JOURNAL OF MEDICINAL FOOD药用食品杂志
JOURNAL OF MEDICINAL FOOD(英文缩写 J MED FOOD),ISSN 1096-620X,eISSN 1557-7600,中文译名:药用食品杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.542 | Q3 |
| 2022 | 2.400 | Q3 |
| 2023 | 1.700 | Q3 |
| 2024 | 2.000 | Q3 |
| 2025 | 1.800 | Q3 |
JOURNAL OF MEDICINAL FOOD 最新收录文献
-
1. {"_":"Standardized Extract Alleviates Scopolamine-Induced Memory Impairment in Mice.","i":["Artemisia argyi"]}
1. 标准化艾蒿提取物缓解东莨菪碱诱导的小鼠记忆障碍PMID:日期:2026-11-01Cognitive dysfunction has become a major health issue in the global aging society. For treating cognitive dysfunction or dementia, several small molecules or innovative drugs, including a monoclonal antibody against the amyloid β protein, have been prescribed. However, their adverse effects require the exploration of alternative treatments. (Asteraceae) has been used as traditional medicine for gastrointestinal disorders and inflammation. Recent reports suggest it has potential neuroprotective effects; however, evidence regarding its cognitive benefits and underlying mechanisms remains limited. We examined the memory-enhancing effects of an ethanolic extract of . (EAA) (10, 30, or 100 mg/kg, once per each behavioral test) in a mouse model of scopolamine-induced cognitive dysfunction and explored its mode of action on memory-related signaling pathways. Memory-related performance was assessed using the Y-maze, novel object recognition, Morris water maze, and passive avoidance tests. Next, Western blotting was used to evaluate changes in signaling molecules, such as CaMKII, ERK, CREB, and brain-derived neurotrophic factor (BDNF) in the hippocampus. EAA administration significantly improved cognitive performance across all tests. It restored the phosphorylation levels of CaMKII, ERK, and CREB, respectively, as well as the expression level of BDNF, after 12 h of treatment. Moreover, it enhanced long-term potentiation without altering basal synaptic transmission within the hippocampus. In summary, EAA facilitated cognitive enhancement during a cholinergic impaired state, attributable to its influence on synaptic plasticity and activation of the CaMKII-ERK-CREB-BDNF signaling cascade.
-
2. Biological Effects of Bovine Lactoferrin on Keratinocyte Proliferation and Migration (Bovine Lactoferrin and Wound Healing Response).
PMID:日期:2026-11-01Lactoferrin (Lf), an iron-binding glycoprotein present in various exocrine secretions, exhibits a wide range of biological activities, including cell proliferation, immune modulation, and antimicrobial effects. This study investigates the bioactivities of commercially available Lf derived from bovine milk. Commercial Lf, with a purity exceeding 95%, was analyzed using chemical and cell-based assays. Fourier-transform infrared spectroscopy confirmed the protein's identity through characteristic peaks. Cell viability assays demonstrated noncytotoxic effects, while cell morphology analysis and proliferation assays revealed that Lf stimulated human keratinocyte (HaCaT) proliferation in a concentration-dependent manner. Wound healing assays showed that Lf promotes wound closure, with optimal effects observed at lower concentrations. However, antimicrobial assays revealed that Lf alone did not exhibit activity against and . These findings highlight the importance of purity and concentration in determining the biological activity of Lf. Further studies are warranted to investigate the molecular mechanisms underlying these effects and the potential applications of bovine Lf in therapeutic contexts.
