Advanced Healthcare Materials先进医疗材料
Advanced Healthcare Materials(英文缩写 ADV HEALTHC MATER),ISSN 2192-2640,eISSN 2192-2659,中文译名:先进医疗材料 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 11.092 | Q1 |
| 2022 | 10.000 | Q1 |
| 2023 | 10.000 | Q1 |
| 2024 | 9.600 | Q1 |
| 2025 | 11.000 | Q1 |
Advanced Healthcare Materials 最新收录文献
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1. Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening.
1. 用于乳腺癌建模的3D生物打印进展：肿瘤微环境、转移与药物筛选PMID:日期:2026-10-05The tumor microenvironment (TME) is a complex and heterogeneous milieu encompassing biological and biochemical events and diverse physical, chemical, and mechanical interactions between tumor and stromal cells. This heterogeneity plays a pivotal role in regulating tumor progression, metastasis, and resistance to therapy. In breast cancer, cancer-associated fibroblasts, adipocytes, endothelial cells, and immune cells all contribute to this intricate environment, necessitating precise spatial and cellular modeling to better replicate physiological conditions. Moreover, angiogenesis and metastasis are key contributors to breast cancer mortality. Therefore, three-dimensional (3D) models that incorporate co-cultures of cancer and stromal cells are essential for recreating realistic TMEs. This review highlights the advances in 3D bioprinting technologies for modeling the breast cancer TME. We discuss their potential in drug screening, explore their advantages and limitations, and outline future directions to enhance their fidelity and translational relevance.
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2. Synthesis, Preclinical Evaluation, and Clinical Application of the FAPI-Dimer Based on the LARM Platform.
2. 基于LARM平台的FAPI二聚体的合成、临床前评估及临床应用PMID:日期:2026-10-04Fibroblast activation protein (FAP) is a promising pan-tumor target for theranostics, but current FAP-targeted radioligands are limited by insufficient tumor retention and suboptimal therapeutic doses. To address these challenges, we developed a novel LARM platform and synthesized the FAPI dimer TH2103-100. The radiochemical labeling efficiency of TH2103-100 with Ga was nearly 100% at room temperature (radio-TLC), significantly surpassing that of FAPI-04 (35.28% at room temperature and 79% at 95°C). The radiochemical purity of Ga-TH2103-100 was >97%. In vitro experiments demonstrated that Ga-TH2103-100 exhibited superior cellular uptake and enhanced binding affinity. In vivo experiments showed that, compared with FAPI-04, tumor uptake was increased by 3.9-fold with prolonged retention and no significant toxicity. In healthy volunteers, the effective dose was 3.69E-02 mSv/MBq. Preliminary clinical studies showed that Ga-TH2103-100 exhibited promising diagnostic performance compared to F-FDG. The LARM-based Ga-TH2103-100 enables efficient room-temperature labeling and superior tumor targeting, providing complementary diagnostic value for cases with inconclusive F-FDG PET/CT findings and offering a new paradigm for next-generation FAP-targeted molecular imaging agents, while its potential as an adjunct to F-FDG warrants further validation.
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3. Cell-Free DNA as a Biomarker of Cell Death and Treatment Response for On-Chip Three-Dimensional Tumor Models.
3. 游离DNA作为芯片三维肿瘤模型细胞死亡和治疗反应的生物标志物PMID:日期:2026-10-04On-chip 3D cancer models are important tools to investigate treatment response and tumor biology. With their increasing adoption, there is a need for non-destructive methods that enable the sequential monitoring of cell death and tumor response over time. This study presents quantifying cell-free DNA (cfDNA) as a proxy for cell death for on-chip 3D sarcoma models. qPCR analysis of media cfDNA from spheroids and micro-dissected tumor explants (MDTs) generated from SK-LMS-1 and MCA-205 cell lines cultured on microfluidic chips showed a correlation between baseline cfDNA concentration and on-chip tumor burden. Furthermore, cfDNA levels increased in a dose-dependent manner following cytotoxic treatments, including staurosporine and hydrogen peroxide. Single-dose radiation therapy also raised cfDNA levels in media from MCA-205 but not SK-LMS-1 MDTs, in accordance with their 2D culture response. Finally, cfDNA release within the first days of culture was shown to reflect patient-derived MDT survival, addressing a critical unmet need for ex vivo culture. This study suggests that media cfDNA quantification could be used as a reliable, non-disruptive, and rapidly quantifiable measure of cell death for on-chip 3D models, which facilitates more robust use of 3D model systems for pre-clinical assessment of treatment-induced cell death and biological response.
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4. A Thermosensitive Mucoadhesive Hydrogel for Nasal Influenza Vaccine Delivery Elicits Robust Systemic and Mucosal Immunity.
