Nature Reviews Urology自然综述：泌尿学
Nature Reviews Urology(英文缩写 NAT REV UROL),ISSN 1759-4812,eISSN 1759-4820,中文译名:自然综述：泌尿学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 16.430 | Q1 |
| 2022 | 15.300 | Q1 |
| 2023 | 12.100 | Q1 |
| 2024 | 14.600 | Q1 |
| 2025 | 13.600 | Q1 |
Nature Reviews Urology 最新收录文献
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1. The potential of soft robotics for the restoration of urinary voiding.
PMID:日期:2026-09-23Current treatment options for chronic urinary retention secondary to detrusor underactivity are limited, and the mainstay is simply drainage by catheterization. The interdisciplinary field of bioelectronics could help to advance the prospect of artificial bladder emptying: first, by restoring continence control using human-in-the-loop mechanical compression to facilitate voiding and, second, by providing some of the components for managing detrusor overactivity, possibly using autonomous, closed-loop neuromodulation to inhibit aberrant contractions during storage. Pneumatic, magnetic and dielectric elastomer actuators are emerging and demonstrate varying levels of technology readiness; each type is associated with mechanical and biological challenges of implantation, including fibrotic encapsulation and power delivery. Furthermore, algorithmic continence control has ethical implications and the regulatory pathways for adaptive machine learning in bioelectronics must be created to outline the definitive roadmap required for this technology to reach clinical reality.
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2. Biomechanical regulation of bladder injury and repair.
PMID:日期:2026-09-16The urinary bladder is a hollow, muscular organ that functions to store and void urine cyclically. The bladder has a dynamic mechanical environment owing to its cyclical expansion and contraction, along with the accumulation and outflow of urine. These complex mechanical stimuli, via diverse mechanosensors and downstream mechanotransduction, modulate bladder sensation, detrusor contraction in the bladder and remodelling of the bladder wall, thereby maintaining the functional homeostasis of the bladder. Mechanical homeostasis of the bladder can be disrupted by disease or injury, such as elevated stretch force and hydrostatic pressure in bladder outlet obstruction and increased matrix stiffness after bladder fibrosis. Abnormal mechanical environments are indicative of bladder diseases and also contribute to the progression of bladder injury and disease. Hence, understanding the effects of regulatory mechanisms of biomechanical cues on bladder function under both physiological and pathological conditions, clarifying the connections and distinctions between these states, and identifying the differential mechanical sensations and transduction pathways that drive bladder diseases and injuries are essential for developing novel therapeutic strategies targeting mechanotransduction pathways to promote the repair of injured or diseased bladders.
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3. Evidence for metastasis-directed therapy in oligometastatic prostate cancer.
PMID:日期:2026-09-01该文献暂无摘要。
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4. Beyond maternal exercise: paternal exercise adaptations mediated by sperm microRNA signatures.
PMID:日期:2026-09-01该文献暂无摘要。
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5. Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.
PMID:日期:2026-09-01Extrachromosomal DNA (ecDNA) has emerged as a major driver of genomic instability and rapid tumour evolution in urothelial carcinoma. In urothelial carcinoma, ecDNA amplifies oncogenes, reshapes 3D chromatin interactions, reprogrammes transcription and modulates the tumour-immune interface. Together, these features fuel intratumour heterogeneity, accelerate APOBEC3-associated mutational evolution and contribute to aggressive disease. Advances in sequencing and imaging technologies have greatly expanded our understanding of ecDNA biology. Importantly, ecDNA can be detected through non-invasive liquid biopsies, including urine and plasma, and inferred from standard histopathology slides via digital pathology. These observations suggest that ecDNA could be a valuable adjunct biomarker, enhancing current strategies for early detection, patient stratification and dynamic monitoring of treatment response.
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6. Revisiting the dual role of androgens and oestrogens in mammalian sex differentiation with a focus on genitalia.
