QUALITY OF LIFE RESEARCH生活质量研究
QUALITY OF LIFE RESEARCH(英文缩写 QUAL LIFE RES),ISSN 0962-9343,eISSN 1573-2649,中文译名:生活质量研究 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.440 | Q2 |
| 2022 | 3.500 | Q2 |
| 2023 | 3.300 | Q1 |
| 2024 | 2.700 | Q2 |
| 2025 | 3.400 | Q1 |
QUALITY OF LIFE RESEARCH 最新收录文献
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1. Impact of child loss on parents' health-related quality of life: evidence from the china health and retirement longitudinal study.
PMID:期刊:日期:2026-10-04Given the profound impact of adverse life events on later-life health, this study examined how the occurrence, timing, and number of child losses were associated with trajectories of health-related quality of life (HRQoL) among middle-aged and older adults in China. It further explored potential mediating mechanisms and heterogeneity by gender and residence. Using data from four waves (2011-2018) of the China Health and Retirement Longitudinal Study (CHARLS), this study included 13,161 individuals. HRQoL was assessed using the 36-Item Short Form Health Survey (SF-36). Linear mixed models were used to estimate longitudinal HRQoL trajectories, and the Karlson-Holm-Breen method was applied to examine potential mediating pathways. Bereaved parents exhibited lower HRQoL than non-bereaved parents. The association between child loss and HRQoL varied by the timing of the loss and followed a dose-response pattern. Mediation analyses identified intergenerational support and social engagement as potential pathways. Moreover, mothers experienced a steeper decline in HRQoL over time than fathers following child loss. These findings suggest that child loss has a persistent and graded negative association with HRQoL, with important variation by timing and gender. The results highlight the need for targeted support and interventions to mitigate long-term health consequences among bereaved older adults.
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2. Psychometric evaluation of the Disability Wellbeing Index (DWI) against the Adult Social Care Outcomes Toolkit (ASCOT) among people with disability.
PMID:期刊:日期:2026-09-27The Disability Wellbeing Index (DWI) is a preference-based wellbeing measure developed among people with disabilities. This study examined the psychometric properties of the DWI in both its Standard and Easy English versions and compared them with two Adult Social Care Outcomes Toolkit (ASCOT) instruments, the ASCOT-SCT4 and ASCOT-ER. We conducted an online survey among National Disability Insurance Scheme (NDIS) participants aged ≥ 15 years in 2024. DWI was scored using an Australian preference-based algorithm, and ASCOT was scored using UK preference weights. Convergent validity was assessed using Spearman's correlations between total utility scores and corresponding domain items. We examined underlying constructs between DWI and ASCOT using exploratory factor analyses (EFAs), and known-groups validity using regression analyses comparing scores across groups based on self-rated health, self-advocacy, participation in meaningful leisure activities, and autonomy in decision-making. A total of 1871 participants were studied; among them, 39% completed the Easy English/Read version, and 30% were aged 15-24 years. Correlations between DWI and ASCOT were moderate for young people (ρ = 0.62, Easy English/Read; ρ = 0.66, Standard) and strong for adults (ρ = 0.74, Easy English/Read; ρ = 0.75, Standard). Convergence was strongest for safety items, whereas convergence was weaker for dignity items. EFA indicated partial overlap in underlying constructs. Known-groups validity was supported for both measures. The findings support the construct validity of DWI. DWI and ASCOT focus on different but overlapping aspects. The DWI places a stronger emphasis on general wellbeing, while the ASCOT focuses on social care related quality of life.
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3. Factors independently associated with in-hospital HRQoL in adults treated at a high-complexity institution in a middle-income country.
