ECOTOXICOLOGY生态毒理学
ECOTOXICOLOGY(英文缩写 ECOTOXICOLOGY),ISSN 0963-9292,eISSN 1573-3017,中文译名:生态毒理学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.935 | Q3 |
| 2022 | 2.700 | Q2 |
| 2023 | 2.400 | Q2 |
| 2024 | 2.700 | Q2 |
| 2025 | 2.700 | Q2 |
ECOTOXICOLOGY 最新收录文献
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1. Environmentally relevant concentrations of thiamethoxam cause cytotoxic and genotoxic damage in bullfrog (Lithobates catesbeianus) tadpoles.
PMID:日期:2026-10-01Neonicotinoids are emerging pollutants of major concern due to their widespread use and potential risks to biodiversity, yet their genetic and lethal toxicity, key parameters in environmental risk assessment, are still poorly explored in anurans. In this study, we evaluated the acute toxicity of thiamethoxam (96 h) in Lithobates catesbeianus tadpoles, determining lethal concentrations (LC, , ) and assessing subindividual effects, including genotoxicity (Comet assay), mutagenicity (Micronucleus test), and cytotoxicity, at environmentally relevant concentrations (lethal: 14.40-3516 µg a.i./L; subindividual: 9.4-59 µg a.i./L). The LC, , were defined as 624.44, 1070.13, and 1833.03 µg a.i./L, confidence interval 95%, respectively. Subindividual exposure induced significant genotoxic effects at a concentration of 31 µg a.i./L, and mutagenic responses with an increased frequency of lobed nuclei, nuclear budding, and anucleated cells, especially at a concentration of 59 µg a.i./L. A positive correlation was observed between Comet assay parameters and nuclear abnormalities. Taken together, these findings demonstrate dose-dependent genomic damage and suggest links between distinct cellular alterations. Integrated with the lethal toxicity data, the results indicate that thiamethoxam disrupts essential cellular processes in amphibians, highlighting L. catesbeianus as a sensitive bioindicator, reinforcing the relevance of genotoxic and mutagenic biomarkers in assessing the impacts of neonicotinoids on aquatic ecosystems.
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2. Growth and chlorophyll-a responses of marine microalgae to biodegradable polypropylene microplastic leachates: an initial toxicity assessment.
PMID:日期:2026-10-01Biodegradable plastics are increasingly promoted as alternatives to conventional plastics; however, their degradation may release leachates containing potentially harmful compounds. Complementary field observations on microplastic occurrence along Indonesian coasts underscore the environmental relevance of this study. In marine environments, such leachates may affect algal communities. This study evaluated the toxicity of leachates derived from biodegradable polypropylene (PP) microplastics on three marine microalgal species (Chlorella sp., Tetraselmis sp., and Navicula sp.). Fourier Transform Infrared (FTIR) analysis confirmed the polymer identity of the biodegradable PP material used in the experiments. Toxicity assays were conducted under controlled laboratory conditions following 96 h exposure. Growth was assessed based on changes in cell density, and chlorophyll-a content was measured for species exhibiting significant inhibition. Preliminary range finder tests revealed species-specific responses. Navicula sp. did not exhibit clear concentration-dependent inhibition and was therefore excluded from the definitive test. Definitive testing was conducted on Chlorella sp. and Tetraselmis sp., both of which showed concentration-dependent growth inhibition. Chlorella sp. exhibited the highest sensitivity (IC₅₀-96 h = 0.49 mg L⁻¹), followed by Tetraselmis sp. (IC₅₀-96 h = 37.84 mg L⁻¹). These findings indicate that biodegradable polypropylene microplastic leachates can induce measurable sublethal effects in marine microalgae, supporting the need for further long term ecotoxicological evaluation.
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3. Microplastic toxicity in marine microalgae: an ecotoxicological synthesis of experimental biological responses.
