Psychiatry and Clinical Psychopharmacology精神医学与临床精神药理学
Psychiatry and Clinical Psychopharmacology(英文缩写 PSYCHIAT CLIN PSYCH),ISSN 2475-0573,eISSN 2475-0581,中文译名:精神医学与临床精神药理学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 1.360 | Q4 |
| 2022 | 0.700 | Q4 |
| 2023 | 0.500 | Q4 |
| 2024 | 0.600 | Q4 |
| 2025 | 1.600 | Q3 |
Psychiatry and Clinical Psychopharmacology 最新收录文献
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1. The Therapeutic Effect of Methylphenidate Hydrochloride in Conjunction with Sensory Integration Training in Children with Attention Deficit Hyperactivity Disorder.
PMID:日期:2026-01-14Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder with existing treatment challenges, and research on the combined therapy of methylphenidate hydrochloride and sensory integration training for it is inconclusive. Thus, this study explored the clinical efficacy of this combined treatment in children with ADHD, finding it significantly improved relevant scores and reduced adverse reactions, suggesting its potential for wider use. From June 2022 to June 2023, a research sample of 102 individuals diagnosed with ADHD was recruited and allocated into 2 groups at an observation group (n=52) and a control group (n=50). Exclusively methylphenidate hydrochloride extended-release tablets were given to the control group as treatment, whereas the observation group underwent combined therapy with methylphenidate hydrochloride extended-release tablets and sensory integration training. The assessment and comparison of sensory integration and praxis tests, full-scale response control quotient, full-scale attention quotient, Conners' behavior rating scale, and adverse reactions during the treatment period were conducted prior to and following 2 treatment cycles in both the observation and control groups. Prior to treatment, there were no remarkable variations ( > .05) in the scores of sensory integration and praxis tests, Integrated Visual and Auditory Continuous Performance Test (IVA-CPT) scores, and behavior rating scale between the 2 groups. Following the treatment, the observation group exhibited notably superior scores in the sensory integration and praxis test, IVA-CPT, and behavior rating scale, with a notably reduced occurrence of complications, in comparison to the control group ( < .05). To summarize, the utilization of methylphenidate hydrochloride alongside sensory integration training has demonstrated promising effectiveness in treating children diagnosed with ADHD and deserves broader implementation.
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2. Investigating the Effects of Vortioxetine in an Experimental Model of Autism Spectrum Disorder: Role of NOD-like Receptor Protein-3 Inflammasome Pathway.
PMID:日期:2025-12-12The aim of the present study was to investigate NOD-like receptor-3 (NLRP-3)-mediated inflammasome activation in macrophage and microglia cells, which is one of the early step mechanisms in the formation of proinflammatory cytokines, in an autism model and also investigate the possible effect of vortioxetine (VTX), which has a multimodal mechanism of action, in the treatment of autism in a valproic acid (VPA)-induced experimental rat model of autism spectrum disorder (ASD). Male Sprague-Dawley rats were divided into 3 groups: Control (n = 12), ASD (n = 16), and ASD + VTX (n = 16). The VTX (5 mg/kg/day) or saline was administered to the male offspring born from pregnant rats administered VPA (400 mg/kg) or saline, between postnatal 30-45 days. Open field, body splash, and social interaction tests were performed in groups on postnatal days 46-52. The NLRP3 inflammasome components such as NLRP3, caspase-1, and ASC levels were investigated in the prefrontal cortex by real-time polymerase chain reaction. Data were analyzed using 1- or 2-way analysis of variance (ANOVA) and Tukey's multiple comparison tests, and differences of P < .05 were considered statistically significant. The ASD model showed increases in locomotor activity and repetitive behaviors like grooming despite decreases in sociability and social interactions. These findings as well as observational malformations supported the formation of an autism model. It was found that sniffing and following behaviors as social interaction markers were significantly increased and avoidance behavior was reduced with VTX treatment. In molecular analyses, NLRP3 inflammasome components, NLRP3, ASC, and caspase-1 were increased in the ASD model. It was observed that VTX treatment statistically significantly reduced the increased NLRP3, caspase-1, and ASC gene expressions in ASD. In light of the findings of the study, it was thought that the NLRP-3 pathway may have an important role in the neurobiology of ASD. VTX, as a multimodal antidepressant, has some beneficial effects for the improvement of the behavioral and molecular parameters of ASD.
