Biomaterials Research生物材料研究
Biomaterials Research(英文缩写 BIOMATER RES),ISSN 1226-4601,eISSN 2055-7124,中文译名:生物材料研究 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 15.863 | Q1 |
| 2022 | 11.300 | Q1 |
| 2023 | 8.100 | Q1 |
| 2024 | 9.600 | Q1 |
| 2025 | 9.800 | Q1 |
Biomaterials Research 最新收录文献
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1. Extracellular Vesicle-Mimetic Nanoplatforms for Integrated Vaccination and Targeted Antibiotic Therapy against MRSA Bacteremia: A Wolf in Sheep's Clothing.
1. 细胞外囊泡模拟纳米平台用于针对MRSA菌血症的集成疫苗接种和靶向抗生素治疗：披着羊皮的狼PMID:日期:2026-09-30Methicillin-resistant (MRSA) remains a critical global health threat, necessitating innovative therapeutic strategies. Inspired by the multi-antigenic features and homotypic binding of MRSA extracellular vesicles (EVs), we aimed to develop a biomimetic nanoplatform cloaked with MRSA-derived EV, termed EV-NP, to integrate vaccine and antibiotic functionalities. EV-NP were efficiently internalized by macrophages and dendritic cells, promoting robust humoral and cellular immune responses, as evidenced by elevated immunoglobulin G titers and CD69 expression. When loaded with rifampicin (RF), the nanoplatform demonstrated homologous targeting to MRSA via EV-mediated adhesion, enhancing drug delivery to intracellular bacteria and biofilm. In a murine bacteremia model, EV-NP vaccination and RF-loaded EV-NP therapy each significantly reduced bacterial burden and proinflammatory cytokine expression, improving survival to 62 and 41 h, respectively. Sequential prophylaxis and therapy extended survival to 140 h. The EV-NP system also attenuated EV-associated hemolysis and showed no acute toxicity. This "wolf-in-sheep's-clothing" strategy offers a versatile approach for both prevention and treatment of MRSA infection.
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2. Advanced Hydrogel Functionalization Strategies for Burn-Related Wound Treatment.
2. 用于烧伤相关伤口治疗的高级水凝胶功能化策略PMID:日期:2026-09-28Burn injuries cause deep, extensive skin damage and are associated with high morbidity and mortality. Effective treatment goes beyond superficial wound coverage; it requires regenerative repair that progresses from deeper tissue layers to complete skin restoration. Because of extreme trauma and severity, the fastest treatment strategies play a key role in the treatment of burn injuries. Recently, hydrogel dressings have gained attention as promising wound care options because they maintain a moist environment, provide cooling and pain relief, support autolysis, and promote tissue regeneration. However, the lack of biological function and, consequently, slower tissue regeneration limit the applications of hydrogels. In recent years, collaboration between doctors, materials scientists, and biologists has substantially improved the biological functionality of hydrogels. Integrating bioactive agents, such as proteins, peptides, antimicrobial compounds, drugs, metal nanoparticles, cell-based vesicles, and extracellular matrix, enables the development of multifunctional, active burn wound dressings. This review highlights advances in the functionalization of hydrogel dressings for burn care, including fabrication methods, biological efficacy, and therapeutic mechanisms. The literature provides a comprehensive overview of the area where further advancement could be pursued.
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3. Piezoelectric Iron (II) Tungstate-Integrated Three-Dimensional-Printed Polycaprolactone Scaffolds for Ultrasound-Triggered Osteosarcoma Therapy and Ultrasound-Free Bone Repair.
