Revista Espanola de Patologia西班牙病理学杂志
Revista Espanola de Patologia(英文缩写 REV ESP PATOL),ISSN 1699-8855,eISSN 1988-561X,中文译名:西班牙病理学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2024 | 0.500 | Q4 |
| 2025 | 0.600 | Q4 |
Revista Espanola de Patologia 最新收录文献
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1. Clinicopathologic spectrum and developmental reactivation in adenomatoid odontogenic tumour: A 35-year retrospective study.
PMID:期刊:日期:2026-09-23Adenomatoid odontogenic tumour (AOT) is an uncommon benign epithelial odontogenic tumour characterised by distinctive clinicopathological and histopathological features. This study evaluated the clinical, radiographic, and histopathological spectrum of AOT, compared intra-follicular (IF-AOT) and extra-follicular (EF-AOT) variants, and assessed the potential utility of machine learning for variant classification. A retrospective analysis of 29 histopathologically confirmed intraosseous AOTs diagnosed over a 35-year period (1989-2024) was performed. Demographic, clinical, radiographic, histopathological, treatment, and follow-up data were evaluated. Cases were classified as IF-AOT or EF-AOT based on their relationship with impacted teeth. Associations between variant type and clinical characteristics were assessed using Fisher's exact test. A decision-tree model incorporating clinical variables was used to classify AOT variants. The mean age at diagnosis was 19.07 years, with a female-to-male ratio of 3:1. The maxilla was affected in 58.6% of cases, with a predominance of lesions in the anterior region. IF-AOT accounted for 69.0% of cases and EF-AOT for 31.0%. Histopathological examination demonstrated duct-like structures, whorled epithelial nests, sheet-like and rosette-like arrangements, together with less common findings, including CEOT-like calcifications, stellate reticulum-like cells, squamous metaplasia, and dentigerous cyst-associated changes. No statistically significant associations were identified between AOT variant and the clinical features evaluated (p > 0.05). The decision-tree model achieved an overall classification accuracy of 88.9%. Postoperative follow-up ranged from 6 months to 2 years, with no recurrences documented during the follow-up period. AOT demonstrates considerable clinicopathological and histopathological diversity while retaining its characteristically favourable biological behaviour. Integration of clinical, radiographic, and histopathological findings facilitates accurate recognition of its variants and uncommon morphological presentations. Machine learning may provide an adjunctive approach to variant classification; however, validation in larger datasets is required.
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2. Adenoid ameloblastomas: expanding the clinicopathological spectrum with five new cases.
PMID:期刊:日期:2026-09-23To describe the clinicopathological and immunohistochemical characteristics of adenoid ameloblastoma (AdAM), a rare odontogenic neoplasm recognised as a distinct entity in the 2022 WHO classification, and to highlight the diagnostic challenges associated with its overlapping features. A retrospective analysis was performed on five cases of AdAM diagnosed between 2021 and 2023 at a tertiary care institution. Clinical presentation, radiographic findings, histopathological features, and immunohistochemical profiles were reviewed and systematically analysed. All patients presented with painless jaw swelling, with a mean age of 40.8 years and a female-to-male ratio of 4:1. Three lesions involved the posterior mandible and two involved the maxilla. Radiographically, four tumours were radiolucent, whereas one exhibited mixed radiolucent-radiopaque features. Histologically, all cases demonstrated characteristic pseudoductal and cribriform patterns with whorled epithelial formations. Additional findings included clear cells, dentinoid deposition, spindle cell areas, ghost cells, and keratin pearl formation. Immunohistochemically, al tumours were positive for AE1/AE3, CK5/6, CK14, and CK19 and negative for CK7. The Ki-67 proliferation index ranged from 2% to 30%, with low-level p53 expression in all cases. One tumour showed BRAF V600E positivity. AdAM represents a distinct but diagnostically challenging odontogenic tumour with locally aggressive behaviour and potential for recurrence. Recognition of its characteristic histopathological patterns, supported by immunohistochemical findings, is critical for accurate diagnosis and appropriate therapeutic management.
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3. A decade of dysplasia: clinicopathological patterns and malignant transformation with Candida co-infection.
PMID:期刊:日期:2026-09-22Oral epithelial dysplasia (OED) is a key precursor to oral squamous cell carcinoma (OSCC); however, predicting its malignant transformation remains a clinical challenge due to its multifactorial aetiology and regional variations in risk-related habits. This study aimed to analyse the clinicopathological characteristics and malignant transformation potential of OED, including Candida-associated lesions, over a 10-year institutional period. A 10-year retrospective analysis (2014-2025) was conducted on 305 histopathologically confirmed OED cases from the Department of Oral Pathology, Saveetha Dental College, Chennai. Demographic characteristics, lesion site, habits, dysplasia grade, oral submucous fibrosis (OSMF) stage, Candida colonisation, treatment modality, and progression to OSCC were recorded and analysed using SPSS v26. Middle-aged males predominated (87%), with the buccal mucosa being the most common site (52%). Pan chewing without tobacco was the leading habit (31%). OSMF was present in 41% of patients, most of whom had advanced-stage disease, and moderate dysplasia accounted for 43% of cases. Candida colonisation was identified in 2.3% of cases, with no statistically significant association with transformation (p > 0.05). Among the 58 patients with documented follow-up, 15 (25.9%) demonstrated progression to OSCC during the available 12-month follow-up period. Malignant transformation occurred in 15 patients (4.9% of the total cohort) during follow-up. Surgical excision was the most frequent management approach, although long-term follow-up adherence remained low (19%). OED in this South-Indian cohort exhibited a distinct aetiological profile dominated by pan chewing and OSMF; however the limited duration of follow-up precluded reliable estimation of the long-term malignant transformation rate. Candida infection appeared to be a minor co-factor rather than a direct predictor of progression.
