健康筛查人群中空腹血糖与肺功能异常之间的剂量-反应关系
Dose-response relationship between fasting plasma glucose and abnormal lung function in a health screening population.
摘要(中文译文)
新出现的证据提示糖代谢与肺部健康之间存在复杂关系。然而，空腹血糖（FPG）与肺功能之间关联的性质仍未被充分阐明。本研究旨在探讨这一关联并提供进一步证据。本横断面研究分析了中国健康体检队列中6，597名成年人的数据。肺功能被分为正常和异常两组。采用二元logistic回归分析以识别FPG与肺功能异常风险之间的关联。使用限制性立方样条（RCS）对FPG与肺功能的关系进行建模，并按性别、年龄和BMI进行分层。发现FPG与肺功能异常之间存在显著的非线性剂量反应关系（p < 0.05）。RCS分析显示，FPG从4.78升高至5.6 mmol/L可使肺功能异常风险增加32.0%（OR = 1.32，95% CI：1.17-1.49）。性别差异明显，女性的风险梯度更陡（OR = 1.43，男性为1.29）。超重/肥胖个体（BMI ≥24 kg/m²）表现出更强的关联（OR = 1.45），而正常体重者为（OR = 1.21）。FPG被确定为肺功能异常的独立预测因子，呈现出明显的非线性剂量反应关系。将FPG维持在5.6 mmol/L以下可能有助于预防肺功能损害，凸显了早期血糖监测在预测肺功能方面的重要性。
Abstract
Emerging evidence has suggested complex relationships between glucose metabolism and pulmonary health. However, the nature of the association between fasting plasma glucose (FPG) and lung function remains inadequately characterized. This study aimed to explore this association and provide further evidence. This cross-sectional study analyzed data from 6,597 adults in a Chinese health check-up cohort. Lung function was classified into two groups: normal and abnormal. Binary logistic regression was performed to identify the association between FPG and the risk of lung function abnormalities. Restricted cubic splines (RCS) were used to model the FPG-lung function relationship, stratified by sex, age, and BMI. A significant non-linear dose-response relationship (p < 0.05) was found between FPG and lung function abnormalities. RCS analysis showed that increasing FPG from 4.78 to 5.6 mmol/L elevated the risk of lung function abnormalities by 32.0% (OR = 1.32, 95% CI: 1.17-1.49). Gender disparities were evident, with women exhibiting a steeper risk gradient (OR = 1.43 vs. 1.29 in men). Overweight/obese individuals (BMI ≥24 kg/m²) demonstrated a stronger association (OR = 1.45) compared to those of normal weight (OR = 1.21). FPG was determined to be an independent predictor of lung function abnormalities, exhibiting a pronounced non-linear dose-response relationship. Maintaining FPG below 5.6 mmol/L may help prevent lung function impairment, underscoring the importance of early glycemic monitoring in predicting lung function.
如何引用
AMA
Ying Tang, Tong Wu, Jinhan Nan, Yu Zhu, Ying Zhu, Jia Li, et al. Dose-response relationship between fasting plasma glucose and abnormal lung function in a health screening population.. Complementary medicine research. 2026; doi:10.1159/000552382.
APA
Ying Tang, Tong Wu, Jinhan Nan, Yu Zhu, Ying Zhu, Jia Li, et al (2026). Dose-response relationship between fasting plasma glucose and abnormal lung function in a health screening population.. Complementary medicine research. https://doi.org/10.1159/000552382
GB/T 7714
Ying Tang, Tong Wu, Jinhan Nan, Yu Zhu, Ying Zhu, Jia Li, et al. Dose-response relationship between fasting plasma glucose and abnormal lung function in a health screening population.[J]. Complementary medicine research, 2026 doi:10.1159/000552382.
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