Annual Review of Genetics遗传学年评
Annual Review of Genetics(英文缩写 ANNU REV GENET),ISSN 0066-4197,eISSN 1545-2948,中文译名:遗传学年评 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 13.826 | Q1 |
| 2022 | 11.100 | Q1 |
| 2023 | 8.700 | Q1 |
| 2024 | 8.600 | Q1 |
| 2025 | 9.100 | Q1 |
Annual Review of Genetics 最新收录文献
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1. {"_":"The History of Transposable Element Invasions in .","i":["Drosophila melanogaster"]}
PMID:日期:2026-09-09As a fundamental biological principle, genomic information is typically transmitted vertically from parent to offspring. Occasionally, however, genetic material is transferred horizontally between species. Transposable elements (TEs) are frequently involved in such horizontal transfer (HT), possibly due to their ability to move in genomes. HT has been particularly well-studied in , a key model organism for evolutionary and ecological research. Recent studies have revealed that HT triggered the invasion of 12 different TEs in the genome over the past 200 years. This finding challenges our traditional view of genome evolution, suggesting that TE invasions may not only be isolated events that can be ignored as rare exceptions but could represent recurrent events that continuously reshape genomes. In this review, we trace the history of how these 12 invasions were discovered and outline the lines of evidence supporting them. We also discuss the potential evolutionary consequences of these TE invasions, including their roles in adaptation, genome evolution, speciation, and extinction risk. Finally, we highlight open questions and directions for future research. In particular, it will be essential to test whether other organisms also exhibit similarly high rates of recent TE invasions and to assess whether human activity triggered the high rate of invasions.
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2. Signaling Cascades in Meiotic Chromosome Dynamics.
PMID:日期:2026-09-01Meiosis is a specialized cell division essential for sexual reproduction, generating haploid gametes through two consecutive nuclear divisions following a single round of DNA replication. During an extended meiotic prophase I, chromosomes undergo elaborate rearrangements, such as pairing, synapsis, and recombination, culminating in crossovers that physically link homologs for accurate segregation. Errors in these processes cause aneuploidy, a leading contributor to infertility, miscarriage, and congenital disorders. These chromosomal events must be precisely coordinated with cell cycle transitions through signaling pathways involving cell cycle and DNA damage checkpoint kinases, as well as ubiquitin-mediated regulation. These pathways control the timing and levels of programmed DNA double-strand breaks, monitor synapsis and crossover formation, and enforce surveillance checkpoints that eliminate defective cells. This review examines how signaling networks orchestrate chromosome dynamics during meiotic prophase, highlighting conserved principles and organism-specific adaptations that ensure faithful genetic transmission across generations.
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3. Noncanonical Functions of DICER-Mediated Pathways.
PMID:日期:2026-09-01Dicer has long been viewed as the RNAse III enzyme that generates small regulatory RNAs to drive RNA interference (RNAi) machinery and posttranscriptional gene silencing. However, a growing body of evidence reveals that Dicer's functional landscape extends far beyond its canonical role in the cytoplasmic RNAi pathway. In this review, we delineate the classical, RNAse III-dependent small RNA processing activities from an expanding set of noncanonical functions in which Dicer operates independently of RNAi outputs. We highlight emerging principles that underlie these functions, including structural and regulatory principles, with a focus on nuclear functions, posttranslational regulation, and noncanonical substrates. We then explore how Dicer intersects with genome integrity pathways, transcriptional programs, and cellular response to DNA damage. Finally, we propose an integrated conceptual framework in which Dicer acts as a multifunctional regulator of chromatin architecture and genome stability, as we consider how perturbations of these pathways contribute to disease.
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4. Stemness as a Systems-Level State: From Ancestral Plasticity to Systemic Control in Regeneration, Aging, and Cancer.
PMID:日期:2026-09-01Multicellularity necessitated the evolution of cellular diversity and specialization, yet across organisms, the retention of cellular plasticity within defined physiological contexts is a recurring principle. Here, we examine early-diverging metazoans to reevaluate the evolutionary logic of stemness. Rather than viewing stem cells as exceptional, we argue that cellular plasticity represents a deeply conserved attribute of early life. The ability of cells to remain responsive, multipotent, and regenerative under ecological or physiological contexts challenges the notion of cellular identity. We integrate evidence across three layers: evolutionary origins of cellular plasticity, systemic physiological axes that govern stem cell behavior, and metabolic and epigenetic mechanisms that execute fate decisions. This synthesis reveals that stemness is not a default cellular state but a licensed state, permitted when organism-level physiological signals align with local tissue demands. Within this framework, regeneration, age-associated decline, and cancer emerge as evidence of how effectively systemic governance regulates cellular plasticity across multicellular life.
