ARCHIVES OF ORAL BIOLOGY口腔生物学文献集
ARCHIVES OF ORAL BIOLOGY(英文缩写 ARCH ORAL BIOL),ISSN 0003-9969,eISSN 1879-1506,中文译名:口腔生物学文献集 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.640 | Q3 |
| 2022 | 3.000 | Q2 |
| 2023 | 2.200 | Q2 |
| 2024 | 2.100 | Q2 |
| 2025 | 2.300 | Q2 |
ARCHIVES OF ORAL BIOLOGY 最新收录文献
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1. Effects of umbilical cord mesenchymal stem cell-derived exosomes on periodontal ligament stem cells: An exploratory study.
PMID:日期:2026-11-01To investigate whether exosomes derived from human umbilical cord mesenchymal stem cells (UCMSCs) at two osteogenic induction stages (undifferentiated and late-stage) differentially affect periodontal ligament stem cells (PDLSCs), and to explore the potential molecular basis. UCMSCs and PDLSCs were isolated and cultured. Exosomes were harvested from undifferentiated UCMSCs (Exo-D0) and UCMSCs after 14 days of osteogenic induction (Exo-D14). PDLSCs were treated with both exosome types. Proliferation and migration were analyzed using EdU and scratch assays, the latter under serum-free conditions. Early osteogenic differentiation was assessed by alkaline phosphatase staining and quantitative reverse transcription PCR (qRT-PCR). Differentially expressed miRNAs were identified by high-throughput sequencing and further analyzed through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Both exosome types promoted PDLSC migration. Exo-D0 enhanced early osteogenic differentiation, whereas Exo-D14 enhanced proliferation but reduced early osteogenic marker expression. Sequencing identified 21 differentially expressed miRNAs (13 upregulated, 8 downregulated). Bioinformatic prediction suggested that the putative target genes were enriched in Ras signal transduction, regulation of kinase activity, and focal adhesion, and further predicted significant enrichment in the MAPK, Ras, and PI3K-Akt signaling pathways, which are central to cell proliferation and osteogenic differentiation. Exosomes from undifferentiated and osteogenically induced UCMSCs exerted distinct effects on PDLSCs, potentially associated with differentially packaged miRNAs. These findings offer a basis for hypotheses about exosome-mediated mechanisms and support matching exosome sources to the intended therapeutic outcome as potential cell-free strategies for periodontal tissue regeneration and alveolar bone repair.
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2. Erythritol attenuates cariogenic traits in single-species models and alters bacterial composition in a dual-species biofilm.
PMID:日期:2026-11-01To evaluate the effects of erythritol on functional cariogenic traits in separate single-species Streptococcus mutans and Lacticaseibacillus acidophilus models and to characterize relative species composition in a simplified dual-species biofilm. Functional microbial, biochemical, structural, molecular, and hard-tissue outcomes were evaluated in separate single-species models. Species-specific qPCR was used to quantify the relative abundance of S. mutans and L. acidophilus in a simplified dual-species biofilm. Erythritol reduced bacterial growth and viable colony formation in both species. Medium acidification was attenuated, with slower pH decline and lower lactic acid accumulation in erythritol-treated groups. Biofilm biomass and metabolic activity were lower at both 24 h and 48 h. In the dual-species biofilm, the relative abundance of S. mutans decreased, whereas that of L. acidophilus increased correspondingly. Microscopy showed reduced viable bacterial distribution, weaker dentin-surface adhesion, less compact biofilm architecture, and diminished extracellular matrix deposition. Separate single-species hard-tissue analyses demonstrated lower Ca2 + release, higher endpoint surface microhardness, lower surface hardness loss, and higher cross-sectional microhardness profiles. RT-qPCR showed reduced expression of selected virulence-related genes, particularly in S. mutans. Across most assays, the effects observed at 6% and 8% erythritol were similar. Erythritol attenuated multiple cariogenic traits in separate single-species S. mutans and L. acidophilus assays and altered relative species composition in a dual-species biofilm. The composition data do not establish reduced dual-species functional virulence or clinical carioprotection.
