JDR Clinical & Translational Research牙科研究杂志：临床与转化研究
JDR Clinical & Translational Research(英文缩写 JDR CLIN TRANSL RES),ISSN 2380-0844,eISSN 2380-0852,中文译名:牙科研究杂志：临床与转化研究 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 未收录 | N/A |
| 2022 | 3.000 | N/A |
| 2023 | 2.200 | Q2 |
| 2024 | 2.200 | Q2 |
| 2025 | 2.000 | Q2 |
JDR Clinical & Translational Research 最新收录文献
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1. Salivary Lysozymes, Anti-inflammatory Cardiac Medications, and Cardiovascular Mortality.
PMID:日期:2026-09-11Infections and subsequent innate immune activation may contribute to atherogenesis. Salivary lysozyme (SLZ) is a bactericidal enzyme expressed by neutrophils and macrophages in the innate immune system. SLZ hydrolyzes peptidoglycan (PGN) in the bacterial cell wall and generates muramyl dipeptide (MDP), a ligand for nucleotide-binding oligomerization domain-containing receptors that can trigger innate immune activation, which is an established pathway to atherogenesis. We examined the association between baseline SLZ levels and cardiovascular disease (CVD) mortality in a prospective follow-up study with a median follow-up of 18.8 y. Using Cox regression analyses among 471 subjects, we evaluated the association between CVD mortality and SLZ using restricted cubic spline analyses. We compared CVD mortality in group Q1 (SLZ between 25%ile and 75%ile) and Q2 (SLZ ≥ 75%ile) to the reference group Q0 (25%ile) adjusting for age, sex, smoking status, hypertension, diabetes, dyslipidemia, and education. Next, we tested if innate immunity assessed by SLZ is independent of metabolic inflammation measured by the median C-reactive protein level (CRP). Lastly, we assessed whether anti-inflammatory cardiac medications alter the association between SLZ and CVD mortality, given that angiotensin-converting enzyme inhibitors (ACE-i) and statins are known to decrease systemic inflammation. The multivariable-adjusted hazard ratio for CVD mortality for Q1 was 2.53 (95% confidence limit [CL]: 1.38 to 4.64) and for Q2 was 2.86 (CL: 1.45 to 5.66). The association between SLZ and CVD mortality was independent of CRP level or cardiac anti-inflammatory medications. However, adjusting for some cardiac medications such as ACE-i or statins slightly increased the association between SLZ and CVD mortality. Oral innate immune activation assessed by SLZ was associated with an increased risk of CVD mortality. This association was independent of metabolic inflammation or anti-inflammatory actions of cardiac medications.Knowledge Transfer Statement:The current article reports that salivary lysozymes are markers for oral innate immune activation, which is triggered by many oral infections such as aphthous ulcers, dental caries, gingivitis, and other soft-tissue infections. Our results can be used by clinicians, researchers, and policymakers. Future randomized trials are warranted to corroborate or refute the results presented in this article.
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2. Saliva and Oropharyngeal Swabs as Screening Tools for Mpox: A Systematic Review and Meta-analysis.
PMID:日期:2026-08-20The global mpox outbreak that began in 2020 was declared a public health emergency of international concern in 2024. However, there is limited scientific evidence regarding the use of salivary and/or oropharyngeal swab samples to detect the virus. In this review, we systematically examined existing literature to evaluate the potential of saliva and/or oropharyngeal swab samples as screening tools for mpox detection. The final analysis included 15 articles comprising 2,610 participants, including mpox-infected individuals (polymerase chain reaction confirmed) whose saliva and/or oropharyngeal samples (OPSs) tested positive for the virus. After a quality assessment, a random-effects model with logit transformation was used to pool the positivity rates. The pooled positivity rate of mpox virus DNA was 76.7% (95% confidence interval [CI], 27.9%-96.6%) in saliva and 69.7% (95% CI, 40.1%-88.8%) in OPSs. The high heterogeneity between the studies (I = 99.5%) for both specimen types was addressed through sensitivity analyses. The median shedding durations were 19 and 21 d for saliva and OPSs, respectively. The high positivity rates and sustained shedding in saliva and OPSs indicate that these methods can serve as noninvasive, adjunct, early-phase alternatives for rapid mpox detection, supporting enhanced surveillance, outbreak monitoring, and global public health preparedness.Knowledge Transfer Statement:The findings of this systematic review are directly relevant to clinicians, dental surgeons, and infection control specialists in understanding the diagnostic value of saliva and oropharyngeal samples for mpox. This knowledge can aid in screening, infection control, and patient management within health care settings.