-
3. Method Validation for Phenylalanine Analysis in Unconventional Food Plants.
PMID:日期:2026-11-01Dietary restriction of high-protein foods is the primary treatment strategy for phenylketonuria, a disease considered an inborn error of metabolism associated with phenylalanine. The diet of these patients is monotonous, consisting mainly of certain types of fruits and vegetables, and is often supplemented with the use of phenylalanine-free formulas. Considering that Brazil is one of the countries with the most incredible biodiversity in the world, Non-Conventional Food Plants (NCPPs) become food options that can be regularly introduced into the diet of phenylketonuric patients. In the present study, a method for quantifying phenylalanine in NCPPs was validated using high-performance liquid chromatography with an ultraviolet detector. The phenylalanine content was determined in 15 NCPPs samples from the Brazilian Cerrado. The validated method demonstrated selectivity for the amino acid phenylalanine, with linearity in the range of 1-10 nmol/mL, indicating no matrix effect, and provided proven recovery, repeatability, and precision. The detection and quantification limits were 0.0011 mg/100 g and 0.0035 mg/100 g, respectively. The phenylalanine content ranged from 20.28 to 235.58 mg/100 g. It was observed that leafy vegetables had a higher phenylalanine content than the taro stem (20.28 mg/100 g), the chayote fruit (32.67 mg/100 g), the sepal of the sorrel plant (38.21 mg/100 g), and the nasturtium flower (116.24 mg/100 g). These data suggest that these vegetables can be incorporated into the diet of phenylketonuric patients, thereby contributing to dietary diversity and making it less monotonous and more palatable.
-
4. Pilot Study of Gallic Acid Cream as a Potential Treatment for Plaque Psoriasis.
PMID:日期:2026-11-01Gallic acid, a catechin polyphenol in tea, completely inhibited angiogenesis in assays of human tissue at 10 M. Psoriasis is a skin disease caused by excessive secretion of angiogenenic factors by keratinocytes and stromal skin cells. In a double-blind pilot study, six subjects with bilateral plaque psoriasis were treated with 10 M gallic acid in a cream base or with a cream base placebo over 8 weeks, four times a day, and treatments were randomly assigned to either the left or the right side. The gallic acid cream was well tolerated, but it did not reduce the psoriasis more than the placebo. One subject wanted to extend treatment for an additional 8 weeks. At the end of 16 weeks, the subject had complete resolution of the psoriatic plaque treated with gallic acid cream. In contrast, the plaque treated with placebo cream was not reduced and stayed equivalent to week six. Gallic acid is inexpensive and does not cause side effects. A longer trial evaluating 10 M gallic acid cream for the treatment of psoriasis seems indicated.
-
5. {"_":"A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of Extract for Fat-Mass Reduction in Adults with Overweight/Obesity.","i":["Salacia reticulata"]}
PMID:日期:2026-11-01Salacia reticulata has long been used in traditional medicine for metabolic disorders, but clinical evidence for obesity-related outcomes remains limited. We conducted a 12-week randomized, double-blind, placebo-controlled trial to evaluate the preliminary efficacy and safety of a standardized extract (SLE) on body-fat outcomes. Adults with overweight and/or obesity were randomized to receive SLE capsules or a matching placebo twice daily for 12 weeks. The coprimary endpoints were changes from baseline to week 12 in total body fat mass (g) and body fat percentage (%) measured by dual-energy X-ray absorptiometry. The primary efficacy analysis was conducted in the full analysis set (mITT) using analysis of covariance with baseline values and sex as covariates. Per-protocol set analyses were performed as supportive sensitivity analyses. Among randomized participants, the mITT included 66 participants in the SLE group and 67 in the placebo group, and baseline characteristics were comparable. After 12 weeks, total body fat mass decreased in the SLE group, whereas little change was observed in the placebo group. The between-group difference favored SLE (ANCOVA-adjusted LS mean difference, -482.30 g; 95% CI, -907.05 to -57.54 g). The corresponding between-group comparison was statistically significant (Wilcoxon rank-sum test, = .0158). Body fat percentage also decreased in the SLE group, but the between-group difference was not statistically significant (ANCOVA-adjusted LS mean difference, -0.30%; 95% CI, -0.73 to 0.12%; Wilcoxon rank-sum test, = .1453). Several secondary body-composition outcomes, including trunk, android and gynoid fat measures, showed directionally favorable changes in the SLE group. In this 12-week trial, SLE was associated with a modest reduction in total body fat mass, whereas the second coprimary endpoint, body fat percentage, did not differ significantly between groups. These mixed coprimary findings provide only preliminary clinical evidence and should be interpreted with caution, particularly given the study's retrospective trial registration.