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4. Effects of Buspirone Combined with Mindfulness-Based Cognitive Therapy on Emotional Improvement, Sleep Quality, and Serum Cortisol Level in Patients with Generalized Anxiety Disorder.
PMID:日期:2025-11-13Buspirone shows a certain efficacy in patients with generalized anxiety disorder (GAD), but its combination therapy with mindfulness-based cognitive therapy (MBCT) remains unclear. To compare buspirone + MBCT versus buspirone alone for GAD in a retrospective cohort. According to the treatment regimens, patients were assigned to the experimental group (n = 50) to receive 120 minutes of MBCT sessions per week plus buspirone, or the control group (n = 50) to receive buspirone only. Comprehensive evaluations were conducted at 5 time points (baseline (Week 0, W0), W1, W2, W4, and W8), including clinician-rated measures (Hamilton Anxiety Scale [HAMA]), self-reported symptoms (Hospital Anxiety and Depression Scale - Anxiety [HADS-A]), sleep parameters (Pittsburgh Sleep Quality Index [PSQI] and Athens Insomnia Scale [AIS]), and morning serum cortisol levels (enzyme-linked immunosorbent assay; μg/mL). Group-by-time effects were modeled with repeated-measures mixed models; 2-sided α = 0.05. The combination therapy demonstrated superior outcomes across all measures from W1 onward (all P < .05). By W8, the experimental group showed significantly greater reductions in HAMA (6.1 ± 1.5 vs. 10.1 ± 1.8, P < .001), HADS-A (4.2 ± 1.6 vs. 5.6 ± 1.8, P < .001), PSQI (5.1 ± 2.0 vs. 7.2 ± 2.2, P < .001), and AIS (2.6 ± 1.5 vs. 3.9 ± 1.6, P < .001). Cortisol levels decreased more substantially in the combination group (209.8 ± 33.1 μg/dL vs. 264.0 ± 48.5 μg/dL, P < .001). Treatment effects emerged rapidly, with significant differences in HAMA (P < .001) and cortisol (P < .001) evident by W1. Adverse events were mild and comparable. Adding MBCT to buspirone was associated with faster and greater clinical and biomarker improvements; prospective randomized trials are warranted.
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5. Rethinking Catatonia in Neurodevelopmental Conditions: Toward a Refined Typology and Research Framework.
PMID:日期:2025-11-07Catatonia is a transdiagnostic syndrome observed across psychiatric, medical, and developmental disorders. In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), it is not classified as a stand-alone disorder but as a specifier or syndrome that accompanies other conditions. This review examines the current state of knowledge on catatonia in children, adolescents, and individuals with neurodevelopmental disorders, particularly autism spectrum disorder and intellectual developmental disorders. Several DSM-5-TR criteria overlap with baseline behaviors in these populations, creating a risk of false-positive diagnoses. To improve specificity, a refined framework that requires at least 2 of 5 core signs-stupor/immobility, new-onset mutism, posturing or catalepsy with waxy flexibility, severe negativism or withdrawal, and stimulusindependent excitement/agitation-each demonstrably new or worsened from baseline is proposed. The Bush-Francis Catatonia Rating Scale and its Pediatric Catatonia Rating Scale adaptation is reviewed, highlighting their limitations in developmental contexts. Catatonia typologies relevant to neurodevelopmental conditions are also outlined, the cautious use of the lorazepam challenge test is discussed, and converging neurobiological evidence implicating gamma-aminobutyric acid, glutamate, dopamine, cortico-striato-thalamo-cortical circuitry, and immune mechanisms is summarized. Future directions include psychometric validation of pediatric tools, empirical item reduction, integration of biomarkers, and treatment prediction studies to refine developmental assessment and clinical care.