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3. Nonlinear Association between Density of Dental Clinics and Dental Visits among Older Japanese.
PMID:日期:2026-08-20Correcting clinic maldistribution is key to universal health care. The imbalance in dental clinic supply, characterized by both oversupply and undersupply, remains underexplored, and few studies link geographic distribution with patient utilization patterns. This study examined the association between the density of dental clinics and dental visits among the older Japanese population. This repeated cross-sectional study used data from 3 waves (2016, 2019, and 2022) of the Japan Gerontological Evaluation Study targeting functionally independent older adults aged ≥65 y. The dependent variables were dental visits for prevention and treatment. The independent variables were the density of dental clinics based on habitable areas, measured as both categorical and continuous variables. Covariates included age, sex, marital status, equivalent household income, and educational status. Multilevel Poisson regression analysis was conducted to calculate the prevalence ratios (PRs) and 95% confidence intervals (CIs) of preventive and treatment dental visits according to the density of dental clinics. A total of 48,088 participants were included (mean age: 73.9 y, 50.7% of men). Living in an area with the lowest density of dental clinics (0.0000-0.0199 clinics/km) was significantly associated with lower preventive visits (PR = 0.70; 95% CI, 0.57-0.85) and lower treatment visits (PR = 0.78; 95% CI, 0.68-0.91) compared with the highest density category (≥5.00 clinics/km). Similar associations were observed up to the density of 0.400 to 0.599 clinics/km. However, at 0.600 clinics/km or more, there was no increase in dental visits, suggesting an oversupply of dental clinics. Living in an area with fewer than 0.600 clinics/km was significantly associated with lower dental visits, particularly for preventive care. On the other hand, no increase in dental visits was observed at 0.600 clinics/km or more. This study emphasizes the importance of equitable clinic distribution in sustaining access to dental care.Knowledge Transfer Statement:This study suggests that the density of dental clinics is associated with the frequency of dental visits. Additionally, a ceiling effect was observed in this effect, suggesting the possibility of an oversupply of dental clinics. This study provides valuable guidance for researchers and policymakers in assessing dental health systems and addressing the uneven distribution of dental clinics to improve oral health.
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4. Trends in Dental Utilization among Children with Special Health Care Needs.
PMID:日期:2026-08-20To identify trends in dental utilization and factors associated with using dental services before and during the pandemic among children with special health care needs (CSHCNs) aged 0 to 17 y. This cross-sectional study analyzed data from the National Survey for Children's Health (NSCH), including a total sample of 78,006 CSHCNs aged 0 to 17 y from 2016 to 2023. Dental utilization trends across the years, including prepandemic and pandemic periods, were analyzed using chi-square tests of independence, while trends stratified by met and unmet dental needs were assessed using the Cochran-Armitage trend test. Pooled multivariable logistic regression analyses were performed to examine the associations between dental utilization and sociodemographic factors. CSHCNs were 30% more likely to forgo dental care during the pandemic than in prepandemic years (odds ratio = 1.33; 95% confidence interval, 1.27-1.39). Unmet dental needs, age, household poverty level, caregiver education, caregiver employment, insurance coverage, and race were associated with dental utilization among CSHCNs in pooled regression models and in prepandemic and pandemic regression models. This study found lower odds of dental care utilization among CSHCNs during the pandemic. It also demonstrated that factors like unmet dental needs, age, caregiver education, and household poverty level were associated with dental utilization among CSHCNs. Future research should explore the effectiveness of strategies to promote dental care utilization among CSHCNs.Knowledge Transfer Statement:This study found that dental service utilization among CSHCNs significantly decreased during the pandemic compared to prepandemic years. In addition, factors such as unmet dental needs, age, sex, race, caregiver education, insurance coverage, family structure, and household poverty level were associated with dental utilization among CSHCNs. These findings can inform efforts by policymakers to address gaps in access to care and ensure continuity of care, especially during times of instability, such as the COVID-19 pandemic.
