CLINICAL HEMORHEOLOGY AND MICROCIRCULATION临床血液流变学与微循环
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION(英文缩写 CLIN HEMORHEOL MICRO),ISSN 1386-0291,eISSN 1875-8622,中文译名:临床血液流变学与微循环 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.411 | Q3 |
| 2022 | 2.100 | Q3 |
| 2023 | 2.100 | Q3 |
| 2024 | 未收录 | N/A |
| 2025 | 1.700 | Q3 |
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 最新收录文献
-
1. Red blood cell aggregation and atherosclerosis: Curvilinear clinical implications.
PMID:日期:2026-09-23The progression of atherosclerosis is closely associated with red blood cell (RBC) aggregation. By increasing blood viscosity and reducing shear stress, RBC aggregation induces blood flow stasis and microcirculatory dysfunction, thereby facilitating lipid deposition within the vascular wall. Moreover, aggregated RBCs activate endothelial inflammatory responses and trigger oxidative stress, forming a pathological cycle characterized by "aggregation-inflammation-oxidation." The red blood cell aggregation index (EAI) correlates with the severity of atherosclerosis and may serve as a potential biomarker for early diagnosis. In integrative Chinese and Western medical approaches, blood-activating and stasis-resolving traditional Chinese medicines exhibit multitarget regulatory effects, particularly in improving hemorheological properties and suppressing inflammation, providing novel insights into the prevention and treatment of atherosclerosis.
-
2. Clot microstructure in infective and non-infective exacerbation of COPD, are they different?
PMID:日期:2026-09-17ObjectivePatients with Chronic Obstructive Pulmonary Disease (COPD) often develop exacerbations that could be infective or non-infective and are prone to develop thrombosis. To assess thrombogenicity in this group, a functional biomarker of clot microstructure namely fractal dimension () is utilised. This sub-group analysis intent to compare the changes in between infective and non-infective exacerbation of COPD.Methods85 patients with acute exacerbations of COPD were recruited from the Emergency Department. Blood samples were taken to determine biomarkers of inflammation, haemostasis and rheology at four time points (0 h, 4-6 h, 24 h and 3-7 days).ResultsThe biomarker of clot microstructure did not attain significance in the infective group when compared to the non-infective group at four time points.ConclusionsThe study demonstrates that exacerbation caused by infection does not cause more thrombogenicity compared to non-infective causes utilising clot microstructure.
-
4. Experimental characterization of blood rheology and development of a computational rheological Index during progressive hemorrhagic shock.
PMID:日期:2026-09-15Hemorrhagic shock is associated with profound disturbances of microcirculatory perfusion in which alterations of blood rheology may contribute to tissue hypoxia and organ dysfunction. Historically, the concept of hemorrhagic shock has evolved from an initial focus on systemic hemodynamic failure toward recognition of the critical role of microcirculatory dysfunction and impaired tissue oxygen delivery. More recent experimental and clinical research has further emphasized the contribution of blood rheological abnormalities to the progression of hemorrhagic shock and organ dysfunction. However, the relative contribution of individual hemorheological parameters during progressive hemorrhagic shock remains insufficiently characterized. To investigate stage-dependent changes in blood rheology in an experimental rat model of hemorrhagic shock and to evaluate the relationship between conventional hemorheological parameters and a newly proposed computational rheological index derived from routine hematological variables. Hemorrhagic shock was induced in 60 anesthetized rats by controlled withdrawal of 2.0, 2.5, or 3.5 mL of arterial blood, corresponding to progressive stages of shock. 20 intact animals served as controls. Erythrocyte aggregation, erythrocyte deformability, plasma viscosity, hematocrit, and the computational rheological index were assessed 15 min after blood withdrawal. Progressive blood loss resulted in stage-dependent deterioration of hemorheological properties. Erythrocyte aggregation demonstrated the greatest relative increase and was strongly associated with shock severity. Changes in erythrocyte deformability were less pronounced, whereas plasma viscosity and hematocrit remained relatively stable throughout the experimental stages. The computational rheological index exhibited changes parallel to erythrocyte aggregation, suggesting that it reflects progressive rheological impairment. Experimental hemorrhagic shock is accompanied by progressive deterioration of blood rheology, with erythrocyte aggregation representing the most sensitive laboratory marker. The proposed computational rheological index demonstrated a close association with experimentally observed rheological alterations and warrants further validation in independent experimental and clinical studies.
