Complementary Medicine Research补充医学研究
Complementary Medicine Research(英文缩写 COMPLEMENT MED RES),ISSN 2504-2092,eISSN 2504-2106,中文译名:补充医学研究 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 1.449 | Q4 |
| 2022 | 1.800 | Q4 |
| 2023 | 1.100 | Q3 |
| 2024 | 0.800 | Q4 |
| 2025 | 1.000 | Q4 |
Complementary Medicine Research 最新收录文献
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1. Stick-Point Massage Combined With Acupuncture for a Large Dorsocervical Fat Pad: A Case Report.
1. Stick-Point Massage联合针刺治疗大型颈背部脂肪垫：一例病例报告PMID:日期:2026-09-18Dorsocervical fat pad is characterized by localized fat accumulation at the cervicothoracic junction and may be associated with neck stiffness, limited mobility, cosmetic concern, and altered cervical biomechanics. Evidence regarding conservative, nonpharmacological management for large dorsocervical fat pads remains limited. This case report describes the clinical course of a patient treated with a combined intervention of stick-point massage and acupuncture. A 51-year-old woman presented with a 2-year history of recurrent neck and shoulder stiffness, pain, discomfort, and dizziness, with aggravation during the preceding 6 months. Physical examination showed a large posterior cervical fatty mass measuring approximately 10 cm x 12 cm. Imaging demonstrated cervical degenerative changes without clear nerve compression or spinal cord involvement. The patient received daily stick-point muscle manipulation massage followed by acupuncture for 1 month. Symptoms improved progressively, the visible dorsocervical mass decreased compared with baseline photographs, the visual analog scale score decreased from 7 to 3, and the Neck Disability Index score improved from 23 to 14. In this case, stick-point massage combined with acupuncture was associated with reduced symptoms and visible improvement of a large dorsocervical fat pad over 1 month. This nonpharmacological integrative intervention may provide a practical conservative option for selected patients, although controlled studies with objective imaging-based measurements and longer follow-up are required.
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2. Bridging 400 Years of Empirical and Scientific Evidence for Regulatory Assessments: A Systematic Appraisal of Arnica montana Using the Pragmatic Historical Assessment (PHA) Tool.
2. 弥合监管评估中400年的经验与科学证据：使用实用性历史评估（PHA）工具对山金车进行系统评价PMID:日期:2026-09-16This case study on Arnica montana applies the newly developed Pragmatic Historical Assessment (PHA) tool to systematically collate and evaluate nearly 400 years of pharmacological and pharmaceutical evidence. By sourcing data from qualified historical and contemporary bibliographic records, the study addresses a critical gap: the lack of a clear methodology for compiling and assessing evidence of traditional use, which currently hampers approvals for indications, plant parts, and posology of traditional herbal medicines within European regulatory frameworks. Data acquisition and triangulation involved four steps: (1) selecting representative sources from three key categories-historical and contemporary medical textbooks by senior clinicians, pharmacopoeial commentaries, and contemporary herbal monographs; (2) applying a coding framework to organise data into a structured matrix for longitudinal analysis of indications, plant parts, preparations, dosages and safety observations; (3) analysing the emergence, persistence, or disappearance of therapeutic uses across historical periods and evidence streams; and (4) triangulating these qualitative data with modern scientific evidence and clinical trials. The convergence of the principal indications of Arnica montana across all bibliographic (qualitative) and scientific (quantitative) evidence streams over ∼400 years indicates that the German-language professional materia medica constitutes a reliable and verifiable record of medicinal plant use. The intergenerational consistency and historical continuity relate to injury recovery (i.e., in modern terms, sprains and strains, torn muscles and ligaments, bruises, oedema, and haematoma), injury-related pain management, and dermatological applications, supporting the validity of longstanding empirical medical knowledge. While similar continuity was observed for internal use of Arnica with low-dose preparations in trauma care, cardiovascular stimulation, infections, and inflammatory conditions, this was disrupted by the 1984 German Commission E decision to restrict all internal use. Most contemporary clinical trials focused on topical applications (e.g., bruises, arthritis, and musculoskeletal injuries and pain) and generally reported positive outcomes, especially when aligned with traditional use parameters. The Arnica case study demonstrates that the PHA tool reliably identifies consistent therapeutic indications, plant parts, posology and safety profiles from the professional materia medica. Triangulation with current regulatory literature and scientific studies confirms the verifiability of long-standing empirical medical knowledge, providing a practical framework for evidence-based assessment of traditional herbal uses. By systematically integrating the professional materia medica as an additional evidence source, the PHA broadens the evidentiary base for herbal therapeutics in Traditional European Medicine (TEM) and supports pragmatic approval assessment in European regulatory systems, thereby facilitating formal patient access to a wider range of traditional plant medicines. Further research is required to assess the tool's robustness across more medicinal plants, medical traditions, and cultural contexts.
