ORGANIC LETTERS有机化学快报
ORGANIC LETTERS(英文缩写 ORG LETT),ISSN 1523-7060,eISSN 1523-7052,中文译名:有机化学快报 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 6.072 | Q1 |
| 2022 | 5.200 | Q1 |
| 2023 | 4.900 | Q1 |
| 2024 | 5.000 | Q1 |
| 2025 | 4.700 | Q1 |
ORGANIC LETTERS 最新收录文献
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1. Transfer Hydrogenation of Nitrones to Hydroxylamine Derivatives with PhSiH3.
PMID:日期:2026-09-28Herein, we report a practical metal- and additive-free method for transfer hydrogenation of nitrones, employing a readily available PhSiH3 as the hydrogen donor. The findings demonstrated the effective conversion of a wide range of ketone- and aldehyde-derived nitrones into their corresponding hydroxylamine derivatives in good to excellent yields under mild conditions. The reaction is readily scalable and demonstrates broad functional group tolerance, accommodating bromo, chloro, fluoro, trifluoromethyl, thioether, thiophene, and furan substituents. Hence, the proposed operationally simple protocol provides a practical and sustainable strategy, facilitating the synthesis of structurally diverse hydroxylamine derivatives.
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2. A Janus Aglycone-Based Divergent Strategy for the Synthesis of the PGL-I Epitopes Ready for Conjugation.
PMID:日期:2026-09-25An efficient synthesis of epitopes of PGL-I glycolipids of Mycobacterium leprae was achieved using the 4-methoxyphenyl (MP) group as dual-mode Janus aglycone. Cleavage of the MP aglycone in a disaccharide gave a hemiacetal precursor of the glycosyl donor that was used for the assembly of the trisaccharide PGL-I epitope through α-selective [2+1] rhamnosylation (96:4 α:β). Selective demethylation of the MP aglycone in di- and trisaccharides followed by alkylation of the resulting phenolic hydroxy group gave diverse spacer aglycones suitable for the synthesis of neoglycoconjugates.
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3. Conformational Locking Enables Chemoselective Direct 2-Deoxyglycosylation of C-4 Equatorial Glycals under Bi-Catalysis.
PMID:日期:2026-09-12We demonstrate the chemoselective 2-deoxyglycosylation of formidable C-4 equatorial glycals enabled by a conformationally constrained protecting-group strategy. A proof-of-principle for the Bi(OTf)3-mediated 2-deoxyglycosylation of trans-fused 3,4-O-TIPDS-protected l-rhamnal, d-glucal, and d-xylal is illustrated using carbohydrates, amino-acids, and bioactive-natural products, providing structurally diverse 2-deoxy and 2,6-dideoxyglycoconjugates. Mechanistic insights into the distinctive structures of the glycosyl species revealed that conformational locking restricts the accessible 5H4 glycal and 4H3 oxocarbenium ion conformations, thereby favoring 1,2-addition and circumventing the Ferrier pathway.
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4. Heteroarylation of Functionalized Alkenes via Hexafluoroisopropanol-Assisted Redox Activation of Areneazo-2-(2-nitro)propanes.
PMID:日期:2026-09-11The hexafluoroisopropanol (HFIP)-assisted thermal denitrogenative fragmentation of areneazo-2-(2-nitro)propanes enabled heteroarylation of functionalized alkenes through cooperative radical and redox processes. Bench-stable areneazo-2-(2-nitro)propanes served as versatile aryl radical precursors for carboheterocyclization with alkenyl esters, affording diverse arylated lactones and heterocycles with broad functional group tolerance. Mechanistically, the radical fragmentation-nitro-nitrite isomerization of areneazo-2-(2-nitro)propanes generated nitric oxide that underwent a redox process with tertiary radical intermediates to promote heterocyclization. The oxidant-free conditions generated dinitrogen and acetone as benign byproducts.
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5. Correction to "RNA Acylation Method via a DNA-Templated Acyl Transfer Reaction".
