MOLECULES分子
MOLECULES(英文缩写 MOLECULES),ISSN 1420-3049,eISSN 1420-3049,中文译名:分子 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
MOLECULES 最新收录文献
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1. {"_":"RETRACTED: Das et al. Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling. 2019, , 4176.","i":["Molecules","24"]}
PMID:日期:2026-09-18The journal retracts the article titled "Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling" [...].
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2. {"_":"RETRACTED: D'Agostino et al. Molecular Mechanisms at the Basis of Pharmaceutical Grade Extract Efficacy in Prompting Keratinocytes Healing. 2020, , 431.","i":["Triticum vulgare","Molecules","25"]}
PMID:日期:2026-09-18The Journal retracts the article "Molecular Mechanisms at the Basis of Pharmaceutical Grade Extract Efficacy in Prompting Keratinocytes Healing" [...].
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3. {"_":"Learning Compact Multispectral Signatures for Geographical-Origin Authentication of via Correlation-Guided Deep Modeling.","i":["Pinellia ternata"]}
PMID:日期:2026-09-07Geographical authentication of medicinal plant materials remains challenging because multispectral variables are often highly collinear and sample grouping can complicate reliable model validation. Existing correlation-based feature-selection strategies also require careful adaptation to multiclass problems to avoid artificial ordering of class labels and information leakage during model development. Therefore, this study aimed to develop a compact and leakage-controlled multispectral learning framework for geographical-origin discrimination. This study analyzed 800 physical samples from Gansu Xihe, Sichuan Neijiang, Sichuan Chengdu, and Chongqing Dianjiang (200 samples per origin). Each physical sample was represented by 31 mean grayscale intensities calculated from Otsu-segmented multispectral regions of interest. A Pearson-correlation-guided deep multilayer perceptron (PCG-DeepMLP) was constructed by estimating one-vs-rest band relevance and inter-band redundancy only within the training data. The key methodological innovation is a unified multiclass-aware, relevance-redundancy spectral-learning framework in which class-specific one-vs-rest Pearson relevance is coupled with inter-band redundancy control and embedded within leakage-controlled grouped model development. By learning the spectral subset exclusively from each training partition before nonlinear classification, the framework produces compact and complementary multispectral signatures while preserving multiclass structure and strict independence of held-out groups. Model and feature-selection settings were chosen by three-fold grouped cross-validation within each training partition. PCG-DeepMLP retained 9-21 bands and achieved the highest mean accuracy (0.9812 ± 0.0135), macro-F1 (0.9812 ± 0.0135), Matthews correlation coefficient (MCC; 0.9752 ± 0.0179), and macro-AUC (0.9994 ± 0.0006) among seven models. Its macro-F1 was higher than that of 1D-CNN, 1D-ResNet, full-band MLP, PLS-DA, and random forest after Holm correction. Performance was estimated through a strict nested group-wise internal validation scheme, with every outer test fold remaining isolated from feature selection, preprocessing, and model optimization. These findings demonstrate that multiclass-aware relevance-redundancy learning can retain complementary origin-discriminative information in a compact and stable spectral representation, enabling accurate geographical-origin authentication while providing a principled basis for reduced-channel acquisition and future independent multi-batch validation.
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4. Nanoparticle-Based Targeted Drug-Delivery Systems for Cardiomyopathy: Mechanisms and Therapeutic Advances.
4. 基于纳米颗粒的靶向药物递送系统用于心肌病：机制与治疗进展PMID:日期:2026-09-07Cardiomyopathy comprises heterogeneous diseases characterized by structural or functional myocardial abnormalities and caused by conditions such as hypertension and coronary atherosclerotic heart disease. Current management relies mainly on pharmacotherapy and lifestyle interventions, but these approaches are limited by poor bioavailability and adverse effects. Nanoparticles (NPs) can deliver therapeutic drugs to cardiac muscle tissue through passive or active targeting, protecting the drugs they carry from premature degradation. They also show good biocompatibility and minimize damage to healthy tissues. This review summarizes the applications of NPs in cardiomyopathy and their active and passive targeting strategies, and provides a brief overview based on the mechanisms reported in individual published studies. It aims to provide therapeutic strategies for clinical management of cardiomyopathy and a theoretical foundation for future translational research.
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5. Membrane Emulsification Preparation of ADN/PVA Composite Particles Exhibiting Excellent Thermal Properties and Anti-Hygroscopicity.