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3. Phyto adaptogens in stress management and health optimization: Current understanding and future perspectives.
PMID:日期:2026-09-10Adaptogens are primarily plant-derived bioactive compounds that enhance the body's resistance to physical, chemical, and biological stressors, thereby showing promise in managing stress-related disorders, neurodegenerative diseases, inflammation, and ageing, among others. This narrative review summarizes current evidence on the mechanisms, therapeutic applications, and clinical relevance of adaptogens, particularly in neurological and inflammatory disorders, and identifies limitations and future research directions. This narrative review included peer-reviewed literature from PubMed and Scopus using keywords such as "adaptogens," "stress response," "HPA axis," "neuroprotection," and names of specific adaptogens. Both in vitro and in vivo studies, as well as human clinical trials, were considered. Studies indicate that adaptogens modulate multiple molecular pathways, including the hypothalamic-pituitary-adrenal (HPA) axis, Nuclear Factor - kappa B (NF-κB), mitogen-activated protein kinase 9 (MAPK), and antioxidant defence systems, exerting neuroprotective, anti-inflammatory, immunomodulatory, endocrine-regulating, antifatigue, and mood-enhancing effects. Prominent adaptogens include Withania somnifera, Panax ginseng, Rhodiola rosea, Schisandra chinensis, and Eleutherococcus senticosus. Though pre-clinical findings are promising, clinical trials are often limited by small sample sizes, short durations, and heterogeneity in herbal preparations. Adaptogens demonstrate significant potential in stress management and as adjunctive therapy for chronic diseases. However, further large-scale, standardized clinical studies are needed to confirm their efficacy, elucidate mechanisms, and support integration into mainstream medicine.
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4. Entwicklung einer Definition "Äusserer Anwendungen" - Integrative Review und Delphi-Studie.
PMID:日期:2026-09-05External applications historically are a part of healthcare and nursing. They encompass therapeutic interventions based on naturopathy that act on the skin and nervous system through direct or indirect touch. Despite having been in use for many years, there is still no standard definition. To address this gap, a definition was developed as part of an integrative literature review and agreed upon using the Policy Delphi method. The resulting definition comprises three key sections: 1) the characteristics of external applications, 2) their mechanisms of action, and 3) the various types of application. The findings show that external applications are complex interventions that influence physiological, psychological and social aspects of human beings and can be used in a targeted manner in professional nursing and healthcare settings. The definition developed provides a basis for further research, integration into nursing practice, and for training and quality assurance measures.
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5. Efficacy of Herbal Remedies for Burn: A Scoping Review.
