INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES国际分子科学杂志
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(英文缩写 INT J MOL SCI),ISSN 1661-6596,eISSN 1422-0067,中文译名:国际分子科学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 最新收录文献
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1. {"_":"RETRACTED: Atiq et al. Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson's Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment. 2023, , 9942.","i":["Int. J. Mol. Sci.","24"]}
PMID:日期:2026-09-17The Journal retracts the article "Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson's Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment" [...].
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2. {"_":"RETRACTED: Li et al. Blockade of Y177 and Nuclear Translocation of Bcr-Abl Inhibits Proliferation and Promotes Apoptosis in Chronic Myeloid Leukemia Cells. 2017, , 537.","i":["Int. J. Mol. Sci.","18"]}
PMID:日期:2026-09-16The Journal retracts the article "Blockade of Y177 and Nuclear Translocation of Bcr-Abl Inhibits Proliferation and Promotes Apoptosis in Chronic Myeloid Leukemia Cells" [...].
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3. Recent Advances in ZIF-8 Performance for Electrochemical Applications: A Comprehensive Review.
PMID:日期:2026-09-07Zeolitic imidazolate framework-8 (ZIF-8) has emerged as a material for electrochemical energy conversion, serving dual primary roles in fuel cell technologies: (i) as an electrocatalyst precursor for oxygen reduction reaction (ORR) and methanol oxidation reaction (MOR) through pyrolysis-derived N-doped porous carbons and metal-nitrogen-carbon (M-N-C) structures, and (ii) as a membrane component that enhances proton conductivity via imidazole-mediated Grotthuss hopping while suppressing fuel crossover through molecular sieving. This comprehensive review systematically evaluates ZIF-8 performance across multiple fuel cell types, including primarily proton exchange membrane fuel cells (PEMFCs), as well as direct methanol fuel cells (DMFCs), anion exchange membrane fuel cells (AEMFCs), and microbial fuel cells (MFCs), while also covering related electrochemical applications such as zinc-air batteries, supercapacitors, and water splitting devices, where ZIF-8-derived materials demonstrate improved catalytic activity. The review examines structure-performance relationships, highlighting strategies such as heteroatom doping, bimetallic synergy, hierarchical porosity engineering, and polymer composite fabrication that have enabled ZIF-8-based catalysts to achieve ORR half-wave potentials and PEMFC power densities, rivaling commercial Pt/C systems. ZIF-8 composite membranes demonstrate proton conductivities in polybenzimidazole systems and effective methanol blocking. Despite improved progress, challenges persist regarding long-term stability, scalable synthesis, and degradation mechanism understanding. This review critically analyzes recent advances, identifies performance-limiting factors across applications, and outlines future research directions for developing commercially viable ZIF-8-based electrochemical technologies.
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4. Antiparasitic Activity of Sesquiterpene γ-Lactones and the Search for New Pharmaceutical Agents.
PMID:日期:2026-09-07This study presents a comparative in vitro evaluation of 24 natural sesquiterpene γ-lactones and selected semisynthetic derivatives against three trypanosomatid parasites responsible for neglected tropical diseases: , , and . The compounds were screened for antiparasitic activity across different parasite life stages, and their cytotoxicity was assessed in mammalian cells. Several compounds demonstrated high inhibitory activity (>95%) at 10 µg/mL, including estafiatin (), grossheimin (), cynaropicrin (), argolide () derivatives, and arglabin (). However, a marked decrease in activity was observed at lower concentrations and in intracellular parasite models, particularly for and amastigotes. Among the tested compounds, dihydroargolide () and pulchellin C () exhibited comparatively lower cytotoxicity and were further evaluated, yielding IC values of 10.51 ± 1.72 µg/mL and 2.51 ± 1.13 µg/mL against , respectively. Against promastigotes, estafiatin (), 8α-chloroacetoxygrossheimin (), and arglabin () showed IC values of 0.16 ± 0.13, 0.35 ± 0.18, and 0.58 ± 0.11 µg/mL, respectively, although their selectivity indices remained limited. Comparative analysis of the dataset indicates that specific structural elements, such as the α-methylene-γ-lactone moiety and selected substituents (e.g., epoxy and acetyl groups), may influence antiparasitic activity in a species-dependent manner. At the same time, the generally low selectivity indices and reduced activity in intracellular models highlight important limitations of these compounds as direct drug leads. Overall, this work provides a systematic comparative dataset and identifies preliminary structure-activity trends that may guide further chemical optimization of sesquiterpene γ-lactones as antiparasitic hit compounds.