PMID:期刊:日期:2026-09-27Health systems are increasingly oriented toward value-based care, emphasizing patient-centered outcomes such as health-related quality of life (HRQoL). During hospitalization, HRQoL reflects the interplay of sociodemographic, geographic, and clinical factors, which may be particularly influential in middle-income settings where structural inequities can affect patient-reported outcomes. To identify factors independently associated with HRQoL measured during hospitalization in adults treated at a high-complexity institution in a middle-income country. We conducted a cross-sectional analytical study nested within an institutional prospective cohort (2023-2025). We included hospitalized adults with a complete in-hospital HRQoL assessment using the EQ-5D-3L descriptive system and the EQ visual analogue scale (EQ VAS). The EQ VAS score was analyzed as the primary continuous outcome. Associations were evaluated using bivariate analyses and multivariable linear regression. A total of 46,083 patients were included, with a median EQ-VAS score of 70 (IQR, 60-80). Functional impairment was most commonly reported in usual activities (62.46%). In the multivariable linear regression model, lower EQ-VAS scores were independently associated with increasing age (β = - 0.150 per year) and ICU admission (β = - 1.661), whereas professional education (β = 2.364) and surgical admission (β = 1.672) were associated with higher scores. Across diagnostic groups, mental and behavioural disorders (β = - 2.949) and respiratory diseases (β = - 2.036) showed the strongest negative associations, while pregnancy-related conditions were associated with the highest scores (β = 3.982). EQ VAS scores measured during hospitalization were independently associated with sociodemographic and clinical factors, underscoring the multifactorial determinants of self-rated health in acute hospital settings.
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4. Mapping EORTC-QLQ-C30 scores to EQ-5D-5L utility values for gynecological cancer survivors in follow-up care.
PMID:期刊:日期:2026-09-27To develop mapping algorithms from the EORTC-QLQ-C30 to EQ-5D-5L utilities for gynecological cancer survivors in follow-up care, enabling cost-effectiveness analyses when EQ-5D-5L utilities are unavailable. We used data from a Norwegian multicentre longitudinal study of gynecological cancer survivors in post-treatment follow-up (LETSGO), including 663 patients with 2,624 observations. Ten model types were estimated for three EQ-5D-5L value sets (Norwegian, UK, US): ordinary least squares, Tobit, beta and fractional logistic regression, linear mixed models, an adjusted limited dependent variable mixture model, and two-part models combining logistic regression for the probability of perfect health with OLS, mixed, beta or fractional logistic regression for utilities below 1. Each was fitted with three prespecified covariate sets comprising all EORTC-QLQ-C30 scales, with and without age, comorbidities and treatment type. Stratified five-fold cross-validation at the patient level was used for internal validation. Performance was assessed using mean absolute error (MAE), root mean squared error (RMSE), proportion of predictions with absolute error (AE) ≤ 0.05 and Lin's concordance correlation coefficient (CCC) and summarized using an average ranking value. A two-part fractional logistic model with all covariates ranked highest, with MAE 0.0539-0.0660, RMSE 0.0806-0.0960, AE ≤ 0.05 for 54.8-67.1% of observations and CCC 0.7559-0.8034. Differences between the best-performing specifications were small. Accuracy declined at low utility levels, though overall mean bias was minimal. The algorithm enables estimation of EQ-5D-5L utilities from EORTC-QLQ-C30 scores in populations with severity profiles similar to the LETSGO cohort. Accuracy is reduced in poor health states.
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5. Adaptation and initial psychometric validation of the Latvian version of EORTC QLQ-C30 and QLQ-BR45 in women with breast cancer.
PMID:期刊:日期:2026-09-25To culturally adapt and initially evaluate the psychometric properties of the Latvian versions of the EORTC QLQ-C30 and breast cancer-specific EORTC QLQ-BR45 in women with breast cancer. The study was conducted within a pilot project implementing the ICHOM Breast Cancer Standard Set in a specialised university hospital in Latvia. Translation and cultural adaptation followed the EORTC procedure and included expert review and cognitive debriefing. Psychometric evaluation used baseline data from 142 women and six-month follow-up data from 47. Analyses included item-level indicators, internal consistency, multitrait scaling, inter-scale correlations, correlations with the Stress Symptom Scale, and paired change analyses. Conditional QLQ-BR45 items were treated as structurally missing when not applicable. Expert review and cognitive debriefing supported linguistic, conceptual, and cultural appropriateness. Reliability and item-scale correspondence were acceptable for several domains, with particularly strong multitrait scaling results for QLQ-BR45 Body Image, Sexual Functioning, and Breast Symptoms. Correlations between EORTC functioning and symptom domains and the Stress Symptom Scale were generally in the hypothesised directions. Six-month findings showed clinically plausible changes in functioning and treatment-related symptoms, but estimates were based on a smaller follow-up sample and reduced valid samples for some conditional scales. The Latvian EORTC QLQ-C30 and QLQ-BR45 showed acceptable preliminary psychometric performance. The findings provide initial support for their use to assess HRQoL and breast cancer-specific symptoms in Latvia, while larger multicentre and longitudinal studies are needed to evaluate additional measurement properties and responsiveness.
