HIGH ALTITUDE MEDICINE & BIOLOGY高原医学与生物学
HIGH ALTITUDE MEDICINE & BIOLOGY(英文缩写 HIGH ALT MED BIOL),ISSN 1527-0297,eISSN 1557-8682,中文译名:高原医学与生物学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.183 | Q3 |
| 2022 | 2.100 | Q3 |
| 2023 | 1.600 | Q3 |
| 2024 | 1.400 | Q3 |
| 2025 | 1.300 | Q3 |
HIGH ALTITUDE MEDICINE & BIOLOGY 最新收录文献
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1. {"_":"PPARα Activation Attenuates Right Ventricular Hypertrophy by Regulating Myocardial Glucose and Lipid Metabolism in High-Altitude Pulmonary Hypertension and .","i":["In Vivo","In Vitro"]}
PMID:日期:2026-09-24Zhang, Xiaoying, Jiajia Wu, Yuchan Zhang, Yuquan Xie, Qi Si, Shadi Li, and Yiwei Han. PPARα activation attenuates right ventricular hypertrophy by regulating myocardial glucose and lipid metabolism in high-altitude pulmonary hypertension and . 00:00-00, 2026. Right ventricular hypertrophy (RVH) and cardiac function are key prognostic determinants in patients with high-altitude pulmonary hypertension. Meanwhile, their initiation and progression are driven by disturbances in glucose and lipid metabolism in cardiomyocytes. This study established an SU5416-associated hypobaric hypoxia-induced RVH (H-RVH) rat model and a CoCl-induced hypoxic cardiomyocyte model to explore glucose and lipid metabolism alterations and mechanisms. The metabolomic cluster analysis of metabolites primarily focused on lipid metabolism, along with Kyoto Encyclopedia of Genes and Genomes-enriched pathways, including glycolysis/gluconeogenesis, glycerophospholipid metabolism, and the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Compared with the control group, glucose transporter-4 (GLUT-4) and pyruvate dehydrogenase (PDH) kinase were increased by 320% and 220% in H-RVH rats, respectively ( < 0.05), whereas PDH and citrate synthase (CS) were decreased by 39% and 58%, respectively ( < 0.05), collectively indicating a shift toward glycolysis and away from glucose oxidation. Seahorse Extracellular Flux (XF) assay revealed that basal glycolysis and compensatory glycolytic capacity were significantly elevated in the CoCl-induced hypoxic cardiomyocyte model compared with the control group (288.5 ± 9.82 vs. 344.1 ± 10.24, 335.9 ± 11.58 vs. 385.7 ± 14.74, < 0.05). The expression levels of PPARα and carnitine palmitoyltransferase 1α (CPT-1α) in the H-RVH group were 48% and 56% lower than those in the control group, respectively ( < 0.05); acetyl-CoA and adenosine triphosphate (ATP) were also reduced ( < 0.05). Fenofibrate mitigated CoCl-induced hypoxic damage through 1.6-fold activation of PPARα. Cardiac-specific PPARα overexpression via an adeno-associated virus (AAV9) effectively attenuated RVH, as evidenced by the reduction in Fulton's index (0.37 ± 0.09 vs. 0.46 ± 0.02, < 0.05), right ventricular anterior wall diastolic (RVAWd) (0.64 ± 0.04 vs. 0.93 ± 0.02, < 0.01) and RVAWs (0.68 ± 0.05 vs. 0.97 ± 0.02, < 0.01). In contrast, PPARα knockdown did not significantly alter the Fulton index but markedly increased both RVAWd (1.00 ± 0.01 vs. 0.77 ± 0.03, < 0.01) and RVAWs (1.00 ± 0.02 vs. 0.70 ± 0.05, < 0.01). In this study, our findings demonstrate that PPARα exerts a protective effect against RVH, at least in part, by promoting fatty acid oxidation through upregulation of its downstream target proteins CPT-1 and acyl-CoA oxidase 1.
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3. Determination of Color Vision in School Children in High Altitude, Leh, India.