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3. Machine-learning analysis of short-term within-person salivary flow variation in a longitudinal cohort.
PMID:日期:2026-11-01Machine learning (ML) approaches have the potential to capture complex, non-linear relationships and may improve the prediction of salivary flow variation. This study aimed to evaluate the feasibility and internally validate ML models to estimate within-person variation in unstimulated (ΔUSF) and stimulated (ΔSSF) salivary flow over a short-term follow-up period. Data were derived from the "Brasília 2023 cohort," and included participants with paired salivary flow measurements obtained at baseline and after a mean follow-up of 11 ± 3 months. Participants underwent salivary biochemical profiling, hematological testing, dental examinations, and collection of sociodemographic, anthropometric, dietary, and behavioral data. Machine learning models were developed to predict changes in salivary flow and were internally validated using 10-fold cross-validation. Seventy-two participants had paired salivary flow measurements. Mean ΔUSF and ΔSSF were -0.07 ± 0.29 mL/min and -0.02 ± 0.40 mL/min, respectively. RF models demonstrated high apparent in-sample prediction; however, internal cross-validation demonstrated limited predictive ability. Similar predictive performance was observed for Random Forest, Elastic Net, and Gradient Boosting, suggesting no clear advantage of one algorithm over another in this dataset. Binary analysis using two clinically anchored threshold showed no meaningful event discrimination. ML models demonstrated modest ability to estimate short-term within-person changes salivary flow in this dataset. Nevertheless, this exploratory study provides methodological guidance for future salivary prediction research by informing sample-size requirements, candidate variable domains, and the impact of outcome definition on event prevalence and model performance. Larger longitudinal cohorts are needed to develop externally validated models and establish clinically relevant definitions of short-term salivary flow decline.
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4. Targeting endocarditis-associated Streptococcus biofilms: The antibacterial potential of Lippia sidoides essential oil.
PMID:日期:2026-11-01Streptococcus species such as Streptococcus sanguinis and Streptococcus gordonii are key contributors to infective endocarditis due to their ability to form resilient biofilms. This study evaluated the antibacterial and antibiofilm potential of Lippia sidoides essential oil (LSEO) against clinical isolates obtained from blood and the oral cavity. Sixteen clinical isolates of S. sanguinis and S. gordonii, comprising eight oral isolates and eight blood isolates obtained from patients with infective endocarditis, were evaluated. Antimicrobial activity was determined using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. Antibiofilm activity was assessed through inhibition and viability reduction of 18-hour biofilms, and effects on initial biofilm formation were analyzed by scanning electron microscopy (SEM). Cytotoxicity was evaluated in human gingival fibroblasts (HGF), and systemic toxicity was assessed using Galleria mellonella larvae. Gas chromatography identified carvacrol as the major compound of LSEO. The oil exhibited pronounced antibacterial activity against both oral and bloodstream isolates, with MIC values ranging from 0.1562 to 1.25 mg/mL against both species. LSEO inhibited biofilm formation by 30-96% and reduced biofilm viability by 4-100%, showing antibiofilm activity comparable to chlorhexidine under the experimental conditions. SEM analysis revealed marked disruption of early biofilm architecture. Toxicity assays demonstrated that LSEO was non-cytotoxic to HGF cells at MIC and MIC× 2 and exhibited low systemic toxicity in Galleria mellonella. LSEO demonstrated potent antibacterial and antibiofilm effects against endocarditis-associated Streptococcus isolates while maintaining a favorable safety profile, highlighting its potential as a natural strategy for preventing biofilm-related infections.
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5. Associations of serum vitamin D and fibroblast growth factor-23 with periodontitis severity: A cross-sectional study.
