaves collected in March, May, and September were evaluated for photosynthetic pigments, total polyphenols, flavonoids, and tannins. HPLC analysis was used to characterize individual phenolic and flavonoid constituents, while major compounds were isolated and structurally identified. The extracts were further assessed for antioxidant and radical-scavenging, antidiabetic, anti-Alzheimer's, anti-inflammatory, anti-arthritic, and cytotoxic activities. Harvest time markedly affected the phytochemical composition and biological activities of the leaves. The May-harvested leaves showed the highest levels of total chlorophyll, polyphenols, flavonoids, and tannins, whereas carotenoids were comparatively higher in the September and March samples. HPLC analysis revealed greater accumulation of phenolic and flavonoid constituents in the May extract, with chlorogenic acid, rosmarinic acid, gallic acid, and naringenin among the predominant compounds. Consistently, the May extract exhibited the strongest antioxidant and radical-scavenging activities and showed superior inhibitory effects in the antidiabetic, anti-Alzheimer's, anti-inflammatory, anti-arthritic, and cytotoxic assays compared with the other harvest periods. Harvest time substantially influences the accumulation of bioactive constituents and the in vitro biological potential of V. vinifera leaves. Among the investigated periods, May appeared to be the most favorable harvest time for obtaining grape leaves enriched in bioactive phytochemicals with promising biological activities, supporting their potential valorization as a value-added viticultural by-product.
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4. The effect of dance movement therapy on traumatized refugee women - a clinical controlled trial.
PMID:日期:2026-09-25Women worldwide are fleeing war, persecution and violence. Typically, they experienced multiple traumata in the home country, on the way, and in the host country. In Germany, less than 10% of the refugees in need receive mental health treatment. Dance movement therapy (DMT) was tested as a treatment option for traumatized refugee women regarding its potential to reduce symptoms of trauma, stress, depression and anxiety. In a controlled within-group design, N = 24 traumatized refugee women from six countries, dwelling in communities of Southern Germany, were tested at baseline (t1), pretest (t2), and posttest (t3), with an exploratory follow-up (N = 10) on symptoms of trauma, stress, depression and anxiety. We employed the RHS-15 as the primary outcome measure, and the DASS21 and PCL-S as secondary measures. Scales were administered in an interview format in the participants' native or a well-spoken language. After an initial 8-week waiting period, the intervention-integrating participants' emotionally meaningful music and their own dance improvisations-was conducted in 8 weekly group sessions of 1.5 h. In the study period, no woman had any other psychotherapy. Results were analyzed with Greebhouse-Geisser corrected F-tests and with t-tests for related samples. Results suggest that (a) the trauma symptoms of all women were clinically relevant at baseline, that (b) all symptoms remained unchanged after the waiting period, and that (c) symptoms of trauma, stress, depression, and anxiety dropped significantly after the DMT intervention; in the case of trauma (PCL-S) so markedly that they fell under the clinical cutoff value. The exploratory follow-up suggests that effects carry on after eight weeks, but not after one year. Limitations of the study are the use of a within-group design, and a relatively small, yet fully powered, sample. The refugee women in this study experienced a pronounced symptom reduction regarding trauma, stress, depression, and anxiety after an 8-week DMT intervention. Based on this preliminary evidence, DMT seems to be a promising low-threshold and cost-effective therapy approach that can improve the mental health and wellbeing of refugee women of diverse cultural backgrounds suffering from PTSD symptoms. The lack of high-quality studies with proper control conditions and follow-ups points to the need for future research with more rigorous methodologies. OSF clinical trial registration (retrospectively registered at Center for Open Science on 27/03/2023). https://doi.org/10.17605/OSF.IO/EG7SD .
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5. Real-life use of non-pharmacological strategies and their relationship with symptom burden in primary dysmenorrhea: a cross-sectional study.
5. 原发性痛经中非药物策略的实际使用及其与症状负担的关系：一项横断面研究PMID:日期:2026-09-17Primary dysmenorrhea is a common health problem among women of reproductive age that negatively affects quality of life. Due to the limitations of pharmacological treatments, many women adopt non-pharmacological strategies. However, little is known about how the use of these strategies relates to multidimensional symptom profiles. This study aimed to examine the association between pain intensity, multidimensional menstrual symptom profiles, and the use of non-pharmacological strategies. This descriptive cross-sectional study included 199 women aged ≥ 18 years. Data were collected using a Descriptive Information Form, the Menstrual Symptom Questionnaire (MSQ), and the Visual Analog Scale (VAS). Descriptive statistics, independent samples t-test, one-way ANOVA, and Pearson correlation analysis were performed. As this was an exploratory study, only unadjusted bivariate analyses were conducted. Statistical significance was set at p < 0.05. The mean age of participants was 23.18 ± 4.30 years, and the mean age at menarche was 13.16 ± 1.41 years. A family history of dysmenorrhea was reported by 60.3% of participants, and 44.7% stated that dysmenorrhea substantially affected daily life. Overall, 68.8% reported using non-pharmacological methods. Among CAM users (n = 137), the most commonly reported methods were heat application (80.3%), massage (35.8%), chamomile or fennel tea (35.8%), and consumption of dark chocolate (32.8%). Pain intensity was positively correlated with MSQ total and subscale scores (p < 0.001). Women using heat application, massage, progressive muscle relaxation, and dark chocolate had significantly higher lower abdominal pain scores than non-users (p < 0.05). Women with primary dysmenorrhea experienced a multidimensional symptom burden extending beyond pain intensity. Greater symptom burden and the use of non-pharmacological methods frequently co-occurred. However, because of the cross-sectional and exploratory design, these findings should not be interpreted as evidence of treatment effectiveness or causal relationships. Routine multidimensional symptom assessment may support patient-centered, evidence-informed counseling on non-pharmacological management options.
