EPILEPSY RESEARCH癫痫研究
EPILEPSY RESEARCH(英文缩写 EPILEPSY RES),ISSN 0920-1211,eISSN 1872-6844,中文译名:癫痫研究 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.991 | Q3 |
| 2022 | 2.200 | Q3 |
| 2023 | 2.000 | Q3 |
| 2024 | 2.000 | Q3 |
| 2025 | 2.300 | Q3 |
EPILEPSY RESEARCH 最新收录文献
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1. Impact of Ramadan on seizure-related emergency department visits in Qatar.
PMID:日期:2026-09-29Whether Ramadan fasting influences seizure occurrence or severity is an important clinical question for Muslim patients with epilepsy. Prior studies are limited and show conflicting results. We conducted a retrospective observational study of all seizure-related emergency department (ED) visits in Hamad Medical Corporation hospitals (Qatar) during Ramadan and the adjacent month before and after, over 2021-2023. Patient data (demographics, seizure features, outcomes, and management) were collected. We compared Ramadan versus non-Ramadan periods, including subgroup analyses for first-time seizures and known epileptic patients. Additionally, an age- and sex-matched case-control analysis (n = 142) was performed, matching fasting Ramadan cases to non-Ramadan controls. Among 1492 seizure-related ED visits (470 during Ramadan; 1022 in combined non-Ramadan months), the proportion of total ED visits due to seizures was similar during and outside Ramadan (0.8%). No significant differences were found in clinical severity markers (rates of status epilepticus, seizure clustering, hospital admissions, ICU admissions, or 72-hour revisits) between Ramadan and non-Ramadan periods (all p > 0.05). In the matched case-control subset, fasting patients were more likely to receive intravenous antiseizure medication loading in the ED (40.0% vs 18.3%, p = 0.005). Fasting patients with history of epilepsy had a higher rate of prior good seizure control (69.8% vs 32.7%, p < 0.001) and were less likely to be started on new antiseizure medication (5.7% vs 20.4%, p = 0.026). Ramadan was not associated with increased seizure-related ED burden. Emergency physicians modified acute management for fasting subjects by favouring intravenous antiseizure medication loading and deferring new oral regimen initiation.
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2. Reduced-lead electroencephalography performed at the discretion of emergency physicians in pediatric cases of altered mental status: A retrospective observational study.
PMID:日期:2026-09-26Altered mental status (AMS) is frequently encountered among children in emergency departments (ED) and represents a nonspecific manifestation of brain dysfunction. However, the extent to which reduced-lead electroencephalography (EEG) findings obtained and interpreted by ED physicians influence treatment decisions and predict clinical outcomes has not yet been adequately evaluated. Epileptologists retrospectively analyzed the medical records and reduced-lead EEG findings of pediatric patients (aged <18 years) presenting to the ED with AMS and suspected electrographic seizures (ESz) between March 1, 2019, and February 28, 2023, yielding 51 EEG recordings with minimal artifacts for final analysis. Subsequently, we investigated whether ED physicians implemented appropriate clinical interventions guided by these EEG results. Anti-seizure medication (ASM) was administered during EEG monitoring in 20 of 27 patients with febrile seizures (FS) (74.1%), four of eight patients with acute encephalopathy/encephalitis (AE/AES) (50.0%), and 14 of 16 patients with epilepsy (87.5%). ESz were identified in eight patients with FS (29.6%), two patients with AE/AES (25.0%), and 15 patients with epilepsy (93.8%). ESz resolved during EEG monitoring in all patients except for one patient with FS. Five patients with AE/AES (62.5%) and one patient with epilepsy (6.3%) developed neurological sequelae, whereas no patients with FS developed neurological sequelae. Reduced-lead EEG can be effectively performed by ED physicians and may be a useful tool to facilitate timely intervention for ESz. However, we were unable to determine whether the intervention for ESz in the hyperacute phase of the ED contributed to improved outcomes.
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3. Antiseizure medications in children with acute symptomatic seizures: A quality improvement project.
