International Journal of Surgery国际外科杂志
International Journal of Surgery(英文缩写 INT J SURG),ISSN 1743-9191,eISSN 1743-9159,中文译名:国际外科杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 13.400 | Q1 |
| 2022 | 15.300 | Q1 |
| 2023 | 12.500 | Q1 |
| 2024 | 10.100 | Q1 |
| 2025 | 9.000 | Q1 |
International Journal of Surgery 最新收录文献
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1. Temporal changes in circulating metabolites after metabolic and bariatric surgery and risk of incident coronary heart disease: evidence from prospective cohort and nested case-control studies.
1. 代谢减重手术后循环代谢物的时间变化与冠心病发病风险：来自前瞻性队列和巢式病例对照研究的证据PMID:日期:2026-06-03Metabolic and bariatric surgery (MBS) has notable cardiovascular benefits beyond weight loss. The Gut Microbiome in Metabolic Surgery Study (GUMMY) enrolled patients who underwent first-time Roux-en-Y gastric bypass or sleeve gastrectomy, with blood samples collected at pre- and 3- and 12-month post-surgery. Significant metabolite changes were identified using paired signed-rank tests with a false discovery rate (FDR) < 0.05 and |log fold change| > log1.5, comparing 3-month post- vs. pre-surgery (early phase) and 12- vs. 3-month post-surgery (late phase). Significantly changed metabolites were classified into three patterns: early changed, late sustained; early changed, late reversed; and early unchanged, late changed. Subsequently, a nested case-control study within the Southern Community Cohort Study (SCCS) assessed the associations between surgery-altered metabolites and incident coronary heart disease (CHD) risk using conditional logistic regression. The same untargeted metabolomic assay was conducted in GUMMY and SCCS plasma samples. Among 115 surgical patients, the mean (SD) age was 44.9 (9.5) years, and 90 (78%) were women. Significant changes were observed in 224 metabolites, mainly encompassing sustained increases in bile acids and decreases in branched-chain amino acids, lactoyl, and lysine amino acids; reversed changes in some ketone bodies, phospholipids, lysophospholipids, and glycogen metabolites; late increases in taurine, caffeine, benzoate, and some tryptophan metabolites; and late decreases in ceramide metabolites and certain fatty acids. In the SCCS ( = 1194; 597 case-control pairs), 37 surgery-altered metabolites were significantly associated with incident CHD (FDR < 0.1), 28 with concordant effects, i.e., post-surgical increases were associated with reduced CHD risk and vice versa. MBS elicits substantial metabolomic alterations, with many altered metabolites associated with incident CHD. These findings provide mechanistic insights into the cardiovascular benefits of MBS and suggest potential therapeutic targets for CHD prevention.
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2. SurvGRN: a multi-feature fusion framework for bladder cancer survival prediction.
2. SurvGRN：一种用于膀胱癌生存预测的多特征融合框架PMID:日期:2026-06-02Bladder cancer survival outcomes exhibit significant heterogeneity, influenced by multifaceted factors. While digital pathology-based survival models leveraging artificial intelligence show promise, they often overlook complementary data sources. Conversely, imaging lacks cellular detail, and genomics/proteomics entail complexity and cost. To integrate multidimensional data for enhanced survival prediction, we propose SurvGRN, a multi-feature fusion framework. SurvGRN synergistically combines clinical variables, transcriptomics, and digital pathology slides using a gated residual network architecture. Pathological features are extracted via multiple instance learning, while clinical and transcriptomic data are processed as static inputs. These features are dynamically fused using a long short-term memory (LSTM) network for comprehensive survival risk assessment. Evaluated on 400 bladder cancer patients, SurvGRN significantly outperformed existing methods: improving the C-index by 12.6% over DeepMISL; 20.6% and 7.1% over graph-based models (DeepGraphConv and Patch-GCN); and 5.4% and 4.0% over attention-based approaches (Surformer and HVTSurv). Ablation studies confirmed the contributions of pathology features (extracted via ResNet-50 pre-trained on bladder tissue), clinical/transcriptomic data, and the LSTM fusion. SurvGRN also enabled significant stratification of patients into distinct risk cohorts. This work demonstrates that holistic integration of multi-source data through tailored fusion architectures substantially improves bladder cancer survival prediction.
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3. Letter to the Editor: Wallace versus Bricker anastomosis for urinary diversion after radical cystectomy: a systematic review and meta-analysis.
3. 致编辑的信：根治性膀胱切除术后尿流改道中Wallace与Bricker吻合术的比较：一项系统评价与荟萃分析PMID:日期:2026-05-28该文献暂无摘要。
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4. Endoscopic sleeve gastroplasty video annotation: analysis of the learning curve of three annotators to achieve procedure proficiency.