PMID:日期:2026-10-01As a pervasive form of marine pollution, microplastics (MPs) are widely distributed across coastal and oceanic systems, raising concerns about their ecological impacts. This review provides an evidence-based synthesis of microplastic-microalgae interactions, integrating physiological responses and associated toxicity pathways. Marine microalgae are particularly relevant in this context because they constitute the foundation of marine food webs and play a central role in primary productivity and global biogeochemical cycling. This study synthesizes experimental ecotoxicological evidence on the effects of microplastics on marine microalgae, with the aim of identifying dominant toxicity endpoints and key knowledge gaps relevant to ecotoxicological evaluation. Publications indexed in Web of Science and Scopus from 1970 to August 2025 were systematically screened, resulting in 59 selected publications, of which 43 experimental studies met the criteria for the comparative ecotoxicological synthesis. The analysis revealed a rapid expansion of research on microplastic-microalgae interactions, with experimental studies predominantly investigating polystyrene and polyethylene, across a broad range of particle sizes. The most frequently investigated biological responses included growth/population parameters, cellular stress and damage indicators, and photosynthetic responses. Despite this progress, several ecologically relevant endpoints and processes remain insufficiently investigated, including aggregate formation, particle sinking dynamics, DNA damage, and long-term exposure under environmentally realistic conditions. Furthermore, most experimental studies rely on short-term laboratory assays using simplified exposure scenarios, which may limit the ecological relevance of current knowledge. Taken together, the available evidence highlights key research priorities and outlines directions for improving experimental ecotoxicological studies.
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4. Behavioral toxicity of polyhydroxyalkanoate microplastics in Drosophila melanogaster larvae revealed by deep-learning pose estimation.
PMID:日期:2026-10-01Polyhydroxyalkanoates (PHAs) are microbially synthesized polyesters developed as biodegradable alternatives to conventional plastics, but incomplete degradation can leave PHA-derived particles in the environment, and their biological effects remain poorly characterized. This study investigated whether 96-h dietary exposure to 5-µm PHA particles altered locomotor organization in third-instar Drosophila melanogaster larvae. Larvae were exposed to 0.25, 2.5, or 7.5 mg L⁻¹ PHA, and movement in the standardized 5-65 s window was quantified using SLEAP tracking, speed and angular-speed interval distributions, and nine spatial trajectory features. PHA exposure altered larval locomotion, with the broadest response at 7.5 mg L⁻¹. Relative to the control, this treatment reduced mean crawling speed by 37.8% and distance travelled by 40.7%, increased low-speed occupancy, decreased medium- and high-speed occupancy, and reduced displacement, straightness, convex-hull perimeter and area, and radius of gyration. Angular-speed occupancy shifted from the low category toward the medium and high categories, whereas mean angular speed did not differ significantly among groups. Changes in the low-speed and low-angular-speed proportions were also detected at 0.25 mg L⁻¹. These coordinated changes identify a sublethal alteration of locomotor organization under the tested conditions. Locomotion supports resource acquisition, habitat use, dispersal, and escape; the observed response constitutes an ecologically relevant effect in a terrestrial insect. The findings show that biodegradable-polymer particles can elicit sublethal effects in terrestrial insects and warrant inclusion in ecological hazard assessment.
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5. From plastic to pathophysiology: polyethylene (PE) and polyvinyl chloride (PVC) microplastics disrupt fish blood, metabolism, and growth.
PMID:日期:2026-10-01Rising global plastic use has led to widespread synthetic polymer pollution in aquatic ecosystems, threatening aquatic life. The combined toxicity of prevalent plastics like polyethylene (PE) and polyvinyl chloride (PVC) under realistic conditions remains largely unexplored. This study provides the first evaluation of the impact of environmentally relevant concentrations (0.5 mg/L) of PE- and PVC-MPs, individually and in combination, on Channa punctatus over a 21-day exposure period, uniquely revealing the enhanced toxicity of combined MPs through an integrated assessment of hematological, biochemical, genotoxic, and growth biomarkers. Hematological assessments revealed declines in hemoglobin and erythrocyte count, alongside increments in leukocytes, suggesting anemia and immune activation. Biochemical analyses revealed significant (p < 0.05) physiological stress, as reflected by elevated SGOT, SGPT, ALP, LDH, creatinine, blood urea nitrogen, glucose, cholesterol, triglycerides, and disturbances in protein profiles, including albumin, globulin, and the A/G ratio. Erythrocytic nuclear abnormalities such as micronuclei, nuclear bud, binucleated cells, blebbed, tear-drop, kidney-shaped and notched nuclei reflected genotoxic and cytotoxic stress. Growth performance was markedly impaired, with reductions in weight gain, %weight gain, specific growth rate, feed intake ratio and condition factor. Notably, the co-exposed group exhibited the most severe alterations across all parameters, underscoring the mixture toxicity of combined MPs. Pearson correlation analysis further established strong associations among all studied parameters, strengthening the diagnostic potential of these biomarkers for MPs toxicity in sentinel fish species. These findings sound an urgent call to recognize and mitigate the silent yet combined threat of mixed microplastic pollution in freshwater ecosystems.