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5. Functional Nanostructured Carbon Honeycomb Monoliths for Hemoadsorption: Preliminary Studies on Biocompatibility, Protein-Bound Uremic Toxins and Inflammatory Cytokines Elimination.
PMID:日期:2026-09-07Rice husk (RH) is a renewable siliceous lignocellulosic waste providing a unique, greener and less toxic alternative to conventional synthetic polymeric precursors in the production of carbon-based materials for biomedical applications. In this work we studied the porous structure of RH-lignin-based activated carbon produced in the form of honeycomb carbon monoliths and assessed their potential as hemoadsorbents for blood purification in the treatment of patients with serious medical conditions, such as kidney failure and sepsis. To determine their clinical suitability for such an application, the hemocompatibility and cytotoxicity of the monoliths were investigated using the standard ISO guidelines. The monoliths did not cause any changes in the cell viability or cell lysis. High micro/mesoporosity and surface chemistry of the initial monolith-C, N- and P-doped nanostructured carbon honeycomb monoliths were established by low-temperature nitrogen adsorption (LTNA) studies, mercury porosimetry data (MIP), SEM/EDS analysis and FT-IR spectroscopy. The micro-mesoporous, activated carbon-based filtration/adsorbent prototype devices, in the form of three-dimensional (3D) carbon matrix, functionalized with ion-exchange amino- and phosphate groups and encased in polyolefin heat shrink cable sleeve, have been developed with the capacity to remove protein-bound uremic toxins (PBUTs), such us PCS and IS, as well as inflammatory cytokines (IL-6 and IL-8) from human plasma in a flowing model system. The ammoxidized monolith-N, derived from the monolith-C, had the highest removal efficiency (40.05% for PCS, and 28.4% for IL-6). By contrast, phosphorylated monolith-P demonstrated the highest removal efficiency (54.62% for IS, and 54.4% for IL-8), whilst the monolith-C has the lowest removal efficiency for these adsorbates. These results do not correlate with the LTNA and MIP study results, suggesting that the interaction of surface chemical functional groups with the solutes play key roles in the adsorption mechanism. The ion-exchange mechanism of PBUTs and inflammatory cytokine chemisorption by the monoliths, modified with surface N- and P-containing functional groups, has been proposed.
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6. {"_":"A Sesquiterpenoid from Protects C17.2 Neural Stem Cells Against Oxidative Stress Through Modulation of GPCR-Associated Signaling Pathways.","i":["Schizophyllum commune"]}
PMID:日期:2026-09-07The chemical constituents and neuroprotective potential of remain insufficiently characterized. Therefore, we isolated and identified five secondary metabolites (-) from , and investigated their neuroprotective activities and underlying mechanisms. Compound showed the most significant protective effect against HO-induced cytotoxicity in C17.2 neural stem cells. Spectroscopy was used to structurally characterize the isolated compounds. Using RNA sequencing (RNA-seq), compound was found to significantly modulate genes associated with G protein-coupled receptor (GPCR)-related signaling pathways and neuroactive ligand-receptor interactions. Differentially expressed genes, including , , , , and , were validated using quantitative real-time PCR. They are associated with GPCR-related signaling and neurotransmission pathways, consistent with the RNA-seq data. As indicated by the functional enrichment analysis, compound may regulate neuronal stress responses through GPCR-associated signaling networks. In the Western blot, compound markedly attenuated HO-induced protein kinase A (PKA) C phosphorylation without altering total PKA C expression, suggesting that modulation of the cAMP/PKA signaling pathway may contribute to the neuroprotective effects of compound . Collectively, compound may exert neuroprotective effects against oxidative stress-induced neuronal injury, potentially through the modulation of GPCR-mediated PKA signaling. is a promising natural bioactive compound source for further development in neuroprotective research.
