World Journal of Surgical Oncology世界外科肿瘤学杂志
World Journal of Surgical Oncology(英文缩写 WORLD J SURG ONCOL),ISSN 1477-7819,eISSN 1477-7819,中文译名:世界外科肿瘤学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
World Journal of Surgical Oncology 最新收录文献
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1. Systematic versus perilesional sampling in transperineal MRI-fusion biopsy: is perilesional sampling ready for prime time? A high-volume center analysis.
PMID:日期:2026-09-23Multiparametric MRI has improved prostate cancer (PCa) diagnostics. The current standard combines MRI-targeted fusion biopsy (TB) with 12-core systematic biopsy (SB); current guidelines allow replacing SB with perilesional sampling (PB) penumbra to maintain diagnostic performance while reducing biopsy burden. We retrospectively analyzed 314 biopsy-naive men with Prostate Imaging Reporting and Data System (PI-RADS) 3-5 lesions who underwent transperineal MRI-fusion biopsy (TB plus 12-core systematic biopsy) under local anesthesia. A simulated PB strategy was evaluated post hoc by selecting four of the twelve systematic cores located in the directly adjacent sectors to the MRI-visible lesion on the standardized PI-RADS sector map and compared with SB. The primary objective was to assess whether PB replicates the diagnostic performance of SB for detecting clinically significant PCa (csPCa; ISUP grade group ≥ 2). We also compared biopsy and prostatectomy ISUP-grading, NCCN (National Comprehensive Cancer Network) -classification and the Briganti nomogram-based lymph-node metstasis risk. Statistical analyses used R and SPSS, with chi-square or Fisher's exact tests for categorial and t-tests for continuous variables; two-sided p < 0.05 was considered significant. PCa was detected in 79.9% (251/314) of men, including 68.8% (216/314) with csPCa. TB alone detected 94.4% of csPCa, while SB detected 73.1%. The simulated TB + PB approach achieved 98.0% overall PCa detection and 99.1% csPCa detection (p = 0.48 vs. TB + SB). Concerning the impact on NCCN risk assessment, ISUP grade distribution was comparable across TB-based strategies, whereas SB alone detected fewer cancers and showed a trend towards lower ISUP grades. In the prostatectomy subgroup, ISUP grade concordance did not differ significantly between TB + SB and TB + PB (both 62.0%; p = 1.0). Mean Briganti scores did not differ significantly between TB + SB and TB + PB, with a minimal absolute difference of 0.17%. A 75% reduction of biopsy cores would be reached by a replacement of SB with PB. There was no significant loss of detection for csPCa (ISUP grade group 2-5; 99.1%) and no association with a loss of diagnostic yield for all ISUP grade groups. 11% reduction in detected cases was confined to ISUP grade group 1 (Supplementary Table S2). A TB plus 4-core PB may serve as an efficient alternative to conventional 12-core SB, without a significant reduction in diagnostic accuracy or a change in pretreatment risk assessment while markedly reducing procedural burden and resource use.
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2. The evolving role of open abdominal surgery in gynecological malignancies in the era of minimally invasive and precision oncology.
PMID:日期:2026-09-07Oncological surgery is undergoing profound transformation driven by advances in systemic therapy, immunotherapy, and minimally invasive techniques. This narrative review examines whether open abdominal surgery retains clinical relevance in gynecological malignancies or has been superseded by modern alternatives. A literature search was conducted in PubMed combining terms related to gynecological malignancies, abdominal surgical procedures (open, laparoscopic, robotic, cytoreduction, pelvic exenteration), and personalized systemic therapies. Original articles, reviews, and guidelines in German and English were included. Two independent reviewers screened titles, abstracts, and full texts, extracting data on study design, interventions, and clinical endpoints (R0 resection, morbidity, progression-free and overall survival). For cervical cancer, open radical abdominal hysterectomy as the standard of care was internationally confirmed. In endometrial cancer, minimally invasive approaches are established for early-stage disease, while laparotomy remains the gold standard in advanced stages requiring cytoreductive surgery. For ovarian, tubal, and primary peritoneal carcinoma, open cytoreductive surgery with the goal of macroscopically complete resection remains guideline recommended. Emerging biomarkers such as circulating tumor DNA may further refine patient selection and surgical decision-making. Open abdominal surgery remains indispensable in gynecological oncology. Rather than being replaced, it is evolving into a specialized, biology-adapted component of multimodal treatment strategies. Surgical indications are becoming less frequent but more complex and individualized. Patient selection in experienced centers remains the decisive factor.
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3. Modified Albert-Lembert coloanal anastomosis with diverting ileostomy versus Turnbull-Cutait pull-through delayed coloanal anastomosis after intersphincteric resection for low rectal cancer: a single-center retrospective comparative study.