PMID:日期:2026-09-11该文献暂无摘要。
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6. Phosphine-Catalyzed [3 + 2] Annulations of Indole N-Alkynamides with Ynones: Direct Synthesis of Arylidene Spiro-Cyclopentanone Pyrroloquinolinediones.
PMID:日期:2026-09-11We report a phosphine-catalyzed [3 + 2] annulation of indole N-alkynamides with ynones, providing efficient access to arylidene spiro-cyclopentanone pyrroloquinolinediones. The reaction proceeds through the in situ generation of a reactive enedione intermediate and exhibits broad substrate scope, high regioselectivity, and gram-scale applicability. Mechanistic studies support the involvement of transient enedione and phosphine-derived zwitterionic intermediates. This strategy unveils a previously unexplored reactivity of indole N-alkynamides and enables rapid construction of structurally unique spirocyclic frameworks.
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7. Palladium-Catalyzed Self- and Cross-Dimerization Annulation of β-CF3-1,3-Enynamides: An Access to Functionalized Bicyclo[4.2.0]trienes.
PMID:日期:2026-09-11An efficient and general method for the synthesis of highly functionalized bicyclo[4.2.0]trienes via a palladium-catalyzed self-dimerization annulation of β-CF3-1,3-enynamides and cross-dimerization annulation of β-CF3-1,3-enynamides with 1,3-enynes was developed. β-CF3-1,3-enynamides bearing a Ts group were identified as optimal reagents for cross-dimerization of two different enynes. In all cases, the reactions proceeded in a regiospecific manner, affording highly functionalized bicyclo[4.2.0]trienes which are challenging to prepare via conventional approaches. Further synthetic transformations of the bicyclo[4.2.0]trienes were explored, highlighting their distinctive reactivity profile and outlining their application in diverse syntheses.
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8. Arene-Selective Asymmetric Buchner Dearomatization of Biaryl Compounds.
PMID:日期:2026-09-11We report arene-, stereo-, and regioselective functionalizations of biaryl compounds (A-A') with α-cyanodiazoacetates via Rh(II)-catalyzed enantioselective Buchner dearomatization. Density functional theory calculations suggest that selectivity for ring A' of A-A' biaryl and regioselectivity on arene A' are both determined by steric effects, resulting in high constitutional isomer selectivity among the ≤12 possible. Electron-withdrawing and -donating groups on ring A retain high site selectivity, despite the latter activating ring A toward electrophilic Rh(II)-carbenoid.
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9. Chiral Bis-Urea Embedded Pillararenes with Self-Sorted Planar Chirality.
PMID:日期:2026-09-11A new class of chiral bis-urea-embedded pillararenes, each containing two chiral bis-urea units, was synthesized through a modular two-step strategy. Efficient chirality transfer affords well-defined all-pS or all-pR planar chirality, with the corresponding chiroptical responses remaining essentially unchanged over the investigated temperature range. Remarkably, macrocyclization of racemic precursors undergoes spontaneous chiral self-sorting to preferentially afford homochiral macrocycles. This strategy provides a new approach to the generation and stabilization of planar chirality in pillararenes.
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10. Photocatalytic Dialkylaminyl Radical-Triggered Strain-Release Coupling of [1.1.1]Propellane with Dialkylamines and N-Heterocycles.
PMID:日期:2026-09-11The synthesis of dialkylamino bicyclo[1.1.1]pentanes (BCPs) has been hindered by the weakly nucleophilic and hydrogen atom transfer (HAT)-prone nature of dialkylaminyl radicals, which precludes their use in strain-release functionalization of [1.1.1]propellane. Herein, we report a photoredox-catalyzed three-component strain-release dialkylamino-heteroarylation of [1.1.1]propellane using secondary amines with NCS via dialkylaminyl radicals. This mild protocol provides modular access to structurally diverse alkylamines in a single operation, accommodating a wide range of amines and N-heterocycles to afford products in moderate to excellent yields. Gram-scale synthesis, late-stage functionalization of complex natural products and drugs, and mechanistic studies collectively support the proposed radical pathway and demonstrate the synthetic utility of this protocol.