PMID:日期:2026-11-01Periodontitis is a chronic inflammatory disease associated with alveolar bone loss and alterations in mineral metabolism. Although 25-hydroxyvitamin D (25(OH)D) has been extensively investigated in the context of periodontal disease, data regarding fibroblast growth factor-23(FGF-23) remain limited, particularly across the different clinical stages of periodontitis. A total of 100 systemically healthy individuals (20 controls; 80 periodontitis patients classified as Stage I-IV) were included. Periodontal examinations were performed, and serum 25(OH)D and FGF-23 levels were measured using ELISA. Group comparisons, correlation analyses, ROC curve analysis, and multivariate logistic regression adjusted for age, sex, and body mass index were conducted. Serum 25(OH)D levels decreased, whereas FGF-23 levels increased with advancing periodontitis severity. (p = 0.01). 25(OH)D showed moderate negative, whereas FGF-23 showed moderate positive correlations with clinical periodontal parameters (p < 0.05). Both biomarkers showed moderate differentiation performance between advanced (Stage III-IV) and early disease stages (Stage I-II) (FGF-23: AUC = 0.714; 25(OH)D: AUC = 0.706). Bootstrap-adjusted multivariable linear regression analyses demonstrated that advanced periodontitis stage was independently associated with higher serum FGF-23 levels (B = 72.179, p = 0.006) and lower serum 25(OH)D levels (B = -6.818, p = 0.018). Furthermore, multivariate logistic regression analysis showed that FGF-23 (OR = 1.016; p = 0.003) and 25(OH)D (OR = 0.865; p = 0.022) remained independently associated with advanced periodontitis CONCLUSIONS: The observed increase in serum FGF-23 and the concomitant decrease in 25(OH)D levels across periodontitis stages may be associated with alterations in bone-mineral metabolism accompanying periodontal tissue destruction.
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6. PTEN-mediated regulation of dental mesenchymal stem cell function: A scoping review.
PMID:日期:2026-11-01Phosphatase and Tensin Homolog (PTEN) is a key negative regulator of intracellular signalling pathways that govern cell growth, survival, differentiation, and inflammatory responses. Growing evidence suggests that PTEN plays a critical role in regulating the biological functions of dental mesenchymal stromal cells (MSCs) with stem-like properties, which are central to dental tissue regeneration and repair. This review focuses on the functional roles of PTEN in dental MSCs DESIGN: A literature search was conducted in PubMed and SCOPUS from inception through October 12, 2025. English-language original studies investigating PTEN-mediated regulation of dental MSC function in vitro models were included. Data were synthesised qualitatively due to heterogeneity in experimental designs. Nine studies met the inclusion criteria. The findings demonstrate that PTEN regulates key biological processes in dental MSCs, including dental pulp stem cells, stem cells derived from exfoliated deciduous teeth, periodontal ligament stem cells, and gingival fibroblast cells, primarily through the PI3K/AKT signalling axis. Other mechanisms, including DNA methylation, microRNAs, and circular RNAs, participate in PTEN modulation, which is associated with altered cell behaviours, influencing lineage commitment, inflammatory responses, apoptosis, and differentiation. PTEN functions as a context-dependent regulator of the fate and homeostasis of dental MSCs. Precise modulation of PTEN signalling holds translational potential for modulating cell responses.
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7. Study on pathogenic mechanisms of metabolic pathways and key metabolites associated with black stain with or without severe early childhood caries.
PMID:日期:2026-11-01To investigate dental plaque metabolic profile differences between preschoolers with Black Stain and Caries-free (BSCF) versus Severe Early Childhood Caries with Black Stain (SECCBS) to elucidate S-ECC pathogenesis. Dental plaque was collected from 59 preschoolers aged 3-6 (BSCF, n = 29; SECCBS, n = 30) and analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry. Differential metabolites (DMs) were identified via partial least squares discriminant analysis. KEGG pathway analysis and Metorigin provided functional and source-tracking insights. Weighted Gene Co-expression Network Analysis (WGCNA) identified hub metabolites linked to clinical traits, while 10 machine learning models were developed for diagnostic prediction. Profiling identified 1069 metabolites, predominantly lipids/lipid-like molecules (24.60%) and organic acids/derivatives (11.51%). Eighty-five DMs were identified between groups; four were significantly downregulated ( Δ17-6-keto prostaglandin F1α, VLH, DPK, and N'-[1-(2-hydroxyphenyl)ethylidene]-3-methoxybenzohydrazide). L-glutamate was significantly upregulated in SECCBS, whereas L-(+)-citrulline was downregulated. KEGG analysis mapped DMs primarily to nucleotide, carbohydrate, amino acid, and lipid metabolism. Metorigin revealed 78.6% of metabolites were co-derived from diet, microbiota, and pharmaceuticals. WGCNA identified 31 modules, two positively correlating with SECCBS. The top-performing machine learning model achieved robust AUC performance for clinical stratification. Distinct plaque metabolomic profiles differentiate SECCBS from BSCF. Alterations in nucleotide metabolism, the pentose phosphate pathway, and specific amino acid pathways drive SECC progression. Furthermore, 2'-deoxyuridine and 6-phosphogluconic acid emerge as potential biomarkers for early SECC diagnosis, prevention, and targeted clinical intervention.