3. 改良Albert-Lembert结肠肛管吻合术联合转流性回肠造口与Turnbull-Cutait拖出式延迟结肠肛管吻合术在低位直肠癌括约肌间切除术后的比较：一项单中心回顾性对比研究PMID:日期:2026-08-27Reconstruction after intersphincteric resection (ISR) for low rectal cancer remains technically challenging. Turnbull-Cutait pull-through delayed coloanal anastomosis (DCAA) has been used as a sphincter-preserving delayed reconstructive strategy, but it requires exteriorization of the colon and a planned second-stage perineal procedure. To improve anastomotic stability after ISR, we performed modified Albert-Lembert coloanal anastomosis (MALA) with diverting ileostomy. This study aimed to compare the short-term clinical outcomes of MALA with diverting ileostomy versus DCAA after ISR for low rectal cancer. This single-center retrospective comparative study was conducted at Henan Provincial People's Hospital. Between February 2023 and October 2025, consecutive patients with low rectal cancer who underwent laparoscopic ISR followed by hand-sewn coloanal anastomosis were reviewed. Among them, 58 patients underwent Turnbull-Cutait pull-through delayed coloanal anastomosis (DCAA group), and 42 patients underwent modified Albert-Lembert one-stage coloanal anastomosis with diverting ileostomy (MALA group). Clinical outcomes were compared between the two groups. The primary outcome was overall postoperative morbidity within 30 days after the first surgery. A total of 100 patients were included, with 58 in the DCAA group and 42 in the MALA group. Baseline demographic, clinical, and tumor characteristics were comparable between the two groups. The 30-day overall postoperative morbidity rates were 32.8% and 23.8% in the DCAA and MALA groups, respectively, with no statistically significant between-group difference (P = 0.378). No statistically significant differences were observed in the rates of Clavien-Dindo grade I-II complications (19.0% vs. 16.7%, P = 0.799) or grade III or higher complications (13.8% vs. 7.1%, P = 0.350). Operative time (201.8 ± 28.6 min vs. 206.5 ± 32.4 min, P = 0.463), intraoperative blood loss [60 mL (range, 30-150) vs. 60 mL (range, 30-110), P = 0.408], harvested lymph nodes [19 (range, 15-23) vs. 22 (range, 16-24), P = 0.356], R0 resection rate (100% vs. 100%, P = 1.000), and postoperative hospital stay [15 days (range, 13-21) vs. 14 days (range, 12-20), P = 0.225] did not differ significantly between the two groups. MALA with diverting ileostomy is a technically feasible sphincter-preserving reconstructive strategy in selected patients undergoing laparoscopic ISR for low rectal cancer, and no statistically significant difference in 30-day postoperative morbidity was observed between the MALA and DCAA groups.
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4. Early recurrence prediction after curative-intent surgery of intrahepatic cholangiocarcinoma using a novel weighted tumor burden score.
PMID:日期:2026-08-26Recurrence after curative-intent resection of patients with intrahepatic cholangiocarcinoma (ICC) remains common and difficult to predict. Tumor burden scores (TBS) incorporating tumor size and tumor nodule number have been proposed, but the relative contribution of multifocality remains unclear. Patients undergoing curative-intent surgery for ICC in a large hepatobiliary center between 2009 and 2024 were retrospectively analyzed. A simplified weighted tumor burden score (wTBS) was developed using tumor size and tumor nodule number (wTBS = largest tumor diameter (cm) + 5 × tumor nodule number). The score was derived in a primary cohort and externally validated in an independent cohort. Early recurrence was defined as recurrence within 12 months after surgery. Predictive performance was assessed using logistic regression analysis, receiver operating characteristic (ROC) analysis, Kaplan-Meier survival curve analysis and Cox regression models. A total of 198 patients were included in this study. In the study cohort, the wTBS was significantly associated with early recurrence (OR 1.12 per point, 95% CI 1.07-1.18, p < 0.001) and recurrence-free survival (RFS; HR 1.06 per point, 95% CI 1.04-1.09, p < 0.001). ROC analysis demonstrated improved discriminatory performance compared to tumor size or tumor nodule number alone (area under the curve [AUC] 0.69). Using a cutoff of ≥ 14, patients with high wTBS had significantly shorter RFS (median 9 vs. 21 months, p < 0.001). These findings were confirmed in an independent validation cohort comprising 162 patients, in which wTBS remained significantly associated with early recurrence (OR 1.12) and RFS (HR 1.08, p < 0.001) with a median RFS of 7 vs. 26 months for high- vs. low-risk patients. A simplified wTBS incorporating tumor size and tumor nodule number was associated with early recurrence after ICC resection and showed consistent prognostic value in an independent cohort. Given its moderate discriminatory ability, the score should currently be regarded as an adjunct for postoperative risk stratification rather than a stand-alone tool for treatment selection. Prospective validation and evaluation of clinical utility are required before implementation in treatment algorithms.