PMID:日期:2026-09-26There is a dearth of literature about the duration of treatment with antiseizure medications (ASM) of children after acute symptomatic seizures (ASyS). Our goal was to explore the impact of a quality improvement (QI) project on the use of regular ASM in children after ASyS admitted in a quaternary paediatric hospital. This was a retrospective study over the period 2022-2024. As per our QI project, we introduced a plan during patient admission to start weaning or consider weaning ASM, if this was deemed to be clinically appropriate. The QI was implemented over the period June 2023-October 2023. Eligible patients (0-18 years) were identified through the electronic patient record and were divided into 2 groups: Group A (prior to the quality improvement project) and Group B (after the quality improvement project). The primary endpoint of our study was the number of patients in whom at least 1 ASM had been withdrawn within 6 months after the initiation of regular ASM treatment. The total number of children included in the study was 91 (53 in Group A, 38 in Group B) with a median age of 18.5 months and 31.9% being female. The most frequent causes of ASyS in our cohort included CNS infection (18.7%), hypoxic/ischemic injury (17.6%) and posterior reversible encephalopathy syndrome (13.2%). At least 1 ASM had been withdrawn in 21/47 (44.7%) patients of Group A compared to 25/34 (73.5%) patients of Group B (p = 0.009) at 6 months follow-up. In total, 17/47 patients (36.2%) of Group A and 21/34 patients (61.7%) of Group B were off all ASM at 6 months (p = 0.022). The median duration of follow-up was 18 months (IQR 9-26). Seizure recurrence after ASM withdrawal occurred only in 3 patients in our cohort. The vast majority of children (75/81, 92.6%) were seizure-free on their last follow-up. Regression analysis did not reveal any factors significantly associated with ≥ 1 ASM weaning at 6 months apart from the QI implementation. The implementation of a weaning protocol through our QI project contributed to a reduction in the duration of ASM use among children with ASyS admitted to our hospital without considerable impact on seizure outcomes.
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4. Beyond the classic ketogenic diet: A systematic review of alternative and adjunctive therapies for GLUT1 deficiency syndrome.
PMID:日期:2026-09-23Glucose transporter type 1 deficiency syndrome (GLUT1-DS) is a rare, paediatric onset, neurometabolic disorder caused by impaired cerebral glucose transport, leading to chronic brain energy deficiency. The classic ketogenic diet (CKD) is its established cornerstone therapy but it is not universally effective, well tolerated or sustainable. A growing number of alternative and adjunctive therapies has been explored, but their clinical roles remain unclear due to the fragmented and heterogeneous nature of the evidence. Systematic synthesis and appraisal of clinical evidence for non-ketogenic and adjunctive therapeutic strategies in paediatric GLUT1-DS with a focus on patients who are unable to initiate, maintain, or adequately respond to classic KD. A systematic review was conducted in accordance with PRISMA 2020 guidelines. PubMed, Embase, Scopus, Web of Science, and ClinicalTrials.gov were searched from inception to November 2025. Eligible studies included paediatric patients with confirmed GLUT1-DS diagnosis receiving therapeutic interventions beyond the CKD. Outcomes included: seizure control, paroxysmal movement disorders, neurodevelopmental and functional measures, treatment tolerability, and quality of life. Owing to substantial clinical and methodological heterogeneity across studies, a narrative synthesis was performed. Twenty-two studies- involving 290 GLUT1-DS patients-were included, consisting of: randomized controlled trials, non-randomized interventional studies, observational studies, case series and case reports. Evaluated interventions included: modified Atkins diet (MAD) variants, triheptanoin, intravenous sodium lactate, acetazolamide, zonisamide, diazoxide, intermittent glucose administration, and combined dietary-pharmacologic approaches. MAD variants and acetazolamide were associated with the most consistently favourable clinical outcomes across the available studies. Triheptanoin showed conflicting efficacy. Evidence for lactate- and glucose-based strategies was limited to small, high-risk studies with narrow applicability. While CKD remains the reference standard for GLUT1-DS management, selected alternative and adjunctive therapies may offer clinically meaningful benefit in specific clinical contexts. The current evidence base, however, is limited. These findings support cautious and individualized use of alternative therapeutic strategies while highlighting the need for larger prospective studies and standardized outcome measures to better define their role in GLUT1-DS management.
