BIOMARKERS生物标志物
BIOMARKERS(英文缩写 BIOMARKERS),ISSN 1354-750X,eISSN 1366-5804,中文译名:生物标志物 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.663 | Q3 |
| 2022 | 2.600 | Q3 |
| 2023 | 2.000 | Q3 |
| 2024 | 1.900 | Q3 |
| 2025 | 2.200 | Q3 |
BIOMARKERS 最新收录文献
-
1. Lessons learned from predicting hospital admission criteria comparing two COVID-19 waves: An Emergency Department's perspective.
PMID:期刊:日期:2026-09-16Emergency Departments (ED) play a central role in providing healthcare during crises such as pandemics. Evaluation of admission criteria under the circumstances of wave-dynamics is the bottleneck question for both clinical practice and planning on a structural level. This study compares patient characteristics, clinical biomarkers and outcomes during wave 1 (W1) and wave 2 (W2) of the COVID-19 pandemic at two tertiary care EDs in Berlin. We validated parameters predicting hospital admission by a CART-analysis of W1 in W2 and compared the findings to a CART-model derived from W2 by a decision curve analysis. A total of 1,204 patients with suspected COVID-19 presented in W1 and 1,440 in W2; 106 in W1 and 722 in W2 tested positive. Patients in W2 were older (>65 years, W1: 22.2%; W2: 34.6%) and multimorbid. Mortality of positive tested (W1: 1.9%; W2:8.6%) rose in W2. The admission-predicting parameters O2 saturation <95%, dyspnea, and cardiovascular comorbidities of W1 were applicable with a sensitivity of 98.5% (CI-95%: 96.3% - 99.4%) and specificity of 68.4% (61.0%-74.9%) in W2. Our results show transferability of admission-criteria despite changing pandemic conditions and serve as lessons learned to support future pandemic preparedness and capacity planning.
-
2. Time-dependent changes in YKL-40 and inflammatory markers in experimental acute mesenteric ischaemia.
PMID:期刊:日期:2026-09-10Early diagnosis of acute mesenteric ischaemia (AMI) remains challenging due to the lack of reliable biomarkers. This study aimed to investigate the time-dependent changes in chitinase-3-like protein 1 (YKL-40) and selected inflammatory markers in an experimental AMI model. A randomized controlled experimental study was conducted on 48 Wistar-albino rats. Mesenteric ischaemia was induced by ligation of the superior mesenteric artery. Blood and tissue samples were collected at 1, 3 and 6 h. Serum YKL-40, interleukin-6 (IL-6), interleukin-10 (IL-10) and lactate levels were measured, and histopathological damage was assessed. IL-6 levels increased significantly as early as 1 h ( = 0.010) and showed a progressive rise over time ( < 0.001), with a strong positive correlation with histopathological damage ( = 0.805). Lactate levels increased significantly at later time points. YKL-40 levels did not differ in the early phase but were significantly elevated at 6 h ( < 0.001). IL-10 levels decreased significantly in advanced ischaemia ( = 0.005). IL-6 showed an early increase and a strong association with histopathological damage, whereas YKL-40 appeared to be associated with later-stage inflammation rather than early ischaemic injury. These findings highlight the importance of time-dependent biomarker interpretation and support further evaluation of combined biomarker strategies in AMI.
-
3. Effect of colchicine on C-reactive protein level following hospitalization for myocardial infarction: a meta-analysis of randomized, placebo-controlled trials.
PMID:期刊:日期:2026-09-07C-reactive protein (CRP) is a biomarker of vascular inflammation with prognostic value for future cardiovascular events. This meta-analysis investigates the effect of colchicine, a cheap and widely available anti-inflammatory medication, on CRP levels in the months following myocardial infarction (MI). PubMed, EMBASE, and Cochrane were queried from inception to April 2026 to identify randomized controlled trials comparing colchicine to placebo for at least 1 month following MI. The primary outcome was mean CRP level at follow-up. Effect estimates were pooled with random-effects models and reported as mean differences for continuous variables using 95% confidence intervals. Four studies met inclusion criteria comprising 3384 patients (mean age 60.7 years; 78.3% male), including 1669 patients randomized to the colchicine arm, and 1715 to placebo. Median follow-up period was 3 months (range: 1-6 months). Colchicine following MI resulted in a statistically significant decrease in mean CRP level (mg/L) at follow-up versus placebo (MD: -0.69; [-1.21, -0.17], = 0.009). Heterogeneity of effect size estimates was high (I = 97%). Daily colchicine following MI decreases CRP at a median follow-up period of 3 months compared to placebo. The correlation between CRP reduction with colchicine and adverse cardiovascular event reduction warrants additional study.
