BRITISH JOURNAL OF BIOMEDICAL SCIENCE英国生物医学科学杂志
BRITISH JOURNAL OF BIOMEDICAL SCIENCE(英文缩写 BRIT J BIOMED SCI),ISSN 0967-4845,eISSN 2474-0896,中文译名:英国生物医学科学杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.432 | Q3 |
| 2022 | 1.900 | Q3 |
| 2023 | 2.700 | Q2 |
| 2024 | 4.600 | Q1 |
| 2025 | 11.900 | Q1 |
BRITISH JOURNAL OF BIOMEDICAL SCIENCE 最新收录文献
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1. Longitudinal agreement of repeated critical haemoglobin measurements as evidence of sustained analytical quality.
1. 重复关键血红蛋白测量的一致性纵向吻合作为持续分析质量的证据PMID:日期:2026-08-03该文献暂无摘要。
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2. Nucleic acid testing-optimized HIV diagnostic algorithms: a multimethod comparative effectiveness analysis in clinical practice.
2. 核酸检测优化的HIV诊断算法：临床实践中的多方法比较有效性分析PMID:日期:2026-07-29Global and Chinese efforts still face significant gaps in achieving the first 95% of the "95-95-95" target, with persistently high and rising rates of late HIV diagnosis. This study evaluates RNA/DNA quantification, RNA qualitative, and ELISA assays to optimize HIV testing strategies. A prospective cross-sectional study evaluated 215 first-time HIV testers from June 2024 to May 2025. Using clinical diagnosis as the reference standard, we assessed four methods' sensitivity, specificity, and subgroup performance, with tandem testing strategies simulation for optimal detection. DNA quantitative detection demonstrated optimal performance with 100% sensitivity and specificity. RNA quantitative assay showed 99.02% sensitivity and 100% specificity, while ELISA achieved 99.02% sensitivity and 98.23% specificity. RNA qualitative testing exhibited 99.02% sensitivity but lower specificity (75.22%). ROC revealed superior diagnostic performance for DNA quantitative (AUC = 1.000) and RNA quantitative (AUC = 0.995) compared to RNA qualitative (AUC = 0.871). All methods maintained consistent sensitivity across CD4 T cell levels. Simulation of tandem strategies identified ELISA combined with DNA quantitative testing as optimal (net sensitivity: 99.02%, net specificity: 100%, total tests: 318). For 18 WB-indeterminate samples, DNA/RNA quantitative methods achieved 100% diagnostic accuracy, outperforming RNA qualitative (94.44%) and ELISA (83.33%). DNA quantitative detection shows high diagnostic value in initial HIV testing, overcoming challenges from undisclosed ART-induced RNA suppression and resolving WB-indeterminate misclassifications to reduce late diagnosis risks. This study supports Nucleic acid tests into diagnostic algorithms and validates the superior performance of ELISA screening followed by DNA confirmation, offering actionable strategies to shorten diagnostic delays and advance national AIDS control objectives.
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3. {"_":"Intracranial parapsilosis infection occurring 2 years after burr-hole drainage for chronic subdural hematoma: a case report.","i":["Candida"]}
3. {"_":"慢性硬膜下血肿钻孔引流术后2年发生颅内近平滑念珠菌感染：一例病例报告。","i":["念珠菌"]}PMID:日期:2026-07-29Chronic subdural hematoma (CSDH) is a common condition affecting patients undergoing neurosurgical treatment for which burr-hole drainage remains the standard treatment. Postoperative fungal infections following this procedure are extremely rare, but can lead to severe consequences. A 66-year-old male with a history of hypertension and schizophrenia underwent bilateral burr-hole drainage for bilateral frontotemporoparietal CSDH at another hospital 2 years prior to presentation. In the intervening years following this procedure, he experienced recurrent headaches, developed involuntary tongue protrusion and limb shaking, and suffered one episode of seizure 10 days before admission. Imaging suggested recurrence and possible organization of the bilateral CSDH. Bilateral craniotomy for hematoma evacuation was performed. Intraoperative examination revealed the organization and thickening of the subdural hematoma membrane, with a maximum thickness of approximately 1 cm. Postoperative pathological examination unexpectedly revealed structures suggestive of fungal hyphae. Subsequent cerebrospinal fluid culture confirmed the presence of parapsilosis infection, establishing the definitive etiological diagnosis. The patient was successfully cured through surgical evacuation, antifungal therapy consisting of sequential voriconazole and fluconazole treatment, temporary lumbar drainage, and comprehensive management of complications, although the course of hospitalization was further complicated by intestinal obstruction, pneumonia, and bacteremia. This report describes a rare case of intracranial C. parapsilosis infection occurring 2 years after burr-hole drainage for the management of a CSDH. This case highlights the diagnostic challenges associated with delayed postoperative fungal infections and emphasizes the importance of pathological examination when encountering atypical surgical findings. A multidisciplinary approach combining aggressive surgical debridement with targeted antifungal therapy is crucial for achieving a favorable outcome.