-
5. Dalcetrapib decreases red blood cell sickling propensity in sickle cell disease.
PMID:日期:2026-08-12The aim of the present study was to compare the effects of dalcetrapib and voxelotor on the rheology of red blood cells (RBCs) from sickle cell patients, as well as on hemoglobin oxygen affinity. Oxygen gradient ektacytometry was used to determine RBC deformability in normoxia and hypoxia, as well as the propensity of RBCs to sickle. Hemoglobin oxygen affinity was also measured following dalcetrapib and voxelotor incubation. Both voxelotor and dalcetrapib increased RBC deformability in hypoxia and decreased the propensity of RBCs to sickle under deoxygenation. However, in contrast to voxelotor, the affinity of hemoglobin S (HbS) to oxygen was not affected by dalcetrapib. The combination of both voxelotor and dalcetrapib led to greater RBC rheological improvement. Our findings suggest that dalcetrapib could inhibit RBC sickling during deoxygenation.
-
6. Blood viscosity values for predicting pathological stroke types (ischemic stroke, hemorrhagic stroke, and stroke mimic) at DR. Cipto Mangunkusumo National Referral Hospital.
PMID:日期:2026-06-12IntroductionStroke is the leading cause of morbidity and mortality, and its management differs among ischemic stroke, hemorrhagic stroke, and stroke mimics. Non-contrast CT has limited sensitivity for early ischemia. This study compared blood and plasma viscosity across different stroke types and identified cutoff values for predicting stroke type.MethodA cross-sectional study at the Emergency Department of Dr. Cipto Mangunkusumo National Referral Hospital (March-June 2025). Blood and plasma viscosity were measured using the Neo Digital Microcapillary device then compared using appropriate statistic tests. A -value < 0.05 was considered statistically significant.ResultsSeventy of 97 suspect stroke patients were included (36 ischemic, 16 hemorrhagic, 18 mimics). There were significant differences of blood viscocity between ischemic and hemorrhagic stroke compared with stroke mimic (median 5.65 cP ischemic; 5.29 cP hemorrhagic; 4.84 cP mimic; < 0.0001), whereas no significant difference was observed in plasma viscosity across the groups ( = 0.411). A blood viscosity cutoff of 5.17 cP yielded an AUC of 0.84 ( < 0.0001), 71.2% sensitivity, 94.4% specificity, 97.37% PPV, and 53.13% NPV for stroke prediction.ConclusionBlood viscosity shows potential as an adjunctive diagnostic tool for distinguishing stroke from stroke mimics with high specificity, aiding in predicting types of stroke.
-
7. Suppression of macrophage enriched miRNA 210-3p improves cardiac fibrosis and cardiac function following myocardial infarction.
PMID:日期:2026-05-01BackgroundAlthough it is well-known that immune cells such as monocytes or macrophages play important roles during the early phase of inflammatory response following cardiac damage, little is known about the role of immune cell-derived exosomes, especially their contents such as micro RNAs (miRNAs), in the immune cell-mediated regulation of cardiac remodeling. This study investigated the role of macrophage-derived exosomal miR-210-3p, which was found to be increased following cardiac damage, on cardiac fibroblast activation using a rat myocardial infarction (MI) model.MethodsCell population change in the heart following MI was assessed by single cell analysis. Differentially expressed miRNAs in the exosomes derived from THP-1 cultured under hypoxia/ischemia condition was evaluated by miRNA sequencing. The effect of macrophage exosome enriched miR-210-3p on cardiac fibroblast was examined. The effect of anti-miR-210-3p administration on the MI-induced cardiac fibrosis, cardiac function, and macrophage infiltration were evaluated.ResultsMacrophages were identified as the major type of immune cells present in the ischemic tissue following MI. miR-210a-3p was one of the 10 miRNAs increased (>10-fold) in THP-1 in response to hypoxia/ischemia condition, and it exerted pro-fibrotic effect in cardiac fibroblasts. Conditioned media of THP-1 cultured under hypoxia/ischemia condition also activated cardiac fibroblasts, and this was abrogated by anti-miR-210 treatment. Intramuscular injection of anti-miR-210-3p improved cardiac fibrosis and cardiac function 14 day after MI.ConclusionsMacrophage derived exosomes were enriched with miR-210-3p under hypoxia/ischemic condition, and they activated cardiac fibroblast. Suppression of miR-210-3p improved cardiac fibrosis and cardiac function following MI. Macrophage-derived exosomal miR-210-3p may play a significant role in the regulation of early inflammatory response following cardiac injury.