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6. Mitigation of serotonin-caused suppression of osteoblast function by extracts of the psychoactive indigenous plant Sceletium tortuosum.
PMID:日期:2026-08-22Sceletium tortuosum is an endemic plant in Southern Africa, traditionally used as kanna by the indigenous people and also exploited commercially due to its mood-elevating properties. Mesembrine, a major alkaloid from this plant, acts as a selective serotonin reuptake inhibitor (SSRI), a group of drugs commonly used in antidepressant therapy but with the undesirable side effect of impairing bone mineral formation. The aim of this study was to investigate the potential effects and mechanisms of extracts from this plant on mineralization. Both aqueous and ethanolic extracts were prepared from S. tortuosum. Their effects on mineralization were studied using bone-forming SaOS-2 cells. In addition to the effects on cell viability and alkaline phosphatase (ALP) activity, the radical scavenging activity of the extracts was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2',7'-dichlorodihydrofluorescein diacetate (HDCF-DA) assays. The alkaloid composition was analyzed by liquid chromatography-mass spectrometry (LC-MS). It is shown that the S. tortuosum extracts, in contrast to SSRIs, have a significant mineralization-promoting activity in vitro. This result was obtained despite the fact that, as is characteristic for SSRIs, the transient attenuation of the serotonin-induced suppression of cell viability that occurs with increasing serotonin concentrations was inhibited in SaOS-2. The activity of ALP, a marker of differentiated osteoblasts, remained unchanged. It was found that the plant extracts exhibit a pronounced radical scavenging activity not only in the DPPH assay, but also intracellularly using the cell-permeant probe HDCF-DA. The alkaloid fraction of the aqueous extract of S. tortuosum consists primarily of the two bioactive alkaloids mesembrine and mesembrenone. Mesembrine proved to be only a weak inducer of mineralization. The results suggest that the observed osteogenic effects of S. tortuosum are due to a tuned interaction with signaling pathways involving serotonin receptors, serotonin transporters and reactive oxygen species. Due to its mineralization-promoting properties, we conclude that S. tortuosum is of potential interest for the long-term treatment of depressive disorders as an adjunct to antidepressant drugs that increase the risk of osteoporosis.
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7. Ginger in supportive therapy against side effects of oncological treatment: a systematic review.
PMID:日期:2026-08-18Oncology patients experience many side effects of their cancer treatment, which can affect their daily life. Phytotherapy is commonly used to reduce side effects or to support the treatment. Especially ginger plays a key role in the treatment of nausea and vomiting. The aim of this systematic review is to summarize the current scientific status of ginger in supportive therapy against side effects of oncological treatment. In January 2025 a systematic search was conducted searching five electronic databases (Embase, Cochrane, PsychInfo, CINAHL, Medline). Studies concerning the use, effectiveness and potential harm of ginger therapy on cancer patients were included. There was no time limit on the publication date of the studies. 25 publications concerning 24 studies with 2409 patients were included in this systematic review after removing publications that did not meet the inclusion criteria. The patients were mainly diagnosed with breast cancer. The therapy concepts include ginger-capsules, -powder, -tea, and aromatherapy. Study outcomes were treatment associated symptoms, e.g. chemotherapy-induced nausea and vomiting, xerostomia, patients' nutrition, fatigue, and quality of life. The studies had low to high quality and reported heterogeneous results: some studies reported significant improved symptoms of chemotherapy-induced nausea and vomiting, xerostomia, nutrition, fatigue, and quality of life, while other studies did not find any changes concerning these endpoints. Furthermore, two studies found disadvantages of ginger concerning chemotherapy-induced nausea and vomiting. Ginger can be considered a promising candidate for complementing the supportive therapy against the side effects of cancer treatment of oncological patients. The data on this is still limited due to heterogeneous results and methodical limitations of the included studies. As this is a systematic review, clinical trial number is not applicable.
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8. Antibacterial characteristics of black currant fruit extracts.