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4. Use of EQA for assessing variation in post-analytical interpretation of results using a clinical case of ?adrenal insufficiency taking into consideration variation in analytical performance of cortisol.
4. 使用EQA评估结果分析后解读的变异，通过一个肾上腺皮质功能不全的临床案例，并考虑皮质醇分析性能的变异PMID:日期:2026-07-29Laboratory medicine is evolving at a rapid rate, not only in terms of the repertoire of tests available and automation of the laboratory and procedures, but also in how laboratory data is used within "calculated tests," algorithms and guidelines. The goal is diagnostic and treatment improvements for the patient; however, there are real patient safety concerns if the limitations of what is often described as the "simple blood test" are not sufficiently understood and appreciated. The aim of this study was to investigate how laboratories take into consideration variation in cortisol assays when managing potential cases of adrenal insufficiency when they had a single cortisol measurement. For English laboratories also assessed compliance to NICE Guidance NG243 - "Adrenal insufficiency: identification and management," published in 2024. The UK NEQAS for Steroid Hormones Scheme provides an External Quality Assessment (EQA) service for Cortisol. In December 2025, three serum specimens were distributed for cortisol analysis and interpretation based on a provided scenario - each specimen taken from a 25-year-old female at 08:30, clinical details - ?Adrenal insufficiency. Participants were required to interpret results into three categories - (1) Person may have adrenal insufficiency, (2) Probability of adrenal insufficiency uncertain or (3) Adrenal insufficiency very unlikely. Data has been evaluated based on the reported cortisol result and corresponding interpretation, broken down by manufacturer and location of laboratory. Cortisol results were returned by ∼370 Participants with ∼300 interpretating their result. Specimen 536A had a cortisol of 122 nmol/L (SD 9 nmol/L, %CV 7.5%), 536B - 307 nmol/L (SD 24 nmol/L, %CV 7.8%) and 536C - 260 nmol/L (SD 19 nmol/L, %CV 7.2%) based on a mass spectrometry method mean (validated by a candidate reference method). According to NG243, these cortisol results should correspond to Codes (1), (3) and (2) respectively. As expected, there was variation in the cortisol result reported and the subsequent interpretation. This study utilises EQA to look at the variation in cortisol measurement specifically in the context of identifying adrenal insufficiency. By linking post-analytical interpretation to the analytical measurement we have identified variation in both cortisol assays and interpretation of results.