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5. Untreated Caries in Persons with Taste or Smell Dysfunction.
PMID:日期:2026-08-11We examined whether taste or smell dysfunction was associated with untreated caries and if sugar intake modified the association. We used cross-sectional National Health and Nutrition Examination Survey (NHANES) data from 5,882 adults aged 40+ who completed the dental examination and Taste and Smell protocols in 2011-2014. Self-reported dysfunction was defined as reporting at least 1 problem with taste and smell. Objectively measured dysfunctions (2013-2014 only) included inability to identify bitter and salty solutions on whole-mouth taste tests and ≤5 odorants correctly identified on the 8-item Pocket Smell Test (PST). Caries was assessed by calibrated dental examiners. Logistic regression estimated the odds and 95% confidence intervals (CIs) for untreated caries among persons with dysfunction compared with those without dysfunction. Covariates included age, sex, race/ethnicity, smoking, flossing frequency, alcohol use, dry mouth, and diabetes. Effect modification by added sugar level (<10% vs. ≥10% of calories) was examined. Results were weighted to account for the NHANES survey design. Fourteen percent of participants self-reported problems with smell, 9% with taste, and 9% with both. Measured taste dysfunction prevalence was 11% to 17%, and 12% had significant smell loss on the PST. Adjusted odds of untreated caries were higher in participants who self-reported both taste and smell problems compared to neither (odds ratio [OR] = 1.38; 95% CI, 1.03-1.84). Added sugar level modified the association between measured ability to taste bitterness and caries: nontasters with high added sugar intake had twice the odds of caries as tasters with low added sugar intake (OR = 2.03; 95% CI, 1.35-3.05). Smell dysfunction alone, self-reported or measured, was not significantly associated with caries. Perceived dysfunction of taste and smell and inability to taste bitterness at high added sugar intakes were associated with increased odds of untreated caries. Screening for chemosensory dysfunction may identify persons with greater risk of dental caries and facilitate referral to a dentist.Knowledge Transfer Statement:Screening for taste dysfunction in primary care and community-based settings may identify persons with greater risk of dental caries and facilitate referral to a dentist.
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6. Oral Nicotine Pouch Use and Associations with Periodontal Status and Salivary Microbiome Dysbiosis.
PMID:日期:2026-08-11Oral nicotine pouches (ONPs) are increasing in use, yet data on potential oral health effects are scarce. We evaluated whether ONP use is associated with clinical periodontal measures and salivary microbiome dysbiosis in a field-based regional sample. We recruited firefighters, as this population has historically featured an elevated prevalence of oral tobacco use. In this preliminary, cross-sectional study, 26 eligible participants (100% male; ages 26-53 y) were enrolled from fire stations near Sacramento, California (USA), in April-May 2025. Clinical measures from full-mouth periodontal examinations (probing depth, gingival margin position, clinical attachment loss, bleeding on probing) were compared between ONP use (≥15 in the past 30 d, no more than minimal use of other tobacco, n = 12) and tobacco nonuse (n = 14) groups. We conducted 16S rRNA gene amplicon sequencing of saliva samples to determine genus-level profiles using differential abundance testing and Bray-Curtis beta diversity analyses. Clinical periodontal measures were numerically worse with ONP use, including a higher percentage of sites with ≥3 mm clinical attachment loss (P = 0.009). Across all samples, approximately 130 genera were detected (Streptococcus most abundant). ONP use (vs. tobacco nonuse) was associated with higher abundance of Comamonas, Alloscardovia, F0058, and Dialister and lower abundance of the [Eubacterium] sulci group, Aminipila, Mannheimia, and Peptostreptococcus. Principal coordinates analysis showed substantial overlap between groups, whereas beta dispersion was lower in the ONP group (P = 0.035). In this hypothesis-generating study, ONP use was associated with worse periodontal status and salivary microbiome shifts. While these results await confirmation in future studies and additional populations, they suggest plausible oral health risks that should be incorporated into any comprehensive assessment of potential ONP harms.Knowledge Transfer Statement:Although preliminary, these findings provide some of the first evidence that use of oral nicotine pouches is associated with indicators of worse periodontal health. These results should encourage further research to confirm these signals and clarify potential mechanisms. Patients, providers, and product regulators should include oral health when evaluating the risk profile of this product.
