Korean Journal of Family Medicine韩国家庭医学杂志
Korean Journal of Family Medicine,ISSN 2005-6443,中文译名:韩国家庭医学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
Korean Journal of Family Medicine 最新收录文献
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1. Nonarteritic anterior ischemic optic neuropathy after rapid weight loss during semaglutide therapy: a case report.
1. 塞马格利特治疗期间体重快速下降后的非动脉性前部缺血性视神经病变：病例报告PMID:日期:2026-09-18Semaglutide, a glucagon-like peptide-1 receptor agonist, is increasingly used for obesity management; however, concerns have recently emerged regarding potential ocular adverse events, including nonarteritic anterior ischemic optic neuropathy (NAION). Herein, we report a case of NAION that developed after marked, rapid weight loss during semaglutide therapy in a young man with multiple vascular risk factors. A 42-year-old man presented with acute visual disturbance in the right eye after losing approximately 40 kg over 2 months while receiving semaglutide (Wegovy) for obesity treatment. The patient's medical history included diabetes mellitus, hypertension, dyslipidemia, and a history of smoking. Ophthalmic examination revealed right optic disc edema and a corresponding inferior visual field defect. Magnetic resonance imaging and laboratory investigations revealed no other definite causes of optic neuropathy. He was diagnosed with NAION, which was temporally associated with semaglutide therapy and rapid weight reduction. Semaglutide was discontinued, and high-dose intravenous methylprednisolone was administered. At 6 months, the optic disc edema had resolved, leaving mild disc pallor, though the visual field defect persisted. Although causality cannot be established from a single case, this report highlights the need for clinical vigilance regarding optic neuropathy in patients receiving semaglutide, particularly in the setting of rapid weight loss.
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3. Association between phase angle and albuminuria in Korean adults aged 40 years or older: a cross-sectional study of the 9th Korea National Health and Nutrition Examination Survey (2022-2023).
PMID:日期:2026-09-07Phase angle (PhA), derived from bioelectrical impedance analysis, reflects cellular health and membrane integrity and is reduced in chronic diseases. Albuminuria is an early marker of endothelial and microvascular injury and predicts renal and cardiovascular diseases. This study aimed to investigate the association between PhA and albuminuria in Korean adults aged 40 years or older. We conducted a cross-sectional analysis of data from the 9th Korea National Health and Nutrition Examination Survey (2022-2023). After excluding participants younger than 40 years of age, those with diabetes, elevated serum creatinine levels, and those with missing data, 3,283 adults (1,495 men and 1,788 women) were included. Whole-body PhA at 50 kHz was used as the independent variable. Albuminuria was defined as a urine albumin-to-creatinine ratio of ≥30 mg/g. Survey-weighted, sex-stratified multivariate logistic regression models were adjusted for age, lifetime smoking, drinking frequency in the previous year, hypertension status, body mass index, glycated hemoglobin, low- and high-density lipoprotein cholesterol, triglycerides, serum creatinine, blood urea nitrogen, high sensitivity C-reactive protein, and skeletal muscle mass index. Albuminuria was identified in 7.0% of the participants (7.2% of men and 6.9% of women). In women, each 1° increase in PhA was associated with substantially lower odds of albuminuria (adjusted odds ratio, 0.47; 95% confidence interval, 0.26-0.86). In men, the relationship showed a J-shaped pattern, with the lowest risk at mid-range PhA values and a marked increase at higher values; both linear and quadratic PhA terms were significant. In Korean adults, PhA showed sex-specific associations with albuminuria, with an inverse association in women and a J-shaped association in men. As a noninvasive and widely available measure, PhA could potentially serve as a supplementary tool for identifying individuals at risk for early renal microvascular injury.
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4. Gold Standards Framework to identify palliative care needs in primary care: a qualitative study of implementation in Brunei Darussalam.
4. 黄金标准框架用于识别初级保健中的姑息治疗需求：文莱达鲁萨兰国实施情况的定性研究PMID:日期:2026-08-25The early identification of patients who may benefit from a palliative approach remains challenging in primary care. The Gold Standards Framework (GSF) provides a structured approach to identify patients who may be approaching the end of life; however, its implementation in primary care settings outside the United Kingdom remains poorly understood. To explore general practitioners' experiences of using the GSF prognostic indicator guidance to identify patients with palliative care needs in primary care in Brunei. This qualitative study was part of a broader mixed-methods project that evaluated the use of the GSF in primary care. Focus group discussions and small-group interviews were conducted with general practitioners who had applied the GSF in routine clinical practice following a structured training workshop. Data were audio-recorded, transcribed verbatim, and thematically analyzed using an inductive approach. Ten general practitioners participated in this study. Four overarching themes were identified: (1) adapting the GSF to primary care practice, (2) structural constraints within primary care, (3) prognostic uncertainty and role discomfort, and (4) system enablers for integrating a palliative approach. While the GSF was perceived as a useful framework, its application required contextual adaptation and was influenced by both clinician- and system-level factors. The GSF can support the identification of patients with palliative care needs in primary care settings. However, effective implementation requires alignment with local workflows, improved continuity of care, and system-level support, including clear referral pathways and integrated care planning.