-
6. Effects of Bromelain in Maternal Deprivation and Social Isolation Models of Schizophrenia in Male BALB/c Mice.
PMID:日期:2026-10-01Bromelain is a mixture of enzymes found in several parts of the pineapple plant, including the stem, fruit, leaves, and peel. Its use was recommended to slow down the progression of neurological disorders such as Parkinson's disease. Although studies have examined the beneficial effects of bromelain (Br) in neurological disorders, its detailed benefits in schizophrenia are still poorly understood. We, thus, modeled schizophrenia using two developmental methods. In the first experiment, postweaning social isolation (SI) method where male mice were weaned at postnatal day (PND) 21 and isolated in individual cage for 5 weeks was used to induce schizophrenia. The second experiment used a maternal deprivation (MD) model, where mothers were separated from their pups for 24 h at PND 9. In both experiments 1 and 2, Br was administered orally from PND 21 to PND 56. At PND 56, there were behavioral assessments of nest building, anxiety, depression, and locomotion, while oxidative stress, neuroinflammation, brain-derived neurotrophic factor, and astrocyte expression in the prefrontal cortex and hippocampus were assessed at the end of the behavioral studies. Our study found that both SI and MD caused anxiety, depression, and hyperlocomotion. This was accompanied by oxidative stress in the prefrontal cortex and hippocampus, and neuroinflammation was observed only in the hippocampus. While SI rearing caused poor nest-building capacity, MD rearing did not impact nest-building capacity of the mice. The study found that administration of 50 mg/kg of Br reversed oxidative stress and neuroinflammation and significantly reduced anxiety level, hyperlocomotion, and depression in the mice. Mice administered Br also had a better nest-building capacity. Br may, therefore, benefit individuals at ultra-high risk and patients with schizophrenia, alleviating the positive, negative, and cognitive symptoms of the disease, without the side effects reported in the use of psychotic drugs.
-
7. {"_":"Effects of KABP051 Probiotic on Body Composition, Microbiome and Mood in Healthy Overweight Adults.","i":["Lactiplantibacillus plantarum"]}
PMID:日期:2026-10-01Obesity and mental health disorders are among the greatest public health challenges of the 21st century. Interestingly, an altered microbiome profile has been associated with both conditions. The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effects of dietary supplementation with a specific probiotic strain ( KABP051) on body composition and gut microbiome balance, together with measures of mood state, in a population of healthy overweight subjects. Sixty healthy, moderately stressed, nondepressed and overweight or obese volunteers were supplemented for 12 weeks with probiotic ( KABP051; 1 billion colony forming units/day) or placebo (microcrystalline cellulose). The KABP051 group experienced significantly greater improvements compared with placebo on body composition measurements, including a reduction in body weight and waist circumference, which decreased in 1.97 ± 0.77 (mean ± SE) kg and 2.15 ± 0.81 (mean ± SE) cm versus placebo at the end of the intervention (both < .05, mixed model for repeated measures [MMRM] and analysis). Microbiome composition improved in KABP051 group, with significant increase in the relative abundance of spp. versus placebo. Body fat percentage, profile of mood states fatigue, and confusion sub-scores showed a global trend toward improvement compared with placebo, with the change at 12 weeks being significant in the three measurements in analysis ( = .015, = .014, and = .016, respectively). No serious adverse events were registered during the intervention period. These results suggest that a specific strain of probiotic bacteria ( KABP051) may have both metabolic and psychobiotic effects and may be beneficial for enhancing weight loss and body composition, improving energy (less fatigue) and mood levels while embarking on a healthy lifestyle regimen. ClinicalTrials.gov identifier: NCT06808061.
-
8. Modulation of Antioxidant and Anti-Inflammatory Response in the Eyes of CKD Animals Supplemented with Larch Arabinogalactan.
