JOURNAL OF COMPARATIVE NEUROLOGY比较神经学杂志
JOURNAL OF COMPARATIVE NEUROLOGY(英文缩写 J COMP NEUROL),ISSN 0021-9967,eISSN 1096-9861,中文译名:比较神经学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.028 | Q1 |
| 2022 | 2.500 | Q1 |
| 2023 | 2.300 | Q1 |
| 2024 | 2.100 | Q1 |
| 2025 | 2.300 | Q1 |
JOURNAL OF COMPARATIVE NEUROLOGY 最新收录文献
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1. Structure Guides Function: Beyond Pairwise Neural Interactions.
1. 结构引导功能：超越成对神经交互PMID:日期:2026-10A central theme in Jon Kaas' research, celebrated in this issue, is the relationship between brain structure and function. As a tribute, we examine how certain neuroanatomical structures enable higher order (higher arity) functions whose joint effects cannot be recovered from pairwise measurements. Specifically, we argue that neurons exploit coincident input detection to realize higher order operations that cannot be derived by studying any of the pairwise combinations in isolation. Pairwise statistics can miss these irreducible higher order (more-than-pairwise) effects. We advocate for an extension of graph-based models to hypergraphs to formally capture and analyze these irreducible higher order neural interactions. Based on several recent studies, we discuss both the applicability and benefits of higher order neural data analyses.
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2. Most Early-Born Subplate Neurons Persist as Layer 6b Neurons in the Adult Mouse Neocortex.
2. 大多数早期生成的板下神经元在小鼠成年新皮质中保留为第6b层神经元PMID:日期:2026-09-28Subplate neurons (SpNs) are early-born neurons in the mammalian neocortex and play a pivotal role in cortical development. It is widely believed that SpNs are predominantly lost due to postnatal cell death, with only a few remnants contributing to layer 6b (L6b) neurons in the adult neocortex, but the extent to which SpNs persist as L6b neurons remains largely unknown. To address this, we conducted a comprehensive birthdate analysis using multiple ethynyl deoxyuridine (EdU) injections over 24 h, thereby precisely tracking the survival and distribution of SpNs in the adult mouse neocortex. We further estimated the total number of SpNs and L6b neurons based on the total volumes of the subplate and L6b, quantified by employing 3D tissue clearing. Our findings reveal that a significant proportion of L6b neurons are remnants of SpNs and comprise diverse subtypes reminiscent of those in the postnatal period (SpNs: 319,588 ± 49,263, L6b neurons: 316,720 ± 11,268). This study provides direct evidence showing that most L6b neurons in the adult mouse neocortex originate as SpNs during the earliest stages of neurogenesis and persist throughout life.
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3. Patterns of Proliferation in the Pacific Hagfish (Eptatretus stoutii) Retina Suggest an Ancient Origin for Adult Neurogenesis.
3. 太平洋盲鳗（Eptatretus stoutii）视网膜中的增殖模式表明成年神经发生具有古老的起源PMID:日期:2026-09-28Comparative morphology has revealed fascinating structural and organizational differences in the eyes of cyclostomes (jawless vertebrates) compared to gnathostomes (jawed vertebrates). This work has helped us to better understand the evolutionary origin of the vertebrate retina, but certain questions remain unresolved. Here we complement that approach by examining retinal development. We sought to characterize post-larval ("adult") retinogenesis in a representative cyclostome, the Pacific hagfish (Eptatretus stoutii). Knowledge of hagfish neurodevelopment is limited by poor access to embryos, but evidence suggests continued retinal neurogenesis occurs late into their ontogeny. A brief pulse of EdU was used to detect proliferating cells, if any, in the retina. This was followed by in situ hybridization to test whether homologs of gnathostome genes might have conserved expression patterns that direct retinogenesis in a jawless vertebrate. EdU+ cells were detected at the retinal periphery of the hagfish (a region reminiscent of the ciliary marginal zone of gnathostomes) and within the central retina. In addition, hagfish eyes were found to express several key genes required for vertebrate retinal neurogenesis. At least two of these genes, OtxA and Rx (retinal homeobox), were enriched within the proliferative retinal periphery. These findings support adult retinogenesis as an ancient and deeply conserved trait within the vertebrate lineage.
