AMERICAN JOURNAL OF HUMAN BIOLOGY美国人类生物学杂志
AMERICAN JOURNAL OF HUMAN BIOLOGY(英文缩写 AM J HUM BIOL),ISSN 1042-0533,eISSN 1520-6300,中文译名:美国人类生物学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.947 | Q1 |
| 2022 | 2.900 | Q1 |
| 2023 | 1.600 | Q1 |
| 2024 | 1.700 | Q1 |
| 2025 | 1.900 | Q1 |
AMERICAN JOURNAL OF HUMAN BIOLOGY 最新收录文献
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1. Placental DNA Methylation of HSD11B2 and IGF2 Is Associated With Fetal Growth in the Cebu Longitudinal Health and Nutrition Survey.
PMID:日期:2026-09-30The intrauterine environment exerts lasting impacts on fetal growth and development, with potential long-term effects on later health. We examined whether placental DNA methylation at HSD11B2 and IGF2-two key regulators of the intrauterine environment-is associated with fetal growth among participants in the Cebu Longitudinal Health and Nutrition Survey (CLHNS). We analyzed DNA methylation in placental samples from 19 births in the CLHNS using the Illumina Infinium HumanMethylation450 BeadChip. Focusing on CpG sites within HSD11B2 and the IGF2/H19 imprinting control region (ICR), we used linear regression models adjusted for gestational age to assess associations of DNA methylation with birth weight, head circumference, length, and neonatal adiposity. Higher methylation at three CpG sites within HSD11B2 was significantly associated with reduced fetal growth: one site was associated with reduced birth weight and head circumference, and two sites were associated with shorter birth length. Within the IGF2/H19 ICR, two CpG sites were significantly associated with both increased birth weight and head circumference. Both CpGs overlapped with predicted CCCTC-binding factor (CTCF) binding sites, consistent with known regulatory mechanisms linking increased methylation at the ICR to increased IGF2 expression. These findings support the hypothesis that DNA methylation at regulatory regions of HSD11B2 and IGF2 contributes to variation in fetal growth, linking placental epigenetic patterns to birth outcomes.
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3. Body Proportions and Cardiometabolic Risk Factors in Rural Indian Adults.
PMID:日期:2026-09Body proportions may reflect early-life growth and developmental exposures associated with later cardiometabolic risk, but evidence from rural India is limited. We assessed cardiometabolic risk factors and their associations with sitting height, leg length, and sitting-height ratio among rural Indian adults. This cross-sectional study analyzed baseline data from 2196 adults (1098 men and 1098 women) enrolled in YUVAAN multigenerational cohort in rural Pune, Maharashtra. Anthropometric, body-composition, clinical, biochemical, and dietary assessments were performed. Associations between body-proportion measures and cardiometabolic risk factors were examined. Sitting-height and leg-length models were adjusted for age, sex, and standing height; and sitting-height ratio for age and sex. Low HDL cholesterol was the most prevalent lipid abnormality (75.5%); hyperglycemia, hypertriglyceridemia, and hypercholesterolemia affected 19.5%, 18.3%, and 11.1% of participants, respectively. Adiposity and central obesity were more prevalent among participants with sitting height above the sex-specific 75th percentile than counterparts (68.2% vs. 54.5% and 71.8% vs. 54.5%, respectively). In unadjusted analyses, each 1-cm increase in sitting height was associated with higher odds of dyslipidemia, hypertension, obesity, adiposity, and elevated waist circumference. Greater leg length was associated with lower odds of dyslipidemia, obesity, and adiposity, while high sitting-height ratio was associated with obesity and elevated waist circumference. After adjustment, greater sitting height and sitting-height ratio remained associated with an adverse cardiometabolic profile, whereas greater leg length was inversely associated with these outcomes but not hyperglycemia. Greater sitting height and sitting-height ratio, and shorter leg length, were associated with an adverse cardiometabolic profile among rural Indian adults.
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4. Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators.
PMID:日期:2026-09Sleep duration, sun exposure, and obesity are important and potentially interconnected factors in child health. In this study, we aimed to analyze the associations between sleep duration, sun exposure, and obesity indicators in Portuguese children. This cross-sectional study included 4755 children aged 3-10 years from public and private schools across Portugal. Parents reported children's sleep duration, sun exposure, screen time, active play, and physical activity using validated questionnaires. Trained professionals measured weight and height to calculate Body Mass Index (BMI) and assessed skinfold thickness to estimate body fat percentage (%BF). Multiple linear regression analyses, stratified by sex and adjusted for demographic, behavioral, and anthropometric factors, analyzed associations between sun exposure and sleep duration. In partially adjusted models (Model 1), negative associations persisted among boys, and positive associations emerged in girls for average sleep duration (β = 2.11; 95% CI: 0.25 to 3.96; p = 0.026) and weekdays (β = 2.40; 95% CI: 0.47 to 4.33; p = 0.015). In fully adjusted models (Model 2), the negative association remained only for boys on Sundays (β = -4.57; 95% CI: -8.22 to -0.91; p = 0.014), with no significant associations in girls. Sun exposure exhibits modest, sex-specific associations with sleep duration in children. These findings emphasize the importance of considering behavioral and environmental factors when designing interventions to promote healthy sleep, support growth, and prevent childhood obesity.