3. 压电钨酸亚铁集成三维打印聚己内酯支架用于超声触发骨肉瘤治疗与无超声骨修复PMID:日期:2026-09-22The demand for effective therapeutics addressing osteosarcoma necessitates multifunctional solutions integrating both antineoplastic and osteogenic properties. This study presents a novel approach involving a 3-dimensional (3D)-printed polycaprolactone (PCL) scaffold integrated with piezoelectric iron (II) tungstate (FeWO) nanorods (NRs), designed to concurrently combat osteosarcoma and foster bone regeneration. Through the amalgamation of FeWO NRs' piezoelectric catalytic characteristics and PCL scaffold's structural attributes, the composite scaffolds exhibit dual functionality: inducing oxidative stress in tumor cells via ultrasound-triggered piezo-sonoydnamic effects while facilitating stem cell attachment and proliferation without ultrasound. The physicochemical attributes and catalytic efficacy of the composite scaffolds are meticulously investigated. Both in vitro and in vivo tests confirm the strong ultrasound-triggered antitumor and ultrasound-free bone-forming effects of the PCL@FeWO composite scaffold. This study introduces a novel class of piezoelectric nanomaterial-functionalized 3D-printing scaffolds, presenting new avenues for ultrasound-triggered osteosarcoma therapy and ultrasound-free bone regeneration.
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4. Bioinspired TIMP-1 Nanoparticles Mimic Extracellular Vesicle Anti-angiogenic Activity in Ewing Sarcoma.
PMID:日期:2026-09-22Anti-angiogenic therapies targeting the vascular endothelial growth factor (VEGF) axis have achieved transient benefits, as tumors rapidly activate compensatory vascular programs. Here, we present a bioinspired nanoplatform that reproduces the anti-angiogenic signaling of mesenchymal-stromal-cell-derived extracellular vesicles (EVs) by delivering the endogenous metalloproteinase inhibitor tissue inhibitor of metalloproteinases-1 (TIMP-1). Poly(methyl methacrylate) nanoparticles (NP_TIMP1) were engineered to retain TIMP-1 bioactivity, inhibit matrix metalloproteinase activity, and efficiently interact with endothelial cells. In vitro, NP_TIMP1 suppressed endothelial sprouting and tip-cell formation in 2-dimensional and 3-dimensional microfluidic systems. In zebrafish patient-derived xenografts of Ewing sarcoma, NP_TIMP1 localized to tumor-associated vessels and substantially reduced vascular infiltration, reproducing the efficacy of TIMP-1-enriched EVs. In contrast, soluble TIMP-1 failed to elicit these effects, indicating that nanoparticle-mediated delivery enhances protein stability and spatial engagement with the endothelium. This study establishes TIMP-1 as a key stromal regulator of angiogenesis and demonstrates that EV-mimetic nanoparticles can recapitulate its therapeutic potential, providing a scalable bioengineering approach to overcome the limitations of natural vesicles and develop next-generation anti-angiogenic nanotherapeutics.
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5. 2D Titanium-Based Nanozyme Induced a Ferroptosis-like Strategy for Triple-Negative Breast Cancer Therapeutics.
PMID:日期:2026-09-21Ferroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, has emerged as a promising strategy for cancer therapy. Nevertheless, the direct delivery of iron can lead to systemic toxicity. In this study, a nonferrous ferroptosis-like strategy employing 2D TiC MXene nanosheets was developed. The TiC nanozyme has been shown to possess peroxidase- and catalase-like activities, capable of decomposing HO into cytotoxic·OH and O, respectively. When exposed to near-infrared II laser irradiation, TiC induced a localized increase in temperature and amplified reactive oxygen species production, resulting in a synergistic effect that led to mitochondrial damage and glutathione peroxidase 4 inactivation. In vivo studies demonstrated tumor suppression in triple-negative breast cancer (TNBC) models, accompanied by M1 macrophage polarization and CD8 T cell activation. This work provides a novel paradigm for nanocatalytic ferroptosis therapy, combining enzymatic activity, photothermal effects, and immunomodulation to overcome TNBC resistance.
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6. A Glutathione-Responsive Prodrug Nanosystem for Colorectal Cancer: Synergistic Co-Delivery of Paclitaxel and Curcumin to Combat Multidrug Resistance and Reinvent the Immunosuppressive Microenvironment.