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5. {"_":"VSL#3 supplementation improves fatigue in long COVID: results from the DELong#3 randomized placebo-controlled trial.","sup":["®"]}
5. VSL#3®补充剂可改善长新冠疲劳：DELong#3随机安慰剂对照试验结果PMID:日期:2026-07-27[中文摘要] 长新冠（Long COVID）常以持续性疲劳和生活质量受损为特征。越来越多的证据表明，肠道菌群失调和免疫调节异常可能促进症状的持续存在。我们评估了益生菌制剂VSL#3®在长新冠患者中的效果。在这项随机、双盲、安慰剂对照试验（ClinicalTrials.gov注册号：NCT05874089）中，具有临床相关疲劳的长新冠患者接受VSL#3®或安慰剂治疗4周。主要终点为采用Chalder疲劳量表（CFS）评估的疲劳改善情况。次要分析和探索性分析包括患者报告结局、肠道菌群谱分析、免疫表型分析、细胞因子分析以及靶向代谢组学。共48例患者完成研究（安慰剂组n=25；VSL#3®组n=23）。与安慰剂相比，补充VSL#3®显著改善疲劳，CFS评分降幅更大（24.24% vs. 6.06%；p=0.037），应答者比例更高（68% vs. 35.7%；p=0.019）。临床获益在停止治疗后持续存在，并伴有部分生活质量及胃肠道症状领域的改善。补充VSL#3®与健康相关细菌类群的选择性富集相关，包括、 、 和 ，同时伴随炎症及免疫相关通路的调节。探索性多组学分析发现，微生物群来源代谢物、免疫标志物与临床结局之间存在协同关联。补充VSL#3®改善了长新冠患者的疲劳及部分临床结局，并与微生物群和免疫的协同变化相关。这些发现支持在长新冠中进一步研究以微生物群为靶点的干预措施。
[英文摘要] Long COVID is frequently characterized by persistent fatigue and impaired quality of life. Increasing evidence suggests that gut microbiota dysbiosis and immune dysregulation may contribute to symptom persistence. We evaluated the effects of the probiotic formulation VSL#3® in patients with long COVID. In this randomized, double-blind, placebo-controlled trial (ClinicalTrials.gov identifier: NCT05874089), patients with long COVID and clinically relevant fatigue received VSL#3® or placebo for 4 weeks. The primary endpoint was fatigue improvement assessed by the Chalder Fatigue Scale (CFS). Secondary and exploratory analyses included patient-reported outcomes, gut microbiota profiling, immune phenotyping, cytokine analyses, and targeted metabolomics. Forty-eight patients completed the study (placebo n = 25; VSL#3® n = 23). VSL#3® supplementation significantly improved fatigue compared with placebo, with a greater reduction in CFS score (24.24% vs. 6.06%; p = 0.037) and a higher proportion of responders (68% vs. 35.7%; p = 0.019). Clinical benefit persisted after treatment discontinuation and was accompanied by improvements in selected quality-of-life and gastrointestinal symptom domains. VSL#3® supplementation was associated with selective enrichment of health-associated bacterial taxa, including , , , and , together with modulation of inflammatory and immune-related pathways. Exploratory multi-omic analyses identified coordinated associations among microbiota-derived metabolites, immune markers, and clinical outcomes. VSL#3® supplementation improved fatigue and selected clinical outcomes in patients with long COVID and was associated with coordinated microbiota and immune changes. These findings support further investigation of microbiota-targeted interventions in long COVID.
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6. Immunohistochemical testing of GISTs using CD117 markers: the UK NEQAS ICC & ISH external quality assessment data show significant differences in the performance of methods in regular use.