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6. Effects of dichlofluanid in tropical marine bivalves exposed to water and spiked sediments: an assessment of biomarker responses.
PMID:日期:2026-10-01Antifouling paints have been used to control biofouling on submerged surfaces for decades. They contain biocidal compounds that may be released into the environment and harm aquatic ecosystems; however, their effects on tropical organisms are little known. Dichlofluanid, or N-dichlorofluoromethythio-N',N'-dimethyl-N-phenylsulfamide (CHClFNOS), is a biocide present in antifouling paints and its toxicity to tropical marine organisms is poorly understood. This study aimed to evaluate the effects of dichlofluanid at the cellular and biochemical levels in bivalves exposed to seawater and sediment contaminated with this biocide, considering sediments with two different concentrations of organic matter. Aqueous-phase tests were performed using the mussel Perna perna, and tests with sediments were performed using the clam Anomalocardia flexuosa. Then, cellular and biochemical biomarkers were analyzed. The neutral red retention time assay (NRRT), a cellular biomarker, was assessed only in mussels, while biochemical biomarkers (DNA damage, LPO, GSH, and activities of GST, GPx, EROD, and AChE) were analyzed in both organisms. Particle size, calcium carbonate content, and organic matter analyses were also conducted on the sediments. At higher concentrations, the NRRT assay showed effects on mussel hemocytes, indicating a loss of lysosomal stability. Mussels also showed changes in the biochemical biomarkers of the digestive glands and gills. In clams exposed to sediment, adverse effects occurred in both organs and were more evident in animals exposed to sediments with higher levels of organic matter. Our study demonstrated that dichlofluanid can affect marine bivalves at realistic environmental concentrations and that organic matter may contribute to dichlofluanid exposure to clams.
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7. Bioaccumulation dynamics of perfluorooctane sulfonic acid (PFOS) and a binary mixture of PFOS and perfluorohexane sulfonic acid (PFHxS) in northern bobwhite (Colinus virginianus): a mini review.
PMID:日期:2026-09-30Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with significant bioaccumulation potential and toxicological concerns. Specifically, perfluorooctane sulfonic acid (PFOS) has been shown to reduce growth, reduce hatching success and decrease hatchling survivability, and arrest developmental cycles in birds. While the transfer of PFAS from exposed adult birds to their offspring is recognized, the routes of maternal transfer are not yet fully elucidated. Therefore, this mini review synthesizes previously collected. PFAS tissue residue data from a series of chronic toxicity studies in Northern bobwhite (NOBO) conducted in our laboratory, integrating findings from adult tissues, whole eggs, the chorioallantoic membrane (CAM), and hatchling tissues. Our goal was to provide a better understanding of tissue-specific PFAS bioaccumulation in the adult, and maternal transfer to the developing chick. The available data revealed that the liver serves as the primary site for PFAS bioaccumulation in adult and hatchling NOBO, following the trend: adult liver > adult brain > post-hatch CAM > whole egg > hatchling liver > hatchling brain. Hatchling tissues exhibited lower PFAS concentrations in brain and in liver compared to those same tissues in adult females; hatchlings received PFAS exposure only through maternal transfer during embryonic development. The data from our studies further highlight that assessing the post-hatch CAM, rather than the whole egg, is important because it serves as a direct link between the embryo and the egg's internal environment, thus reflecting a PFAS burden that is available to the developing chick; whole egg measurements capture total PFAS deposited by the female NOBO into the egg. Findings from controlled PFAS exposures to birds conducted in our laboratory indicate that maternal PFAS burdens influence hatchling exposure and contribute to PFAS bioaccumulation patterns.
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8. Harnessing the interplay between metal toxicity and DNA methylation in plants.
