Micro and Nano Systems Letters微米与纳米系统快报
Micro and Nano Systems Letters(英文缩写 MICRO NANO SYST LETT),ISSN 2213-9621,eISSN 2213-9621,中文译名:微米与纳米系统快报 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
Micro and Nano Systems Letters 最新收录文献
-
1. Enhanced operation of female reproductive microphysiological system (MPS) for rapid mechanistic study.
PMID:日期:2025-12-19Microphysiological systems (MPS) have shown their capabilities in mimicking in vivo-like structural and functional complexity and are seeing significant increase in their utilization in the field of drug discovery and toxicology. However, the major time-consuming steps in the fabrication, utilization, and analyses of MPS devices limit the throughput for broader adoption. Here, we advanced the previously developed two-chamber MPS model of the female reproductive tracts from a single unit chip to an array type chip that is compatible with multi-channel pipettor or automated liquid handling robot for rapid and more efficient operation. To enable this array model, a new microfabrication method was developed, incorporating a microplate holder, bonding guide plate, and soft lithography cassette to minimize device-to-device variation. To validate its compatibility with multi-channel pipettors in chemical toxicity testing, cadmium, a chemical previously shown to elicit cytotoxicity in the two-chamber feto-maternal interface MPS model, was utilized to demonstrate highly uniform cell loading (variance < 100 cells/mm) and consistent dose-dependent cytotoxic response. Additionally, a liquid handling robotic system was also utilized, with no operational errors such as air bubble introduction (zero bubbles out of 100 devices) during cell/chemical loading process, and no unintended cytotoxic effects (> 97% viability). These results highlight that this automation-compatible array type MPS device can provide highly consistent cell culture performance and significantly reduced chip-to-chip and operation-to-operation variations, overcoming the limitations of typical MPS devices. The online version contains supplementary material available at 10.1186/s40486-025-00246-0.