-
4. Combined metabolic-inflammatory biomarkers for predicting complicated acute appendicitis: a comparative analysis.
PMID:期刊:日期:2026-09-02Early identification of complicated acute appendicitis remains clinically important for guiding timely surgical management. Composite indices integrating metabolic and inflammatory parameters have recently been proposed as potential predictors of disease severity. This study aimed to compare the diagnostic performance of metabolic-inflammatory composite indices with conventional hematological markers in predicting complicated acute appendicitis. This retrospective cohort study included adult patients who underwent appendectomy between January 2022 and January 2025. Complicated appendicitis was defined by intraoperative findings of perforation, gangrene, periappendiceal abscess, or generalized peritonitis. Various inflammatory and metabolic indices were calculated from routine laboratory parameters. Diagnostic performance was evaluated using ROC analysis and logistic regression models. A total of 1,871 patients were included, of whom 210 (11.2%) had complicated appendicitis. The C-reactive protein-to-albumin ratio (CAR) showed the highest diagnostic performance (AUC = 0.734). In multivariable analysis, both CAR and the inflammatory metabolic index (IMI) remained independent predictors. The final model incorporating age, sex, CAR, and IMI demonstrated the best discriminative performance (AUC = 0.795). Metabolic-inflammatory composite biomarkers, particularly CAR, may provide valuable adjunctive information for early prediction of complicated acute appendicitis.
-
5. Integrated molecular, epigenetic, microbial and liquid biopsy biomarkers in colorectal cancer: implications for prognosis and precision therapy.
PMID:期刊:日期:2026-09-01Colorectal cancer (CRC) is a biologically diverse malignancy driven by a complex interplay of genetic mutations, epigenetic changes, tumour microenvironmental factors and host-microbial interactions. Foundational molecular events including APC-associated Wnt/β-catenin dysregulation, TP53 inactivation, KRAS and BRAF mutations and aberrant PI3K/AKT signalling due to PIK3CA and PTEN alterations, contribute significantly to disease initiation, progression and therapeutic resistance. Microsatellite instability (MSI), arising from defective DNA mismatch repair, defines a distinct subset of CRC with characteristic biological and therapeutic behaviour. This review critically evaluates established and emerging molecular biomarkers for CRC, highlighting their mechanistic significance and translational relevance in the evolving precision oncology landscape. A comprehensive narrative evaluation of the literature was conducted, focusing on pathways regulating oncogenes, regulatory microRNAs, gut microbiota dysbiosis and liquid biopsy approaches, particularly circulating tumour cells (CTCs) and circulating free DNA (cfDNA). Core molecular alterations remain central to CRC pathogenesis and influence treatment responsiveness. Increasing evidence also supports the role of microRNA dysregulation and microbiome imbalance in modulating tumour progression and immune escape. Liquid biopsy technologies offer minimally invasive, real-time assessment of tumour development. An integrated understanding of molecular drivers and emerging biomarker platforms is essential for advancing personalized CRC management.
-
6. Stage-dependent shifts in peritoneal cytokine profiles drive monocyte functional reprogramming in endometriosis.
PMID:期刊:日期:2026-09-01Endometriosis is a chronic inflammatory disease in which monocytes/macrophages play a key pathogenetic role. The peritoneal fluid (PF) cytokine profile can modulate recruited monocyte functions, determining their contribution to disease progression. To investigate stage-specific changes in the PF cytokine profile and their impact on functional reprogramming of monocytes in endometriosis. The study included 26 patients with endometriosis (stages I-III) and 6 controls. PF cytokine concentrations were measured by multiplex analysis (Bio-Plex). The effect of PF on MerTK, CCR2, PD-1 and PD-L1 expression by healthy donor monocytes was assessed by flow cytometry. PF composition changed dynamically with disease stage: At stage I, RANTES and IL-6 increased; at stage II, IL-12 decreased and IL-1ra increased; and at stage III, IFN-γ and IL-12 decreased. Stage I PF inhibited MerTK expression on monocytes, whereas stages II-III PF upregulated MerTK, PD-L1, PD-1 and CCR2. Pro-inflammatory cytokines negatively correlated with MerTK and PD-1 changes, while Th2 cytokines positively correlated with MerTK expression. Th2 cytokine levels were directly associated with serum CA-125 concentration. Stage-specific shifts in the PF cytokine profile initiate the switching of monocytes from a pro-inflammatory to an immunosuppressive phenotype. Endometriosis diagnosis remains challenging due to the limited sensitivity of CA-125, particularly in early-stage disease. This study demonstrates that stage-specific shifts in peritoneal fluid cytokine and chemokine profiles - including changes in RANTES, IL-6, IL-12, IFN-γ and IL-1ra - drive measurable reprogramming of monocyte surface markers (MerTK, PD-1, PD-L1 and CCR2). These exploratory findings suggest that profiling peritoneal fluid cytokines together with monocyte phenotypic markers may, in principle, provide additional information relevant to disease staging and to the future identification of immune biomarkers; however, the present cohort is small and single-centre, and these observations require validation in larger, independent cohorts before any diagnostic or clinical application can be proposed. Delineating the stage-dependent transition from a pro-inflammatory to an immunosuppressive monocyte phenotype may also help to inform future research into immunomodulatory approaches in endometriosis.
