European Review for Medical and Pharmacological Sciences欧洲医学与药理学评论
European Review for Medical and Pharmacological Sciences,ISSN 1128-3602,eISSN 1128-3602,中文译名:欧洲医学与药理学评论 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2020 | 3.507 | Q2 |
| 2021 | 3.784 | Q2 |
| 2022 | 3.300 | Q3 |
European Review for Medical and Pharmacological Sciences 最新收录文献
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1. Retraction Note.
1. 撤稿说明PMID:日期:2026-09The Editor-in-Chief, in accordance with the Publisher, has retracted the following articles published between 2017 and 2019 on the grounds of figure duplication and manipulation, subsequent to concerns raised on PubPeer. The corresponding authors of all articles have been contacted several times and were asked to provide the original data, but no responses were received. This retraction notice pertains to the following articles and is carried out in accordance with the recommendations of the Committee on Publication Ethics (COPE): 1. Cao YX, Wang ZQ, Kang JX, Liu K, Zhao CF, Guo YX, Jiao BH. miR-424 protects PC-12 cells from OGD-induced injury by negatively regulating MKP-1. Eur Rev Med Pharmacol Sci 2018; 22(5): 1426-1436-DOI: 10.26355/eurrev_201803_14490-PMID: 29565504. 2. Wang CL, Wang D, Yan BZ, Fu JW, Qin L. Long non-coding RNA NEAT1 promotes viability and migration of gastric cancer cell lines through up-regulation of microRNA-17. Eur Rev Med Pharmacol Sci 2018; 22(13): 4128-4137-DOI: 10.26355/eurrev_201807_15405-PMID: 30024601. 3. Chen LL, Xu Y. Epigallocatechin gallate attenuates uric acid-induced injury in rat renal interstitial fibroblasts NRK-49F by up-regulation of miR-9. Eur Rev Med Pharmacol Sci 2018; 22(21): 7458-7469-DOI: 10.26355/eurrev_201811_16287-PMID: 30468495. 4. Qin WW, Xin ZL, Wang HQ, Wang KP, Li XY, Wang X. Inhibiting lncRNA ROR suppresses growth, migration and angiogenesis in microvascular endothelial cells by up-regulating miR-26. Eur Rev Med Pharmacol Sci 2018; 22(22): 7985-7993-DOI: 10.26355/eurrev_201811_16427-PMID: 30536347. 5. Zhao J, Sun H, Zhang JM, Wang M, Du XJ, Zhang JL. Long non-coding RNA ANRIL down-regulates microRNA-7 to protect human trabecular meshwork cells in an experimental model for glaucoma. Eur Rev Med Pharmacol Sci 2019; 23(8): 3173-3182-DOI: 10.26355/eurrev_201904_17675-PMID: 31081068. 6. Bai M, Pan CL, Jiang GX, Zhang YM, Zhang Z. CircHIPK3 aggravates myocardial ischemia-reperfusion injury by binding to miRNA-124-3p. Eur Rev Med Pharmacol Sci 2019; 23(22): 10107-10114-DOI: 10.26355/eurrev_201911_19580-PMID: 31799682. 7. Lin N, Li XY, Zhang HM, Yang Z, Su Q. microRNA-199a-5p mediates high glucose-induced reactive oxygen species production and apoptosis in INS-1 pancreatic β-cells by targeting SIRT1. Eur Rev Med Pharmacol Sci 2017; 21(5): 1091-1098-PMID: 28338182. The authors have been informed about the retraction but remained unresponsive. These articles have been retracted. The Publisher apologizes for any inconvenience this may cause.
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2. Predictive value of the triglyceride-glucose index combined with novel body shape indices for cardiovascular disease: a cross-sectional study based on NHANES.