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6. Erector spinae plane block (ESPB) versus paravertebral plane block (PVB) in managing post-operative pain in breast cancer patients: a systematic review and meta-analysis.
PMID:日期:2026-08-22Breast cancer surgeries remain the cornerstone of treatment for early-stage disease. Nonetheless, a substantial proportion of patients experience moderate-to-severe acute or chronic postoperative pain, adversely affecting quality of life and functional recovery. Regional anesthetic techniques have emerged as effective strategies for perioperative pain control. This study compares the erector spinae plane block (ESPB) and the thoracic paravertebral block (PVB) in breast cancer surgeries. Four databases were systematically searched for randomized controlled trials (RCTs) using ESPB and PVB in breast cancer surgeries. Primary extracted outcomes include post-operative morphine consumption, analgesia duration, resting and dynamic pain scores. Methodological quality was assessed using the ROB-2 tool, while data were pooled using the R software, Version 4.4.2. Nineteen RCTs reporting on 1527 patients were included. Postoperative morphine consumption, PONV incidence, and intraoperative fentanyl use were comparable in both groups. Similarly, pain scores at rest and movement reported no significant differences. The two techniques also demonstrated similar results regarding the number of patients requiring rescue analgesia and analgesia duration. ESPB was associated with a significant, however clinically negligent, shorter surgery duration compared to PVB [MD -0.04, 95% CI; -0.07 to 0.00, P = 0.023]. ESPB and PVB provide comparable analgesic efficacy and perioperative outcomes in breast cancer surgeries. ESPB may offer a shorter surgical duration, supporting its use as a simpler yet equally effective alternative to PVB, however this must be taken cautiously.
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7. Prognostic utility of the Charlson comorbidity index in pancreatic cancer: a systematic review and meta‑analysis.
PMID:日期:2026-08-07The prognosis of pancreatic cancer is extremely poor, and patients frequently present with multiple comorbidities. The Charlson Comorbidity Index (CCI) and its age-adjusted version (CACI) are widely used to quantify the burden of comorbidity. This systematic review and meta-analysis aimed to evaluate the association between CCI/CACI and survival outcomes in patients with pancreatic cancer. We systematically searched the Cochrane Library, Embase, PubMed, and Web of Science for relevant literature up to May 2025. Observational studies primarily investigating the association between CCI/CACI and overall survival (OS) in patients with pancreatic cancer were included. Two reviewers independently screened the literature, extracted data, and evaluated the quality of eligible studies using the Newcastle-Ottawa Scale. A random-effects model was employed to pool adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Heterogeneity was assessed using the I² statistic. Subgroup analysis, sensitivity analysis, and regression analysis were also conducted. This analysis incorporated 28 studies comprising 548,660 participants. Most of the studies were of high quality. The meta-analysis demonstrated that a higher CCI was associated with an inferior OS (pooled HR = 1.26, 95% CI: 1.09-1.47, P = 0.002). A similar association was observed for CACI (pooled HR = 1.40, 95% CI: 1.17-1.67, P < 0.001). Subgroup analyses confirmed that this association was generally consistent across different geographical regions, study designs, sample sizes, treatment modalities, and cut-off values of CCI. However, the assessment of heterogeneity revealed substantial heterogeneity in the analyses involving the CCI (I² = 63.6%, P = 0.005). Due to the limited number of eligible studies, quantitative synthesis could not be conducted for secondary endpoints, including progression-free survival and recurrence-free survival. The current meta-analysis provides quantitative evidence from observational studies to support the CCI and CACI as factors associated with survival in patients with pancreatic cancer. However, given the substantial heterogeneity and observational design of the included studies, these indices should be interpreted as prognostic association markers rather than standalone clinical decision tools. The findings should be cautiously interpreted. Future prospective studies are required for validation. Integrated prediction models combining these indices with molecular markers should be explored.
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8. Bridging the gap: modern pharyngolaryngoesophagectomy techniques and the rise of neoadjuvant/immunotherapy approaches.