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5. Comparison of amyloid-β, total tau and phospho-tau in clinical AD patients with and without epileptiform EEG patterns.
PMID:日期:2026-09-21Epilepsy is a relevant comorbidity of dementia due to Alzheimer's Disease (AD) and probably directly related to its pathology. We aimed to generate hypotheses how interictal epileptiform discharges (IEDs) may be associated with pathological levels of AD markers from cerebrospinal fluid (CSF). To perform bivariate analyses between IEDs or EEG background slowing to CSF AD markers including amyloid-β42 to amyloid-β40 ratio (Aβ ratio), total tau and phospho-tau. In this retrospective cross-sectional study, we identified 26 clinical AD patients who presented with at least one of three pathological neurodegeneration markers in the CSF (Aβ ratio ≤0.5, total tau ≥370 pg/ml, phospho-tau ≥66 pg/ml) and received at least one routine EEG. IEDs and EEG background slowing were present in 5/26 and 14/26 patients, respectively. We observed that patients with IEDs or EEG background slowing had significantly lower phospho-tau levels than patients without (Cohen's d=0.91, P = 0.044 and Cohen's d=1.33, P = 0.005, respectively). Consistent with this, a positive history of seizures tended to be associated with lower phospho-tau levels (Cohen's d=0.79, P = 0.059). Moreover, phospho-tau levels were significantly correlated to dominant posterior EEG frequencies (Spearman's ρ=0.524, P = 0.006), and Aβ ratios were significantly lower in patients with normal EEG background frequencies than in those with EEG slowing (Cohen's d=1.31, P = 0.017). Our bivariate analyses revealed the unexpected observation that the presence of IEDs was associated with lower rather than higher phospho-tau levels in clinical AD patients. This finding awaits further confirmation in a larger cohort.
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6. Feasibility, safety and preliminary effectiveness of an epilepsy treatment smartphone application in rural primary care: A two-arm prospective observational study from India.
PMID:日期:2026-09-19The epilepsy treatment gap remains a major public health challenge in low- and middle-income countries, including India, where up to 90% of people with epilepsy in rural settings receive no treatment. Smartphone applications capable of guiding non-specialist doctors through diagnosis and individualized treatment have been proposed as a scalable solution. We evaluated the feasibility, safety, and preliminary effectiveness of a novel decision-support application -the Epilepsy Treatment Aid (ETA) in rural primary care settings in Chhattisgarh, India. We conducted a two-arm prospective observational study across two rural blocks in Chhattisgarh, India. Primary care doctors at both sites received structured epilepsy training; doctors at the intervention site (Nagri) additionally used the ETA to manage consecutively-presenting people with suspected epilepsy (PWSE). Specialist neurologist assessment at six months served as the reference standard for safety (treatment agreement) and preliminary effectiveness (seizure frequency change) outcomes. Seventy-two PWSE were recruited at the intervention site and 41 at the control site, yielding evaluable samples of 33 and 29 respectively after exclusions and loss to follow-up at completion of study. The ETA was successfully deployed in all presenting PWSE. Diagnostic agreement with the specialist was 91% in the app group versus 86% in controls. Full treatment agreement was achieved in 71% of the app group versus 48% of controls. Seizure frequency improved in 68% of the app group versus 48% of controls. None of these differences reached statistical significance. The ETA was feasible to deploy in routine rural primary care and was not associated with inferior diagnostic or treatment outcomes compared with epilepsy-trained care alone. These preliminary findings support further evaluation of the ETA as a tool to reduce the epilepsy treatment gap in resource-limited settings.
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7. Losartan's regulation of PI3K/AKT signaling underlies its combined anti-seizure and antidepressant effects in epileptic rats.