PMID:日期:2026-08-18Our group previously reported on the high bactericidal potential of berry juices, particularly those derived from blackcurrant fruits. In the present study, we tested the efficiency of various juice fractions from blackcurrant fruits (all-fruit juice: AFJ, squeezed juice: SJ, non-dialyzable juice material: NDFM, alcoholic fraction from berry skins: AFBS, aqueous fraction from berry skins: AQFBS) in their efficiency to suppress various oral gram-positive and gram-negative bacteria. AFJ, SJ, NDFM, AFBS, and AQFBS were prepared from freshly harvested blackcurrant fruits. These fractions were used for direct contact tests with planktonic cultures of Fusobacterium nucleatum (F.n.), Aggregatibacter actinomycetemcomitans (A.a.), Porphyromonas gingivalis (P.g.), Streptococcus gordonii (S.g.), Streptococcus mutans (S.m.), Streptococcus sobrinus (S.s.), Actinomyces naeslundii (A.n.), and Enterococcus faecalis (E.f.). AFJ was the most efficient fraction, causing complete suppression of F.n., P.g., and S.g., and inducing a major reduction in A.a., A.n., and E.f. colony count. Bactericidal efficiency of the juices presents as follows: AFJ> AFBS > SJ> AQFBS> NDFM. Gram-negative bacteria were more susceptible to blackcurrant extracts compared to gram-positive species. AFJ efficiency was similar to 0.2% chlorhexidine solution in suppressing F. n., P. g., and S. g. All-fruit juice from blackcurrant shows a strong bactericidal activity on F.n., A.a., P.g., S.g., and A.n. Further research should investigate the potential of blackcurrant fruit extracts in controlling oral biofilm formation.
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9. Chemical investigation and anti-trichinellosis activity of some ficus species leaves: in silico supported in vitro study.
PMID:日期:2026-08-14Worldwide, trichinellosis is a zoonotic illness. Albendazole (ALB), the nowadays anti-trichinellosis drug, has side effects and insufficient effectiveness. Ficus species have ubiquitous health benefits. The current work aimed to assess the in vitro anti-trichinellosis potential of seven Ficus species compared to the reference drug, ALB. Fourteen crude extracts from seven Ficus species (spp.) leaves were prepared using 70% methanol and aqueous solvents. Trichinella spiralis (T. spiralis) adult worms were isolated from infected mice, cultivated on a 24-well tissue culture plate, and subjected to the crude Ficus spp. extracts and ALB in culture media. The efficacy of the tested compounds was evaluated using parasitological analysis and electron microscopy (SEM). Preliminary phytochemical screening and total phenolic content were performed on Ficus spp. extracts showing the most promising effects. In addition, GC-MS analysis was performed on the most active extract to determine its chemical composition. The parasitological analysis revealed that Ficus microcarpa (F.m) had the most promising effects, followed by Ficus sycomorus (F.s) and Ficus nitida (F.n) with the methanolic extracts' LC of 12.8 µg/mL, 31.5 µg/mL, and 42.9 µg/mL, respectively, compared to the ALB (52.5 µg/mL). SEM results documented changes and a loss of the typical tegumental structure and morphology in adult T. spiralis worms. The GC-MS analysis of F.m methanolic extract yielded 26 compounds, including fatty acids, esters, tricyclic diol, and glucosinolates. Molecular docking studies further supported these results, with high binding affinities among the major compounds of F.m and the tubulin beta chain of T. spiralis, an essential protein for parasite survival. The current study emphasizes the promising potential of Ficus species, especially F.m, as natural sources for the development of antiparasitic agents for the therapy of trichinellosis.
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10. Eucalyptus camaldulensis leaf extract enhances thalidomide efficacy in acute myeloid leukemia cells through modulation of mitochondrial energetics.
PMID:日期:2026-08-13Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by high relapse rates and poor prognosis. Leukemic stem cells (LSCs), a major driver of therapy resistance, rely predominantly on mitochondrial oxidative phosphorylation (OXPHOS) for survival. Targeting mitochondrial metabolism represents a promising therapeutic strategy. This study investigated the effect of Eucalyptus camaldulensis Dehnh. leaf extract, alone and in combination with thalidomide, on mitochondrial energetics in AML cells. An in vitro study was conducted using the human AML Kasumi-1 cell line. Cells were divided into four groups: control, thalidomide-treated, E. camaldulensis extract-treated, and combination-treated groups. The ethanolic extract was characterized by GC-MS and HPLC. Cell viability was assessed using WST-1 assay and IC₅₀ values were calculated. Gene expression of CD34, MFN1, MFN2, OPA1, and IL-6 was quantified by qRT-PCR. ATP levels were measured by ELISA. Mitochondrial length was assessed by transmission electron microscopy. E. camaldulensis extract significantly reduced Kasumi-1 cell viability in a concentration-dependent manner, both alone and in combination with thalidomide. The combination demonstrated an additive cytotoxic effect (CI = 1). The IC₅₀ values were 197.80 µg/mL for thalidomide, 30.26 µg/mL for the extract, and 28.26 µg/mL for the combination. Thalidomide alone or combined significantly downregulated IL-6 expression, while thalidomide increased MFN1 expression. The extract significantly downregulated IL-6 and mitochondrial fusion genes and reduced CD34 expression. Extract treatment decreased ATP levels and shortened mitochondrial length compared with untreated cells (p < 0.05). Eucalyptus camaldulensis extract disrupts mitochondrial energetics and LSC-associated pathways in AML cells. Its combination with thalidomide shows additive activity and may represent a complementary strategy to overcome metabolic-driven therapy resistance in AML.