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5. Neighborhood Social Fragmentation and Excessive Body Weight Among Children-A View From a Portuguese Inner City.
5. 社区社会碎片化与儿童超重——来自葡萄牙某内城区的视角PMID:日期:2026-09This cross-sectional study examined the association between neighborhood social fragmentation and excessive body weight in childhood. The sample included 832 children aged 3-10 years living in the municipality of Porto, Portugal. Excessive body weight was classified using International Obesity Task Force sex- and age-specific cut-offs. Neighborhood social fragmentation was assessed using a composite index derived from 2021 Portuguese Census data at the statistical section level. Associations were estimated using sex-stratified multivariable logistic regression adjusted for relevant confounders. No association was observed between neighborhood social fragmentation and excessive body weight among boys. In contrast, girls living in the least fragmented neighborhoods had lower odds of excessive body weight compared with those in the most fragmented neighborhoods (OR = 0.55, 95% CI = 0.32-0.94, p = 0.030). These findings suggest that neighborhood social structure may be differently associated with childhood body weight by sex and may contribute to observed gender disparities in excess body weight among children.
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6. Comparison of External Measurement Methods of the 2D:4D Digit Ratio.
PMID:日期:2026-09External methods for measuring digit length differ in the hand surface and anatomical landmarks used, but the comparability of resulting 2D:4D ratios is unclear. This study compared 2D:4D ratios obtained using four external measurement methods and evaluated between-method differences, correlations, and reliability. Digit lengths were measured in 231 Turkish university students (103 males, 128 females). Measurements were obtained directly with calipers from the dorsal and ventral surfaces and indirectly from photocopies and photographs. The 2D:4D ratio was calculated as second-digit length divided by fourth-digit length. Right and left hands were analyzed separately for effects of measurement method, sex, and hand side. Males had lower 2D:4D ratios than females for all methods and hand sides except direct dorsal measurement of the left hand. Mean ratios were lowest with direct dorsal measurement and highest with direct ventral measurement. Differences among methods were significant for both hands (p < 0.001). Between-method correlations ranged from r = 0.529-0.771 for the right hand and r = 0.440-0.776 for the left hand (all p < 0.001). Intraobserver and interobserver reliability in the pilot sample was high (ICC = 0.85-0.95). The 2D:4D ratio varies systematically according to the external measurement method used. Measurement protocols should therefore be reported explicitly, and absolute 2D:4D values obtained using different methods should be compared cautiously. These findings highlight the importance of standardizing measurement methods in 2D:4D research and suggest that the detection of sex differences may vary according to both the measurement method and hand side.
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7. Science and Videogames: From Scientific Dissemination to Knowledge Production.
PMID:日期:2026-09Videogames are played by 42% of the global population. As an interactive medium, they require participants to engage actively in the constant construction of knowledge. Their relevance to human biology has been increasing and expanding, ranging from scientific dissemination to knowledge production. This article examines each of the videogames' possible scientific uses, including "commercial" games used for teaching and scientific dissemination, games created by scientists for science dissemination and science education, online games that enable players to help solve scientific problems, and citizen science platforms such as Foldit. The example of Demis Hassabis, whose achievements in using AI to predict and design the structure of proteins earned him a Noble Prize in Chemistry, started his research on AI when he was a game designer. This further demonstrates how videogames can contribute to scientific innovation. Together, these examples show that videogames can be powerful tools for both scientific dissemination and knowledge production.
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8. Cardiometabolic Health in P'urépecha Migrant-Sending Communities in Michoacan, Mexico.
PMID:日期:2026-09Migration-health research frequently attributes cardiometabolic risk among migrants to post-migration dietary and lifestyle change, despite limited empirical evidence from migrant-sending communities. This assumption is particularly salient in studies of indigenous populations, where pre-migration contexts are often treated as culturally traditional and implicitly protective. Using a mixed-methods biocultural design, this study examines cardiometabolic risk among never-migrant P'urépecha adults living in migrant-sending communities in Michoacán, Mexico, to assess whether commonly used sociocultural indicators are associated with cardiometabolic outcomes and to situate origin-community health within broader population trends. We collected anthropometric measures, cardiometabolic biomarkers, and survey data from 193 adults and integrated these data with ethnographic observations of local food environments and comparisons to national surveillance benchmarks from ENSANUT. Cardiometabolic risk was widespread. Seventy-five percent of participants were overweight or obese, 59% were hypertensive, 34% exhibited dysglycemia (HbA1c ≥ 5.7% or medication use), and 77% met criteria for metabolic syndrome. In multivariable analyses, age and sex were consistently associated with cardiometabolic risk, while income, perceived stress, language proficiency, and cultural/ethnic identification were not independently associated with outcomes. Although bivariate differences by language group were observed, these associations disappeared after adjustment for age. When interpreted alongside ethnographic observations and population-level benchmarks, these findings reveal that cardiometabolic risk is already embedded within the everyday environments of indigenous migrant-sending communities. The lack of consistent associations between commonly used sociocultural indicators and health outcomes suggests that shared community-level exposures may be more important than individual measures of language or cultural identification in shaping cardiometabolic health. By integrating biomarker, survey, and ethnographic data, this study demonstrates the value of a biocultural approach for understanding health before migration and provides a critical point of comparison for future migration-health research.