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9. Dental phenotypes associated with novel PHEX variants in X-linked hypophosphatemia.
PMID:日期:2026-11-01X-linked hypophosphatemia (XLH) is a genetic disorder related to bone, mainly due to the mutations in PHEX gene. Previous studies have reported that XLH patients had various tooth phenotypes. It is unclear whether there are any rules about these abnormal tooth phenotypes, especially in those XLH cases with PHEX mutations. The objectives of this study were to find the most representative dental characteristics of XLH and the possible phenotype-genotype correlation. Two unrelated patients with XLH underwent clinical, radiographic, biochemical, and genetic evaluation. Whole-exome sequencing and whole-genome sequencing were used to identify pathogenic variants. The ultrastructure of extracted teeth was analyzed using a stereomicroscope, micro-CT, and scanning electron microscopy. In addition, a PubMed search (up to January 2026) identified 22 articles involving 366 patients for descriptive phenotype comparison. Two novel PHEX variants were identified: a novel complex structural variant (NC_000023.11, g.22035649-22041668delins) and a novel heterozygous splice-site variant (NM_000444.6, c.850-1 G>A). Radiographic examination showed enlarged pulp chambers and irregular pulp morphology. Ultrastructural analysis revealed dentin defects, including globular dentin, irregular interglobular dentin, disrupted dentinal tubules, and exposed collagen fibrils. Literature-based analysis indicated prevalent clinical manifestations (pulp necrosis, tooth loss, periodontitis) and radiographic findings (enlarged pulp chamber, and prominent pulp horn). In these two patients, novel PHEX variants were associated with a recurrent dentin-pulp phenotype. Integrated clinical, radiographic, ultrastructural, and literature evidence supports dentin defects as a central component of the dental phenotype in XLH and underscores the importance of early dental assessment.
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10. Comparing the efficacy of human serum, plasma, and saliva on neoplastic and non-neoplastic epithelial cell viability.
PMID:日期:2026-11-01This study aimed to compare the use of different human biological fluids in the viability of epithelial and oral cancer cells. For this purpose, human serum (HSR), plasma (HPL), whole saliva (HWS), and centrifuge saliva (HCS) samples were tested at different concentrations (5%, 10%, 15% and 20% volume per volume (v/v) and periods (24 h, 3, 5 and 7 days) in the culture of normal oral and skin epithelial cells (NOK-SI and HACAT, respectively) and cell lines derived from oral squamous cell carcinoma (SCC9, SCC25 and Cal27). MTT and clonogenic assays were used to analyze cellular metabolic activity and colony formation potential, respectively. Fetal Bovine Serum (FBS) at 10% (v/v) was used as a control. HSR was the most effective fluid in maintaining metabolic activity in SCC9, SCC25, Cal27, and HACAT cells in different culture times. HPL generally resulted in lower cellular metabolic activity than HSR and FBS across the experimental conditions evaluated. HCS and HWS induced a lower viability compared to FBS in all cell lines tested in the long term. However, HCS and HWS maintained the metabolic activity of NOK-SI, SCC25, and Cal27 cells for shorter periods. In clonogenic assays, HSR induced colony formation in SCC25, NOK-SI, and HACAT cells at different culture times. HSR is the most effective biofluid for maintaining the viability of both oral cancer and normal epithelial cells, a property that makes it potentially applicable in translational research.