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7. Integrative Approaches to Atopic Dermatitis: Exploring Biomarkers, Current Therapies, and the Potential Role of Osteopathic Manipulative Medicine.
PMID:日期:2026-09-07Atopic dermatitis (AD) is a chronic, relapsing, and remitting condition that affects approximately 10% of the population. It is a multifactorial disease involving immune dysregulation, gene mutations, and environmental factors that ultimately disrupt skin barrier restoration, causing pruritic lesions. Given the marked heterogeneity of AD and the presence of multiple immune and clinical endotypes, no single therapeutic strategy is likely to be universally effective. Instead, a growing panel of distinct biomarkers offers an avenue for true precision medicine by enabling more accurate endotype classification, prediction of treatment response, and tailored treatments. In this context, ongoing research is increasingly focused on individualized, biomarker-informed strategies, as well as the evaluation of adjunctive approaches that can be integrated with standard therapies to optimize long-term disease control. Given the central role of systemic inflammation and barrier dysfunction in AD, the mechanistic focus of osteopathic manipulative medicine (OMM) on circulation, lymphatic drainage, and autonomic regulation offers another biological treatment to use alongside conventional therapies. This concise review examines the pathogenesis of AD, current treatments and their limitations, and the expanding role of biomarkers in refining diagnosis, prognosis, and therapeutic decision-making. It also explores the potential integration of OMM as a biologically plausible adjunct to support individualized, endotype-aware treatment strategies, while emphasizing the current lack of empirical evidence and the need for rigorous mechanistic and clinical studies.
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8. {"_":"Cardiac Glycoside 3β-Bufalin Suppresses Cancer Cell Proliferation by Coupling with Na,K-ATPase and Volume-Regulated Anion Channel Within Membrane Microdomains.","sup":["+","+"]}
PMID:日期:2026-09-07Bufadienolides are toad-derived cardiotonic steroids with anti-cancer activity; however, their Na,K-ATPase-mediated anti-cancer mechanisms remain incompletely understood. Here, we compared the anti-proliferative effects of six bufadienolides, bufalin (3β-bufalin), resibufogenin, cinobufagin, telocinobufagin, cinobufotalin, and desacetylcinobufagin, on human colorectal cancer HT-29 cells. Among them, only 3β-bufalin significantly suppressed cell proliferation in a concentration-dependent manner, with an IC of 1.8 nM, whereas its hepatic metabolite, 3α-bufalin, showed markedly weaker activity, with an IC of 488 nM. 3β-Bufalin inhibited Na,K-ATPase activity with an IC of approximately 37 nM, indicating that it suppressed growth at concentrations lower than those required for pump inhibition. The Na,K-ATPase α1-isoform can function as a receptor-type (non-pumping) signaling platform linked to volume-regulated anion channel (VRAC) activation in membrane microdomains of cancer cells. 3β-Bufalin activated the VRAC with an EC of 4.6 nM, whereas 3α-bufalin and the other bufadienolides showed no detectable activation. The pharmacological inhibition of the VRAC and the disruption of cholesterol-rich membrane microdomains significantly attenuated the anti-proliferative effect of 3β-bufalin. Furthermore, 3β-bufalin induced G2/M cell cycle arrest, which was attenuated by VRAC inhibition. These findings indicate that 3β-bufalin selectively suppresses cancer cell proliferation by coupling with receptor-type Na,K-ATPase to activate the VRAC in membrane microdomains rather than inhibiting Na,K-ATPase pump activity.