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6. Comparison of Clinical Outcomes, Diagnosis Timing, or Treatment Differences Based on Motor Subtypes of Delirium in Critically Ill Patients: A Retrospective Study.
PMID:日期:2025-10-24Delirium is a common problem in critically ill patients, and it can increase mortality; however, the epidemiology of delirium, especially based on motor subtypes, is not fully understood. The aim of this study was to compare and identify differences in demographics, treatments, and outcomes between delirium subtypes among critically ill patients with an accurate diagnosis by consultation-liaison psychiatry (CLP). This single-center, retrospective cohort study was carried out from January 1, 2021, to December 31, 2022. All adult patients who were admitted to the intensive care unit (ICU) or high care unit (HCU) and who had been diagnosed with delirium by CLP were enrolled. The main outcome measure was all-cause in-hospital mortality. The subjects were assigned to either the hyperactive delirium group or the hypoactive/mixed delirium group, and backgrounds, treatments, and outcomes were compared between the groups. Among 1910 patients admitted to the ICU and HCU during the study period, 82 adult patients were included in this study. Of these, 62.2% had hyperactive delirium and 37.8% had hypoactive or mixed delirium. The diagnosis, vital signs at admission, and psychotropic drugs for delirium did not differ between groups. In-hospital mortality was higher in the hypoactive/mixed delirium group than in the hyperactive delirium group (16.1% vs. 2.1%; P=.027). Most patient characteristics, diagnoses, severity of vital status, and medications for delirium prescribed by CLP were similar between the 2 groups. However, in-hospital mortality was higher in the hypoactive/mixed delirium group than in the hyperactive delirium group.
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7. Effect of Acceptance and Commitment Therapy on Malnutrition, Psychological Flexibility, and Emotional Well-being in Patients Undergoing Peritoneal Dialysis: A Randomized Controlled Study.
PMID:日期:2025-10-17Malnutrition is prevalent among patients with peritoneal dialysis and is closely related to psychological distress and reduced psychological flexibility. This study aimed to explore the association between psychological status and nutritional health and to evaluate the impact of acceptance and commitment therapy (ACT) on psychological and nutritional outcomes. A total of 75 patients undergoing peritoneal dialysis were assessed for anxiety, depression, psychological flexibility, and nutritional status using self-rating anxiety scale (SAS), self-rating depression scale (SDS), acceptance and action questionnaire-2nd edition (AAQ-II), and modified quantitative subjective global assessment (MQSGA), respectively. Pearson correlation analysis was performed. In a subsequent randomized controlled trial, 52 eligible patients were divided into intervention and control groups. The control group received standard care, while the intervention group received ACT over 4 weeks. Assessments were conducted at baseline, 4 weeks, and 12 weeks. Psychological indicators (SAS, SDS, and AAQ-II) were positively correlated with malnutrition severity (MQSGA) (P < .05). The ACT significantly reduced anxiety, depression, and psychological inflexibility over time compared to controls (P < .05). Nutritional markers including transferrin saturation and hemoglobin also improved in the ACT group (P < .05). The ACT is effective in improving both psychological well-being and nutritional status in patients with peritoneal dialysis. Psychological flexibility may serve as a modifiable target for nutritional rehabilitation in this population.
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8. Earthquake-Related Anxiety and Earthquake Preparedness Plans of Medicine Students.