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9. Second-to-Fourth Digit (2D:4D) Ratio as A Risk Factor for Osteoporosis and Osteoarthritis: A Systematic Review.
PMID:日期:2026-09The second-to-fourth digit (2D:4D) ratio is an established marker of prenatal sex hormone exposure and has been associated with various health outcomes across the lifespan. Increasing evidence suggests that developmental factors reflected by the 2D:4D ratio may contribute to susceptibility to musculoskeletal disorders, including osteoarthritis (OA) and osteoporosis (OP). This systematic review aimed to synthesize the available evidence regarding the association between 2D:4D ratio and the risk of OA and OP. This systematic review was conducted according to the PRISMA guidelines and registered in PROSPERO (CRD420261439840). A comprehensive literature search was performed in PubMed, Web of Science, and Scopus between April and May 2026. Observational studies investigating the relationship between 2D:4D ratio and OA or OP related outcomes were included. Study selection, data extraction, and methodological quality assessment were independently performed by three reviewers. Methodological quality was evaluated using the Joanna Briggs Institute critical appraisal tools. Nine studies met the inclusion criteria, comprising eight studies on OA and one study on OP. Most studies reported that lower 2D:4D ratios or Type III finger patterns were associated with increased OA risk, greater radiographic severity, and a higher likelihood of severe knee OA requiring joint replacement. Associations were particularly evident for knee and hand OA, with several studies reporting stronger associations in women than in men. In contrast, evidence regarding OP was limited, as only one eligible study specifically investigated OP. Methodological heterogeneity was observed across studies regarding digit ratio assessment methods and disease definitions. Current evidence suggests that lower 2D:4D ratios are associated with OA-related outcomes, particularly in knee and hand OA, with several studies indicating stronger associations in women. These findings suggest that variation in 2D:4D may reflect developmental and sex-dependent patterns of musculoskeletal health rather than a causal relationship. However, evidence regarding OP remains insufficient to draw definitive conclusions. Further large-scale prospective studies using standardized assessment methods are needed to clarify these associations and their underlying biological mechanisms.
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10. Direct and Indirect Effects of Adolescent Motherhood on Under-Five Mortality in Pakistan: Evidence From a Nationally Representative Survey.
PMID:日期:2026-09Adolescent motherhood is associated with adverse child survival outcomes, particularly in low- and middle-income settings. Maternal and child health (MCH) service utilization may represent an important pathway linking adolescent motherhood with child survival, but evidence from Pakistan remains limited. This study examined the association between adolescent motherhood and under-five mortality and assessed the statistical indirect association through MCH service utilization. We analyzed nationally representative data from the 2018 Pakistan Demographic and Health Survey, including 8159 mother-child observations. Under-five mortality was examined as a time-to-event outcome. We used multivariable generalized structural equation modeling with a Weibull proportional hazards specification to estimate associations between adolescent motherhood, MCH service utilization, and under-five mortality. We constructed the MCH service utilization index from indicators of antenatal care, skilled delivery care, and postnatal care. Indirect associations were evaluated using 5000 bootstrap replications and 95% bias-corrected bootstrap confidence intervals. All analyses were conducted using STATA version 17.1. Overall, 4.09% of children died before age five, and 37.55% were born to adolescent mothers. After adjustment for prespecified covariates, adolescent motherhood was associated with higher under-five mortality (HR = 2.05, p < 0.001) and lower MCH service utilization (β = -0.02, p = 0.044). Higher MCH service utilization was associated with lower under-five mortality (HR = 0.26, p < 0.001). After accounting for MCH service utilization, adolescent motherhood remained associated with higher under-five mortality (HR = 1.99, p < 0.001). The indirect association through MCH service utilization was positive and statistically supported (β = 0.0223; bootstrap SE = 0.0103; 95% [BCCI: 0.0038-0.0398]). Adolescent motherhood was associated with higher under-five mortality and lower MCH service utilization, while greater MCH service utilization was associated with lower under-five mortality. The findings suggest that differences in MCH service utilization account for part of the observed association between adolescent motherhood and under-five mortality. Improving access to and utilization of MCH services, alongside interventions addressing adolescent pregnancy and broader social determinants of child health, may contribute to improved child survival in Pakistan.