PMID:日期:2026-09-01Androgen signalling is the primary driver of male sexual differentiation in mammals, directing masculinization during a crucial fetal window. In male fetuses, high levels of fetal androgens, mainly from the testes, promote male reproductive tract development through androgen receptor activation, whereas low levels of androgens in female fetuses enable the development along the female pathway. This androgen-centric view of reproductive development has long dominated the field, casting oestrogens as passive bystanders. However, both historical and emerging evidence challenges this narrative, pointing to an active role of oestrogens in shaping reproductive development through complex, tissue-specific interactions with androgen pathways. Oestrogen receptors are expressed in developing reproductive tissues of both sexes, and disruptions in oestrogen signalling - shown in genetic and pharmacological models - can lead to reproductive abnormalities. Oestrogens might counteract androgen action at the tissue level and modulate androgen receptor expression, independently of effects on androgen production. Moreover, combined exposure to anti-androgens and oestrogenic compounds can amplify developmental disruptions, underscoring the importance of hormonal crosstalk. These findings question the adequacy of an androgen-only model, especially when assessing endocrine disruptors. Understanding the role of oestrogens is essential for interpreting normal development and chemical risks. Reproductive differentiation seems to depend on the integrated balance between androgen and oestrogen pathways, rather than on isolated signals.
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7. Urinary tract infections in children.
PMID:日期:2026-09-01Bacterial urinary tract infections (UTIs) are prevalent in childhood and adolescence. Paediatric UTIs present unique challenges with respect to diagnosis, prevention and management, and the potential for adverse sequelae. Uropathogenic Escherichia coli (UPEC) accounts for the majority of UTIs and is the best studied uropathogen. Novel discoveries have advanced our understanding of host-pathogen interactions, cellular and molecular mechanisms of host defence, and risk factors for UTI recurrence. Emerging evidence also highlights an association of the gut, vaginal and urinary microbiota in influencing UTI risk and recurrence. Yet, key knowledge gaps persist regarding UTI pathogenesis, host susceptibility, optimal diagnostic and management strategies and prevention of UTI recurrence and sequelae, especially in paediatric populations. The development of standardized clinical pathways offers an opportunity to improve care consistency and outcomes by integrating evidence-based practices into routine management. As technologies evolve and understanding deepens, future efforts must integrate host, microbial and clinical insights to optimize UTI prevention and treatment in paediatric populations.
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9. Fathers matter too: sperm-borne epigenetic messages link paternal exposures to next-generation health.
PMID:日期:2026-09-01该文献暂无摘要。
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10. Sperm DNA fragmentation and its influence on mammalian reproduction.
10. 精子DNA断裂及其对哺乳动物生殖的影响PMID:日期:2026-09-01Sperm DNA fragmentation is a recognized factor in male infertility with direct implications for embryo development, implantation and pregnancy outcomes. Historically, standard semen analysis has not included assessments of DNA integrity, creating a clear need for advanced diagnostic tools. DNA damage can arise through pathways such as apoptosis, oxidative stress and exposure to environmental toxins, all of which compromise reproductive potential. Several methodologies exist for measuring sperm DNA fragmentation, including the sperm chromatin structure assay, terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL), the Comet assay and sperm chromatin dispersion, each of which has unique advantages and limitations. Novel automated imaging platforms incorporating machine learning algorithms have emerged, enabling high-throughput, single-sperm assessment and reducing subjectivity associated with manual scoring. Species differences further complicate the understanding of DNA stability and sperm quality, especially in livestock and models of artificial insemination; nonetheless, physiological similarities between humans and species close to humans provide useful translational insights. Emerging sperm selection technologies, including microfluidics, hyaluronic acid affinity systems and magnetic-activated cell sorting, show promise in reducing DNA fragmentation, improving reproductive outcomes and decreasing pregnancy loss. As the field progresses toward increasingly personalized fertility treatments, measures of DNA integrity will remain central to optimizing assisted reproduction success rates across species.