6. 使用CD117标记物对GIST进行免疫组化检测：英国NEQAS ICC & ISH外部质量评估数据显示，常规使用的方法在性能上存在显著差异PMID:日期:2026-07-17[中文摘要] CD117（c-KIT）是一种酪氨酸激酶受体蛋白，其突变在胃肠道间质瘤（GIST）的肿瘤发生中具有重要意义。CD117的免疫组化检测是其诊断的主要识别特征。英国NEQAS ICC & ISH开展了一项针对GIST中CD117表达的室间质量评价（EQA）计划。2020年5月至2025年5月期间，共进行了20轮该EQA。对存档数据进行分析，以寻找有关检测质量以及一抗与染色质量之间关联的证据。总提交数为2,656份（每轮平均132.8份；范围125-140份）。获得至少可接受染色质量评分的提交数为2,642份（99.5%）。未通过的总提交数为14份（每轮平均比例0.5%；范围0.0%-2.4%）；获得临界评分的共158份（平均比例5.9%；范围0.7%-10.9%）；获得可接受评分的共394份（平均比例14.8%；范围4.3%-24.4%）；获得良好/优秀评分的共2,090份（平均比例78.7%；范围57.7%-94.2%）。获得良好/优秀质量评分的提交比例随时间推移呈明显上升趋势。使用了四种一抗：克隆9.7（102份提交，3.9%）、YR145（263份提交，10.0%）、Leica Biosystems提供的EP10（EP10(LB)，415份提交，15.8%）、Roche Diagnostics提供的EP10（EP10(RD)，505份提交，19.2%），以及Agilent Dako提供的多克隆抗血清（1,263份提交，48.1%）。使用其他一抗或供应商的共76份提交（2.9%）被排除在分析之外。大多数实验室对GIST中CD117过表达的展示达到了极高质量标准。对于Dako Agilent自动化平台的使用者，使用同一供应商提供的多克隆抗血清可获得最高质量的染色。在Leica Biosystems和Roche Diagnostics自动化平台的使用者中，使用与提供其自动化平台的同一供应商来源的一抗可获得最佳染色。建议不应使用克隆9.7（Roche Diagnostics），因其产生的结果在统计学上显著劣于所有其他抗体。
[英文摘要] CD117 (c-KIT) is a tyrosine kinase receptor protein, mutations in which are important in the tumourigenesis of gastrointestinal stromal tumour (GIST). Immunohistochemical detection of CD117 is the primary identifying feature in its diagnosis. UK NEQAS ICC & ISH conducts an EQA programme for CD117 expression in GIST. Between May-2020 and May-2025, 20 runs of this EQA were undertaken. The archived data was analysed to look for evidence regarding the quality of testing and associations between primary antibodies and stain quality. Total submissions were 2,656 (mean per run = 132.8; range = 125-140). The number of submissions awarded a quality score indicating at least acceptable stain quality was 2,642 (99.5%). The total number of submissions that failed was 14 (mean proportion per run = 0.5%; range = 0.0%-2.4%); those obtaining a borderline score totalled 158 (mean proportion = 5.9%; range = 0.7%-10.9%); those obtaining an acceptable score totalled 394 (mean proportion = 14.8%; range = 4.3-24.4%); and those obtaining a good/excellent score totalled 2,090 (mean proportion = 78.7%; range = 57.7%-94.2%). There was a strong trend for the proportion of submissions obtaining a good/excellent quality score to increase over time. Four primary antibodies were used: Clone 9.7 (102 submissions, 3.9%), YR145 (263 submissions, 10.0%), EP10 supplied by Leica Biosystems (EP10(LB), 415 submissions, 15.8%), EP10 supplied by Roche Diagnostics (EP10(RD), 505 submissions, 19.2%), and a polyclonal antiserum supplied by Agilent Dako (1,263 submissions, 48.1%). A total of 76 submissions (2.9%) that used other primaries or suppliers were excluded from analysis. Demonstration of CD117 overexpression in GIST was undertaken to a very high quality standard in the majority of laboratories. For users of Dako Agilent supplied automation the highest quality staining was produced by using the polyclonal antiserum from the same supplier. Among users of Leica Biosystems and Roche Diagnostics automation the best staining was produced by using primary sourced from the same supplier that provided their automation. It is recommended that Clone 9.7 (Roche Diagnostics) should not be used as the results it produced were statistically significantly inferior to those of all other antibodies.
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7. Concordance between crude extract and component allergens in a multiple allergen simultaneous test: a large-scale retrospective analysis.