PMID:日期:2026-09-14Patyal, Sagarika, Jasdeep Singh, Kanika Bhardwaj, and Uday Yanamandra. Determination of color vision in school children in high altitude, Leh, India. 00:00-00, 2026. Color vision deficiency (CVD) is a heritable condition predominantly affecting males due to its X-linked recessive inheritance. High altitude may exacerbate color discrimination impairment through hypobaric hypoxia-mediated depression of retinal function, particularly affecting short-wavelength cone pathways. Population-based data on CVD from high-altitude Indian communities are absent from the literature. A cross-sectional study was conducted at Lamdon School, Leh, Ladakh, India (11,400 ft/3,474 m above sea level). A total of 505 schoolchildren (204 boys; 301 girls) aged 11-18 years underwent a structured ophthalmical examination and color vision testing using the 38-plate Ishihara pseudoisochromatic plate test under standardized conditions. CVD was detected in 53 of 505 children (10.50%): 22 boys (10.78%) and 31 girls (10.30%). No statistically significant sex difference in CVD prevalence was detected (Fisher's exact test, = 0.883). Severity analysis revealed a significant sex interaction: girls predominated in mild (21/33) and moderate (9/12) CVD categories, while boys constituted 7 of 8 severely color-deficient children (≥5 plate errors). CVD prevalence rose with age, peaking at 20.7% in 18-year-olds. Plates 9 and 17 generated the highest error frequencies; plate 9 elicited errors exclusively in boys, and plate 17 elicited errors exclusively in girls. Plate-specific misidentification patterns deviated from standard Ishihara predictions in both sexes. The overall CVD prevalence in this high-altitude Ladakhi population substantially exceeds rates reported at sea level in India and most global populations, mirroring the altitude-related pattern documented in Nepal. The severity paradox, girls dominating mild CVD while boys dominate severe CVD, suggests that carrier females heterozygous for CVD-associated alleles may be expressing phenotypically detectable color discrimination impairment at altitude, possibly through hypoxia-mediated amplification of their marginal trichromatic capacity.
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4. {"_":"Role of Mitochondrial tRNA 12320 A>G Mutation on Heart Rate Variability and Blood Pressure at Low-Altitude and in a High-Altitude Hypoxic Environment.","sup":["Leu"]}
4. 线粒体tRNALeu 12320 A>G突变对低海拔和高海拔缺氧环境下心率变异性和血压的作用PMID:日期:2026-09-01Pan, Cuiping, Qunyuan Wang, Minglei Zhang, Ruizhe Li, Yining Liu, and Zongbin Li. Role of mitochondrial tRNA 12320 A>G mutation on heart rate variability and blood pressure at low altitude and in a high-altitude hypoxic environment. 27:152-158, 2026. Mutations-gene mutations-can exert dual, environment-dependent effects on cardiovascular disease. We analyzed clinical data and mitochondrial DNA from 84 young Han Chinese men ascending from low-altitude to high-altitude regions (>4,000 m). Nine subjects harbored the mitochondrial tRNA A12320G mutation. Notably, none of these 9 mutation carriers developed acute mountain sickness (AMS), whereas 34 (40.5%) of the 84 volunteers in the cohort were diagnosed with AMS, indicating a significant protective association (). In the low-altitude environment, time domain parameters of heart rate variability (HRV) in the mutant volunteers were significantly lower than those in the unmutated volunteers (SDNN: 141.76 ± 30.75 ms vs.169.08 ± 32.83 ms, = 0.020; RMSSD: 29.70 ms vs. 41.35 ms, = 0.022; HRV triangular index: 41.8% vs. 52.4%, = 0.024; SDSD: 37.4 ms vs. 50.5 ms, = 0.016; PNN50: 3.1% vs 7.6%, = 0.008); 24-hour mean systolic blood pressure (118.63 ± 9.54 vs. 113.39 ± 6.30 mmHg, = 0.029), nocturnal mean diastolic blood pressure (67.37 ± 7.91 vs. 61.11 ± 7.08 mmHg, = 0.015) were also higher; HRV and blood pressure were not statistically different between the mutant and nonmutant groups in the high-altitude environment. Hematological analysis revealed mutants at high altitude had significantly lower plateletcrit (0.23% vs. 0.26%, = 0.019) and total protein (72.78 ± 3.84 g/L vs.75 .65 ± 3.0 g/L, = 0.008). The A12320G mutation acts as a cardiovascular risk factor (reduced HRV, increased blood pressure) at low altitude, whereas at high altitude it was associated with a reduced incidence of AMS, possibly through metabolic adaptive mechanisms, reflecting the environmentally dependent dual roles of this gene effect.
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6. High-Altitude Environment and Chronic Obstructive Pulmonary Disease: Epidemiology, Pathological Mechanisms, and Clinical Management.
6. 高原环境与慢性阻塞性肺疾病：流行病学、病理机制和临床管理PMID:日期:2026-09-01Wei, Shuna, and Xiaoju Liu. High-altitude environment and chronic obstructive pulmonary disease: epidemiology, pathological mechanisms and clinical management. 27:189-202, 2026Background:Chronic obstructive pulmonary disease (COPD) is a significant global health concern. Environmental factors such as low oxygen and temperature, along with poor living habits in high-altitude areas, contribute to regional variations in the occurrence and progression of COPD. There is currently a lack of systematic reviews on the relationship between high-altitude environments and COPD, which hinders effective prevention and treatment. This narrative review comprehensively sorts out and analyzes the research on COPD in high-altitude areas from three aspects: epidemiological characteristics, pathophysiological mechanisms, and clinical management. Epidemiologically, COPD mortality increases with altitude; however, prevalence rates remain debated. Pathophysiologically, factors include hypoxia-inducible factor regulation, hemodynamic changes, air pollution particles promoting inflammation and oxidative stress, as well as gene mutations like PPARA and SERPINA1. Clinically managing COPD in high-altitude regions requires individualized approaches that consider environmental conditions. High-altitude environments exacerbate COPD through hypoxic stress, pollutant exposure, and genetic variations. Future efforts should focus on developing a risk prediction model for COPD that incorporates altitude parameters to enhance targeted prevention and treatment strategies in these areas.