-
8. Downregulation of PCAF inhibits vascular smooth muscle cells senescence by reducing oxidative stress injury via activating the Nrf2/ARE pathway.
PMID:日期:2026-05-01Vascular aging represents the common pathological basis of aging-related diseases, with vascular smooth muscle cells (VSMCs) senescence playing a pivotal role. P300/CBP-associated factor (PCAF), a transcriptional coactivator linked to diverse physiological processes, has an undefined role in VSMCs aging. This study investigated PCAF's function in VSMC senescence and its underlying mechanisms. Using siRNA adenovirus to downregulate PCAF and angiotensin II (AngII) to induce senescence, we assessed β-galactosidase activity, senescence-associated secretory phenotypes (SASP), and cell cycle proteins (p53, p21, p16). Transcriptomic analysis revealed PCAF's association with oxidative stress and the Nrf2-ARE pathway. Results demonstrated that PCAF downregulation significantly attenuated VSMCs senescence and AngII-induced oxidative stress by enhancing Nrf2-ARE pathway activity. Crucially, Nrf2 silencing reversed these protective effects. In conclusion, PCAF inhibition mitigates VSMCs senescence via Nrf2-ARE-mediated antioxidant activation, identifying PCAF as a promising therapeutic target for vascular aging.
-
9. Impairment of cutaneous microcirculation and vasoreactivity in primary hypothyroidism.
PMID:日期:2026-05-01The aimof this study was to identify potential diagnostic markers of microcirculation disorders in patients with primary hypothyroidism.Materials and methodsThis cross-sectional study included patients with overt (OH, n = 14) and subclinical (SH, n = 37) hypothyroidism, and healthy volunteers (HV, n = 50). Using laser Doppler flowmetry (LDF), mean cutaneous blood flow in the dorsal forearm was assessed at rest (M), during cooling to 10 °C (M), heating to 35 °C (M) and to 42 °C (M). The standard deviation (σ) and the coefficient of variation of cutaneous blood flow (Kv=σ/M) at rest were calculated. The amplitudes of microvascular blood flow oscillations in frequency ranges corresponding to the neurogenic, myogenic, respiratory, and pulse mechanisms of microcirculation modulation were also calculated (A, A, A, A). Laboratory parameters were evaluated.ResultsThe OH group had reduced blood flow variability (σ) compared to the HV (p=0.025) and SH (p=0.037) groups. Kv was lower in OH compared to SH (p=0.041). Acard was decreased in the OH group compared to the HV (p=0.001) and SH (p=0.012) groups. M was reduced in OH compared to HV (p=0.014). Hypercholesterolemia and increased IL-6 were found in the OH and SH groups compared to HV. In OH, the red blood cell distribution width (RDW) was increased compared to HV (p=0.026).ConclusionOvert hypothyroidism is associated with decreased total and pulse variability of cutaneous microvascular blood flow, decreased cutaneous hyperemia during local heating to 42 °C, and increased RDW. These microcirculatory disorders are accompanied by hypercholesterolemia and increased IL-6 levels.
-
10. Adaptations of blood fluidity markers to progressive resistance training in men.
PMID:日期:2026-03-01BackgroundEpidemiological evidence suggests that endurance training improves musculoskeletal health and influence blood parameters, but the effects of RT were less clear.ObjectiveThe present study investigated the effect of 12-weeks of RT on resting (pre-exercise) values and responses of blood fluidity parameters to a resistance exercise trial (RET).MethodsEighteen untrained males (Mean ± SD; age, 24.8 ± 1.2 years) were randomly assigned to training ( = 10) or control ( = 8) groups. Subjects in the training group performed a 12-week progressive RT program with 4 sessions per week. The training program consisted of three distinct phases: adaptation, hypertrophy, and strength, increasing intensity from 40-50% to 80-85% of their one-repetition maximum (1RM). Prior and after the 12-week program, both groups underwent a RET. Blood samples were taken before and after each RET.ResultsSignificant ( < 0.05) increases in blood viscosity, plasma viscosity, plasma fibrinogen, and hematocrit were found following the acute RET. However, neither the resting values nor responses to RET were affected by RT. Interestingly, 12 weeks of progressive RT attenuated responses of RBC indexes significantly ( < 0.05).ConclusionsThe study concluded that although 12 weeks of RT does not alter resting blood fluidity, it reduces the acute changes in RBC indexes during high-intensity resistance exercise.