4. 内镜下袖状胃成形术视频标注：三名标注者达到手术熟练度的学习曲线分析PMID:日期:2026-05-21Endoscopic interventional skills acquisition generally relies on apprenticeship-based training. Limitations of this learning model include the availability of trainers and human-factor biases. Increased routine surgical and endoscopic video recording and storage promote video-based learning (VBL) methods. VBL could shorten the learning curve by increasing trainer availability and democratizing training access for procedures such as endoscopic sleeve gastroplasty (ESG), which is carried out by a few expert operators. The aim of this work was to evaluate video annotation as a learning tool for ESG. Videos of ESG performed at a single center were collected and annotated. An annotation manual developed by an ESG expert was used by three annotators with different levels of endoscopic and ESG expertise. Pairwise Cohen's kappa was used to assess inter-rater reliability (IRR). Completion of the learning curve for each phase and feature of ESG was calculated as the probability of accordance among annotators and estimated by a moving average optimization model with an expectation-maximization algorithm. In total, 40 ESG videos were annotated. IRR pairwise kappa scores ranged between 0.44 (Annotator 1 and 3) and 0.58 (Annotator 2 and 3). Learning curve analysis showed that a different number of procedures need to be annotated to master the various phases of ESG, with the "other suture phase" needing the highest number of procedures ( = 36). The overall learning curve showed variability across different aspects of ESG, with an overall average of 28.40 procedures needed to achieve proficiency. The learning process differs among trainees, as mirrored in the variable number of procedures needed to master ESG. Tailoring training for different trainees could lead to the shortening of learning curves. Some features of ESG are mastered more quickly; however, careful and repeated practice is essential for minimizing errors in more complex features. VBL could play a role in the democratization of high-level learning.
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5. Mobilizing stem cells and inhibition of autoimmunity synergistically modify autoimmune disease to relieve pain: a potential MRG-001 therapy for rheumatoid arthritis.
5. 动员干细胞和抑制自身免疫协同改变自身免疫性疾病以缓解疼痛：一种治疗类风湿性关节炎的潜在MRG-001疗法PMID:日期:2026-05-07Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, bone erosion, cartilage destruction, and debilitating pain. Current therapies often fall short in preventing structural damage and restoring immune balance. To address these limitations, we evaluated MRG-001 - a fixed-dose combination of plerixafor (AMD3100) and low-dose tacrolimus (FK506) with reported immunoregulatory and regenerative potential - in preclinical models of RA. The therapeutic efficacy of MRG-001 was assessed in collagen-induced arthritis and collagen antibody-induced arthritis mouse models. Mice received subcutaneous MRG-001, and clinical, histological, molecular, and behavioral endpoints were evaluated to examine inflammation, immune modulation, bone integrity, angiogenesis, and pain. MRG-001 treatment significantly reduced joint swelling, arthritis scores, and pro-inflammatory cytokine expression (TNF-α, IL-6, IL-17a) in both models. It was associated with mobilization of CD45Sca1CD29 mesenchymal stem cells, increased CD4CD25Foxp3 regulatory T cells, and reduced CD4RORγt Th17 cells in peripheral blood. MRG-001 preserved cartilage integrity was associated with reduced osteoclast-mediated bone erosion, and improved trabecular bone structure. It was associated with reduced fibroblast-like synoviocyte activation, lower TGF-β signaling activity, and decreased RANKL expression in joint tissues. Additionally, MRG-001 was associated with reduced pathological angiogenesis (CD31EMCN vessels) and sensory nerve innervation (PGP9.5, CGRP fibers), corresponding with improved pain-like behaviors and physical function. MRG-001 exerts broad therapeutic effects in RA by modulating immune responses, preserving joint architecture, and alleviating pain. These findings support its potential as a novel, multi-modal disease-modifying therapy for RA and warrant further clinical investigation.