5. 草药疗法治疗烧伤的疗效：范围综述PMID:日期:2026-08-20[中文摘要] 烧伤是一种全球范围内常见的损伤类型。烧伤最常见的致伤原因包括火焰与火、烫伤、接触高温物体、电击和化学物质。本研究旨在对草药治疗烧伤创面的疗效进行系统评价。本系统评价遵循系统评价与荟萃分析优先报告条目（PRISMA）所规定的原则进行文献检索。通过检索六个文献数据库，共发现1，282篇文献。随后应用PRISMA流程对文献进行系统评价，其中50篇文章因重复而被排除。对剩余研究的标题和摘要进行了相关性评估，发现1，216篇不符合纳入标准。在对相关文献进行进一步的合格性审查后，最终共有16篇论文被选入本研究。本综述强调，芦荟是用于烧伤创面最常用的植物，具有减轻炎症、促进增殖和支持重塑等多种益处。本综述强调了草药疗法在烧伤创面愈合中的潜力，草药可促进再上皮化、胶原合成和血管生成。其生物活性化合物具有抗炎、抗菌和再生益处。仍需进一步研究以阐明其作用机制并规范临床使用，整合草药治疗可能有望增强烧伤护理并改善患者结局。
[英文摘要] Burns, a prevalent form of injury that can be found throughout the world. The most common causes of burns are fire and flame, scalding, contact with objects, electrical, and chemical. This study is to conduct a systematic review on the efficacy of herbal medicine in the treatment of burn wounds. This systematic review adhered to the principle set forth by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for performing the literature search. An amount of 1,282 publications were found via searches of six literature databases. The PRISMA process was then applied to systematically review the literature, with 50 articles excluded due to duplicates. The titles and abstracts of the remaining studies were assessed for relevance, and 1,216 were found to not meet the inclusion criteria. After further review of the relevant literature for eligibility, a total of 16 papers were chosen for inclusion in this study. This review highlights that Aloe vera is the most commonly used plant for burn wounds, offering numerous benefits such as reducing inflammation, aiding proliferation, and supporting remodeling. This review highlights the potential of herbal therapies in burn wound healing, with herbs promoting re-epithelialization, collagen synthesis, and angiogenesis. Their bioactive compounds offer anti-inflammatory, antimicrobial, and regenerative benefits. Further research is needed to clarify their mechanisms and standardize clinical use, with the integration of herbal treatments potentially enhancing burn care and improving patient outcomes.
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6. Effect of Electroacupuncture Combined with Dexmedetomidine on Postoperative Cognitive Dysfunction in Hip and Knee Arthroplasty Patients.
PMID:日期:2026-08-14Postoperative cognitive dysfunction (POCD) is a prevalent and burdensome complication in elderly surgical patients, yet effective preventive interventions remain insufficiently established. The potential synergistic effect of combining electroacupuncture (EA) with dexmedetomidine (Dex) on POCD has not been well characterized. In this single-center, prospective, randomized controlled trial, 120 elderly patients were randomly assigned to three groups: the EA group, the Dex (D) group, and the combination (ED) group. All participants underwent elective hip or knee arthroplasty. Of the 120 randomized participants (mean [SD] age, 72.9 ± 5.9 years), 113 completed the study. The incidence of POCD was significantly lower in the EA+Dex group (10%) compared with the EA group (30%) and the Dex group (32.5%) (p < 0.05). Additionally, postoperative serum levels of S-100β, TNF-α, and IL-6 were significantly reduced in the combination group compared with the monotherapy groups (p < 0.05). The findings suggest that the ED group appears superior to the EA group in reducing the incidence of POCD at 1 month after hip or knee arthroplasty in elderly patients, without implying the generalizable efficacy of this combined therapy. The observed reduction in serum biomarkers indicates a potential role of the combination therapy in modulating neuroinflammation. It should be noted that the study design was based on ethical considerations and preliminary evidence supporting the potential efficacy of both EA and Dex interventions. Further multicenter studies are warranted to validate these findings and elucidate the precise mechanisms.
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7. Dose-response relationship between fasting plasma glucose and abnormal lung function in a health screening population.