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4. Development of Thalamo-Telencephalic Circuits in a Reptile.
4. 爬行动物中丘脑-端脑回路的发育PMID:日期:2026-09-27Neuronal circuits are a core component required for proper brain function and organization. How these circuits are built remains incompletely understood. The vast majority of studies on forebrain development have investigated mammals. Whether the described observations found in mammals apply to other vertebrates is unknown. The present report examined the development of forebrain circuits that interconnect the dorsal thalamus and the telencephalon in Alligator mississippiensis. A tracer, neurobiotin, which is transported in both an anterograde and retrograde fashion, was used. Four circuits were identified after neurobiotin placement into either the diencephalon or in the forebrain bundles themselves. Three circuits ascended from the dorsal thalamus to the telencephalon. These were: the ipsilateral lateral forebrain bundle and the ipsilateral and contralateral medial forebrain bundles. The other circuit descended from the basal nuclei to connect with the dorsal thalamus. The first circuit to develop was the basal nuclei to dorsal thalamus circuit followed by the lateral forebrain bundle and lastly by the medial forebrain bundle. Because it preceded the formation of the three other circuits, the basal nuclei to the dorsal thalamus tract is suggested to serve as a scaffold for the other three circuits to follow. The formation of synapses by lateral forebrain bundle axons in the telencephalon was determined by immunohistochemistry using a synaptic vesicle glycoprotein. Synapse formation in the telencephalon from lateral forebrain bundle axons occurred before hatching. This suggested that information carried by the lateral forebrain bundle was critical for survival upon hatching. Medial forebrain bundle axon connections may become functional only after hatching.
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5. On the Larval Sensory Organs and Central Nervous System of the Zoea 1 of the Asian Shore Crab Hemigrapsus sanguineus (Decapoda, Brachyura).
5. 亚洲海岸蟹Hemigrapsus sanguineus（十足目，短尾下目）溞状幼体第一期幼体感觉器官与中枢神经系统研究PMID:日期:2026-09Many decapod crustaceans occupy different habitats during their ontogeny and undergo a niche shift during the transition from the larval to the juvenile phase. Their life cycle comprises pelagic larvae and, in most species, benthic juvenile-adult stages. Already at hatching, decapod larvae possess a wealth of organ systems, necessary to autonomously survive and develop in the plankton. They also exhibit a rich behavioral repertoire to appropriately respond to environmental stimuli such as light, gravity, hydrostatic pressure, tidal currents, temperature, salinity, chemical cues, and food concentration. Considering the impressive larval behavioral performance, neuroanatomists in the past have already studied selected aspects of the functional morphology of larval nervous systems, but this knowledge is distributed across a wide taxonomic range. Our study aims to provide a concise description of the morphology of selected sensory organs and that of the central nervous system in the Zoea 1 of the Asian shore crab Hemigrapsus sanguineus using multiple neuroanatomical methods such as three-dimensional (3D) reconstruction from histological section series, scanning electron microscopy, and immunohistochemistry combined with confocal laser-scan microscopy. The larval developmental cycle of this includes five zoea stages and one megalopa stage. In the Zoea 1, our data reveal well-developed visual and olfactory organs comprising hundreds of sensory receptor neurons and also complex primary visual and olfactory neuropils related to processing this sensory input. We observed a particularly high investment of nervous tissue in the central visual pathway. Furthermore, the larval brain comprises several characteristic secondary neuropils which, as higher order neuropils, in the adult crustacean brain are thought to integrate highly processed multimodal sensory input. These are, for example, the lateral protocerebrum (which in adult crabs will house the mushroom bodies) and the median protocerebrum that includes the central body. The discussion of our findings is framed against the knowledge of the larval behavioral performance and, considering the larval investment in higher order neuropils, the possibility of complex behavioral decisions that integrate aspects of learning and memory.
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6. Correction to "Afferent Projections to the Calca/CGRP-Expressing Parabrachial Neurons in Mice".