PMID:日期:2026-09-07Ammonium dinitramide (ADN) is a high-energy green oxidizer with significant potential for use in solid propellants; however, its practical application is restricted by its strong hygroscopicity and low safety. In this study, morphology control and surface coating were simultaneously addressed by preparing ADN/PVA composite particles with different PVA contents by membrane emulsification. At a PVA content of 5%, the ADN/PVA composite microspheres exhibited favorable morphology and a high degree of sphericity, with no phase transition induced and the crystal structure well preserved. DSC results showed that the initial decomposition temperature of ADN/PVA increased by 21.88-26.50 °C compared to that of raw ADN, and the exothermic peak became narrower, indicating that the energy release of ADN was more concentrated and its thermal stability was significantly improved. Meanwhile, the impact sensitivity and friction sensitivity were reduced by 33.33% and 16.67%, respectively, relative to raw ADN, and the moisture absorption rate was reduced by 87.92%. Therefore, the ADN/PVA composite particles prepared by membrane emulsification exhibit excellent thermal stability and anti-hygroscopicity.
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6. Aptamer-Functionalized Liposomes for Targeted Delivery of Anticancer Drugs in Lung Cancer.
PMID:日期:2026-09-07Aptamer-functionalized liposomes are a promising strategy to improve the selectivity of anticancer therapies. AT11-L2 is a G-quadruplex (G4)-forming aptamer with high affinity for nucleolin (NCL), which is overexpressed at the surface of non-small cell lung cancer (NSCLC) cells. Here, we developed AT11-L2-functionalized liposomes loaded with doxorubicin (DOX) or BRACO-19 for targeted delivery to NSCLC cells. The effects of both compounds on AT11-L2 stability and the ability of the aptamer to retain G4 folding after liposome conjugation were evaluated. Liposomes were characterized for size, polydispersity, surface charge, stability, encapsulation efficiency, and release profile. Biological activity was assessed in A549 and MRC-5 cells. Liposomes had an average size of approximately 110 nm, with a slight size increase and reduced surface charge after AT11-L2 functionalization. The aptamer retained G4 folding in 100 mM KCl after conjugation. Encapsulation efficiency was approximately 90%. DOX showed substantial release within 72 h, whereas BRACO-19 exhibited a more sustained profile. AT11-L2-DOX liposomes showed preferential effects in A549 cells, while BRACO-19 formulations displayed lower selectivity and cytotoxicity. Additionally, the NCL-dependent internalization of AT11-L2-functionalized liposomes was supported by a protein-blocking assay using an anti-NCL antibody. These results support AT11-L2-functionalized liposomes as a versatile NCL-targeted delivery system for NSCLC.
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7. Multifunctional Conductive Polymer Nanocomposite for Intelligent Pesticide Sensing: Trends, Challenges, and Future Prospects.
7. 用于智能农药传感的多功能导电聚合物纳米复合材料：趋势、挑战与未来展望PMID:日期:2026-09-07Widespread use of organophosphate pesticides (OPPs) raises environmental, food safety, and public health concerns, and drives demand for rapid, sensitive, portable analytical technologies. We reviewed conductive polymer composite (CPC)-based electrochemical OPP sensors, focusing on the structure-performance relationships of representative polymers, polyaniline (PANI), polypyrrole (PPy), polythiophene (PTh), and poly(3,4-ethylenedioxythiophene) (PEDOT), and their hybrids with carbon nanomaterials, metal nanoparticles, metal oxides, MXenes, and metal-organic frameworks. We provided a critical comparison of conductive polymer systems, composite architectures, and enzymatic, molecularly imprinted polymer-based, and direct electrocatalytic sensing strategies, highlighting how material selection influences performance and applicability. Reported CPC-based sensors achieved limits of detection from micro- to femtomolar and successful application in real environmental and food samples; however, these results illustrate the capabilities achieved by selected high-performing reported platforms rather than the overall performance of CPC-based sensors. Despite these advances, reproducibility, long-term operational stability, matrix effects, sensor variability, and field implementation still limit deployment. We discussed future directions to address these challenges, including AI-assisted data analysis, standardised validation, portable field platforms, and sustainable fabrication. Rather than identifying a universally superior platform, this review emphasises rational material selection and composite design to guide CPC sensor development and translation for environmental monitoring and food safety applications.
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8. Fungal Melanins as Potential Reactive Oxygen Species-Scavenging Neuroprotective Agents.