7. 健康筛查人群中空腹血糖与肺功能异常之间的剂量-反应关系PMID:日期:2026-08-08[中文摘要] 新出现的证据提示糖代谢与肺部健康之间存在复杂关系。然而，空腹血糖（FPG）与肺功能之间关联的性质仍未被充分阐明。本研究旨在探讨这一关联并提供进一步证据。本横断面研究分析了中国健康体检队列中6，597名成年人的数据。肺功能被分为正常和异常两组。采用二元logistic回归分析以识别FPG与肺功能异常风险之间的关联。使用限制性立方样条（RCS）对FPG与肺功能的关系进行建模，并按性别、年龄和BMI进行分层。发现FPG与肺功能异常之间存在显著的非线性剂量反应关系（p < 0.05）。RCS分析显示，FPG从4.78升高至5.6 mmol/L可使肺功能异常风险增加32.0%（OR = 1.32，95% CI：1.17-1.49）。性别差异明显，女性的风险梯度更陡（OR = 1.43，男性为1.29）。超重/肥胖个体（BMI ≥24 kg/m²）表现出更强的关联（OR = 1.45），而正常体重者为（OR = 1.21）。FPG被确定为肺功能异常的独立预测因子，呈现出明显的非线性剂量反应关系。将FPG维持在5.6 mmol/L以下可能有助于预防肺功能损害，凸显了早期血糖监测在预测肺功能方面的重要性。
[英文摘要] Emerging evidence has suggested complex relationships between glucose metabolism and pulmonary health. However, the nature of the association between fasting plasma glucose (FPG) and lung function remains inadequately characterized. This study aimed to explore this association and provide further evidence. This cross-sectional study analyzed data from 6,597 adults in a Chinese health check-up cohort. Lung function was classified into two groups: normal and abnormal. Binary logistic regression was performed to identify the association between FPG and the risk of lung function abnormalities. Restricted cubic splines (RCS) were used to model the FPG-lung function relationship, stratified by sex, age, and BMI. A significant non-linear dose-response relationship (p < 0.05) was found between FPG and lung function abnormalities. RCS analysis showed that increasing FPG from 4.78 to 5.6 mmol/L elevated the risk of lung function abnormalities by 32.0% (OR = 1.32, 95% CI: 1.17-1.49). Gender disparities were evident, with women exhibiting a steeper risk gradient (OR = 1.43 vs. 1.29 in men). Overweight/obese individuals (BMI ≥24 kg/m²) demonstrated a stronger association (OR = 1.45) compared to those of normal weight (OR = 1.21). FPG was determined to be an independent predictor of lung function abnormalities, exhibiting a pronounced non-linear dose-response relationship. Maintaining FPG below 5.6 mmol/L may help prevent lung function impairment, underscoring the importance of early glycemic monitoring in predicting lung function.
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8. Dietary Saturated Fatty Acid and Protein Intakes Are Inversely Associated with Hyperandrogenism Risk among Lean Adult Women: An Analysis of NHANES 2013-2016.
8. 膳食饱和脂肪酸和蛋白质摄入量与瘦体重成年女性高雄激素血症风险呈负相关：基于NHANES 2013-2016的分析PMID:日期:2026-07-16[中文摘要] 高雄激素血症（HA）是一种常见的内分泌疾病，以雄激素分泌过多为特征，对女性健康造成显著不良影响。HA患者既包括体型偏瘦者，也包括肥胖者，且症状各异。HA的治疗方法多种多样，其中饮食控制是关键环节。然而，针对偏瘦型HA患者的饮食研究较为有限。本研究旨在探讨偏瘦成年女性膳食摄入与HA风险之间的关系。本研究对2013—2016年美国国家健康与营养调查（NHANES）数据进行了二次分析，采用多因素logistic回归和限制性立方样条模型，探讨育龄期偏瘦成年女性（BMI <25 kg/m²）中饮食与HA的关联。研究队列共纳入1，141名参与者，其中10.95%被判定为具有HA风险。风险HA组与非风险HA组之间在睾酮水平和游离雄激素指数方面存在显著差异。与无风险HA组相比，风险HA组的饱和脂肪酸（SFAs）和蛋白质摄入量显著较低。加权回归分析显示，SFA/蛋白质摄入量与HA风险呈显著负相关。限制性立方样条分析进一步表明，SFA摄入量与风险HA及睾酮水平之间均存在显著的非线性关系。在美国偏瘦成年女性中，膳食SFA和蛋白质摄入量与HA风险呈负相关。这一发现可能提示SFA和蛋白质摄入在偏瘦成年女性HA风险调控中具有潜在作用。
[英文摘要] Hyperandrogenism (HA) is a common endocrine disorder marked by excessive androgen secretion and substantial adverse effects on women's health. HA patients included both lean and obese individuals with distinct symptoms. HA was treated through diverse methods, with dietary control being a key element. However, research on diets for lean HA patients was limited. We aimed to investigate the relationship between dietary intake and the risk of HA in lean adult women. This study conducted a secondary analysis of 2013-2016 National Health and Nutrition Examination Survey (NHANES) data to investigate diet-HA associations in reproductive-aged lean adult women (BMI <25 kg/m2) using multivariable logistic regression and restricted cubic spline modeling. The study cohort included 1,141 participants, with 10.95% identified as having at-risk HA. Significant differences in testosterone levels and free androgen index were observed between at-risk HA and non-risk HA groups. Intake of saturated fatty acids (SFAs) and protein was significantly lower in the at-risk HA group compared to the non-risk HA group. Weighted regression analysis revealed a significant negative correlation between SFA/protein intakes and HA risk. Restricted cubic spline analysis further demonstrated a significant nonlinear relationship between SFA intake and both at-risk HA and testosterone levels. Among lean adult women in the USA, dietary intake of SFA and protein was negatively correlated with the risk of HA. This finding may point to a potential role of SFA and protein intake in HA risk modulation among lean adult women.