PMID:日期:2026-09-16To investigate whether losartan alleviates seizures and depression-like behaviors in epileptic rats, and to explore its potential mechanisms involving the PI3K/AKT signaling pathway and hippocampal neuroprotection. Status epilepticus (SE) was induced in Sprague-Dawley rats using lithium-pilocarpine. Post-SE rats were randomized to receive daily intraperitoneal injections of either losartan (60 mg/kg) or saline for 20 days. A control group was also set. Seizure frequency was monitored over a 24-hour period post-intervention. Depression-like behaviors were evaluated through weekly body weight gain and the sucrose preference test (SPT). Molecular changes in the hippocampus were assessed via RT-qPCR, western blot, and immunofluorescence staining for PI3K/AKT pathway components and apoptosis markers. Losartan treatment significantly decreased the frequency of seizures in SE rats. Concurrently, it ameliorated depression-like phenotypes, evidenced by greater weight gain and a higher sucrose preference rate. At the molecular level, losartan upregulated hippocampal expression of PI3K, the p-AKT/AKT ratio, and the anti-apoptotic protein Bcl-2, while downregulating pro-apoptotic factors Bax, Caspase-3, and Cleaved-Caspase-3. This indicates a reversal of SE-induced suppression of the PI3K/AKT cascade. Immunofluorescence analysis further confirmed that losartan significantly mitigated SE-associated hippocampal neuronal loss. Losartan may attenuate both seizures and depression-like behaviors in epileptic rats by activating the hippocampal PI3K/AKT signaling pathway and inhibiting neuronal apoptosis. These results highlight its potential as an adjunctive therapy for epilepsy with comorbid depression.
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8. Epilepsy-associated labor force exclusion in a multi-ethnic neurology cohort.
PMID:日期:2026-09-16Employment is a key marker of independence, quality of life, and socioeconomic stability. People with epilepsy may face employment barriers related to seizure burden, psychiatric comorbidity, stigma, and workplace constraints. Few studies have evaluated employment outcomes using a contemporaneous same-practice specialty-neurology comparator. We performed a retrospective cross-sectional study of adults evaluated at Hawaii Pacific Neuroscience between January 2019 and January 2020; retrospective chart abstraction was conducted from January through July 2020. The analytic cohort included NHPI, Asian, and White patients with documented employment status (n = 850; epilepsy n = 403; comparator n = 447). Recorded labor-force exclusion was defined as unemployed or disabled versus employed. Conventional multivariable logistic regression evaluated clinical and demographic correlates; stroke-adjusted, stroke-excluded, and outcome-specific sensitivity analyses were performed. Epilepsy patients were less often employed than comparator patients (28.3% vs 49.2%, p < 0.001), more often unemployed (34.5% vs 18.1%, p < 0.001), and more often disabled (10.2% vs 3.1%, p < 0.001). Recorded labor-force exclusion was present in 44.7% versus 21.3%, respectively (p < 0.001). In the primary adjusted model, epilepsy (OR 3.48, 95% CI 2.45-4.94), any psychiatric diagnosis (OR 2.04, 95% CI 1.44-2.89), and current smoking (OR 1.65, 95% CI 1.04-2.60) were associated with labor-force exclusion. The epilepsy association persisted after adjustment for documented stroke (OR 3.28, 95% CI 2.30-4.67) and after exclusion of participants with stroke (OR 3.21, 95% CI 2.21-4.66). In this single-center specialty-neurology cohort, epilepsy was associated with lower documented employment and higher recorded unemployment or disability than a contemporaneous comparator with other neurological conditions. These cross-sectional findings should be interpreted in the context of a clinically selected referral population and unmeasured neurological, functional, occupational, and socioeconomic factors.
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9. Mapping the evidence-practice gap in pediatric post-traumatic seizures and post-traumatic epilepsy: A national practice-pattern survey of pediatric neurologists.