PMID:日期:2026-09-17The management of colorectal cancer is constrained by a self-perpetuating vicious cycle, driven initially by gut microbiota dysbiosis that triggers chronic inflammation, which in turn promotes the establishment of an immunosuppressive tumor microenvironment and multidrug resistance. We engineered a glutathione (GSH)-responsive prodrug micellar nanosystem (PSC/PTX) for the synergistic co-delivery of paclitaxel (PTX) and curcumin (CUR). In this nanoplatform, CUR was covalently conjugated to form a prodrug via disulfide linkages, while PTX was physically encapsulated within the micelles, ensuring the precise release of the 2 drugs in the tumor-specific microenvironment. The nanoplatform reverses P-glycoprotein-mediated drug efflux, prolongs the circulation time, improves the bioavailability, and enhances the accumulation at tumor sites of 2 drugs. This nanoplatform exerts multifaceted therapeutic efficacy. Initially, it reinstates the balance of intestinal microbiota by increasing the abundances of beneficial microorganisms (e.g., , , and ) while decreasing those of harmful bacteria (e.g., and ). Additionally, it inhibits pro-tumor inflammatory factors by attenuating the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), ultimately leading to a remodeling of the immunosuppressive tumor microenvironment (TME). This process involves boosting the infiltration of cytotoxic CD8 T cells, decreasing the number of immunosuppressive regulatory T cells (Tregs), and repolarizing macrophages to the M1 phenotype (CD86↑, CD206↓). Collectively, this integrated and coordinated strategy breaks the self-sustaining vicious cycle of microbiota-driven, inflammation-fueled carcinogenesis and multidrug resistance via the synergistic modulation of chemotherapy sensitization, immunity, and the microbiota, thereby offering a novel and promising therapeutic modality for refractory colorectal cancer.
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7. An Injectable and Photocrosslinkable Hydrogel Based on Recombinant Human Collagen Type XVII Promotes Osteochondral Regeneration by Activating the TGF β/SMAD Signaling Pathway.
7. 一种基于重组人XVII型胶原的可注射光交联水凝胶通过激活TGF-β/SMAD信号通路促进骨软骨再生PMID:日期:2026-09-14The management of articular cartilage defects remains a major clinical challenge owing to the tissue's limited intrinsic regenerative capacity. Conventional collagen-based hydrogels often fail to achieve functional repair due to a mismatch between their biological functions and mechanical properties. Here, for the first time, we apply recombinant human collagen type XVII (rhCOL17) to cartilage repair by engineering an injectable and photocrosslinkable hydrogel based on rhCOL17. A systematic screening identified the 15% methacrylated rhCOL17 (CMA) formulation as possessing optimal mechanical properties and biocompatibility, featuring a suitable 3-dimensional porous structure, moderate swelling, slow degradation, and rapid in situ photocrosslinking capability. In vitro experiments demonstrated that the CMA hydrogel is noncytotoxic and notably promotes the proliferation, migration, and chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) and chondrocytes, as evidenced by the up-regulation of SOX9, COL2, and ACAN. In vivo, using a rat knee joint full-thickness cartilage defect model, the BMSCs-laden 15% CMA composite hydrogel (BMSCs@CMA) achieved superior osteochondral integrated repair, with the regenerated tissue closely resembling native cartilage in macroscopic morphology, subchondral bone mineralization, histological structure, and collagen type II deposition. Mechanistically, transcriptome sequencing, molecular docking, and molecular dynamics simulations collectively demonstrate that rhCOL17 directly binds to transforming growth factor-β1 (TGF-β1) with high affinity and stable interaction, subsequently activating the TGF-β/SMAD signaling pathway to orchestrate BMSCs chondrogenesis. In conclusion, this study establishes the pivotal role of collagen type XVII in cartilage regeneration, presenting a promising, minimally invasive strategy with mechanical adaptability and active inductive functionality for functional cartilage defect repair, and expands the cross-tissue application prospects of rhCOL17.
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8. 3D-Printed Region-Specific Biomimetic Prosthesis for Enhancing Heterogeneous Double-Interface Integration of Bone-Prosthesis and Tendon-Prosthesis.