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5. Transposable Elements and the Impact of Genomic Autoimmunity.
5. 转座元件与基因组自身免疫的影响PMID:日期:2026-08-28Transposable elements (TEs), originally characterized in maize, are ubiquitous features of eukaryotes and replicate within genomes independent of the host replication cycle. This replicative advantage can result in genomes that are almost entirely composed of these selfish genetic elements. Most mutations caused by TE insertions are harmful, and all eukaryotes have evolved mechanisms to limit TE replication. This process requires the careful distinction between self and nonself, or host versus TE. Eukaryotic genome defense commonly relies on Argonaute proteins that block the TE replication cycle, guided by small RNAs that detect harmful TE transcripts. Because no system of immunity is perfect, genes can be caught in the crossfire and inappropriately silenced. Here, mainly focusing on maize and , we discuss how off-target small RNA silencing can arise. This genomic immunity can shape TE evolutionary dynamics, establish novel modes of adaptation and epigenetic inheritance, and establish evolutionary feedback that shapes the evolution of gene silencing itself.
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6. Message in a Bottle: The Therapeutic Potential of Domesticated Capsid Proteins.
6. 瓶中信：驯化衣壳蛋白的治疗潜力PMID:日期:2026-08-26Domesticated genes derived from long terminal repeat (LTR) retrotransposons are widespread in mammals and occur in other metazoans, including and zebrafish. Their protein products commonly contain a capsid (CA) domain, and many retain the ability to assemble capsid-like particles that package RNA, and potentially other biomolecules, with emerging roles in intercellular communication, neuronal signaling, placental gene regulation, and fertility. Biochemical, genetic, and structural studies have identified the core domains that are necessary and sufficient for capsid formation, even in the absence of accessory proteins. Several systems also exhibit selective self-RNA packaging directed by elements, suggesting rules that could be harnessed for programmable cargo selection. Building on this foundation, recent efforts have developed host-encoded Gag CA proteins for delivery applications, ranging from engineered systems to approaches that exploit naturally preloaded capsids. In addition to established platforms such as adeno-associated viruses (AAVs), lipid nanoparticles (LNPs), and nonintegrating lentiviral systems, domesticated Gag CA proteins may offer complementary features such as lower immunogenicity, flexible cargo capacity, and tissue-specific targeting. Open questions remain regarding release and cellular entry mechanisms, in vivo tropism, determinants of immunogenicity across family members, and safety.
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7. The CENtral Identity Crisis: Maintaining Centromere Identity in the Male Germline.
PMID:日期:2026-08-25Centromeres are chromosomal loci required for accurate chromosome segregation in cell division and are defined epigenetically by the centromere-specific histone H3 variant CENP-A. The assembly and maintenance of CENP-A in each cell cycle are critical for continued centromere identity and function. In the germline, centromere identity must be maintained throughout many specialized divisions and preserved in gametes to ensure transgenerational inheritance. The male germline poses a particular challenge for maintaining centromere identity because most histones are removed from sperm chromatin and replaced by protamines in most animal species, causing a potential identity crisis. Here, we discuss the timing and mechanisms of centromere assembly and maintenance throughout spermatogenesis and the impacts on fertility and offspring development. We focus on , which has served as an informative model of the male germline, but also draw comparisons with other species, highlighting any conservation or adaptations. Finally, we outline unanswered questions in the field, identify technical barriers, and propose potential solutions.
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8. The Identification and Impact of 3'UTR Regulatory Variants on Phenotype and Disease.
8. 3'非翻译区调控变异对表型和疾病的影响及识别PMID:日期:2026-08-21[中文摘要] 遗传变异是疾病易感性的主要原因，序列变异可改变蛋白质功能和化学计量。尽管转录后调控是哺乳动物基因表达控制的重要组成部分，但3‘非翻译区（UTR）内的单核苷酸多态性（SNPs）仍是影响人类健康的未被充分探索的变异来源。然而，开创性研究发现，包括表达数量性状位点（eQTLs）在内的功能性相关SNPs在3’UTR中富集。这些发现凸显了3‘UTR内SNPs的重要性。本文概述了用于对3’UTR SNPs进行优先级排序和验证的技术。计算方法，如关联分析和评分框架，可实现对SNP的优先级排序，而近期的实验方法已能够并行验证许多SNPs。我们讨论了与人类健康和发展相关的3‘UTR SNPs实例，以及如何利用3’UTR SNPs的模式和流行程度来识别对构成转录后调控基础的顺式调控位点和反式作用因子的选择。
[英文摘要] Genetic variation is a major cause of disease susceptibility, and sequence variants can change both protein function and stoichiometry. Though posttranscriptional regulation is a major component of mammalian gene expression control, single-nucleotide polymorphisms (SNPs) within 3' untranslated regions (UTRs) remain an underexplored source of variation impacting human health. Nevertheless, seminal studies have found that functionally relevant SNPs, including expression quantitative trait loci (eQTLs), are enriched in 3'UTRs. These discoveries highlight the importance of SNPs within 3'UTRs. Here, we provide an overview of techniques used to prioritize and validate 3'UTR SNPs. Computational methods, such as association assays and scoring frameworks, allow for SNP prioritization, and recent experimental methods have enabled the validation of many SNPs in parallel. We discuss examples of 3'UTR SNPs that are relevant to human health and development, as well as how the patterns and prevalence of 3'UTR SNPs can be used to identify selection on the -regulatory sites and -factors that underlie posttranscriptional regulation.