7. 多过敏原同步检测中粗提物与组分过敏原的一致性：一项大规模回顾性分析PMID:日期:2026-07-16[中文摘要] 多重过敏原同步检测（MAST）日益整合粗提物与分子组分过敏原用于特异性IgE检测。然而，关于这两种方法之间诊断一致性的系统性数据仍然有限。我们在一个大型临床实验室队列中，使用MAST panel评估了粗提物与相应组分过敏原结果之间的一致性。我们回顾性分析了某高通量转诊实验室在两个月期间去重后的MAST结果。针对29种粗提物过敏原与48种相应组分过敏原的配对，采用2级或以上（≥0.70 IU/mL）作为 cutoff 评估阳性率。一致性定义为粗提物和至少一种组分过敏原均为阳性，或两者均为阴性。采用符合率和Cohen's kappa系数评估一致性。共纳入19,949例患者。最高阳性率见于（31.8%）、（29.9%）、rDer f 2（24.2%）和猫上皮（12.2%）。大多数过敏原配对的总体符合率超过90%，主要由高阴性符合率驱动。Cohen's kappa显示十种过敏原具有实质性一致性（κ ≥ 0.6），包括猫皮屑和桦树花粉，而八种过敏原包括和牛奶则因粗提物结果阳性而组分过敏原阳性率低，显示一致性较差（κ < 0.1）。MAST中粗提物与组分过敏原检测之间的诊断一致性因过敏原来源不同而差异显著。这些发现强调，临床实验室在报告包含组分过敏原的MAST结果时，需要制定过敏原特异性解读指南。
[英文摘要] Multiple allergen simultaneous tests (MAST) increasingly incorporate both crude extract and molecular component allergens for specific IgE testing. However, systematic data on the diagnostic concordance between these two approaches remain limited. We evaluated the agreement between crude extract and corresponding component allergen results using a MAST panel in a large clinical laboratory cohort. We retrospectively analysed deduplicated MAST results from a high-volume referral laboratory over a two-month period. For 29 crude extract allergens paired with 48 corresponding component allergens, positivity rates were assessed using a cutoff of class 2 or higher (≥0.70 IU/mL). Concordance was defined as both crude extract and at least one component allergen being positive, or both being negative. Agreement was evaluated using percent agreement and Cohen's kappa coefficient. A total of 19,949 patients were included. The highest positivity rates were observed for (31.8%), (29.9%), rDer f 2 (24.2%), and cat epithelium (12.2%). Overall percent agreement exceeded 90% for most allergen pairs, primarily driven by high negative agreement. Cohen's kappa revealed substantial agreement (κ ≥ 0.6) for ten allergens including , cat dander, and birch pollen, whereas eight allergens including and milk showed poor agreement (κ < 0.1) due to low component allergen positivity despite positive crude extract results. Diagnostic concordance between crude extract and component allergen testing in MAST varies substantially across allergen sources. These findings underscore the need for allergen-specific interpretation guidelines when reporting MAST results incorporating component allergens in clinical laboratories.
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8. Evaluation of analytical performance of the Revvity sFlt-1 and PlGF methods for the assessment of preeclampsia.
8. 评估Revvity sFlt-1和PlGF方法用于子痫前期评估的分析性能PMID:日期:2026-07-15[中文摘要] 血管生成生物标志物胎盘生长因子（PlGF）和可溶性fms样酪氨酸激酶-1（sFlt-1）的检测正日益用于支持子痫前期（PE）在常规临床实践中的预测和诊断。可用于分析这些标志物的方法越来越多，但显示其分析可比性的数据有限。本研究对Revvity公司的PlGF和sFlt-1检测方法进行了评估，并与牛津当前临床实践中使用的Roche方法进行了比较。研究开展了不精密度和配对分析比较研究，并针对数值一致性以及与制造商推荐的PE纳入和排除阈值相关的一致性对数据进行了评价。根据评估期间分析的质量控制材料计算得出的Revvity PlGF和sFlt-1方法的不精密度估计值为3.2至9.0 CV%。Revvity方法从581份双份分析的临床标本中得出的精密度概况显示，PlGF的CV%中位数为1.8%，四分位距为2.3%；sFlt-1的CV%中位数为1.1%，四分位距为1.5%。在437份临床标本中与Roche PlGF和sFlt-1方法的比较显示，PlGF的总体Passing-Bablok回归关系为y = -23.4 + 0.73x（r = 0.983），sFlt-1为y = -87.7 + 0.40x（r = 0.971）。然而，两种方法及计算比值均存在具有统计学显著性的浓度依赖性相对偏倚。sFlt-1:PlGF比值相对于制造商特定纳入和排除阈值的一致性为95.2%。Revvity的PlGF和sFlt-1方法精密度良好，且与Roche方法具有相关性。然而，数值一致性不足以支持结果互换使用以及采用共同的纳入和排除阈值。临床实践中应使用制造商特定的阈值。尚需进一步研究以了解方法差异如何影响临床结局及其原因。