PMID:日期:2026-09-08Pediatric post-traumatic seizures (PTS) and post-traumatic epilepsy (PTE) remain largely managed through extrapolation from adult evidence, with limited pediatric-specific guidance. This study aimed to characterize current clinical practice among pediatric neurologists in Türkiye, quantify evidence-practice divergence, assess whether clinician characteristics explain this variation, and identify priority areas requiring consensus. A national cross-sectional web-based survey including 15 items was conducted among actively practicing pediatric neurologists in Türkiye. Post-traumatic seizures were framed as early (≤7 days) or late (>7 days) after injury; the survey addressed general PTS/PTE management and did not stratify items by traumatic brain injury (TBI) severity (mild, moderate, or severe). A total of 135 complete responses (approximately 30% of the 453 registered national society members) were analyzed. Consensus across decision nodes was classified using predefined thresholds, and a composite adult-guideline concordance score (0-1), benchmarked against adult neuro-trauma guidance used as a proxy, was constructed from four evidence-anchored practices. Associations between clinician characteristics and practice patterns were evaluated using multivariable and exploratory clustering analyses. Prophylactic antiseizure treatment was nearly universal (99.3%, defined as any propensity other than "never"; 75.6% initiated usually or always), and levetiracetam was the predominant first-line agent (91.1%), representing the only domain reaching strong consensus. The most pronounced evidence-practice gap involved treatment duration: only 8.1% reported adult-guideline-concordant prophylaxis of ≤ 7 days, whereas 67.4% continued treatment beyond one month. Consensus was lacking for emergency imaging, follow-up electroencephalography, prophylaxis duration, and research priorities. Respondents met a median of two of the four evidence anchors (mean composite 0.51 ± 0.22), and the composite was treated as a formative index (a count of concordant practices) rather than as a latent construct; no demographic or professional characteristic independently predicted higher concordance, and the study was not powered to exclude modest associations. Practice clustering (exploratory) was consistent with agreement at established evidence nodes and divergence primarily where pediatric evidence remains limited. Pediatric PTS/PTE management in Türkiye shows strong convergence in drug selection but substantial variation in duration and follow-up decisions, reflecting persistent pediatric evidence gaps and highlighting the need for pediatric-specific guidelines and national consensus initiatives.
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10. Risk of ECG abnormalities and arrhythmias in people with post-traumatic epilepsy.
PMID:日期:2026-09-06People with traumatic brain injury (TBI), particularly those who develop post-traumatic epilepsy (PTE, unprovoked seizure >1-week post-TBI), are at a high risk of mortality. Lethal arrhythmias represent one potential cause of mortality. The goal of this study is to investigate the risk of electrocardiographic (ECG) abnormalities and arrhythmias in people with TBI that develop PTE vs. those that do not. Analysis was performed using the TriNetX platform. Selection criteria included one lifetime TBI, 18-55 years old at the time of TBI, and survived > 1-week post-TBI. People with pre-TBI history of seizures, epilepsy, arrhythmias, or heart disease were excluded. We compared the time-dependent risk of arrhythmias and ECG abnormalities > 1-week post-TBI in PTE (seizure or epilepsy diagnosis >1-week post-TBI) versus propensity-score-matched non-PTE cohorts (N = 11,092/group). Follow-up was 1-week to 10-years post-TBI. PTE is associated with a 3-fold increased prevalence of the composite outcome (all ECG abnormalities and arrhythmias) and 5-fold increased prevalence of ventricular arrhythmias. There is decreased freedom from (log-rank p < 0.001), and increased time-dependent risk of the composite outcome (hazard-ratio: 2.26 [2.11-2.42]), and each type of ECG abnormality and arrhythmia. Sub-analysis stratifying for type of TBI, presence/absence of anti-seizure medications, post-traumatic (≤48-hours post-TBI) seizures, and post-traumatic arrhythmias, each demonstrate that people with PTE are at an increased risk of ECG abnormalities and arrhythmias. Results indicate the high risk of ECG abnormalities and arrhythmias in PTE. While PTE is principally a neurological disorder, it is important to take a multi-system approach that includes cardiac monitoring.