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9. Advancing Human Artificial Chromosomes at the Dawn of Synthetic Genomics.
9. 在合成基因组学黎明之际推进人类人工染色体PMID:日期:2026-08-21[中文摘要] 人类人工染色体（HACs）是经过工程化改造的染色体尺度DNA分子，能够在哺乳动物细胞中自主复制和分离，为大规模、稳定、非整合性基因递送提供了独特平台。第一代HACs的出现早于合成基因组学的研究工作，其发展促进了对染色体结构和着丝粒功能的理解。与此同时，微生物合成基因组学证明，整个病毒、细菌和酵母染色体均可被设计、合成、组装并进行功能验证，从而确立了基因组尺度工程的核心原则。近年来，大片段DNA组装、长读长测序以及表观遗传学着丝粒界定等方面的进展，使HACs得以纳入更广泛的合成基因组学框架之中。本文综述并整合了微生物系统的经验与哺乳动物染色体生物学的进展，探讨HACs如何日益成为精确且可定制的平台。当前的研究工作有望拓展其在基因与细胞治疗、功能基因组学、人源化模型以及合成哺乳动物基因组理性构建方面的潜力。
[英文摘要] Human artificial chromosomes (HACs) are engineered, chromosome-scale DNA molecules that replicate and segregate autonomously in mammalian cells, offering a unique platform for large, stable, nonintegrating genetic delivery. The first generation of HACs emerged prior to synthetic genomics efforts, and their development has aided understanding of chromosome structure and centromere function. In parallel, microbial synthetic genomics demonstrated that entire viral, bacterial, and yeast chromosomes can be designed, synthesized, assembled, and functionally validated, establishing core principles for genome-scale engineering. Recent advances in large DNA assembly, long-read sequencing, and epigenetic centromere specification now position HACs within this broader synthetic genomics framework. We review and integrate lessons from microbial systems with advances in mammalian chromosome biology and discuss how HACs are becoming increasingly precise and customizable platforms. Current efforts promise to expand their potential for gene and cell therapy, functional genomics, humanized models, and the rational construction of synthetic mammalian genomes.
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10. Keeping in Sync with an Unpredictable Environment: Insights from Circadian Biology.
10. 与不可预测的环境保持同步：来自昼夜节律生物学的洞见PMID:日期:2026-08-18[中文摘要] 可预测的环境线索，如光照和温度的昼夜与季节周期，在植物和动物中均由生物钟（circadian clocks）整合，以使代谢、生理、生长、发育和行为与一天和一年中的最佳时段相协调。这种时间耦合使生物体能够预判反复出现的环境变化，并维持内部生物过程与外部环境之间的适应性对齐。然而，环境变化的加速——包括环境变异性的增加和线索可靠性的改变——威胁着这种生物钟对齐，可能破坏各类群中历史上具有益处和适应性的关系。在本综述中，我们提供了关于输出性状生物钟调控的跨类群综合，重点阐述了依赖这种同步作用的保守机制和类群特异性机制。我们提供了关于这些时间调控过程在日益动态且更难预测的环境中可能如何被重塑或受损的背景。
[英文摘要] Predictable environmental cues, such as daily and seasonal cycles of light and temperature, are integrated by circadian clocks in both plants and animals to coordinate metabolism, physiology, growth, development, and behavior with optimal times of day and year. This temporal coupling enables organisms to anticipate recurring environmental changes and maintain adaptive alignment between internal biological processes and the external environment. However, the accelerating pace of environmental change, including increased environmental variability and altered cue reliability, threatens this circadian alignment, potentially disrupting historically beneficial and adaptive relationships across taxa. In this review, we provide a cross-taxonomic synthesis of circadian regulation of output traits, highlighting conserved and taxa-specific mechanisms that rely on this synchronization. We provide context on how these timing processes may be reshaped or compromised in increasingly dynamic and less predictable environments.