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5. Association between metabolic score for visceral fat and hypertension in Korean adults: a nationwide population-based study.
PMID:日期:2026-08-24Hypertension, one of the major risk factors for cardiovascular disease, is associated with visceral adiposity accumulation. Accordingly, we aimed to investigate the association between the metabolic score for visceral fat (METS-VF), a novel surrogate marker of visceral adiposity, and hypertension in Korean adults. This cross-sectional study included 27,565 adults from the 2019-2023 Korea National Health and Nutrition Examination Survey. Weighted multivariable logistic regression analyses were performed to examine the association between METS-VF tertiles and hypertension. Discriminatory performance was evaluated using receiver operating characteristic (ROC) curve analysis, and the areas under the ROC curves were compared with those of other adiposity-related indices. The prevalence of hypertension increased significantly across the METS-VF tertiles. After adjustment for potential confounders, the odds ratios and 95% confidence intervals for hypertension were 2.50 (2.04-3.06) in the second tertile and 2.76 (2.09-3.63) in the highest tertile, compared with the lowest METS-VF tertile. Moreover, METS-VF showed greater discriminatory performance for hypertension than the other adiposity-related indices. These findings indicate that METS-VF is strongly associated with hypertension in Korean adults and provides a more comprehensive assessment of cardiovascular risk than conventional adiposity-related indices.
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6. Association between serum homocysteine levels and mortality stratified by liver fibrosis index: a retrospective cohort study of US adults.
PMID:日期:2026-08-20Elevated serum homocysteine (Hcy) levels have been associated with increased mortality; however, whether this association varies with the liver fibrosis burden remains unclear. We analyzed 16,541 adults from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2006 with mortality follow-up through December 31, 2019, via the National Death Index linkage. Serum Hcy levels were categorized as <10, 10-15, or >15 μmol/L. Liver fibrosis was assessed using the fibrosis-4 (FIB-4) index. Cox proportional hazard regression models, accounting for the complex survey design, were used to estimate the associations. During a mean follow-up of 182.4 months, 3,740 deaths occurred. Hcy >15 μmol/L was associated with increased all-cause mortality regardless of liver fibrosis status. In contrast, moderate elevations (10-15 μmol/L) were associated with higher mortality only among participants with a higher FIB-4 index (hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.19-1.42), but not among those with a lower FIB-4 index (HR, 1.24; 95% CI, 0.92-1.67). Kaplan-Meier curves showed greater separation across Hcy categories in the high FIB-4 group. Natural cubic spline analyses demonstrated nonlinear associations between Hcy and mortality that differed according to fibrosis status. Cause-specific analyses indicated that these associations were primarily driven by metabolic and other nonmalignant deaths, rather than malignant mortality. The findings were consistent across fibrosis quartiles, subgroup analyses, and sensitivity analyses. The association between serum Hcy levels and mortality differed across liver fibrosis strata. These findings suggest that stricter Hcy thresholds are warranted in populations with a higher risk of liver fibrosis.
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7. Bridging the knowledge divide: a national cross-sectional analysis of urban-rural disparities in the stunting knowledge index among mothers/caregivers in Indonesia.