[英文摘要] The measurement of the angiogenic biomarkers placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) are increasingly used to support the prediction and diagnosis of preeclampsia (PE) in routine clinical practice. There are an increasing number of methods available for the analysis of these markers but data showing their analytical comparability is limited. The assays for PlGF and sFlt-1 from Revvity were evaluated and compared against Roche methods that are used in current clinical practice in Oxford. Imprecision and paired analytical comparisons studies were undertaken and data evaluated for numeric agreement and concordance relative to manufacturer recommended rule-in and rule-out thresholds for PE. Imprecision estimates for the Revvity PlGF and sFlt-1 methods calculated from quality control material analysed during the evaluation were between 3.2 and 9.0 CV%. Revvity method precision profiles derived from 581 clinical specimens analysed in duplicate had a median CV% for PlGF of 1.8%, IQR 2.3% and for sFlt-1 a median CV% of 1.1%, IQR 1.5%. Comparison against the Roche PlGF and sFlt-1 methods in 437 clinical specimens showed an overall Passing-Bablok regression relationship for PlGF of y = -23.4 + 0.73x (r = 0.983) and for sFlt-1, y = -87.7 + 0.40x (r = 0.971). However, there was statistically significant () concentration dependant relative bias for both methods and the calculated ratio. Concordance of the sFlt-1:PlGF ratio relative to manufacturer specific rule-in and rule-out thresholds was 95.2%. The Revvity methods for PlGF and sFlt-1 are precise and correlate with the Roche methods. However, numeric agreement precludes result interchangeability and the use of common rule-in and rule-out thresholds. The manufacturer specific thresholds should be applied in clinical practice. Further work is required to understand how method differences impact clinical outcomes and their causes.
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9. Supporting quantitative skills in biomedical science with smart worksheets: intentions, impact and barriers to engagement.
9. 利用智能工作表支持生物医学科学中的定量技能：意图、影响与参与障碍PMID:日期:2026-06-29[中文摘要] 大学生群体日益多样化，凸显了包容性支持策略的迫切需求。学生的学习成果往往仍与社会经济因素和三级资格证书相关联，这对高校提出了营造公平学习环境的挑战，尤其是在定量分析等基础技能方面。本研究探讨了扩大参与（widening participation，WP）特征对学生参与和感知由LearnSci与生物医学科学研究所合作开发的新型异步数字化智能工作表（Smart Worksheets）的影响。研究对象为英国诺森比亚大学攻读生物医学科学模块三级至六级的学生（N = 779），通过问卷调查评估其计算信心、课外事务负担及使用智能工作表的意愿。在智能工作表部署后，再次对学生进行调查，以分析使用意愿与实际使用之间的相关性，探讨WP特征的影响，并阐明影响参与度的其他因素。令人意外的是，学生感知的课程参与度和初始计算信心总体较高。然而，具有多项WP特征的学生报告的计算信心显著较低（ = 0.002）。尽管93.9%的学生表达了使用这些资源的强烈意愿，但仅有20%实际参与使用。进一步探究发现，主要障碍为资源知晓度和时间可用性，课外事务负担从三级到六级逐渐增加，最终86.1%的六级学生承担工作或照护责任。无论初始信心如何，学生始终将智能工作表的内容评为适当且极具价值。这些发现表明，学生的课外事务负担在整个大学生涯中不断加重，挑战了关于毕业年级学生更加自主、需要较少支持的传统假设。灵活的高价值资源对时间匮乏的学生至关重要，有助于解决主要与时间和精力相关的参与障碍。本研究强调了为所有学生提供全面且清晰传达的支持机制的日益增长的需求，以帮助他们应对日益复杂的学业、经济和个人环境。
[英文摘要] The growing diversity of university student populations highlights the critical need for inclusive support strategies. Student outcomes often remain linked to socio-economic factors and Level 3 qualifications, challenging universities to create equitable learning environments, particularly for foundational skills like quantitative analysis. This study investigated the impact of widening participation (WP) characteristics on student engagement with, and perceptions of, novel asynchronous digital Smart Worksheets developed by LearnSci in collaboration with the Institute of Biomedical Science. Students (N = 779) enrolled on Biomedical Science modules in Level 3 to 6 at Northumbria University UK, were surveyed to gauge perceived calculation confidence, extracurricular commitments and intent to use the Smart Worksheets. Following deployment of the Smart Worksheets, students were surveyed again to correlate intention versus actual usage, explore the influence of WP characteristics and elucidate other factors that affected engagement. Surprisingly, perceived course engagement and initial calculation confidence was generally high. Students with multiple WP