Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy(英文缩写 SIGNAL TRANSDUCT TAR),ISSN 2095-9907,eISSN 2059-3635 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-21 至 2026-09-21，按本站收录文献的发表日期统计。
指标来源：jcr_cas_ifqb
期刊简介
暂无简介。
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 38.120 | Q1 |
| 2022 | 39.300 | Q1 |
| 2023 | 40.800 | Q1 |
| 2024 | 52.700 | Q1 |
| 2025 | 81.200 | Q1 |
Signal Transduction and Targeted Therapy 最新收录文献
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2. Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities.
PMID:作者:日期:2026-09-18Chromosomal instability (CIN) refers to a high rate of chromosome segregation errors during consecutive cell divisions and is a hallmark of cancers with aggressive behavior and poor prognosis. Cancer cells exhibiting CIN may acquire both numerical (N-CIN) and structural (S-CIN) chromosome alteration…
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3. An integrated multiomic single-vesicle atlas delineates graft exosome heterogeneity in chronic lung allograft dysfunction.
PMID:作者:日期:2026-09-17The underlying mechanisms of exosomes in chronic lung allograft dysfunction (CLAD) remain poorly understood. The primary challenge lies in the substantial functional heterogeneity of exosomes in CLAD. In this study, lung transplantation was initially performed, followed by the generation of a chroni…
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4. Targeting super elongation complex-driven RNA polymerase II elongation reduces plaque vulnerability.
PMID:作者:日期:2026-09-17Atherosclerotic plaque rupture is a major cause of myocardial infarction and stroke, yet the mechanisms governing plaque stability remain incompletely understood. Endothelial activation can trigger endothelial-to-mesenchymal transition, a program linked to endothelial dysfunction and lesion vulnerab…
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5. {"_":"SCF regulates osteoblast differentiation through targeting RUNX2.","sup":["JFK"]}
PMID:作者:日期:2026-09-16RUNX2 (Runt-related transcription factor 2) is a master regulator of osteogenesis, and its genetic mutations are associated with ~65% cases of cleidocranial dysplasia (CCD), an autosomal dominant abnormal bone development disorder in humans with defective intramembranous bone formation. However, how…
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6. HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma.
PMID:作者:日期:2026-09-16Cancer cells must deal with excessive reactive oxygen species (ROS) to survive severe hypoxia and anticancer therapy; however, anti-ROS mechanisms other than the well-known NFE2L2/NRF2 signaling pathway are poorly recognized. Here, we report a ROS scavenging mechanism mediated by HIF1α-KLF4-induced …
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8. Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.
PMID:作者:日期:2026-09-15Liver aging significantly impairs hepatic function and regenerative capacity, increasing the risk of morbidity and mortality from chronic liver diseases. Identifying molecular regulators of these processes may reveal promising therapeutic targets. Although Hepassocin (HPS), a hepatokine with known h…
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9. Interleukin-1 receptor-associated kinase 1 controls chemoresistance and immuno-killing in non-small cell lung cancer.
PMID:作者:日期:2026-09-15Non-small cell lung cancer (NSCLC) shows partial chemoimmunoresistance, driven by the upregulation of the drug efflux transporters ABCB1 and ABCC1 and the downregulation of the immunosensitizer protein ABCA1. To elucidate the molecular mechanisms underlying this chemoimmunoresistant phenotype, by pe…
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10. The histone deacetylase family in health and disease.
PMID:作者:日期:2026-09-15Zinc-dependent classical histone deacetylases, including Classes I, II, and IV, are ubiquitously present in mammals and play vital roles in numerous biological processes. To date, eleven histone deacetylase members have been identified, namely, histone deacetylase 1 through histone deacetylase 11. A…