7. 弥合知识鸿沟：印度尼西亚城乡母亲/照护者发育迟缓知识指数差异的全国性横断面分析PMID:日期:2026-08-19Indonesia continues to encounter a significant public health crisis due to stunting. Maternal knowledge is the key driver of nutritional practices and outcomes. This study aimed to develop a maternal/caregiver stunting knowledge index (SKI), analyze disparities in urban-rural knowledge, and identify the key determinant factors driving these disparities. This cross-sectional study analyzed data points from the 2024 Indonesian Nutritional Status Survey, involving 294,538 mothers and caregivers. Data regarding stunting knowledge, sociodemographic, maternal, and caregiver characteristics, child characteristics, area of residence, and variables related to maternal health knowledge and utilization were collected via interviews conducted with mothers. Height-for-Age Z-score (HAZ) was calculated using age and height measurements. Knowledge level was measured using a constructed SKI categorized as low, moderate, or high. Chi-square tests and multivariate logistic regression were used to identify the predictors of low SKI and risk(s) for stunting. The prevalence of low SKI scores was significantly higher in rural areas, and maternal education was the strongest determinant of low SKI scores in both regions. In rural areas, limited access to formal health information (e.g., lack of a Maternal and Child Health book) was a major predictor. Low SKI was associated with higher odds for stunting risk (urban: adjusted odds ratio [aOR], 1.617; rural: aOR, 1.576), whereas high awareness of the long-term impacts of stunting provided a significant protective effect. Urban-rural knowledge disparities were concentrated among caregivers with lower education and limited health service utilization. Interventions should be tailored regionally, targeting caregivers with low education levels and emphasizing the long-term consequences of stunting to promote preventive behaviors.
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8. Causal effects of diabetes and alcohol intake on Dupuytren's disease: a two-sample Mendelian randomization study in UK Biobank and FinnGen.
8. 糖尿病和酒精摄入对杜普伊特伦病的因果效应：一项基于英国生物银行和FinnGen的双样本孟德尔随机化研究PMID:日期:2026-08-18Dupuytren's disease (DD) is associated with metabolic and lifestyle traits. However, these associations remain uncertain because exposures frequently cluster, and conventional studies are vulnerable to residual confounding and reverse causation. A two-sample Mendelian randomization (MR) analysis using genetic instruments for diabetes, obesity-related, smoking, and alcohol-related traits from genome-wide association studies of large European ancestry was conducted. Summary statistics of DD were obtained from UK Biobank and FinnGen and combined using meta-analysis. Multiplicative random-effects inverse variance weighted MR was used as the primary method, with complementary sensitivity analyses to test robustness. Genetic liability for diabetes was associated with a higher risk of DD (meta-analyzed odds ratio [OR], 1.0157; 95% confidence interval [CI], 1.0070-1.0245; P<0.001). Genetically predicted alcohol intake was also positively associated with DD (alcohol intake OR, 1.0150; 95% CI, 1.0087-1.0212; P<0.001; drinks per week OR, 1.0062; 95% CI, 1.0015-1.0110; P=0.0103). However, we found no convincing evidence that obesity traits or smoking intensity had causal effects on DD. Sensitivity analyses were directionally consistent, the instruments were adequately strong, and there was no substantial evidence of horizontal pleiotropy for the main associations. Although the observed effect sizes were modest, consistent with the multifactorial nature of DD, supporting directional risk associations rather than large individual-level effects. This MR study supported diabetes liability and higher alcohol intake as causal risk factors for DD, whereas genetically proxied obesity and smoking traits showed no clear causal effects. These findings suggest that better glycemic management and lower alcohol exposure may help reduce the risk of DD.
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9. Primary care systems in South Korea and Japan: a comparative review.
9. 韩国和日本初级保健系统：比较综述PMID:日期:2026-08-12The primary care system (PCS) is an essential national health infrastructure defined by the delivery of comprehensive, integrated, and accessible services that serve as the patient's first and sustained point of contact with the healthcare system. A comparative review was performed through searches of PubMed, KoreaMed, and J-STAGE databases using terms including "primary care," "general practitioner," "family physician," "gatekeeping," "Korea," and "Japan." Gray literature from the Japan Medical Association, Korea Medical Association, and OECD (Organisation for Economic Co-operation and Development) was also reviewed. Clinical case examples from one author's practice were included to illustrate real-world general practitioner (GP) challenges. Both Japan and South Korea feature universal health insurance but differ substantially in physician training pathways, gatekeeping enforcement, and community care integration. Japan is transitioning toward a kakaritsuke-i (registered home doctor) model with a nascent GP specialty board, whereas South Korea relies primarily on specialist-led private clinics for primary care delivery. International evidence suggests that structured, continuous family physician (FP) training is associated with improved chronic disease management, preventive care utilization, and patient satisfaction. Strengthening South Korea's PCS requires a clearly defined mandatory FP residency framework, reinforced gatekeeping mechanisms, and greater investment in community-based integrated care. Japan's ongoing reforms offer a useful regional comparator, while international FP models provide a proven evidence base for structural improvement.
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10. Corrigendum: Tobacco use among older Korean men: a classification and regression tree analysis.
10. 更正：韩国老年男性中的烟草使用：分类与回归树分析PMID:日期:2026-08-06该文献暂无摘要。