PMID:日期:2026-09-26Research into how plants adapt to stress through genetic and epigenetic mechanisms is a rapidly evolving field, with epigenetic flexibility serving as a critical factor for survival in heavily contaminated, high-metal environments. Cutting-edge technologies, specifically Whole Genome Bisulfite Sequencing (WGBS) and Reduced Representation Bisulfite Sequencing (RRBS), have revolutionized this area by moving beyond broad, genome-wide surveys to pinpoint specific, gene-level alterations induced by metal stress. These high-throughput methods have fundamentally transformed the landscape of environmental plant research. Critical analysis of the literature revealed that exposure to metal stressors triggers rapid, time-dependent shifts in plant DNA methylation, often occurring within minutes. These epigenetic responses are highly contingent on species and genetic background, and the specific metal stressor involved, facilitating site-specific gene regulation without altering the underlying DNA sequence. This flexibility allows plants to modulate gene expression primarily through hypermethylation (70%) rather than hypomethylation (30%) to maintain homeostasis and develop heritable stress memory. These modifications predominantly target genes associated with metal transport (60%), such as HMA, ZIP, and ABC transporters, followed by sequestration (20%) and other metabolic functions (20%). Ultimately, harnessing these epigenetic mechanisms offers a pathway to developing crop cultivars that not only exhibit enhanced tolerance and productivity in contaminated environments but also restrict the accumulation of toxic metals in edible tissues, thereby improving food safety and supporting sustainable agriculture on Bednarekmarginal lands. Despite major analytical breakthroughs, the precise role of DNA methylation in regulating gene responses to metal toxicity remains a critical, unresolved challenge in research. This review provides an overview of DNA methylation mechanisms and outlines the plant genes that are modified in response to metal exposure.
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9. Cyanotoxins induce hepatic inflammation and disrupt lipid metabolism in Sinocyclocheilus grahami.
PMID:日期:2026-09-26Cyanobacterial blooms release a variety of secondary metabolites, severely impacting the survival of fish species.The multi-layered analytical approach (histology + biochemistry + transcriptomics + lipidomics) was used to investigate hepatic injury in Sinocyclocheilus grahami following a 96-hour exposure to Microcystis aeruginosa exudates (MaE) and their constituent, phytosphingosine (PHS; at 2.9 and 145 ng/mL). The results showed histopathological hepatic damage across treatments, with a significantly decreased hepatosomatic index (HSI) in the high-PHS-exposure group. Total bilirubin were significantly elevated in all treatments. Interestingly, the triglyceride content showed significant increases in the PHS-treated groups. Both MaE and PHS induced inflammation, with significantly up-regulated inflammatory factors, whereas the anti-inflammatory factor IL-10 was significantly down-regulated in the MaE-treated group. Based on biochemical biomarker and multi-omics analyses, MaE mainly induced oxidative stress and lipid peroxidation, whereas PHS tended more to disturb lipid metabolism, markedly down-regulating various metabolites in the liver. In the PHS-treated groups, sphingolipid and retinol metabolisms emerged as the top two most enriched KEGG pathways with the largest number of DEGs and DEMs. In conclusion, the toxicological differences induced by MaE and PHS mainly depended on their chemical property. (1) As a pure sphingolipid compound, the biological processes of PHS were enriched in metabolic processes, its cellular component processes were enriched in the endoplasmic reticulum, the site of sphingomyelin synthesis, and its molecular function processes involved binding with DNAs associated with PPAR and FoxO signaling pathways. (2) As a complex mixture of exudates, MaE mainly triggered responses to toxicins/extracellular stimuli and lipid transporter activity. MaE exerted strong oxidative stress, while PHS tended more to disturb lipid metabolism, and both induced inflammation. This study contributes to the health risk assessment of fish in the context of cyanobacterial blooms.
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10. Sublethal abamectin exposure alters intraguild predation and population structure of predatory mites.
PMID:日期:2026-09-26Chemical contaminants can disrupt predator-prey dynamics in agroecosystems, particularly through intraguild predation (IGP), a key interaction influencing population structure and dynamics. The objective of this study was to investigate intraguild predation between Amblyseius largoensis (Muma) and Euseius alatus DeLeon (Mesostigmata: Phytoseiidae), with particular emphasis on how an extraguild food resource (pollen), sublethal exposure to the acaricide abamectin, and their combined effects influence predator feeding behavior, oviposition, and population dynamics. Adult females of both predators were exposed to intraguild prey (eggs and larvae) in the presence or absence of extraguild food (pollen) and abamectin residues. In addition, population-level experiments were conducted to evaluate long-term interaction outcomes. Experimental results revealed that both feeding activity and oviposition of the two predator species were significantly affected by the presence of pesticide residues and the availability of pollen as an extraguild food source. Population dynamics assays indicated that A. largoensis was the dominant species; however, exposure to pesticide residues reduced the longevity of both predator populations.