6. 对“小鼠中向表达Calca/CGRP的臂旁神经元的传入投射”一文的更正PMID:日期:2026-09该文献暂无摘要。
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7. Ordered Chaos: Photoreceptor Mosaics in the Larval and Adult Turquoise Killifish (Nothobranchius furzeri).
7. 有序的混沌：幼鱼和成鱼绿松石鳉（Nothobranchius furzeri）中的光感受器镶嵌PMID:日期:2026-09An organism's vision is dependent on the photoreceptor types in the eye and how these cells are organized across the retina. The turquoise killifish (Nothobranchius furzeri) is an annual killifish species that lives in the turbid waters of ephemeral pools. Although turquoise killifish are gaining popularity as a model, we know little about their photoreceptors. Here, the turquoise killifish retina was investigated for photoreceptor subtype identity and mosaic organization at the adult and larval stages to assess specialization for their light environment. Turquoise killifish were determined to have cone-dominant retinas, with expression of UV, blue, green, and red cone opsins, as well as rhodopsin. Adult fish were found to have an ordered square mosaic, wherein double cones formed squares with single cones in the center and corners of the squares. Double cones could be comprised of a red and green or two red cone units, while the single cones could be UV, blue, red, or - very rarely - green in identity. Although ordered, the mosaic did not have regularity of cone subtype orientation across the retina. Larvae were found to have retinal regionalization, with a dorsonasal region of increased short-wavelength cone density. In both larvae and adult retinas, red cones were the predominant cone subtype. This study presents the first description of the photoreceptor types and mosaic in an annual killifish, and provides a foundation for future work investigating killifish photoreceptor biology and visual function.
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8. The Molecular Architecture of Somatic Spines of the Lateral Septum.
8. 侧隔体细胞棘的分子结构PMID:日期:2026-08-29The lateral septum is a key subcortical structure and has been implicated in social memory. One aspect of social memory, the ability to recognize relatives, is conserved across vertebrate species and reflected in stable, lifelong memories. Synapses are considered to be the smallest unit of memory storage. Excitatory synapses are typically found on dendritic spines, whereas inhibitory synapses are mostly located on the dendritic shaft. Here, we investigate the synaptic architecture of unusual somatic spines, an apparent synaptic specialization of septal GABAergic neurons. We uncover the formation and molecular organization of septal somatic spines found in the lateral septum in in vivo and in vitro model systems using various microscopy approaches. We use classical label-free methods such as transmission electron microscopy and Golgi stainings and established new culturing methods for dissociated and organotypic septal slices that were kept in culture over multiple weeks. We describe the presence, morphology, ultrastructure, and molecular composition of excitatory somatic spines across multiple developmental stages in various model systems. We propose that the ability to develop such spines is an intrinsic feature of somatospiny neurons that does not depend on extra-septal connectivity. While smaller than dendritic spines, somatic spines exhibited distinct features, frequently containing secretory organelles such as autophagosomes, multivesicular bodies, and endosomes, but often lacking a spine apparatus and ribosomes. Our findings offer insights into the molecular architecture of septal somatic spines and establish a basis for further investigations into the somatic spines of the lateral septum.
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9. Anatomical Investigation Reveals a Second Olfactory System in Locusts.
PMID:日期:2026-08Olfaction in locusts offers a useful model for understanding how the brain encodes environmental information. While previous studies of olfaction in locusts have focused mainly on the antennal pathway, most insects, including locusts, possess olfactory receptors on their palps. Although they are traditionally considered to be gustatory or mechanosensory structures, accumulating molecular, electrophysiological, and behavioral evidence shows locust palps also mediate olfactory processing. The palps therefore initiate a second olfactory pathway, whose neural architecture and sensory functions remain largely unexplored. Here, we used anatomical approaches to characterize the chemosensory system of the palps in Schistocerca americana, mapping pathways from the peripheral sensilla through the brain to third-order neurons. We found that sensory input from the palps projects to two distinct regions: the gnathal ganglion, which integrates gustatory input from multiple head appendages, and the glomerular lobe of the cerebral ganglion, which, traditionally thought of as a gustatory center, appears instead to receive only olfactory input. The glomerular lobe, in turn, provides olfactory input to the accessory calyx of the mushroom body, a region traditionally considered gustatory. Notably, the palp and antennal olfactory pathways remain anatomically segregated through at least the third-order neurons. Our systematic characterization of the palp olfactory system anatomy challenges existing views of olfactory and gustatory integration in hemimetabolous insects and establishes a framework for comparative studies of antennal and palp-based olfactory coding.