4. 一种用于鼻内流感疫苗递送的热敏黏膜黏附水凝胶可引发强效的全身和黏膜免疫PMID:日期:2026-10-03Influenza virus invades the host through the respiratory mucosa, making local immunity at the infection site critical for blocking transmission. However, the nasal mucus-cilia clearance barrier severely hinders antigen retention and limits the efficacy of mucosal vaccines. Here, we developed a thermosensitive hydrogel based on cationic chitosan (CS) for codelivery of hemagglutinin (HA) protein and CpG adjuvant (Gel-Pro-CpG). This platform remains a low viscosity liquid at 25°C for convenient nasal administration, and rapidly undergoes sol-gel transition upon contact with the nasal mucosa (∼34°C), forming a mucoadhesive porous depot that significantly prolongs antigen residence and resists ciliary clearance. In a mouse model, Gel-Pro-CpG synergistically elicited strong immune responses and elevated secretory IgA (sIgA) titers in both nasal mucosa and lungs, establishing an effective mucosal immune barrier. Immunization with Gel-Pro-CpG conferred complete protection against lethal H1N1 challenge, markedly reducing pulmonary viral loads and pathological damage. By overcoming nasal physiological barriers and enabling sustained antigen release, this thermosensitive mucoadhesive hydrogel platform offers a promising strategy for inducing coordinated mucosal-systemic immunity and provides a new direction for developing highly effective vaccines against respiratory infections.
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5. {"_":"In Situ Construction of β-TCP-Containing Bioactive Interfaces on Additively Manufactured AlO/Ce-TZP Ceramics for Enhanced Osseointegration.","sub":["2","3"]}
PMID:日期:2026-10-03High-performance zirconia ceramics possess excellent mechanical reliability but are limited by biological inertness for load-bearing implant applications. Herein, stereolithography (SLA) additive manufacturing combined with microwave-assisted liquid-phase deposition was developed to construct a β-tricalcium phosphate (β-TCP)-containing bioactive interface on AlO/Ce-TZP ceramics. Unlike conventional post-fabrication coating strategies, SLA was utilized as an interface-engineering approach by generating favorable near-surface characteristics for subsequent CaP integration. The SLA-derived interface exhibited a graded CaP/zirconia transition region of approximately 2 µm and enhanced interfacial resistance, with the mean nano-scratch critical load increasing from 10.15 ± 4.93 mN for DP to 21.68 ± 4.18 mN for SLA (n = 3). In vitro evaluations demonstrated low hemolytic response and favorable cytocompatibility, together with enhanced BMSC adhesion and osteogenic differentiation. In vivo rabbit tibial implantation further demonstrated favorable biocompatibility within the evaluated period and improved osseointegration, with 15Ca-TZP implants achieving a bone-implant contact value of 55.6% at 12 weeks. This study presents an interface-engineering strategy that integrates additive manufacturing-derived structural advantages with bioactive functionality for zirconia-based load-bearing implants.
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6. Human iPSC-Derived Tissue-Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model.
6. 人诱导多能干细胞衍生的组织工程黑质纹状体通路用于大鼠帕金森模型中多巴胺能轴突束的长期修复PMID:日期:2026-10-03Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopamine-producing neurons in the substantia nigra, causing motor symptoms. Current surgical interventions fail to restore the native nigrostriatal pathway essential for dopamine regulation. We have developed tissue-engineered nigrostriatal pathways (TE-NSPs) using hyaluronic acid hydrogel microcolumns with a collagen/laminin core encasing aggregated dopaminergic neurons and long-projecting axon tracts. TE-NSPs fabricated using human iPSC-derived dopaminergic neurons extended bundled axon tracts at a rate of 1 mm/day-twice that of neuronal aggregates on planar surfaces. Fully grown engineered microtissue exhibited nigrostriatal-like cytoarchitecture, appropriate dopaminergic phenotypes, evoked dopamine release, and innervation of striatal neurons in vitro. TE-NSPs were then evaluated in a rat 6-OHDA PD model via histology and voltammetry at 3- and 6 months post-implantation. TE-NSPs showed dopaminergic neuronal survival in the substantia nigra, preserved axon tracts within the microcolumn, and outgrowth into host striatum. Voltammetry on ex vivo brain slices containing the implanted microtissue revealed evoked dopamine release at both 3- and 6-months post-implant. This study shows engineered microtissue fabricated using human cells with an anatomically-inspired architecture and subsequently used for chronic replacement of a long-distance brain pathway in a preclinical model, potentially offering a promising future treatment for pathway reconstruction in PD.