PMID:日期:2025-10-16Earthquakes are a significant natural disaster, particularly in regions where they occur frequently. Their psychological impact can lead to heightened anxiety, especially among individuals living in earthquake-prone areas. This study investigates the anxiety levels and preparedness behaviors of medical students who face unique stressors due to their future roles as healthcare providers. This cross-sectional study was conducted with 152 6th-term medical students at Marmara University Faculty of Medicine. Data were collected through a survey that included sociodemographic questions, the Beck Anxiety Inventory, and earthquake preparedness measures based on AFAD (Disaster and Emergency Management Authority) recommendations. Statistical analysis was performed using SPSS v25 (IBM SPSS Corp.; Armonk, NY, USA), with a significance level of P < .05. A significant portion (66.9%) of the students reported severe anxiety, while 33.1% showed moderate anxiety. There was no significant difference between genders in anxiety levels. However, women exhibited higher preparedness levels across various items compared to men. Previous earthquake experience was significantly linked to increased preparedness behaviors. Students who had experienced displacement due to an earthquake showed significantly higher preparedness than those who had not. Medical students at Marmara University displayed high levels of earthquake-related anxiety and inadequate preparedness. Factors such as prior earthquake experience and displacement influenced preparedness behaviors, while psychological support did not significantly affect anxiety levels. These findings highlight the need for enhanced disaster preparedness training and psychological support tailored to the unique challenges medical students face. Future research should explore broader populations and the long-term impacts of preparedness education.
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9. Efficacy of Eszopiclone Plus Acupuncture Therapy by Dispersing the Stagnated Liver-Qi and Regulating the Spirit for Treating Chronic Fatigue Syndrome-Related Sleep Disorders.
PMID:日期:2025-10-10To analyze the overall response of eszopiclone plus acupuncture therapy by dispersing the stagnated liver-qi and regulating the spirit (the acupuncture therapy) for treating chronic fatigue syndrome (CFS)-related sleep disorders. A retrospective analysis was conducted on 107 patients with CFS-induced sleep disorders treated at the Hainan Provincial People's Hospital from February 2021 to February 2023. Among these, 50 patients who received eszopiclone tablets were collected as the control group. The remaining 57 patients who received the acupuncture therapy in addition to the treatment in the control group were collected as the observation group. The Pittsburgh Sleep Quality Index (PSQI) was adopted for evaluating sleep quality before and after treatment in both groups. Clinical overall response rate was compared between the 2 groups. An enzyme-linked immunosorbent assay was conducted for measuring fasting serum levels of 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) prior to and post treatment. Adverse reactions in both groups were also recorded. The observation group got significantly lower PSQI scores than the control group (P < .05). The overall response rate of the observation group seemed to be higher than that of the control group (P=.063). The observation group showed significantly higher post-treatment 5-HT and BDNF levels than the control group (both P < .05). Safety profiles favored the observation group, with fewer adverse reactions reported (7.02% vs 22.00%) (P=.026). Eszopiclone plus the acupuncture therapy enhances the efficacy of treating CFS-induced sleep disorders, effectively improves serum 5-HT and BDNF levels in patients, and reduces adverse reactions.
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10. Therapeutic Drug Monitoring of Psychotropic Drugs in Inpatient Psychiatry: Local Practice and Improvement.
PMID:日期:2025-10-10Therapeutic drug monitoring (TDM) is an important tool to personalize psychopharmacotherapy, thereby optimizing its effectiveness and tolerability. Despite consensus on medications, indications, and implementation of TDM, reports indicate a substantial gap between theory and practice. To further investigate this gap, the current application of TDM was assessed in the adult inpatient settings of the University Hospital of Psychiatry and Psychotherapy of Bern, Switzerland. To assess current practice in TDM, drug level measurements were analyzed in 2022. In parallel, an online survey as well as standardized interviews were conducted with the clinic's physicians. To improve TDM applications, a handout was designed with the core items of the TDM guidelines, revised the orders for TDM in the hospital information system, and held an internal lecture on TDM. In clinical practice, TDM was primarily used for clozapine, lithium, and valproate. Other drugs appear to be underrepresented. Although physicians generally rated their knowledge of TDM as good, they identified the need for improvement in medical knowledge. The main source of error in TDM was the incorrect timing of blood samples. There was disagreement among the physicians about the number of TDMs. Therapeutic drug monitoring is well established for clozapine, lithium, and valproate. Compared to the international consensus, physicians applied TDM to a narrower spectrum of psychotropic drugs. Efforts are needed to improve TDM. To optimize TDM, a handout was created, and the TDM request was adapted in the hospital according to guidelines recommendations based on findings of TDM requests, the survey, and interviews.