Journal of Frailty & Aging衰弱与衰老杂志
Journal of Frailty & Aging(英文缩写 J FRAILTY AGING),ISSN 2260-1341,eISSN 2273-4309,中文译名:衰弱与衰老杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 未收录 | N/A |
| 2022 | 3.900 | N/A |
| 2023 | 3.300 | Q2 |
| 2024 | 3.300 | Q2 |
| 2025 | 3.200 | Q3 |
Journal of Frailty & Aging 最新收录文献
-
1. Physical frailty and functional resilience after hip fracture in older adults: a risk-set matched longitudinal study.
PMID:日期:2026-09-15Functional trajectories after hip fracture vary widely; whether physical frailty amplifies excess decline or instead marks poorer functional prognosis remains unclear. To distinguish these roles of physical frailty after hip fracture. Population-based cohort study with risk-set matching and a case-only prognostic analysis. Community-based, China. Adults aged at least 60 years participating in the China Health and Retirement Longitudinal Study, 2011-2020. Hip-fracture cases were matched to up to 4 same-wave fracture-free comparators. Preceding-wave physical frailty was assessed using an adapted Fried score (0-5). Matched models estimated fracture-associated excess activities of daily living (ADL) and instrumental activities of daily living (IADL) change and Fried-score interactions; case-only models estimated the probability of being alive with ADL maintained at or returned to the pre-event level at the next survey. The analysis included 252 cases (mean age at the first fracture-report interview, 70.6 years; 132 [52.4%] women) and 1005 comparator records. Relative to matched comparators, hip fracture was associated with greater ADL and IADL deterioration, with average excess increases of 0.73 difficulties in ADL (95% confidence interval [CI], 0.47 to 0.99) and 0.31 difficulties in IADL (95% CI, 0.09 to 0.53). The ADL contrast did not clearly vary by Fried score (interaction per criterion, 0.03; 95% CI, -0.28 to 0.34). Among cases, the adjusted probability of being alive with ADL maintained at or returned to the pre-event level declined from 72.9% at Fried score 0 to 46.4% at score 3 (risk difference, -26.5 percentage points; 95% CI, -50.3 to -2.8). Physical frailty was associated with poorer functional prognosis, whereas evidence that it modified fracture-associated excess decline was unclear. Functional assessment should span frailty levels; frailty may inform support and follow-up intensity but should not determine rehabilitation access.
-
2. Diagnosis of urinary tract infection in the emergency department - a real infection or an alarming indication for comprehensive geriatric assessment? A retrospective follow-up study.
PMID:日期:2026-09-11To investigate whether urinary tract infection (UTI) diagnoses assigned in the emergency department (ED) were true UTI infections, characterize hospitalized UTI patients, and analyze the 12-month mortality and institutionalization rates. A retrospective study among older adults (75+) who were admitted to the ED in 2017 and diagnosed UTI by the ED physician. Patients were categorized into four groups based on the level of UTI diagnosis and the follow-up treatment location: discharged cystitis, hospitalized cystitis, discharged pyelonephritis, and hospitalized pyelonephritis. Group differences were analyzed using Chi-squared, Fisher´s exact, or Mann-Whitney U tests. Logistic regression adjused for confounders was used to compare symptoms. Kaplan-Meier and Cox regression analyses were applied to asses mortality and institutionalization during the 12-month follow-up. Of 658 ED-diagnosed UTIs, only 354 (54%) had significant bacterial growth in urine cultures. Nevertheless, antibiotics were prescribed in 98% of cases. Institutionalization was significantly higher among hospitalized (31%) than among discharged (11%) cystitis patients (log-rank test, p < 0.001); age, Carlson Comorbidity Index and frailty adjusted HR=2.72, 95% CI 1.62-4.55, p < 0.001). Interestingly, hospitalized cystitis patients had higher institutionalization rates (31%) than hospitalized pyelonephritis patients (15%) (log-rank test, p = 0.003; age and gender adjusted HR=0.52, 95% CI 0.31-0.87, p = 0.014). In ED UTIs are frequently overdiagnosed in older adults, often masking more complex underlying conditions. Because a hospitalization for cystitis serves as a major red flag for institutionalization within a year, these patients require an urgent comprehensive geriatric assessment rather than just a standard infection diagnosis.
