NATURE REVIEWS NEUROSCIENCE自然综述·神经科学
NATURE REVIEWS NEUROSCIENCE(英文缩写 NAT REV NEUROSCI),ISSN 1471-003X,eISSN 1471-0048,中文译名:自然综述·神经科学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 38.755 | Q1 |
| 2022 | 34.700 | Q1 |
| 2023 | 28.700 | Q1 |
| 2024 | 26.700 | Q1 |
| 2025 | 29.000 | Q1 |
NATURE REVIEWS NEUROSCIENCE 最新收录文献
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5. Early life experiences, the neural epigenome and affective disorder risk.
PMID:日期:2026-10-01Early life stress shapes brain development during sensitive developmental windows through persistent epigenomic changes that influence gene regulation, neural circuit maturation and susceptibility to neuropsychiatric disorders. Evidence from animal models and human studies demonstrates that early adversity remodels DNA methylation, histone post-translational modifications and chromatin organization, leading to lasting alterations in transcriptional programmes. These responses are highly cell-type specific, brain-region specific and developmental-stage specific, with neurons and glia exhibiting distinct molecular adaptations that contribute to behavioural outcomes. Emerging evidence also implicates non-coding RNAs as important regulators of stress-induced gene expression, although their long-term roles remain less well defined than those of other epigenetic mechanisms. Peripheral epigenetic signatures associated with early life stress may provide accessible biomarkers of exposure and disease risk. Integrating epigenomic, transcriptomic, circuit-level and behavioural approaches will be essential for understanding biological embedding and identifying mechanisms that promote resilience and improve therapeutic interventions.
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6. Neural circuits for mammalian parental behaviour.
PMID:日期:2026-10-01Most mammalian offspring are born helpless and depend on sustained parental care for survival, making caregiving one of the most conserved and essential behavioural repertoires in mammals. Yet infant-directed behaviours can be remarkably variable, ranging from care to neglect and aggression, even within the same individual. How neural circuits support both the robustness and the flexibility of parental behaviour remains poorly understood. Here we review recent advances in our understanding of the neural mechanisms of mammalian caregiving, placing circuit-level insights from rodent models into the broader context of parental diversity across mammals. Emerging evidence indicates that internal state and social experience dynamically reshape parental circuits across timescales from hours to weeks and that these circuits adapt their function to generate life stage-appropriate behavioural output. Rather than acting as fixed control systems for instinctive actions, parental circuits are highly plastic and context dependent. Parental behaviour therefore provides a powerful model for understanding how neural circuits are reconfigured to meet changing behavioural demands.
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7. Cerebellar rhythms: mechanisms, functions and translational opportunities.
7. 小脑节律：机制、功能和翻译机会PMID:日期:2026-10-01Cerebellar rhythms provide frequency-specific support for motor, cognitive and affective functions. These oscillations are not epiphenomenal but rather dynamically regulated, spatially organized control signals that contribute to the coordination of prediction, error correction, learning and internal model updating. By synchronizing neuronal activity across cerebellar and distributed brain networks at multiple timescales, cerebellar rhythms enable precise and adaptable behaviour and coordination across neural systems. Accordingly, they offer biologically grounded targets for network-level diagnostics and therapeutic neuromodulation. At the circuit level, cerebellar rhythms within distinct frequency bands, ranging from theta and beta to gamma and very high-frequency oscillations, arise from specific microcircuit mechanisms within the inferior olive, the granular and molecular layers of the cerebellar cortex, and the deep cerebellar nuclei. These rhythms structure spike timing and help shape synaptic plasticity windows, forming a frequency-organized substrate for learning and control. Here we describe a frequency-function-modulation framework that links cerebellar oscillations to their behavioural roles and to neuromodulatory interventions. By integrating evidence from animal studies, computational models and non-invasive stimulation studies, we position cerebellar oscillations as a bridge between cerebellar circuit dynamics and systems-level coordination, thereby providing a mechanistic rationale for precision neuromodulation across motor and cognitive domains in neurological and psychiatric conditions.
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8. Microglial states revisited: from homeostasis to disease.
8. 重新审视小胶质细胞状态：从稳态到疾病PMID:日期:2026-10-01Microglia, the resident macrophages of the CNS parenchyma, are recognized as highly plastic, transcriptionally diverse cells whose phenotypes are moulded by development, region, sex, age, genotype and environment. Advances in single-cell and single-nucleus transcriptomics, chromatin accessibility profiling, and spatial multi-omics have negated binary frameworks of 'resting versus activated' or 'M1 (pro-inflammatory) versus M2 (anti-inflammatory)' and revealed a multidimensional state space that supports brain development, homeostasis and adaptive responses to perturbation. Building on the foundational concepts of the microglial sensome, homeostatic and disease-associated signatures, microglia exhibit transcriptomic state transitions in neurodegeneration, demyelination, infection and systemic inflammation. Moreover, a mechanistic framework for more 'hidden' microglial states has emerged, in which latent programmes that appear homeostatic at baseline are revealed by challenges and are instructed through innate immune training or tolerance. We argue that these covert reprogrammed states, which are shaped by ageing, genotype, sex, location and prior exposures such as sepsis or viral infection, help explain interindividual variability in disease trajectories. We conclude by outlining priorities for unifying state annotation across species and modalities, and for translating state-resolved insights into biomarkers and interventions.
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9. Quantum computing for neuroscience: opportunities beyond classical limits.
PMID:日期:2026-09-24该文献暂无摘要。