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10. Characterization of the Spinal Cord of the Annual Fish Garcialebias charrua: Morphology, Cell Proliferation, and NADPH-Diaphorase Activity.
10. 一年生鱼类Garcialebias charrua脊髓的特征描述：形态学、细胞增殖及NADPH-黄递酶活性PMID:日期:2026-08[中文摘要] 脊髓在感觉运动整合中发挥核心作用，并因生态和行为需求的不同而在脊椎动物中表现出显著的多样性。然而，在真骨鱼类中，对成体脊髓的详细形态学和细胞学分析仍然匮乏。在此，我们首次对一年生鱼类Garcialebias charrua的成体脊髓进行了全面的表征，该物种表现出显著的环境适应性和性二态性。我们使用成体雄性和雌性，将脊髓系统地划分为五个等长的吻尾区域（SI-SV），以评估形态学、神经化学组织和细胞增殖的区域性变异。我们分析了大体形态和横截面特征、NADPH-黄递酶阳性（NADP-d）神经元的分布和形态（作为一氧化氮相关信号传导的指标），以及使用5-溴-2'-脱氧尿苷（BrdU）和5-乙炔基-2'-脱氧尿苷（EdU）掺入法检测的增殖活性。我们的结果揭示了脊髓形态计量学中显著的吻尾异质性，其中与背鳍相关的SIII节段存在二态性变异，NADPH-d神经元群体呈现区域特异性分布模式，并且整个脊髓的灰质和白质中均存在持续的细胞增殖。对具有独特解剖特征的SIII节段的重点分析表明，在雌雄两性中，中央管和背侧区域的增殖活性均高于腹侧区域，而雄性在所有分析区域中均显示出显著增加的增殖。最后，BrdU标记与神经元谱系标记物的结合首次提供了G. charrua成体脊髓神经发生的证据。这些发现凸显了脊髓作为一年生鱼类神经可塑性基础的动态且具有性二态性的底物。
[英文摘要] The spinal cord plays a central role in sensorimotor integration and exhibits substantial diversity across vertebrates in relation to ecological and behavioral demands. In teleost fish, however, detailed morphological and cellular analyses of the adult spinal cord remain scarce. Here, we provide the first comprehensive characterization of the adult spinal cord of the annual fish Garcialebias charrua, a species displaying pronounced environmental adaptation and sexual dimorphism. Using adult males and females, the spinal cord was systematically partitioned into five equally sized rostrocaudal regions (SI-SV) to evaluate regional variation in morphology, neurochemical organization, and cell proliferation. We analyzed gross morphology and cross-sectional features, the distribution and morphology of NADPH-diaphorase-positive (NADP-d) neurons as indicators of nitric oxide-related signaling, and proliferative activity using 5-bromo-2'-deoxyuridine (BrdU) and 5-ethynyl-2'-deoxyuridine (EdU) incorporation. Our results reveal marked rostrocaudal heterogeneity in spinal cord morphometry, with dimorphic variation in the segment SIII associated with the dorsal fin, region-specific patterns of NADPH-d neuronal populations, and sustained cell proliferation throughout the entire spinal cord in both gray and white matter. Focused analysis of segment SIII, which exhibits distinctive anatomical features, demonstrated higher proliferative activity in the central canal and dorsal regions compared to ventral areas in both sexes, with males showing significantly increased proliferation across all analyzed regions. Finally, the combination of BrdU labeling with a neuronal lineage marker provides the first evidence of adult spinal cord neurogenesis in G. charrua. These findings highlight the spinal cord as a dynamic and sexually dimorphic substrate underlying neuroplasticity in annual fishes.