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4. The pathological significance of DNA damage-inducible transcript 3 immunohistochemistry in the diagnosis of myxoid liposarcoma.
PMID:期刊:日期:2026-09-22Myxoid liposarcoma (MLS) is a distinct subtype of liposarcoma characterised by recurrent FUS-DDIT3 or EWSR1-DDIT3 gene fusions and distinctive histological features. DNA damage-inducible transcript 3 (DDIT3) is a key downstream mediator of these fusions and contributes to sarcoma development by disrupting adipocytic differentiation. In this study, we assessed the diagnostic value and biological relevance of DDIT3 by combining immunohistochemistry (IHC) with quantitative real-time polymerase chain reaction (qRT-PCR). The study included 128 soft tissue tumours, comprising 45 cases of MLS and 83 histological mimics. DDIT3 expression was evaluated by IHC, and transcript-level expression was analysed using qRT-PCR. FUS-DDIT3 fusion transcripts were assessed and associations with clinicopathological features and FNCLCC tumour grade were analysed. DDIT3 IHC was positive in 42/45 (93.3%) MLS cases and 3/83 (3.6%) histological mimics (P < 0.001), yielding a sensitivity of 93.3%, specificity of 96.4%, positive predictive value of 93.3%, and negative predictive value of 96.4%. All cases with classic MLS morphology showed positive nuclear DDIT3 staining, whereas the three non-positive MLS cases occurred within the high-grade/round-cell subgroup. Among the mimics, DDIT3 positivity was observed only in 3 of 5 Ewing sarcoma cases. qRT-PCR demonstrated variation in FUS: DDIT3 transcript expression among the analysed cases; however, transcript-level expression did not uniformly parallel immunohistochemical protein detection. DDIT3 is a highly sensitive and specific marker for the diagnosis of MLS. The concordance between protein and transcript expression highlights the biological relevance of DDIT3 and supports its use as a practical, cost-effective adjunct to molecular testing in routine diagnostic practice.
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5. Giant cell interstitial pneumonia associated with occupational iron exposure: an exceptional case report.
PMID:期刊:日期:2026-09-05Multinucleated giant cell pneumonia associated with heavy metals (GIP) is a rare disease of the pulmonary parenchyma, with just over one hundred cases reported in the scientific literature. It has been associated almost exclusively with occupational exposure to tungsten and cobalt. Although its pathogenesis is not fully understood, it has been proposed that exposure to an aetiological agent, together with an immune imbalance, underlies the pathophysiology of the characteristic microscopic findings, including fibrosis, multinucleated foreign-body giant cells and cannibalism. To date, iron has not been described as one of the causative agents. We present the case of a 41-year-old patient with documented occupational exposure to iron who developed respiratory failure. For the first time, findings consistent with GIP were demonstrated in the pulmonary parenchyma, with microscopic features that we consider specific.
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6. Primary vulvar extramammary Paget disease associated with herpes simplex virus infection: A rare case report.
PMID:期刊:日期:2026-09-01Extramammary Paget disease (EMPD) is an uncommon neoplasm with a predilection for apocrine gland-rich areas, such as the anogenital region. Herpes simplex virus (HSV) commonly causes infection in this location. However, the coexistence of both entities within the same lesion is exceptionally rare. We report the case of an 89-year-old woman presenting with a pruritic erythematous vulvar plaque. Skin biopsy revealed intraepidermal glandular proliferation consistent with EMPD, composed of pagetoid cells positive for CK7 and diastase-resistant periodic acid-Schiff (PAS). In addition, acantholytic areas containing multinucleated giant cells with ground-glass nuclei and positive immunohistochemical staining for HSV were identified. Subsequent investigations showed no evidence of an underlying visceral malignancy. The concomitant occurrence of EMPD and HSV is extremely rare, with this representing the fourth reported case in the literature. This case highlights the importance of recognising superimposed HSV infection in EMPD, as it may alter the histological features and pose a diagnostic challenge.
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7. Immunohistochemical evaluation of Ki-67 and GLI1 in sporadic and nevoid basal cell carcinoma syndrome-associated odontogenic keratocysts.