-
3. Systemic barriers to geriatric care in South Africa: a qualitative stakeholder-informed analysis.
PMID:日期:2026-09-09该文献暂无摘要。
-
4. Components and classification of frailty and palliative care.
PMID:日期:2026-09-05Globally, the number of people aged 65 years and older is expected to double by 2050. With increasing age, the risk of frailty and the need for palliative care also rise. A shared understanding of how to assess frailty and determine the need for palliative care could support interprofessional collaboration in clinical practice. The transition from a frail condition to palliative care is a dynamic and individualized process. Although frailty and palliative care are distinct concepts, they may overlap. The present study aimed to examine the components of frailty and palliative care in community-dwelling older people. Early recognition by healthcare professionals of the components that contribute to severe frailty can enable the timely initiation of palliative care. Our second aim was to gain insight into whether an individual should be classified as frail or in need of palliative care according to healthcare professionals. We presented fifteen case studies to respondents who were selected based on their specific expertise in the Netherlands and Belgium. Each respondent was asked to identify, for each case study, the components that indicated frailty, palliative care needs, or both. Additionally, they were asked to rate their level of certainty regarding each indication. Wilcoxon tests were employed to assess differences, and regression analyses were conducted to identify the components most strongly associated with frailty and in need of palliative care. In most cases, differences were observed between the identification of frailty and palliative care needs, with par-ticipants indicating that a patient could exhibit components of frailty without necessarily having palliative care needs (p-value < 0.05). In no case were palliative components recognized with greater certainty than components of frailty. The case in our study with the highest certainty score for frailty components showed a significant difference compared to the corresponding certainty score for palliative care needs. Conversely, the case with the highest certainty score for palliative care needs did not differ significantly from the certainty score for frailty components. Our study showed that healthcare professionals use different components to classify individuals as frail or in need of palliative care. In addition, these professionals were more certain in identifying frailty than in identifying palliative care needs, and may be less likely to recognize palliative care needs in their patients, who may already be quite frail. Improved understanding of the progression from frailty to the need for palliative care may support patient-centered care and increase enhance the quality of life for individuals requiring support.
-
5. Intrinsic capacity and self-perceived health among home-dwelling older adults: The HUNT study.
PMID:日期:2026-09-04To describe intrinsic capacity (IC) distribution across age and sex and investigate its subdomains' association with self-perceived health in home-dwelling older adults. This cross-sectional study used population-based data from the Trøndelag Health Study (HUNT). Self-perceived health was assessed by a 4-point Likert scale and dichotomized into good or poor health. IC consists of five subdomains (vitality, locomotion, cognition, psychological, and sensory capacity), assessed in line with the WHO recommendations. Capacity in locomotion and cognition was assessed by the SPPB and MoCA, while the remaining subdomains were assessed through questionnaires. Associations between subdomains and self-perceived health were examined using simple and multiple regression models, adjusting for age and education. We included 8718 home-dwelling older adults (aged 70-101 years; 52.5% women). Good health was reported by 69.8% among those < 85 years and by 48.6% among those ≥ 85 years. High capacity in ≥ 3 subdomains was observed in 79.3% and 40.9% among individuals < 85 years and ≥ 85 years, respectively. High locomotor capacity showed the strongest association with good self-perceived health. The probability of poor self-perceived health increased with lower IC, but among women, significantly less by older age and more by higher education. We observed a strong association between IC and self-perceived health, suggesting that IC is closely linked to individuals' self-perceived health. Our findings support IC as a relevant tool in the shift toward preventive, health-promoting care, and we believe the use of IC can help tailor interventions to optimize functional ability and well-being.
-
7. Association of plasma growth differentiation factor-15 with the frailty phenotype - Evidence from the COGFRAIL study.
PMID:日期:2026-09-04Growth differentiation factor-15 (GDF-15) has been consistently associated with physical frailty. However, it remains unclear whether GDF-15 further discriminates adverse outcomes among older adults who are already physically and cognitively impaired. To evaluate whether GDF-15 is associated with measures of physical frailty - incident weight loss, decline in muscle strength and gait speed, fatigue, and sedentary behaviours - over a 2-year follow-up. Monocentric prospective study SETTING: Frailty and Memory Clinics, Gérontopôle Toulouse University-Hospital. 206 pre-frail and frail older adults with cognitive impairment from the COGFRAIL study with available plasma GDF-15 concentrations (median age 82.0). Secondary analyses were performed in a subgroup with repeated GDF-15 measurements during follow-up (n = 129). GDF-15 concentrations were analysed as a continuous variable and by tertiles. Exploratory analyses used two thresholds: 1500pg/mL (eligibility cut-off for GDF-15 inhibitor treatment in cancer-cachexia) and 2443pg/mL (upper tertile of the 6-month distribution). Higher GDF-15 levels were associated with a steeper decline in handgrip strength over time (p = 0.047), with no significant associations for weight loss, gait speed, sedentary behaviour, or fatigue. By tertiles, participants in the highest tertile had greater handgrip strength decline compared to those in the lowest (p = 0.018). Participants in the intermediate group had a higher risk of worsening frailty (p = 0.013) and incident weight loss (SHR 2.51; 95% CI: 1.04-6.04; p = 0.040) compared with the lowest tertile. Individuals with persistently high or increasing GDF-15 concentrations (≥2443pg/mL) experienced greater decline in handgrip strength than those with persistently low levels (p < 0.001). Higher plasma GDF-15 concentrations consistently predicted a steeper decline in muscle strength over time. Associations with incident weight loss and worsening frailty were also observed, although they appeared weaker at higher concentrations, possibly because of greater competing mortality in participants with very high GDF-15 levels. Further research should clarify the mechanisms linking GDF-15 to physical decline and weight loss, and whether targeting this pathway could help slow frailty progression.
-
8. Effect of seated aerobic exercise on physical endurance in long-term care recipients: secondary analysis of a cluster non-randomized controlled trial.