characteristics, however, reported significantly lower calculation confidence ( = 0.002). While 93.9% of students expressed strong intent to use the resources, only 20% engaged. Further exploration revealed the primary barriers were resource awareness and time availability, with extracurricular commitments increasing from Level 3 to 6, culminating in 86.1% of Level 6 students having work or caring responsibilities. Regardless of initial confidence, students consistently rated the Smart Worksheet content as appropriate and their content as highly valuable. These findings suggest that students' extracurricular commitments are escalating throughout their university careers, challenging traditional assumptions about final year students being more autonomous and needing less support. Flexible, high-value resources are crucial for time-poor students, addressing engagement barriers that are primarily time and capacity-related. This study underscores the increasing need for comprehensive and clearly communicated support mechanisms for all students navigating an increasingly complex academic, financial and personal landscape.
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10. Artificial intelligence approaches in biological age prediction: current status and challenges.
10. 人工智能在生物学年龄预测中的方法：现状与挑战PMID:日期:2026-06-10[中文摘要] 生物学年龄（BA）预测已成为评估个体健康状况和超越实际年龄（CA）的衰老轨迹的关键研究前沿。人工智能（AI）的最新进展通过实现复杂多模态生物数据的整合与解读，显著加速了该领域的发展。本综述系统概述了AI驱动的BA预测方法，涵盖生物标志物选择、特征工程、模型开发、偏倚校正和性能评估等关键环节。我们进一步强调了异步衰老日益受到关注的现象，即不同器官或生理系统以不同速率衰老，并讨论了AI——尤其是深度学习和多模态融合——如何为捕捉此类系统特异性衰老模式提供强大工具。我们总结了当前从传统机器学习算法到能够建模非线性和异质性衰老过程的先进神经架构的各种方法。本文还审视了基于AI的BA模型在疾病风险评估、老年医学评估和人群健康监测中不断扩展的应用。尽管方法学进展迅速，重大挑战依然存在，包括数据异质性、模型泛化能力有限、可解释性不足以及临床转化的障碍。解决这些问题需要标准化的方法学实践、跨多样人群的稳健验证，以及开发可解释且公平的AI系统。未来研究应优先将多组学和纵向数据集与AI驱动的分析框架相结合，以建立可靠、系统层面且具有临床可操作性的BA预测模型，并将异步衰老纳入考量。
[英文摘要] Biological age (BA) prediction has emerged as a critical research frontier for evaluating individual health status and aging trajectories beyond chronological age (CA). Recent advances in artificial intelligence (AI) have substantially accelerated this field by enabling the integration and interpretation of complex, multimodal biological data. This review provides a systematic overview of AI-driven approaches to BA prediction, covering key components including biomarker selection, feature engineering, model development, bias correction, and performance evaluation. We further highlight the growing recognition of asynchronous aging, a phenomenon in which different organs or physiological systems age at distinct rates, and discuss how AI-particularly deep learning and multimodal fusion-offers powerful tools for capturing such system-specific aging patterns. We summarize current methodologies ranging from traditional machine learning algorithms to advanced neural architectures capable of modeling nonlinear and heterogeneous aging processes. The expanding applications of AI-based BA models in disease risk assessment, geriatric evaluation, and population health monitoring are also examined. Despite rapid methodological progress, significant challenges persist, including data heterogeneity, limited model generalizability, insufficient interpretability, and barriers to clinical translation. Addressing these issues will require standardized methodological practices, robust validation across diverse populations, and the development of interpretable and equitable AI systems. Future research should prioritize the integration of multi-omics and longitudinal datasets with AI-driven analytical frameworks to establish reliable, system-level, and clinically actionable BA prediction models that account for asynchronous aging.