PMID:期刊:日期:2026-09-01Odontogenic keratocyst (OKC) is a developmental odontogenic cyst that may occur sporadically (OKCsp) or in association with nevoid basal cell carcinoma syndrome (NBCCS) (OKC-sy). NBCCS is an autosomal dominant disorder characterised by morphological abnormalities and an increased predisposition to several neoplasms, including basal cell carcinomas. Mutations in the tumour suppressor gene PTCH1 have been reported in patients with OKC and NBCCS. PTCH1 participates in a signalling cascade that culminates in the translocation of GLI transcription factors to the nucleus, thereby activating target genes involved in cell proliferation. Aberrant GLI1 expression has been associated with increased proliferation in lung adenocarcinoma and other cancers. To compare GLI1 and Ki-67 protein expression in OKCs associated with NBCCS versus sporadic OKCs. We included 13 OKCsp and 9 OKCsy from a children's hospital and a dental school. Immunohistochemistry was performed using anti-GLI1 and anti-Ki-67 to assess GLI1 expression and cell proliferation. No significant differences were observed in GLI1 or Ki-67 expression in the epithelial component of OKCsy versus OKCsp. A positive correlation between GLI1 and Ki-67 expression was detected in the total sample (r=0.71, p<0.05). The positive correlation between GLI1 and Ki-67 expression in OKCs suggests an association between SHH pathway activity and cell proliferation in both sporadic and syndromic lesions.
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8. Synchronous collagenous and ulcerative colitis: A case report and review of the literature.
PMID:期刊:日期:2026-08-18Collagenous colitis (CC) and ulcerative colitis (UC) are chronic inflammatory bowel diseases with distinct pathophysiological mechanisms and histological features. Their coexistence is exceptional and poses significant diagnostic and therapeutic challenges. We report the case of a 51-year-old asymptomatic woman who underwent colonoscopy after a positive faecal occult blood test, which revealed mild endoscopic changes. Serial biopsies from three colonic segments (ascending, transverse, and descending and sigmoid colon) demonstrated histological findings characteristic of active ulcerative colitis (architectural distortion, basal plasmacytosis, and crypt abscesses) coexisting with diagnostic criteria for collagenous colitis (a subepithelial collagen band measuring 15-23μm with capillary entrapment). Initial faecal calprotectin was 77.4mg/kg, rising to 1779mg/kg at three months, with subsequent normalisation (77mg/kg) following optimisation of mesalazine therapy. We review the most relevant literature on the synchronous or metachronous coexistence of these two conditions. This case underscores the importance of considering coexisting disease entities when faced with complex histological findings, even in the absence of significant symptoms.
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9. HTLV-1-associated lymphocytic vasculitis presenting as acute appendicitis: A clinicopathological case report.
PMID:期刊:日期:2026-07-17Human T-lymphotropic virus type 1 (HTLV-1) is associated with immune dysregulation, opportunistic infections, and, less commonly, lymphoproliferative and inflammatory disorders. We report the case of a young woman presenting with acute appendicitis, hyperkeratotic skin lesions, onychodystrophy, and subsequent facial diplegia. Investigation revealed HTLV-1 infection and crusted scabies, supporting an underlying immunosuppressed state. Histopathological examination of the appendix showed a transmural, angiocentric lymphocytic infiltrate involving small- and medium-sized vessels, without fibrinoid necrosis or leukocytoclasia. Immunohistochemical analysis demonstrated a predominance of CD4+ T lymphocytes with low proliferative index, consistent with a reactive process. These findings support a diagnosis of lymphocytic vasculitis presenting as acute appendicitis. Although a causal relationship cannot be definitively established, the clinicopathological and immunophenotypic features suggest a potential association with HTLV-1 infection, which has not been previously reported in this setting.
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10. Peritoneal angiosarcoma in a patient with a history of cervical cancer treated with radiotherapy: A case report.
PMID:期刊:日期:2026-07-17Angiosarcoma is a highly malignant endothelial neoplasm that accounts for 1-2% of all soft tissue sarcomas in humans, and its marked biological aggressiveness constitutes a major clinical challenge. Early identification is particularly difficult in patients with a history of malignancies treated with radiotherapy, due to its histopathological heterogeneity and nonspecific clinical presentation, which often leads to confusion with other mesenchymal or epithelial neoplasms. We report the case of a 72-year-old woman with a history of cervical carcinoma treated with radiotherapy who presented with progressive pelvic pain, significant weight loss, and urinary symptoms. Initial imaging studies suggested peritoneal carcinomatosis, while multiple biopsies were negative for tumour recurrence. Given the discordance between morphological findings and initial immunohistochemical studies, a stepwise diagnostic approach using immunohistochemical panels was implemented. This approach confirmed peritoneal angiosarcoma following demonstration of CD31 positivity. This case highlights the importance of maintaining a high index of suspicion in patients with a history of pelvic irradiation, the utility of sequential diagnostic algorithms, the limitations of resource-limited settings, and the value of a multidisciplinary approach in the management of rare sarcomas.