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7. Effects of OXXYSLAB Probiotic Supplementation on Blood Oxygenation and Hypoxic Symptoms in Healthy Individuals: A Controlled Normobaric Hypoxia Trial.
PMID:日期:2026-09-01Marzola, Manuel, Massimiliano Marazzato, Roberto Nutini, Adriano Di Marzio, Francesca Baroli, Manuel Paolucci, Matteo De Angelis, Joanna Giuliano, Ambra Menichelli, Guglielmo Sferrati, Carmen Santangelo, Danilo Bondi, Gerardo Bosco, and Vittore Verratti. Effects of OXXYSLAB probiotic supplementation on blood oxygenation and hypoxic symptoms in healthy individuals: A controlled normobaric hypoxia trial. 27:168-176, 2026. OXXYSLAB, a high-dose, multi-strain probiotic, has shown promise in pathological hypoxemia but remains untested under acute normobaric hypoxia (NH) in healthy volunteers. We evaluated whether OXXYSLAB alters peripheral oxygen saturation (SpO) and alleviates hypoxia-related symptoms in healthy adults exposed to NH. In two randomized, double-blind, crossover phases, young adults were exposed to ∼13.5% inspired O for 1 hour (Phase 1: = 12, 21.6 ± 1.3 years, body mass index [BMI] = 23.2 ± 2.8 kg/m) or 40 minutes (Phase 2: = 20, 21.7 ± 1.5 years, BMI = 22.9 ± 3.2 kg/m). Participants received either a single (8 × 10 colony-forming unit [CFU]) or double (1.6 × 10 CFU) dose of OXXYSLAB or matched placebo in randomized order. NH induced the expected SpO decrease (Phase 1: 90.0 ± 2.1%; Phase 2: 86.7 ± 2.9%), with no significant effect of probiotic supplementation on SpO. In Phase 1, a trend toward lower heart rate (Δ = -3.2 bpm) under OXXYSLAB approached significance ( = 0.053); no effect was seen in Phase 2. Notably, headache incidence under probiotic conditions was reduced by 50% (Phase 1) and 62.5% (Phase 2) compared to placebo ( = 0.046 and = 0.059, respectively). While OXXYSLAB did not enhance systemic oxygenation during acute NH, it significantly attenuated headache, a common symptom of hypoxia. Further research should assess its efficacy under prolonged or clinical hypoxemic conditions.
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8. The Physiological and Altitude Lowering Effects of Different Supplemental Oxygen Flow Rates at Extreme Simulated Altitude: A Pilot Study.
PMID:日期:2026-09-01Wakeham, Denis J., Andrew R. Tomlinson, Giorgio Manferdelli, Matthew M. Howrey, Anna K. Geib, Murugappan Ramanathan, Marcus Payne, Renie Guilliod, James Berry, Tony G. Babb, Peter Hackett, Benjamin D. Levine, and Christopher M. Hearon, Jr. The physiological and altitude lowering effects of different supplemental oxygen flow rates at extreme simulated altitude: a pilot study. 27:143-151, 2026. Approximately 80% of high-altitude climbers use supplemental oxygen >8,000 meters, yet optimal dosing strategies have not been established. Therefore, in six unacclimatized individuals (34 ± 8 years; 2 F/4 M), we quantified the effects of supplemental oxygen flow rates (6, 4, 2, 1 and 0 L/min) using the SUMMIT Oxygen mask at 282 mmHg (rest and cycle ergometry: 60 and 120 Watts) and 253 mmHg (rest only) barometric pressure in a hypobaric chamber. We measured oxygen saturation (SpO) and gas fractions in the mask during 4-minute exposures to each flow rate. Resting at 282 mmHg, SpO (6 L/min: 99% ± 0%; 0 L/min: 70% ± 8%, < 0.001) and mean inspired oxygen fraction decreased (6 L/min: 65.87% ± 14.11%; 0 L/min: 21.50% ± 0.44%, < 0.001) with lowering of supplemental oxygen. Exercise further decreased SpO and oxygen fractions across all flow rates at 282 mmHg. At 253 mmHg, SpO followed a similar trend to data collected at 282 mmHg (6 L/min: 96% ± 2%; 4 L/min: 93% ± 3%; 2 L/min: 87% ± 3%; 1 L/min: 71% ± 0%; 0 L/min: 66% ± 9%). Furthermore, at rest at 253 mmHg, 2 L/min of supplemental oxygen lowered the equivalent altitude to 4,489 meters. All unacclimatized participants were able to tolerate 253 mmHg at rest on as little as 2 L/min of supplemental oxygen.