PMID:日期:2026-09Cardiovascular disease (CVD) remains one of the leading causes of death worldwide. Insulin resistance (IR) and central obesity are key contributors. The triglyceride-glucose (TyG) index is a simple surrogate for IR, while novel adiposity indices, such as the visceral adiposity index (VAI), lipid accumulation product (LAP), cardiometabolic index (CMI), body roundness index (BRI), and a body shape index (ABSI), better reflect body fat distribution. However, the predictive value of combining TyG with these indices for CVD risk remains unclear. This cross-sectional study used data from 19,822 adults aged ≥20 years in the U.S. NHANES (1999-2018). CVD was defined by self-reported physician diagnosis. The TyG index and its derivatives (TyG-BMI, TyG-WC, TyG-WHtR, TyG-CMI, TyG-VAI, TyG-LAP, TyG-BRI, TyG-ABSI) were calculated. Weighted logistic regression and restricted cubic spline (RCS) analyses assessed associations and potential nonlinear relationships. Receiver operating characteristic (ROC) curves compared predictive performance. All TyG-derived indices were significantly associated with higher CVD risk (p<0.05). The strongest associations were observed for TyG-ABSI (OR=3.95, 95% CI: 1.99-7.85) and TyG-BRI (OR=2.10, 95% CI: 1.55-2.85). TyG-VAI and TyG-CMI showed nonlinear relationships with CVD. In ROC analysis, TyG-ABSI achieved the highest discriminative power (AUC=0.69), outperforming TyG and other indices. Subgroup analyses revealed stronger associations among younger, obese, hypertensive, and diabetic males. Combining the TyG index with body-shape indices markedly improved CVD risk prediction. TyG-ABSI, TyG-BRI, and TyG-CMI showed superior diagnostic performance and may serve as cost-effective tools for early CVD risk assessment in clinical and public health settings.
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3. Leflunomide-associated fatal cryptococcal meningoencephalitis presenting as rapidly progressive dementia: a case report.
PMID:日期:2026-09Cryptococcal meningoencephalitis is a serious opportunistic infection, classically associated with advanced immunosuppression. The increasing use of immunomodulatory drugs, such as leflunomide, has broadened the at-risk population. A 66-year-old woman with rheumatoid arthritis, on long-term leflunomide therapy, presented with progressive cognitive decline, behavioral changes, and myoclonus over a six-week period. The initial presentation mimicked rapidly progressive dementia. Cerebrospinal fluid analysis showed elevated opening pressure, hypoglycorrhachia, and hyperproteinorrhachia. India ink staining and culture confirmed Cryptococcus spp., which polymerase chain reaction (PCR) identified as Cryptococcus gattii. Despite antifungal treatment with liposomal amphotericin B and fluconazole, her condition deteriorated, leading to persistent intracranial hypertension, secondary infections, and multiorgan failure, resulting in death. This case highlights the diagnostic challenges of cryptococcal meningoencephalitis with atypical neurological presentation and its potential association with leflunomide-induced immunosuppression. Early clinical suspicion and a multimodal diagnostic approach are essential for improving prognosis.
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4. Association between questionnaire-estimated water intake and urinary biomarkers in older Japanese adults: the KOBE study.
PMID:日期:2026-09Accurate estimation of habitual water intake is crucial for epidemiological studies of water balance among older adults; however, reliable assessment methods for large-scale research remain limited. This study aimed to investigate the association between habitual water intake, as estimated by a "simplified lifestyle questionnaire for predicting habitual water intake" (SQW), and urinary biomarkers related to hydration and water balance in community-dwelling older adults. A cross-sectional analysis was conducted on 268 participants enrolled in the 2022-2023 KOBE Study NEXT survey. Habitual total water intake and source-specific water intake were estimated using the SQW. Early-morning spot urine samples collected after an overnight fast were used to measure urinary osmolality and electrolyte (sodium, potassium, and chloride) concentrations. The association between estimated water intake (analyzed as a continuous variable and by quartiles) and urinary biomarkers was examined using multivariable linear regression models after adjusting for age, sex, body mass index, smoking status, and alcohol consumption. Analyses were performed separately for men and women, and the sex-intake interaction term was tested. In men, higher total water intake was significantly associated with lower urinary sodium and chloride concentrations, but not with urinary osmolality. In women, higher beverage-derived water intake was associated with lower urinary osmolality and lower urinary sodium and chloride concentrations in quartile-based trend analyses, whereas continuous analyses showed similar but non-significant trends. Dietary water intake and alcoholic beverage-derived water intake showed no significant association with urinary biomarkers in either sex. The sex-intake interaction term was not statistically significant. Water intake estimated by the SQW was associated with urinary biomarkers related to hydration and water balance in older Japanese adults, with patterns varying according to water-intake source. These findings suggest that the SQW may serve as a practical tool for assessing habitual water intake in epidemiological and public health settings. Future longitudinal studies should investigate causality and clinical relevance.
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5. Retraction Note.