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7. Multiple Tobacco Product Use and Dental Pain: A Cross-sectional Study.
PMID:日期:2026-08-06Although individual tobacco products, including new tobacco products, have been associated with adverse oral health outcomes, few studies have examined the association between multiple tobacco product (MTP) use and dental pain as an indicator of current oral health status. We conducted a cross-sectional study using data from a nationwide internet survey in Japan. The 2023 survey included the outcome variable, current tobacco product use, and most covariates; however, it did not include the number of remaining teeth, an oral health-related covariate relevant to interpreting dental pain. Therefore, we included participants who responded to the 2023 survey and for whom information on remaining teeth was available from the 2022 survey. Current tobacco product use was assessed for 6 product types: cigarettes, heated tobacco products, electronic cigarettes, cigars, pipe/water pipes, and smokeless tobacco. Participants were categorized as having no current product use, single-product use, or MTP use. The outcome was self-reported dental pain within the past week. Covariates were sex, age, education, household income, living alone, marital status, drinking, self-rated health, psychological distress, number of remaining teeth, and daily toothbrushing. We used multivariable modified Poisson regression to estimate adjusted prevalence ratios (aPRs) and 95% CIs. We analyzed 19,703 participants; the mean age was 50.2 y (SD, 16.9) and 10,165 (51.6%) were men. Overall, 2518 participants (12.8%) reported dental pain within the past week, 2463 (12.5%) used a single tobacco product, and 1040 (5.3%) used MTPs. After adjustment for all covariates, MTP use was associated with a higher prevalence of dental pain (single-product use: aPR, 1.03 [95% CI, 0.92-1.15]; MTP use: aPR, 1.39 [95% CI, 1.25-1.54]). MTP use was associated with dental pain. Longitudinal studies are needed to clarify the temporal and causal relationships between MTP use and oral health.Knowledge Transfer Statement:The findings of this study suggest that collaboration between policy makers in dental and oral health and those in tobacco control may be important for addressing oral health disparities between tobacco users and nonusers.
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8. Beyond Publication: Clinical and Translational Research under Pressure.
PMID:日期:2026-08-03Clinical and translational research (CTR) aims to move scientific knowledge into practice and improve health outcomes. This function is increasingly challenged by declining confidence in institutions, fragmented information environments, and changing roles of researchers in society. CTR's impact depends not only on producing robust findings but also on credibility, legitimacy, and meaningful interaction beyond academia. Expanding roles for both established and early career researchers as public actors bring new opportunities but also risks and structural constraints. The COVID-19 pandemic illustrated both the importance and vulnerability of scientific voices in public discourse. Misaligned academic incentives, limited institutional support, and contested societal environments continue to hinder uptake into policy and practice. CTR will fulfill its promise only if it is embedded in systems that value engagement, support credible actors, and better align scientific work with real-world impact.Knowledge Transfer Statement:The impact of CTR depends not only on evidence generation but also on credibility, communication, and engagement with policy and practice. Clinicians, policymakers, and patients rely on trusted scientific voices and supportive institutions to inform decisions. Recognizing engagement as a core component of research and strengthening institutional and academic support can improve how evidence is translated into care and ultimately enhance health outcomes. The impact of CTR depends on evidence, credibility, communication, and interaction with policy and practice. Strengthening academic support for researchers' engagement improves translation into care and outcomes.