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9. Does Hydrogen-Rich Water Reduce Oxidative Stress in Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.
PMID:日期:2026-09-01Zhang, Fengying, Yang Zhong, Qiuyue Li, Doudou Hao, Zhiyou Shi, Suying Zhu, Qian Zhang, and Yunhong Wu. Does hydrogen-rich water reduce oxidative stress in patients with chronic mountain sickness? a randomized, blinded, controlled trial. 27:133-142, 2026. Oxidative stress is implicated in the pathogenesis of chronic mountain sickness (CMS), providing a rationale for antioxidant therapies. This study evaluated the safety and efficacy of hydrogen-rich water (HRW) as a potential antioxidant in individuals with CMS. We conducted an 8-week, randomized, blinded, placebo-controlled trial at the Tibetan Hospital of Nagqu, China. Adults with untreated CMS (defined by Qinghai score) were randomly assigned (1:1) to receive 990 ml/day of HRW or placebo using a dynamic minimization method. Participants, clinicians, and investigators were blinded to treatment allocation. The primary efficacy endpoint was change in oxidative stress biomarkers from baseline to week 8, including catalase, glutathione, malondialdehyde (MDA), superoxide dismutase, 8-hydroxy-2'-deoxyguanosine, and total antioxidant capacity (T-AOC). Safety was assessed by adverse event reporting. This trial has been completed and is registered at chictr.org under the identifier ChiCTR2400082685. From July 3 to December 24, 2024, 60 participants were randomized; one in the placebo group did not receive treatment and was excluded from the analysis. At week 8, HRW produced greater changes in MDA and T-AOC compared with placebo: MDA, +2.11 (95% CI: 1.13-3.09; < 0.001); T-AOC, +2.86 (95% CI: 0.09-5.64; = 0.043). In participants with body mass index (BMI) ≥24, the increase in MDA was more pronounced (Δ+2.57; = 0.02 for interaction). Adverse events occurred in 50% (15/30) of the hydrogen group and 37% (11/29) of the placebo group; dizziness was the most common. HRW demonstrated both pro-oxidative and antioxidative effects in CMS. However, it did not reduce oxidative stress-induced damage and may increase oxidative risk in individuals with higher BMI.
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10. Improved Pulmonary Gas Exchange at Altitude Is Due to Pulmonary Vascular Adaptation to Chronic Hypoxia in Urban Residents.
PMID:日期:2026-09-01Willixhofer, Robin, Laura Gochicoa-Rangel, Anna Apostolo, Jeness Campodonico, Elisabetta Salvioni, Ada De-Los-Santos-Martínez, Alejandro Reyes-García, Luis Torre-Bouscoulet, Sergio Harari, Federico Tagariello, and Piergiuseppe Agostoni. Improved pulmonary gas exchange at altitudes is due to pulmonary vascular adaptation to chronic hypoxia in urban residents. 27:177-183, 2026. Chronic exposure to high altitude induces physiological adaptations in the lung, but the specific mechanisms of alveolar-capillary gas exchange adaptation in urban populations remain incompletely understood. We assessed altitude-related alveolar capillary membrane gas diffusion adaptations in Milan (lowlanders, 120 m) and Mexico City (highlanders, 2,240 m). A 1:1 nearest-neighbor matching by age and sex was performed. Comparison between healthy young adults ( = 246, age <40 years) showed higher diffusing capacity for carbon monoxide (DCO: 31.7 [27.4-39.0] vs. 28.2 [24.6-32.8] ml/min/mmHg, < 0.0001) and pulmonary capillary blood volume (Vcap: 105 [87-113] vs. 84 [71-98] ml, < 0.0001), but lower membrane diffusing capacity (Dm: 50 [45-60] vs. 61 [51.70] ml/min/mmHg, < 0.0001) in highlanders. The matching procedure yielded 71 pairs ( = 142) with balanced age and sex distributions (standardized mean differences <0.1). These differences remained significant after matching: highlanders showed higher DLCO (31.7 [27.8-39.1] vs. 27.1 [23.7-32.4] ml/min/mmHg, < 0.0001), higher Vcap (104 [85-124] vs. 78 [65-96] ml, < 0.0001), and lower Dm (51 [46-60 vs. 57 [50-68] ml/min/mmHg, = 0.045). These findings suggest vascular, rather than membrane, adaptation to chronic hypoxia in high-altitude urban residents.