PMID:日期:2026-07-31The purpose of this review is to outline the evolution and changing role of pharyngolaryngoesophagectomy (PLE) in the organ-preservation era, and to review advances, including minimally invasive techniques, neoadjuvant therapy, and immunotherapy, and their impact on outcomes in advanced laryngeal, hypopharyngeal, and cervical esophageal cancers. A narrative review of the literature from 2000 to the present was performed, focusing on studies of surgical innovations, oncologic outcomes, quality of life, and combined treatment strategies in PLE. Historically, PLE was associated with high morbidity and mortality. However, advances in surgical techniques, reconstructive methods, and perioperative care have significantly improved its safety and functional outcomes. Minimally invasive and hybrid PLE approaches reduce pulmonary complications and speed recovery without compromising oncologic outcomes. Chemoradiation has become the first-line treatment for many advanced cases, with PLE now reserved for selected cervical esophageal tumors or persistent disease after radiation. Neoadjuvant chemotherapy or chemoradiation can shrink tumors, improve operability, and sometimes allow organ preservation. Immunotherapy before surgery improves pathological response rates and disease-free survival. Recent series report 5-year survival of 20-40% after PLE, and most patients regain swallowing and voice function with rehabilitation. In the organ-preservation era, PLE remains important for certain advanced or treatment-resistant cases. Its role is defined by a multidisciplinary, personalized approach and limited to cases where surgery is essential, often combined with systemic therapy. Ongoing advances in patient selection, minimally invasive techniques, and immunotherapy are expected to further refine PLE's role and improve outcomes.
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9. Diagnostic accuracy of computer-aided detection for colorectal polyps of any size, ≤ 5 mm, and 6-9 mm: a meta-analysis.
PMID:日期:2026-07-30Although computer-aided detection (CAD) is often used for medical diagnostic purposes, its diagnostic effectiveness in colorectal polyps (CPs) remains uncertain. To summarize the diagnostic accuracy of CAD in diagnosing CPs, and provide a specific theoretical basis for clinical practice. From database creation to August 1st 2024, we conducted a comprehensive search of PubMed, Embase, Web of Science (WoS), Scopus, Wanfang, Cochrane Library, and the China National Knowledge Infrastructure (CNKI). The pooled sensitivity, specificity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and Fagan plot analysis were employed to evaluate the overall performance of CAD tests. Furthermore, we assessed publication bias using Deeks' funnel plot asymmetry test. The aggregated diagnostic data from 19 studies (any size), 12 studies (≤ 5 mm polyps) and 2 studies (6-9 mm polyps) were as follows: The sensitivity for polyps of any size, ≤ 5 mm, and 6-9 mm was 0.94 (95% CI, 0.92-0.96), 0.93 (95% CI, 0.89-0.95) and 0.95 (95% CI, 0.92-0.97), respectively. The specificity was 0.91 (95% CI, 0.86-0.95), 0.90 (95% CI, 0.87-0.93) and 0.90 (95% CI, 0.88-0.92), respectively. The AUC was 0.97 (95% CI, 0.96-0.99), 0.96 (95% CI, 0.94-0.98), and 0.92 (95% CI, 0.89-0.94), respectively. Deeks' funnel plot showed that publication bias was not statistically significant in the diagnosis of polyps of any size and ≤ 5 mm CPs (P > 0.05). In summary, CAD is accurate for all types of CPs. Specifically, for polyps of any size and those ≤ 5 mm, CAD was more sensitive and specific for CPs of any size.
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10. Stress-driven reprogramming of plasmacytoid dendritic cells in intrahepatic cholangiocarcinoma defines a reversible targetable immunosuppressive state.
10. 肝内胆管癌中浆细胞样树突状细胞的应激驱动重编程定义了一种可逆的可靶向免疫抑制状态PMID:日期:2026-07-28Plasmacytoid dendritic cells (pDCs) have been implicated in both restraining and promoting intrahepatic cholangiocarcinoma (iCCA), leaving their clinical relevance and therapeutic potential unresolved. Mendelian randomization was used to assess the causal association between circulating pDC levels and iCCA risk. Bulk and single-cell transcriptomic analyses were performed to characterize pDC-related programs and tumor-conditioned states, and multiplex immunofluorescence was used to define spatial distribution and clinical associations in iCCA tissues. To assess reversibility of stress-associated pDC features, IRE1α RNase activity was pharmacologically inhibited with 4µ8C under tumor-conditioned stress in vitro. Genetically predicted higher circulating pDC levels were associated with lower iCCA risk, consistent with a systemic protective association. In bulk cohorts, higher expression of pDC markers (CLEC4C, NRP1, IL3RA) was associated with an immune-inflamed microenvironment and improved survival in early-stage disease. Single-cell analyses indicated that intratumoral pDCs acquired stress-associated transcriptional programs, including enrichment of endoplasmic reticulum stress and unfolded protein response pathways. In vitro, 4µ8C reduced IRE1α-dependent XBP1 splicing and partially restored type I interferon-linked activation and pDC immunogenic readouts under tumor-conditioned stress. Spatial profiling further showed that higher intratumoral CD303⁺IRF7⁺ pDC activation was associated with advanced stage and poorer overall survival, whereas higher activation in adjacent non-tumor tissues correlated with more favorable outcomes. Together, these findings support a context-dependent, stress-associated pDC program in iCCA and provide a rationale for further evaluating the IRE1α-XBP1 stress axis as a potential approach to modulate pDC-associated immune states within the tumor microenvironment.