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7. "Trojan Horse"-Inspired Bionic Coating of Mesh-Like Assembled Lysozyme Nanofibers for Anti-Infection, Anti-Oxidative Stress and Bone Repair.
7. 受“特洛伊木马”启发的网状组装溶菌酶纳米纤维仿生涂层用于抗感染、抗氧化应激和骨修复PMID:日期:2026-10-01Bacterial biofilm infection and sustained oxidative stress response seriously affect the osseointegration of bone implants. Here, this study developed a bioactive Mg loaded tannic acid (TA)/lysozyme amyloid protein fiber (LAPF) composite antioxidative coating to enhance antibacterial, antioxidative and pro-osteogenic functions of bone implants. Inspired by "Trojan horse", the mesh-like TA/LAPF coatings exhibited good antibacterial properties, significantly inhibiting the formation of bacterial biofilms. Interestingly, the TA/LAPF coatings cleared 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) free radicals obviously (scavenging rate of 83.46 ± 1.43%), and inhibited intracellular reactive oxygen species (ROS) of bone marrow mesenchymal stem cells (BMSCs) under an oxidative stress environment. In addition, the biomimetic LAPF coatings exhibited good blood compatibility, promoting the migration of human umbilical vein endothelial cells (HUVECs) and angiogenesis effectively. Notably, the (TA/LAPF)+Mgcoatings could effectively improve early adhesion of BMSCs, and exhibited both great in vitro alkaline phosphatase (ALP) activity and osteogenic mineralization. In 6-week implantation experiments, Mg loaded TA/LAPF coating significantly inhibited in vivo bacterial growth and promoted bone regeneration. The biomimetic mesh-like coatings of antibacterial protein-based nanofiber provide important guidance for the design of anti-infection scaffolds in surface engineering of bone repair.
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8. Polymer-Based Antibacterial Hydrogel Microneedles for Wound Healing.
PMID:日期:2026-10-01Antibacterial hydrogel microneedles (HMNs) have emerged as promising wound-care platforms by integrating the therapeutic versatility of hydrogels with the minimally invasive tissue penetration of microneedles. This review summarizes recent advances in antibacterial HMNs, focusing on the interplay among material composition, structural architecture, antibacterial mechanisms, and wound-specific therapeutic requirements. Natural and synthetic polymers, together with functional modification and composite strategies, are discussed in relation to mechanical integrity, biocompatibility, and drug-loading capacity. Antibacterial strategies, including antibiotic delivery, metal ion-mediated activity, photothermal therapy (PTT) and photodynamic therapy (PDT), reactive oxygen species (ROS) regulation, antimicrobial peptides (AMPs), and biofilm-targeted approaches, are further examined from the perspectives of antibacterial mechanisms and biosafety. In addition, fabrication strategies and wound-specific applications are systematically reviewed. Based on these advances, a pathology-oriented design framework is proposed to guide the rational coordination of material selection, functionalization, structural engineering, and spatiotemporally controlled delivery. Finally, key challenges in biosafety, standardized evaluation, scalable manufacturing, sterilization, and clinical translation are discussed. This review provides a framework for the rational development of clinically relevant and multifunctional antibacterial HMNs for advanced wound management.
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10. Janus-Structured Poly(Lipoic Acid-co-Caffeic Acid) Patch for Asymmetric Underwater Adhesion in Sutureless Gastric Perforation Treatment.
PMID:日期:2026-09-30Bioadhesives for internal organ repair suffer from weak underwater adhesion, poor mechanical compatibility and indiscriminate tissue adhesion. Herein, we report the synthesis of poly(lipoic acid-co-caffeic acid) (poly(LA-CA)) exhibiting tunable adhesive and mechanical properties according to the polymer configuration. By copolymerization of caffeic acid, thermal polymerization of lipoic acid yields branched copolymer of poly(LA-CA), which is viscous and highly adhesive in wet conditions, while radical polymerization initiated by ammonium persulphate produces elastic and non-adhesive linear poly(LA-CA). Robust asymmetrically adhesive Janus patch is then fabricated by coating a branched poly(LA-CA) layer on a linear copolymer substrate. The patch demonstrates combined performances, particularly showing universal, tough, and sustained adhesion in various environments, together with antioxidant, anti-inflammatory and antibacterial properties. Using the Janus poly(LA-CA) patch, gastric perforations of as large as 1 cm in diameter are cured in Bama miniature pigs without suturing. The sutureless treatment simultaneously prevents postoperative adhesion and gastric fluid leakage, resulting in 100% survival of the animals, superior to conventional suture repair method. The poly(LA-CA) material is promising for soft tissue injury repair with high clinical translation potential.