8. 用于增强骨-假体与肌腱-假体异质双界面整合的3D打印区域特异性仿生假体PMID:日期:2026-09-11Large bone defects with loss of natural tendon and soft tissue attachment sites remain challenging in prosthetic reconstruction because both bone-prosthesis and tendon-prosthesis interface integration must be achieved. To address this heterogeneous dual-interface requirement, this study proposes and validates a 3-dimensional printed (3D-printed) region-specific biomimetic titanium alloy prosthesis design strategy. This strategy integrates biomimetic tendon ordered microstructures and biomimetic trabecular-like disordered porous structures within distinct functional regions of the same Ti6Al4V prosthesis. Specifically, the top cap was designed with tendon-like ordered microstructures for soft tissue attachment, whereas the body region was designed with trabecular porous structures for bone integration. In vitro experiments demonstrate that the biomimetic tendon structure markedly promotes the directional alignment and tenogenic differentiation of tendon-derived stem cells, while the biomimetic trabecular-like structure favors osteogenic differentiation and mineralization maturation of bone-marrow-derived mesenchymal stem cells. In vivo animal experiments further validate that a single structure is insufficient to simultaneously meet the dual demands of soft tissue attachment and bone stability. In contrast, the 3D-printed region-specific biomimetic prosthesis establishes spatially partitioned microenvironments for tendon and bone formation in vivo, enabling more coordinated heterogeneous double-interface tissue integration.
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9. Photodynamically Sensitized Mitochondrial-Damage Amplification Strategy Promotes Pyroptosis-Induced Immunotherapy of Osteosarcoma.
PMID:日期:2026-09-09The heterogeneity of osteosarcoma (OS) is the main reason for ineffective treatment and uncontrolled disease. Immunotherapy provides an ideal strategy to overcome the heterogeneity of OS, but effective activation of tumor-intrinsic immunogenicity remains challenging. We developed a biomimetic nanoplatform utilizing mitochondrial damage as a potent immunogenic trigger by employing the mitochondria-targeting compound cinnamaldehyde (CA) derived from traditional Chinese medicine. OS cell membrane-coated hollow MnO nanoparticles were used to deliver CA and chlorin e6. After accumulating at the tumor site and being internalized by tumor cells, CA release induces mitochondrial oxidative damage and produces hydrogen peroxide in combination with hollow manganese dioxide to alleviate the hypoxic microenvironment. Finally, a mitochondrial-damage amplification mechanism is formed to trigger tumor pyroptosis under the synergy of adjustable photodynamic therapy. Released damage-associated molecule patterns and damaged double-stranded DNA inside tumor cells promote dendritic cell maturation by activating the cGAS-STING (cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes) signaling axis. Through CA-triggered amplification of mitochondrial damage, dual immunogenic pathways reshape the immunosuppressive microenvironment, overcoming OS heterogeneity and inhibiting distal metastasis. This strategy provides new opportunities for tumor-intrinsic immunogenic activation.
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10. Intraperitoneal Copper-Manganese Nanozyme Suppresses Peritoneal Metastasis with Antitumor Immune Activation.
10. 腹腔内铜锰纳米酶通过抗肿瘤免疫激活抑制腹膜转移PMID:日期:2026-09-09Peritoneal metastasis from colorectal cancer (CRC) carries a dismal prognosis, and current surgical and medical therapies achieve limited efficacy with high recurrence rates. Here, we developed a copper-manganese-based nanozyme (CM) that integrated MnO-mediated Fenton-like catalysis with copper-induced cuproptosis for intraperitoneal treatment of CRC peritoneal metastasis. Composed of CuO and Cu(OH)Cl crystalline domains embedded in amorphous MnO, the nanozyme has a hydrodynamic diameter of ~140 nm and displays peroxidase-like, glutathione oxidase, catalase, and Fenton-like activities that amplify reactive oxygen species (ROS) under tumor-mimicking conditions. CRC cells efficiently internalize the nanozyme, which penetrates 3-dimensional spheroids and induces strong, selective cytotoxicity via ROS amplification and cuproptosis. Intraperitoneal delivery of CM achieves prolonged peritoneal retention, marked reduction of peritoneal tumor burden and ascites, and remodeling of the local immune microenvironment with activation of antitumor immune responses. This study provides an effective cavity-confined therapeutic approach for CRC peritoneal metastasis based on Fenton-like ROS amplification and cuproptosis.