5. 撤回说明PMID:日期:2026-07The Editor-in-Chief, in accordance with the Publisher, has retracted the following articles published between 2017 and 2019 on the grounds of figure duplication and manipulation, subsequent to concerns raised on PubPeer. The corresponding authors of all articles have been contacted several times and were asked to provide the original data, but no responses were received. This retraction notice pertains to the following articles and is carried out in accordance with the recommendations of the Committee on Publication Ethics (COPE): 1. Mani J, Fleger J, Rutz J, Maxeiner S, Bernd A, Kippenberger S, Zöller N, Chun FK, Relja B, Juengel E, Blaheta RA. Curcumin combined with exposure to visible light blocks bladder cancer cell adhesion and migration by an integrin dependent mechanism. Eur Rev Med Pharmacol Sci 2019; 23(23): 10564-10574-DOI: 10.26355/eurrev_201912_19698-PMID: 31841214. 2. Ma JB, Hu SL, Zang RK, Su Y, Liang YC, Wang Y. MicroRNA-487a promotes proliferation of esophageal cancer cells by inhibiting p62 expression. Eur Rev Med Pharmacol Sci 2019; 23(4): 1502-1512-DOI: 10.26355/eurrev_201902_17108-PMID: 30840272. 3. Ma YX, Zhang H, Li XH, Liu YH. MiR-30e-5p inhibits proliferation and metastasis of nasopharyngeal carcinoma cells by target-ing USP22. Eur Rev Med Pharmacol Sci 2018; 22(19): 6342-6349-DOI: 10.26355/eurrev_201810_16045-PMID: 30338802. 4. Gao AG, Zhou YC, Hu ZJ, Lu BB. Ipriflavone promotes osteogenesis of MSCs derived from osteoporotic rats. Eur Rev Med Pharmacol Sci 2018; 22(14): 4669-4676-DOI: 10.26355/eurrev_201807_15527-PMID: 30058710. 5. Du XY, Liu X, Wang ZJ, Wang YY. SLPI promotes the gastric cancer growth and metastasis by regulating the expression of P53, Bcl-2 and Caspase-8. Eur Rev Med Pharmacol Sci 2017; 21(7): 1495-1501-PMID: 28429358. The authors have been informed about the retraction but remained unresponsive. These articles have been retracted. The Publisher apologizes for any inconvenience this may cause.
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6. Pharmacological modulation of the PD-1/PD-L1 axis: from immune tolerance in colitis to immune escape in colorectal cancer.
PMID:日期:2026-07In recent years, immune-based therapies, particularly checkpoint inhibitors, have been developed to interfere with tumor immune escape. Among various molecular targets, the PD-1/PD-L1 axis represents a central mechanism of tumor-driven immune evasion and a major target for restoring T-cell-mediated anti-tumor activity. Several blocking monoclonal antibodies have been developed to restore antitumor immunity, and anti-PD-1/PD-L1 antibodies have transformed the treatment of solid tumors, including colorectal cancer (CRC). In the colon, the PD-1/PD-L1 axis plays a dual and context-dependent role. During the early stages of intestinal inflammation, such as in inflammatory bowel disease (IBD), PD-1/PD-L1 signaling contributes to immune tolerance and mucosal protection. However, persistent activation of this pathway may become detrimental during the colitis-to-cancer transition, promoting immune evasion and tumor progression. Immune checkpoint inhibitors, such as nivolumab and pembrolizumab, currently approved for specific subsets of CRC, exert their effects by blocking the interaction between PD-1 and PD-L1, thereby restoring antitumor immune responses. Their use, either as monotherapy or in combination regimens, has demonstrated promising efficacy in advanced and mismatch repair-deficient CRC. This review summarizes the biphasic role of PD-1/PD-L1 in IBD and CRC, with particular emphasis on the therapeutic application of PD-1/PD-L1 blockade in CRC. It highlights monoclonal antibody-based approaches and emerging combination strategies, and finally examines current clinical trial evidence, highlighting ongoing challenges, including primary and acquired resistance to anti-PD-1/PD-L1 therapies.
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7. Cognitive impairment in children with β-thalassemia major: influence of clinical and biochemical factors.
PMID:日期:2026-07Children with β-thalassemia major are at risk for neurocognitive impairment due to chronic anemia, iron overload, and possible neurotoxicity from chelation therapy. Despite improved transfusion and chelation protocols, the impact on cognitive function remains unclear. This study evaluated cognitive performance in children with β-thalassemia major and explored selected clinical and biochemical factors associated with cognitive scores. Seventeen patients aged 6-16 years with β-thalassemia major receiving regular transfusions and 17 healthy age- and sex-comparable controls were included. Demographic, anthropometric, and laboratory data (hemoglobin, ferritin, vitamin B12, and vitamin D) were collected. Cognitive performance was evaluated using the Wechsler Intelligence Scale for Children-Revised (WISC-R). Associations between cognitive scores and selected clinical and biochemical variables were evaluated as exploratory analyses, and key associations involving BMI z-score and transfusion duration were additionally adjusted for age. Patients showed significantly lower verbal IQ (81.9 ± 21.9) and full-scale IQ (83.7 ± 21.0) scores compared with controls (109.1 ± 20.1 and 104.6 ± 19.6; p<0.05). All verbal and performance subtests, including picture arrangement and block design, were reduced. In exploratory analyses, age, BMI z-score, and transfusion duration were associated with selected cognitive scores; however, several of these associations were attenuated after adjustment for age. Vitamin D showed positive associations with selected verbal cognitive scores, while ferritin was not significantly associated with cognitive scores in the revised analysis. Children with β-thalassemia major exhibit lower cognitive performance, especially in verbal domains. Associations with clinical and biochemical variables should be interpreted cautiously. Routine cognitive evaluation and metabolic follow-up are recommended for early detection and multidisciplinary care.