PMID:日期:2026-09-04Japan's long-term care insurance (LTCI) system provides rehabilitation services. This study examined whether adding seated aerobic exercises to daycare rehabilitation improves endurance and frailty. We performed a secondary analysis of a cluster nonrandomized trial conducted at 10 Japanese daycare facilities. Certified older adults requiring care were enrolled in September 2023. Facilities were allocated to the aerobic program or the usual rehabilitation. The aerobic program included seated stepping and arm movements at 120 bpm for two 2-minute sets during rehabilitation for 6 months. Outcomes included the 2-minute step test, Borg scale, grip strength, Timed Up and Go (TUG) test, Barthel Index, and frailty classification using Japanese Cardiovascular Health Study criteria (J-CHS). Analyses used baseline-adjusted analysis of covariance (ANCOVA) with group, frailty category, and interaction as fixed effects. Mixed-effects models with facility as a random intercept were used for sensitivity analyses. Of 575 screened individuals, 308 were enrolled, and 252 completed the assessment (aerobic, n = 119; usual, n = 133). The aerobic group showed greater 2-minute step test performance (adjusted mean 103.883 vs. 84.494; mean difference 19.388, 95 % CI 7.350-31.426; p = 0.002). Borg scores were lower in the aerobic group (difference -1.093; 95 % CI -2.202 to 0.015; p = 0.053). Other measures showed no significant between-group differences. Frailty distribution differed at 6 months (p = 0.036), with reduced frailty in the aerobic group. Brief seated aerobic exercise within LTCI daycare rehabilitation improved endurance and modestly improved frailty classification. These findings support aerobic exercise in LTCI rehabilitation; however, nonrandom allocation and lack of blinding limit interpretation.
-
9. Fat-free mass index and apixaban exposure in frail hospitalized older adults: An exploratory study.
9. 体弱住院老年人的无脂体重指数和阿哌沙班暴露：一项探索性研究PMID:日期:2026-09-03Reduced muscle mass may influence creatinine-based renal estimates and direct oral anticoagulant exposure in frail older adults. To explore the relationship between fat-free mass index (FFMI) and apixaban trough concentrations in hospitalized older adults. In this retrospective study, FFMI was assessed by bioelectrical impedance analysis in patients aged ≥75 years treated with apixaban. FFMI was considered a body-composition marker, not a diagnostic criterion for sarcopenia. Among 305 screened patients, 43 receiving apixaban 5 mg twice daily with compliant trough sampling were included. Mean age was 83.6 ± 5.8 years. FFMI correlated inversely with apixaban concentrations in the unadjusted analysis (Spearman's ρ = -0.34, p = 0.024). In univariable linear regression, lower FFMI was associated with higher apixaban concentrations (β = -8.64 ng/mL per kg/m², 95% CI -16.15 to -1.13; p = 0.025), but this association was not confirmed after adjustment for sex and serum creatinine (adjusted β = -6.77, 95% CI -15.20 to 1.65; p = 0.112) or in the sensitivity analysis including both dose groups (n = 82; ρ = -0.06, p = 0.575). Body weight, BMI, and creatinine-based renal estimates were not significantly associated with apixaban concentrations. An inverse relationship between FFMI and apixaban trough concentrations was observed in the unadjusted primary analysis but was not confirmed after multivariable adjustment or in the sensitivity analysis. This preliminary signal should be considered hypothesis-generating and requires confirmation in larger prospective studies.
-
10. Higher cystatin C, but not creatinine, predicts frailty risk in individuals with normal kidney function.
PMID:日期:2026-09-03This study investigates the associations of creatinine and cystatin C with frailty risk in individuals with normal kidney function, using data from the Health and Retirement Study (HRS) and the China Health and Retirement Longitudinal Study (CHARLS). We used CKD-EPI to estimate glomerular filtration rate based on serum creatinine (eGFR) and cystatin C (eGFR), respectively, and an eGFR ≥60 was considered "normal kidney function". Frailty was assessed using a frailty index derived from clinical and functional measures. Cox proportional hazards models were used to evaluate the associations of creatinine and cystatin C with incident frailty, adjusting for demographic, lifestyle, and clinical covariates. Creatinine levels showed no significant association with frailty risk in individuals with normal kidney function across both cohorts. In contrast, cystatin C levels were consistently and significantly associated with an increased risk of frailty in individuals with normal eGFR. For each 1-unit increase in cystatin C, the adjusted hazard ratios (HRs) were 2.05 (95% CI: 1.30-3.22) in HRS and 2.12 (95% CI: 1.60-2.82) in CHARLS. Quartile analyses revealed a dose-response relationship, with the highest quartile of cystatin C associated with significantly higher frailty risk compared to the lowest quartile (HRS: HR = 1.34, 95% CI: 1.02-1.76; CHARLS: HR = 1.70, 95% CI: 1.40-2.07). Higher cystatin C levels, but not creatinine levels, were significantly associated with an increased risk of frailty among individuals with normal kidney function, suggesting that cystatin C may be a useful biomarker for early identification of frailty risk.