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9. Closed-Loop Neuromodulation for Brain Fatigue: From Real-Time Biomarkers to Adaptive Intervention.
PMID:日期:2026-09-07Brain fatigue is a debilitating condition whose molecular complexity-neurotransmitter imbalance, neuroinflammation, and metabolic failure-has long defied effective intervention. Conventional open-loop neuromodulation offers fixed stimulation, but fatigue fluctuates. Closed-loop neuromodulation, adjusting stimulation in real time, holds real promise. Yet its delivery hinges on a single, unresolved bottleneck: the sensing-decision chain. In this review, we deconstruct closed-loop systems into sensing, decision, and intervention, and argue that the true challenge is not technological but informational-how to integrate fast electrophysiological signals with slow molecular biomarkers (inflammatory cytokines, neurotrophic factors, adenosine) into a unified control framework. We show that a "fast-slow variable" architecture offers a practical path forward: fast signals guide immediate responses, slow variables set baselines and thresholds, and their integration enables predictive, pre-emptive intervention. We also examine the molecular correlates of neuromodulation-synaptic plasticity, anti-inflammatory signaling, and neurotrophic regulation-as the mechanistic foundation for therapeutic effect. Finally, we confront the translational triad of causality, inter-individual variability, and the information-energy-time trade-off. We conclude that realizing effective closed-loop neuromodulation for brain fatigue will require parallel advances in both stimulation hardware-improving spatial targeting, dose precision, and modality versatility-and individualized sensing-decision algorithms capable of reliably translating multi-modal biomarkers into timely, safe interventions. Both areas remain active fronts of development, and neither can be neglected in clinical translation.
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10. {"_":"Morphological, Physiological and Transcriptomic Changes in Response to Water Deficit Stress in L.","i":["Brassica napus"]}
PMID:日期:2026-09-07Yield losses due to water-deficit (WD) conditions, especially during the reproductive stages of plant development, pose a significant threat to global canola ( L.) production. Therefore, it is critical to investigate traits contributing to improved productivity under increased WD conditions. Here we present phenotypic, physiological and transcriptomic changes in response to WD across contrasting canola accessions exhibiting variation in drought resistance-related traits. WD significantly reduced shoot biomass, plant height, harvest index, leaf water content, photosynthetic CO assimilation rate, intrinsic water-use efficiency and carbon isotope discrimination. WD caused 49 to 100% of the seed yield reduction: the minimum seed yield reduction (49.66%) was observed in a doubled-haploid (DH) line, 06-5101.137, while the maximum yield reduction (94.1 to 100%) occurred in the late-flowering DH lines (06.5101.088 and 06-5101.306). Seed yield showed a positive correlation ( = 0.29 to 0.95) with shoot biomass and harvest index, leaf water content, photosynthetic CO assimilation rate, intrinsic water use efficiency and carbon isotope discrimination. However, it showed negative correlations with days to flower, leaf specific weight, root length, root biomass ( = -0.04 to -0.79) across water treatments. The specific leaf transcriptome analysis of the two parental lines of DH population that exhibit variation for effective water use under well-watered and water-deficient conditions revealed different categories of differentially expressed genes (DEGs): WD-responsive DEGs in BC1329 parental line (1116) and BC9102 (1205) with 754 and 853 DEGs unique to BC1329 and BC9102, respectively, WD-responsive DEGs (906), genotype-dependent DEGs (8465) and genotype × treatment interaction DEGs (353). DEG annotations revealed that the WD-treatment-affected genes were involved in stress responses and growth and development. We further located 235 DEGs within the QTL regions underlying agronomic and physiological performance. Our study provides a conceptual framework for the morphological, physiological and molecular determinants involved in water-use efficiency. Seedlings' traits with high heritability values, such as shoot biomass, leaf weight, leaf water content and ΔC, serve as proxies for trait-based selection for improved seed yield under both water-limited and non-water-limited conditions.