-
7. Diagnostic and prognostic significance of serum phoenixin-14 and phoenixin-20 levels in patients with endometrial cancer.
PMID:期刊:日期:2026-09-01This study aimed to evaluate the diagnostic utility and prognostic significance of serum phoenixin-14 (PNX-14) and phoenixin-20 (PNX-20) levels in patients with endometrial cancer (EC). A prospective case-control study was conducted, enrolling 52 patients with histologically confirmed EC and 45 healthy controls. Serum PNX-14 and PNX-20 concentrations were measured using enzyme-linked immunosorbent assay. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were performed. Associations between phoenixin levels and clinicopathological parameters were evaluated. Serum PNX-14 (80.70 ± 22.45 vs. 61.75 ± 18.73 pg/mL; < 0.0001) and PNX-20 (888.2 ± 284.9 vs. 646.7 ± 243.8 pg/mL; < 0.0001) levels were significantly elevated in the EC group. Elevated PNX-14 was significantly associated with distant metastasis ( = 0.0463) and disease recurrence ( = 0.0020). Multivariable logistic regression identified PNX-14 as an independent predictor for EC (OR: 1.07; 95%CI: 1.03-1.12; = 0.001). The combined PNX-14/PNX-20 model yielded a superior area under the curve of 0.844. Serum PNX-14 and PNX-20 are significantly elevated in EC and demonstrate diagnostic potential. PNX-14 may serve as a prognostic biomarker for metastasis and recurrence.
-
8. Eosinopenia as an independent predictor of complicated acute appendicitis: usefulness in adults, not in children.
PMID:期刊:日期:2026-09-01The role of eosinophils in acute appendicitis (AA) is not well known. The aim of this study is to analyze whether peripheral blood eosinophil concentration can be useful in predicting episodes of complicated AA in both paediatric and adult populations. A retrospective cohort study was conducted in patients with a clinical diagnosis of AA confirmed by histopathological findings. Receiver operating characteristic (ROC) curve analysis and multivariate models were performed. A total of 531 cases were included (43.7% children). Complicated AA was present in 31.5% of children and 34.4% of adults. Symptom duration among children was ≥36 hours (aOR 2.24, = 0.006) and a neutrophil-to-lymphocyte ratio (NLR) ≥4.7 (aOR 3.63, = 0.006) increased the likelihood of complicated AA. In adults, eosinophil concentration <40 cells/µL (aOR 1.88, = 0.033), being male (aOR 2.53, < 0.001), and having an NLR ≥4.7 (aOR 2.98, = 0.006) were independent factors associated with complicated AA. Peripheral blood eosinophils appear to serve as a valuable biomarker for identifying cases of complicated AA among the adult population but not among children. Prospective studies will help elucidate this phenomenon.
-
9. Assessment of respiratory rate-oxygenation index (ROX), HACOR score and the C-reactive protein for prediction of mechanical ventilation and mortality in acutely intoxicated patients.
PMID:期刊:日期:2026-09-01Acute respiratory toxicity is a common presenting emergency in acutely poisoned patients. Unpredictable respiratory deterioration can occur regardless of the on-admission patients' stable state, leading to increased morbidity and mortality. This study aimed to evaluate the respiratory rate-oxygenation (ROX) index, heart rate, acidosis, consciousness, oxygenation and respiratory rate (HACOR) score and C-reactive protein (CRP) as predictors of mechanical ventilation (MV) in poisoned patients. This prospective study was conducted on poisoned patients with acute respiratory failure presented to the Poison Control Center-Ain Shams University Hospitals (PCC-ASUHs). Upon admission, all patients had their ROX index, HACOR score and CRP level measured at the time of admission and at 24 hours. Seventy-two patients were enrolled in the study, where forty-one cases were mechanically ventilated. The initial ROX index was significantly lower in the mechanically ventilated group with a cut-off ≤ 18.85 at AUC (0.74). The 24-hour ROX index, HACOR score and CRP level were predictors of mechanical ventilation need at AUC (0.97, 0.94, 0.85, respectively). It was concluded from this study that the initial and 24-hour ROX index, 24-hour HACOR and CRP level can be predictors of MV in poisoned patients.
-
10. {"_":"Identification of as a key regulator in mitochondrial dysfunction during radiation-induced intestinal injury.","i":["Mrm2"]}
PMID:期刊:日期:2026-09-01Radiation-induced intestinal injury (RIII) is a serious complication of radiotherapy and is closely associated with mitochondrial dysfunction, but the underlying mechanism remains unclear. Mitochondria‑related differentially expressed genes (DEGs) were identified using online databases in an RIII model. Histopathological staining analysis was performed to evaluate injury severity. The expression of was examined in vivo after irradiation. The core functional modules of the identified DEGs included mitochondrial‑coding genes and apoptosis‑related genes. Histopathological analysis showed that RIII aggravated significantly in a dose‑ and time‑dependent manner. Notably, was continuously upregulated after irradiation in vivo. may serve as a key regulatory factor mediating mitochondrial dysfunction in radiation‑induced intestinal injury.