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9. Behavioral Change Techniques to Enhance Adherence to Oral Appliance Therapy in Patients with Obstructive Sleep Apnea: A Qualitative Study.
PMID:日期:2026-08-02To identify behavior strategies that affect adherence to oral appliance therapy (OAT) in patients with obstructive sleep apnea (OSA). One-to-one interviews were conducted to explore the barriers and facilitators influencing adherence. The Behaviour Change Taxonomy model, Behaviour Change Wheel (BCW), and Capability, Opportunity, and Motivation-Behaviour (COM-B) model were used to identify and categorize key behavior strategies. The abovementioned models identified 8 key behavior strategies influencing patient adherence. Strategies facilitating adherence included recognizing OAT benefits (improved sleep, reduced fatigue), establishing routines, using prompts, receiving social support, and employing self-monitoring tools like mobile apps. Barriers included routine disruptions and distractions, while the lack of social encouragement had a neutral effect. Comparing pre- and posttreatment experiences reinforced adherence, as did counseling on the consequences of nonuse. Clinically, strategies such as reinforcing benefits, encouraging habit formation, and promoting self-monitoring should be used to enhance adherence. Identifying individual facilitators and barriers can help tailor interventions for optimal treatment outcomes.Knowledge Transfer Statement:The results of this study can be used by clinicians when deciding how best to support adherence to oral appliance therapy in adults with obstructive sleep apnea. By identifying key barriers and facilitators related to routine formation, perceived treatment benefits, self-monitoring, and social support, these findings can inform patient-centered counseling and follow-up strategies. This may lead to more tailored clinical approaches and improved long-term treatment outcomes.
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10. Oral Potentially Malignant Disorders in Thailand: Regional Variations and Ecological Determinants.
PMID:日期:2026-07-24To quantify the provincial heterogeneity incidence of oral potentially malignant disorders (OPMDs) and explore geographic disparities and ecological determinants in Thailand through Bayesian disease mapping. An observational ecological study analyzed clinically diagnosed OPMDs from Thailand's national electronic health record database (2023 to 2024) except Bangkok. Spatial autocorrelation with spatial Bayesian hierarchical models were used to evaluate their associations with behavioral, socioeconomic, and oral-health determinants. A total of 5,956 OPMDs diagnoses were identified across 76 provinces. The median age at diagnosis was 62 y, with females comprising 68.2%. Lichen planus (45.9%) and leukoplakia (39.5%) were the predominant subtypes. The age-standardized incidence rate was 1.9 per 100,000 (female: 2.5; male: 1.3), peaking at ages 60 to 69 y. Spatial analyses revealed high-risk clusters in northern Thailand and identified smokeless tobacco use, dentist density, and Gini coefficient as significant ecological predictors of the incidence of OPMDs. This population-based analysis demonstrates spatial disparities in the incidence of OPMDs. Contextual social determinants of health including socioeconomic inequality, smokeless tobacco behaviors, and workforce availability contribute to variations in disease distribution at the population level. Strengthening the integration of big data analytics within oral health surveillance systems can enhance timely, evidence-informed decision-making and support the strategic refinement and resource optimization of Thailand's national oral cancer screening benefit package.Knowledge Transfer Statement:The results provide strategic insights for clinicians, public health professionals, and policymakers identifying high-risk geographic areas where preventive interventions and early detection efforts should be prioritized. By clarifying province-specific risk profiles, the study supports the development of targeted health promotion, prevention, and screening strategies aimed at reducing geographic inequalities and improving oral health outcomes.