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9. A comprehensive strategy to explore the effects of processing on the medicinal properties of the Herba Siegesbeckiae and the component attribution.
9. 探索炮制对豨莶草药性影响及成分归属的综合策略PMID:日期:2026-07-16[中文摘要] 本研究旨在阐明炮制对豨莶草（Herba Siegesbeckiae，HS）药性的影响，并确定其对大鼠神经-内分泌-代谢酶的调节作用及其组分归属。采用D101大孔树脂从生品和炮制品豨莶草中分离化学成分群（chemical component clusters，CCCs）。运用神经-内分泌-代谢网络表征药性。通过解热、镇痛、抗炎及补肝益肾指标判定药味，同时应用电子舌进行味觉量化。采用化学计量学分析探讨炮制对豨莶草及其化学成分群的影响。生品豨莶草及其化学成分群抑制神经-内分泌-代谢酶活性，对应寒性药性；而炮制品豨莶草及其化学成分群则呈现相反作用，显示温性。药味结果表明，S30、S70和Z70分别贡献辛味、苦味和甘味。味觉结果表明，生品豨莶草的苦味主要来源于S95和S70，Z70则是炮制后甜味升高的核心化学成分群。Z70作为关键组分，协调炮制引发的豨莶草药性与药味的同步变化。
[英文摘要] This study aims to clarify the effects of processing on the medicinal properties of the Herba Siegesbeckiae(HS), and to determine its regulatory on the neural-endocrine-metabolic enzymes in the rat and the attribution of its components. D101 macroporous resin was adopted to isolate chemical component clusters (CCCs) from raw and processed HS. A neuro-endocrine-metabolic network was used to characterize medicinal properties. The indicators of antipyretic, analgesia, anti-inflammatory, and liver-tonifying and kidney-reinforcing were performed to determine medicinal flavor, while an electronic tongue was applied for gustatory taste quantification. Chemometric analyses were used to explore the influence of processing on HS and its CCCs. Raw HS and its CCCs suppressed neuro-endocrine-metabolic enzyme activities, corresponding to a cold medicinal property, whereas processed HS and its CCCs exerted opposite effects and displayed warm properties. The medicinal flavor results showed that S30, S70 and Z70 contributed to the pungent, bitter, sweet flavor respectively. The taste results demonstrated that the bitter taste of raw HS primarily originated from S95 and S70, and Z70 functioned as the core CCCs responsible for elevated sweetness after processing. Z70 acts as the pivotal component coordinating processing-triggered synchronous changes in medicinal properties and medicinal flavors of HS.
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10. Case Series: Real-Life Experience with Vitex Agnus-Castus Extract Ze 440 Medication in Adolescents.
PMID:日期:2026-07-09Menstrual disorders are common in adolescents and can significantly impact quality of life. Nonhormonal treatment options are of particular interest in this population, especially for those not requiring contraception. Vitex agnus-castus (VAC) extract Ze 440 is a well-established phytotherapeutic agent shown to be effective in adult women, though clinical data in adolescents remain limited. This case series presents real-life clinical experience with Ze 440 in 6 adolescent patients aged 12-17 years with various menstrual disorders. Patients were followed in routine clinical practice for up to 6 months. Treatment with Ze 440 demonstrated good efficacy in relieving dysmenorrhea and stabilizing the menstrual cycle. In several cases, the use of non-steroidal anti-inflammatory drugs (NSAIDs) could be reduced or discontinued. Two patients with pronounced hypermenorrhea required additional therapy with tranexamic acid; one of them was switched to norethisterone after 6 months due to poor tolerance of tranexamic acid. Ze 440 was well tolerated, and no adverse events were reported. Ze 440 appears to be a practical, well tolerated, nonhormonal option for managing menstrual disorders in adolescents. It supports the natural menstrual cycle without hormonal suppression. Regular clinical follow-up is recommended to optimize treatment outcomes and adjust therapy as needed.