PMID:日期:2026-10-01Chronic kidney disease (CKD) is a systemic condition associated with inflammation and oxidative stress, affecting organs beyond the kidneys. Although rarely emphasized, the eyes may also be affected but underlying molecular mechanisms remain largely unexplored. The gut-kidney and gut-eye axes are emerging as therapeutic targets with prebiotics like ResistAid®-a Larch Arabinogalactan (LAG) supplement with antioxidant and immunomodulatory effects-showing promise through gut microbiota modulation. This study assessed ResistAid®'s effects on ocular gene expression in a CKD rat model. Twenty four Wistar rats were assigned to Sham (S), Sham + Treatment (ST), Nephrectomized (N), Nephrectomized + Treatment (NT) ( = 6 each). CKD was induced by 5/6 nephrectomy. The treatment was administered via gavage for 30 days at a dose of 5.35 mg/day, adapted from human recommendations. At day 30, blood and tissues were collected. Expression of antioxidant enzymes () and other genes () was analyzed by qPCR. Biochemical and well-being assessments were also conducted. Nephrectomy, regardless of treatment, increased and expression in eye and blood; Specific to NT animals, ocular , and expressions were markedly elevated when compared with N animals and blood and ocular expressions were not elevated, differing from N animals. No significant changes were observed between the S and ST groups. CKD induces systemic oxidative and inflammatory responses. ResistAid® partially mitigated these effects in blood and eye, suggesting systemic and local benefits, possibly via gut microbiota modulation.
-
9. Melphalan's Effect on Testicular Prepubertal Rats: Induction of Autophagy and Apoptosis, Modulated by the Potential of Chrysin.
PMID:日期:2026-10-01Melphalan, a widely used alkylating chemotherapeutic agent, is known to cause gonadotoxicity, particularly affecting spermatogenesis and steroidogenesis. This study investigated the protective effects of chrysin, a flavonoid with antioxidant and antiapoptotic properties, on melphalan-induced testicular damage in immature male rats. Forty-eight prepubertal Wistar rats were divided into six groups receiving melphalan (0.5 mg/kg/day, intraperitoneally), chrysin (50 or 75 mg/kg/day, orally), or combinations thereof. Treatment spanned 30 days, covering the prepubertal to pubertal transition. Melphalan exposure significantly reduced testosterone levels, disrupted spermatogenesis, and increased oxidative stress, as indicated by elevated malondialdehyde and decreased glutathione peroxidase levels. Gene expression analysis revealed marked upregulation of autophagy (LC3β, Beclin-1, Atg5, Atg7, Atg12) and apoptosis (BAX, caspase-3) markers, alongside downregulation of the antiapoptotic gene BCL2. Histological analysis showed severe damage to seminiferous tubules and reduced Johnsen scores. Chrysin coadministration, particularly at 75 mg/kg, significantly ameliorated these effects by restoring antioxidant capacity, reducing expression of cell death-related genes, and improving testicular structure and hormone levels. These findings demonstrate that chrysin mitigates melphalan-induced gonadotoxicity through modulation of oxidative stress, apoptosis, and autophagy pathways. Chrysin's dose-dependent protective effects highlight its potential as a natural therapeutic agent to preserve reproductive function in individuals undergoing chemotherapy during prepuberty.
-
10. Inulin, Containing Frutco-Oligosaccharides, and Generalized Anxiety Disorder 7-Item Scale Scores in College Students.
PMID:日期:2026-10-01This study was conducted to determine the effects of fructo-oligosaccharide (FOS) inulin on anxiety symptoms in college students. Forty million adults in the United States suffer from anxiety. Previous studies have viewed gut microbiota and its potential link to anxiety in both humans and mice. However, no previous studies focused on the effect of FOS inulin on college students. Fourteen subjects received 4.9 g per day of FOS inulin as the treatment (TX) or no supplement as the control (CON) for 28 days. Both the TX and CON groups were given the Generalized Anxiety Disorder 7-Item Scale (GAD-7) on days 1 and 28. Both groups were also given a 3-day food log at the beginning of the experiment and otherwise maintained their regular diet. Results showed a statistically significant decrease in median GAD-7 scores in both groups ( = .017, = .637 and = .042, = .587 for the TX and CON groups, respectively). However, when comparing the GAD-7 scores between groups, no statistically significant results were found. FOS inulin supplementation did not alleviate anxiety symptoms in college students participating in this study.