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6. {"_":" basal-like malignant cells: architects of an immunosuppressive microenvironment in bladder cancer: a comprehensive bioinformatics analysis of single-cell and spatial transcriptomics.","i":["RUNX3+"]}
6. {"_":"基底样恶性细胞：膀胱癌免疫抑制微环境的构筑者：单细胞与空间转录组学的综合生物信息学分析。","i":["RUNX3+"]}PMID:日期:2026-04-30Current single-cell and spatial transcriptomic studies on bladder cancer tissue samples are limited, highlighting the need for advanced molecular and single-cell approaches to enhance our understanding of these complexities and identify reliable prognostic indicators. We integrated and analyzed five publicly available single-cell RNA-seq datasets, totaling over 530 000 cells from 62 bladder cancer and normal samples, conducting comprehensive analyses that were validated using single-nucleus and spatial transcriptomic datasets. Additionally, spatial transcriptomics findings were confirmed through RNA fluorescence in situ hybridization. Our integrated single-cell analysis uncovered stage-dependent heterogeneity in bladder cancer, with malignant epithelial cells exhibiting dynamic trajectories and enrichment in the PI3K-AKT-mTOR pathway. A distinct subcluster of malignant epithelial cells characterized by the highest basal score (C8) was identified; this subpopulation appears to be specifically regulated by , is associated with poorer prognosis, and predominantly interacts with exhausted CD8 T cells, + naïve T cells, and + monocytes via the - signaling pathway. Elevated pathway activity scores for both the PI3K-AKT-mTOR and - pathways were observed in single-nuclei and spatial tumor tissues, with notable colocalization of key markers mainly within bladder cancer regions. Our study demonstrates that + basal-like malignant epithelial cells, along with other immunosuppressive cell subtypes, their interactions, and pathway signatures, hold promise as prognostic biomarkers. These insights may facilitate the development of personalized therapeutic strategies for bladder cancer.
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7. Genetically engineered porcine liver: a new era in transplantation.
7. 基因工程猪肝：移植领域的新纪元PMID:日期:2026-04-29The persistent shortage of allogenic donor organs has driven the exploration of xenotransplantation as a viable alternative for patients with end-stage liver disease. This review investigates the progress and challenges in liver xenotransplantation, focusing on the use of genetically engineered animals, particularly pigs, as potential organ donors. This narrative review discusses various sources of xenografts, highlighting their advantages and limitations, and provides a historical overview of liver xenotransplantation, encompassing both clinical and experimental experiences. Key obstacles, such as immunological rejection, coagulation dysfunction, and the risk of zoonotic infections, are analyzed, with emphasis on how these challenges have been addressed through genetic modifications and adjunctive therapies. Recent clinical trials are also reviewed, offering insights into the outcomes and lessons learned from these pioneering efforts. We also explored the regulatory, legal, and ethical considerations critical to advancing liver xenotransplantation into clinical practice, along with future perspectives on the field's evolution. This comprehensive overview aims to provide a clear understanding of the current state of liver xenotransplantation and the strategies being developed to overcome existing barriers, paving the way for future clinical applications.
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8. The challenges of laparoscopic hepatectomy for bilateral hepatolithiasis.
PMID:日期:2026-04-27该文献暂无摘要。
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9. Computer-Assisted Detection (CADe) of colonic polyps during colonoscopy reduces cancer-related healthcare costs - a single Singaporean institution cost effectiveness analysis.
9. 结肠镜检查中计算机辅助检测（CADe）结肠息肉可降低与癌症相关的医疗成本——一项新加坡单一机构的成本效益分析PMID:日期:2026-04-20Colonoscopy remains as an invaluable diagnostic and therapeutic tool used for the screening and evaluation of colonic pathologies. Periodic endoscopic screening allowing for early detection and removal of pre-malignant lesions, resulting in significant overall decreased incidence and mortality from colorectal cancer. Despite its added costs, artificial intelligence (AI) has been increasingly utilized in the field of endoscopy, boasting benefits of improving adenoma detection rates while reducing endoscopists' mental fatigue intra-procedurally. As such, further evaluation of the financial impact of such AI-usage in screening colonoscopies was performed to assess if routine use of AI-guidance in screening colonoscopies was justifiable. This study conducted a cost effectiveness analysis of the GI Genius™ CADx Intelligent Endoscopy Module (US-DG-2000309, 2021 Medtronic) system in our local Singaporean tertiary public healthcare institution. A decision tree model was used to calculate Incremental Cost Effectiveness Ratio (ICER), comparing cancer-related costs for patients who underwent conventional colonoscopy versus colonoscopy with AI guidance. With a calculated ICER value of 0.72, our study suggests that AI-assisted colonoscopy was indeed cost effective. Quality-Adjusted Life Years (QALY) values derived for each subgroup of patients further demonstrated overall improved quality of life reported by patients who underwent AI-assisted colonoscopy, as compared to conventional colonoscopy. Our study supports the incorporation of AI guidance into routine colonoscopic evaluation in view of increased cost effectiveness and improved overall quality of life achieved. However, further studies and analysis must be undertaken before reliably determining the cost-effectiveness of AI on regional or international scales.
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10. Surgical antibiotic prophylaxis duration and surgical site infection in orthopedic surgery: insights from a prospective cohort study.
10. 骨科手术中预防性抗生素使用时长与手术部位感染：一项前瞻性队列研究的启示PMID:日期:2026-03-23该文献暂无摘要。