Environmental Chemistry and Ecotoxicology环境化学与生态毒理学
Environmental Chemistry and Ecotoxicology(英文缩写 ENVIRON CHEM ECOTOX),ISSN 2590-1826,eISSN 2590-1826,中文译名:环境化学与生态毒理学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
Environmental Chemistry and Ecotoxicology 最新收录文献
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1. A Streamlined Automated Liquid Handling and 96-Well Solid-Phase Extraction for Single Low-Volume Urine Aliquot Multiclass Biomarker Analysis in Human Biomonitoring.
PMID:日期:2026-08-21Laboratory automation has gained significant importance in large-scale biomonitoring studies, providing notable advantages in sample handling, pre-treatment, and cleanup processes. This study introduces a validated automated 96-well format method for the simultaneous extraction and analysis of various urinary biomarkers belonging to different chemical classes. These chemical classes, listed in alphabetical order, include compounds or their metabolites belonging to cannabinoids, environmental phenols, organophosphate flame retardants, non-persistent pesticides, polycyclic aromatic hydrocarbons, tobacco, and volatile organic compounds. The automated workflow employs an epMotion 5075 vtc workstation for sample preparation, featuring automated sample aliquoting, enzymatic pre-treatment, and solid-phase extraction cleanup, followed by liquid chromatography-tandem mass spectrometry analysis. Method validation was performed using urine quality control pools spiked with 0.1 to 10 ppb of each analyte. Results demonstrated excellent precision, with coefficients of variation below 20% for both native and internal standard responses across the chemical classes. Recovery rates for spiked samples consistently ranged from 80% to 120%, affirming the method's accuracy and reliability. The consistency in performance across different chemical classes and concentration ranges highlights the robustness of the automated method. The automated system effectively quantified biomarkers at low ng/mL concentrations in native (unspiked) urine samples, demonstrating sensitivity that is appropriate for comprehensive exposure assessment studies.