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8. Spleen stiffness measurement by transient elastography for detecting esophagogastric varices: a systematic review of diagnostic accuracy studies.
PMID:日期:2026-07Clinically significant portal hypertension drives the development of esophagogastric varices. Endoscopy remains the gold standard, but it is invasive and resource demanding. The aim of the study is to evaluate the diagnostic accuracy of spleen stiffness measurement (SSM) by transient elastography in predicting esophagogastric varices. We systematically reviewed 20 studies. Techniques included standard 50 Hz TE and spleen-dedicated 100 Hz probes. Outcomes included AUROC, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), feasibility, and varices prevalence. SSM accuracy was high across studies (AUROC 0.75-0.97). 100 Hz SSM showed superior diagnostic performance and feasibility, even though the sample size was small, leading to important variability in evidence. SSM demonstrated excellent rule-out ability, with NPV consistently >90% in HRV-focused studies. Etiology influenced performance. SSM is a robust, non-invasive tool for detecting varices and may help triage patients to reduce unnecessary endoscopy. Integration into assessment algorithms for clinically significant portal hypertension is strongly supported.
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9. Retraction Note: Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study.
9. 撤回说明：子宫内膜异位瘤是否会成为IVF周期中完成卵母细胞取出的障碍？回顾性研究PMID:日期:2026-06The article "Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study" by G.M. Baldini, A.S. Laganà, A. Mastrorocco, A. Malvasi, D. Baldini, D. Ferri, R. Sciorio, G. Trojano, published in Eur Rev Med Pharmacol Sci 2024; 28 (7): 2827-2836-DOI: 10.26355/eurrev_202404_35911-PMID: 38639522, has been retracted by the Publisher and the Editor in Chief. Following concerns raised on the study data and ethics issues, the journal initiated an editorial investigation in accordance with journal policies and COPE guidelines. The authors were contacted and provided a reply to the issues raised, but were unable to provide the original data due to a technical failure that resulted in the loss of access to the underlying files, nor the original ethics committee approval document. The journal has therefore reassessed the manuscript based on the information provided. The external evaluation identified significant concerns regarding the study's reporting, transparency, and verifiability. Consequently, the concerns raised during the post-publication evaluation could not be satisfactorily resolved, and the reliability of the reported findings and conclusions could not be verified. In light of these issues, the Editor-in-Chief has concluded that the article is retracted. The authors have been informed of this decision and do not agree with the retraction. This article has been retracted. The Publisher apologizes for any inconvenience this may cause.
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10. Retraction Note: A multicenter clinical study with myo-inositol and alpha-lactalbumin in Mexican and Italian PCOS patients.
10. 撤回说明：一项针对墨西哥和意大利PCOS患者的肌醇和α-乳清蛋白的多中心临床研究PMID:日期:2026-06The article "A multicenter clinical study with myo-inositol and alpha-lactalbumin in Mexican and Italian PCOS patients" by I. Hernandez Marin, O. Picconi, A.S. Laganà, L. Costabile, V. Unfer, published in Eur Rev Med Pharmacol Sci 2021; 25 (8): 3316-3324-DOI: 10.26355/eurrev_202104_25743-PMID: 33928619, has been retracted by the Publisher and the Editor in Chief. Following concerns raised by a whistleblower regarding ethics approval issues, statistical analysis, the reliability of the reported results, and potential conflicts of interest, the journal initiated an editorial investigation in accordance with journal policies and COPE guidelines. The authors were contacted and provided a response as well as the original data. An independent statistical expert was appointed to reassess the manuscript. The evaluation identified insufficient documentation of ethics approval across all participating centers and unresolved methodological and statistical concerns, which together limit the reliability and interpretability of the reported findings. In light of these issues, the Editor-in-Chief has concluded that the article's results and conclusions are compromised. The article is therefore retracted. The authors have been informed of this decision and do not agree with the retraction. This article has been retracted. The Publisher apologizes for any inconvenience this may cause.