PMID:日期:2026-09-07Oxidative stress is strongly associated with neuronal damage in neurodegenerative diseases, such as Parkinson's disease (PD). Fungal melanins are remarkable free radical scavengers; however, their capacity to protect neurons from reactive oxygen species (ROS)-induced damage remains understudied. This research evaluated the neuroprotective effects of fungal melanins and their arginine-modified counterparts on SH-SY5Y cells against neurotoxins, as well as their impact on ROS levels. Exposure to 0.6 mM HO or 1 mM MPP markedly elevated ROS levels and reduced cell viability to approximately 56% and 60%, respectively. At 10 μg/mL, melanins from , , and significantly protected cells against HO cytotoxicity, whereas arginine-modified melanin from the skin of significantly attenuated MPP cytotoxicity. Further dose-dependent evaluation revealed that melanin from (10-12 μg/mL) displayed activity comparable to the positive control (164 μg/mL N-Acetylcysteine (NAC)) against HO by increasing cell viability up to 90%. Similarly, arginine-modified melanin from (6-10 μg/mL) and NAC showed a comparable protective effect against MPP, boosting cell viability up to 80%. Both samples suppressed ROS to levels comparable to, or lower than, the untreated control. Melanin from is a promising candidate for further research into complementary therapies for PD.
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9. Effect of Calcium Oxide on the Mechanical and Structural Properties of Metakaolin-Based One-Part Geopolymer.
PMID:日期:2026-09-07One-part geopolymer has emerged as a promising alternative to ordinary Portland cement. In this study, the effect of CaO dosage on the compressive strength of one-part geopolymers was systematically investigated, and its underlying modification mechanism was revealed via multi-scale characterizations including XRD, FTIR, TG, NMR and nitrogen adsorption-desorption. The results show that the compressive strength of the samples at all curing ages exhibits a trend of sharp initial decrease, followed by a slight rebound, and then a secondary decline with the increase in CaO dosage. All CaO-containing specimens exhibit significantly lower strengths than the CaO-free reference. Specifically, the reference sample achieves the highest 28-day compressive strength of 56.6 MPa. The strength of the sample at each curing age drops to the minimum at 5% CaO dosage, with a 28-day strength of only 17.9 MPa. Partial strength recovery of the sample is achieved at 7.5% CaO dosage. The strength deterioration is mainly attributed to the rapid hydration of CaO, which consumes free water and reactive silicon and hinders the generation of N-A-S-H gel rather than directly disrupting the aluminosilicate network. Meanwhile, the hydration products are continuously carbonated to form calcium carbonate, and the carbonation-induced volume expansion at excessive dosage may induce microcracks in the matrix that impair the structural integrity. Only at a moderate dosage of 7.5% CaO can a slight strength rebound be realized through the possible formation of C-S-H-type phases and the pore-filling effect. This study provides a theoretical basis for the material design and performance regulation of one-part geopolymers.
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10. Kombucha-Derived Bacterial Cellulose for Active and Biodegradable Food Packaging: Production, Modification, Performance, and Current Challenges.
PMID:日期:2026-09-07Kombucha fermentation generates two fractions of potential relevance to food-packaging applications: a fermented liquid containing organic acids, polyphenols and other metabolites, and a cellulose-rich pellicle formed by cellulose-producing acetic acid bacteria. However, the fermented beverage, raw pellicle and purified kombucha-derived bacterial cellulose (KBC) differ substantially in composition, functionality and food-contact suitability and should not be treated as interchangeable materials. This review critically examines bacterial cellulose formation during kombucha fermentation, purification and modification strategies, packaging-relevant properties, and the application of kombucha-derived materials in films, coatings and composites. Purified KBC provides a continuous nanofibrillar network and can exhibit good mechanical and oxygen-barrier properties under dry conditions. Its hydrophilic character, however, promotes moisture sorption and swelling, which may impair mechanical integrity and barrier performance at elevated relative humidity. Blending, coating, grafting and crosslinking can improve selected material properties, but their effects are formulation-specific and may involve trade-offs between moisture resistance, mechanical performance, biodegradability and food-contact safety. Fermented kombucha liquid and native or mildly washed pellicles may contribute fermentation-derived bioactive compounds; however, antioxidant or antimicrobial activity measured in the beverage or raw pellicle cannot be automatically attributed to purified KBC or the final packaging material. Current evidence supports the use of KBC as a structural matrix, reinforcing phase, coating component or carrier of active substances. Nevertheless, limited migration data, heterogeneous testing conditions, insufficient real-food studies and a lack of pilot-scale, regulatory and life-cycle assessments currently restrict its broader industrial implementation.