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6. Determining what matters most to patients: qualitative interview techniques and methodological considerations for concept saliency analysis and reporting.
PMID:期刊:日期:2026-09-25This commentary considers how qualitative interview techniques can be used to determine the relative importance or saliency of concepts reported by patients in clinical outcome assessment (COA) development. The objective of this commentary is to explore how researchers can identify which symptoms and impacts are most important to patients using qualitative methods. The paper aims to promote alignment on best practices and terminology. This commentary discusses the implementation of structured qualitative interview tasks that are commonly used to assess concept saliency, including the definition and application of thresholds. These methods are discussed in the context of concept elicitation interviews, with considerations for their design, implementation, and analysis. Ranking and rating tasks offer structured approaches to eliciting concept importance, each with distinct advantages and limitations. Ranking tasks are efficient and engaging but may oversimplify concept prioritization. Rating tasks provide nuanced data but can be time-consuming and burdensome. The authors consider current use of saliency thresholds to be inconsistent, with research generally lacking predefined criteria. A mixed methods analysis approach, combining qualitative insights with descriptive statistics, is recommended by the authors to ensure comprehensive understanding of patient experience. Structured interview tasks enhance the rigor and relevance of qualitative research in COA development. By standardizing terminology and analysis approaches, researchers can more accurately identify and prioritize concepts that matter most to patients. This ensures that measurement strategies in clinical trials and real-world studies are truly patient-centered.
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7. Treatment burden, healthcare experiences, and health-related quality of life among youth with chronic kidney disease treated for hypertension.
7. 接受高血压治疗的慢性肾脏病青少年的治疗负担、医疗体验及健康相关生活质量PMID:期刊:日期:2026-09-24Controlling blood pressure (BP) is essential for slowing chronic kidney disease (CKD) progression. This study examined the associations between treatment burden, assessed by antihypertensive medication use, and health-related quality of life (HRQoL) in youth with CKD and hypertension. Youth (aged 8 to 21 years) were identified through electronic health records from 15 institutions. Youth and caregivers completed an online questionnaire assessing healthcare experiences, medication use, physical symptoms, and BP monitoring. HRQoL and related well-being domains (fatigue, anxiety, sleep disturbance, global health, and life satisfaction) were assessed using PROMIS measures. Analyses focused on youth-reported outcomes. Linear regression estimated associations between antihypertensive medication use and HRQoL outcomes, and scores were compared to the general population. The study included 395 youth (M = 16.8 years, 54% female) and 238 caregivers. Over 95% of caregivers reported generally positive healthcare experiences. Most youth (92%) reported at least one of the physical symptoms asssessed (median [IQR] = 5 [3, 8] symptoms). Twenty-one percent took no antihypertensive medications, 56% took one, and 23% took multiple. Use of multiple medications was associated with slightly lower global health (B = - 2.6; 95% CI: - 4.9, - 0.3) after adjustment for CKD stage. No associations were observed for other HRQoL domains. Overall, youth reported lower QoL than the general population, with the greatest impairments observed in global health and fatigue. Youth with CKD and hypertension reported generally positive healthcare experiences, and antihypertensive medication use, one component of treatment burden, showed minimal association with HRQoL. Despite modest effects, continued attention to HRQoL remains an important aspect of care for youth with CKD and hypertension.
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8. Sample size calculator for reliability and validity evaluation: a Shiny R application.
PMID:期刊:日期:2026-09-24The objective is to provide a user-friendly tool for researchers to compute sample sizes for studies involving psychometric reliability and validity metrics. The application was developed using R Shiny to create an interactive interface to calculate sample sizes for reliability, validity, and group difference assessments. For metrics already included in existing tools, cross-validation was performed to ensure consistency and accuracy. For metrics unique to this app, validation was based on formulas from the original publications. A comprehensive set of sample size calculation modules was included, covering Pearson correlation, Spearman correlation, tetrachoric correlation, point-biserial correlation, Cohen's kappa, Fleiss' kappa, Cronbach's alpha, intraclass correlation coefficient, Kendall's coefficient of concordance, one-way analysis of variance, and one-way analysis of covariance. Researchers can access detailed outputs, including sample sizes, contextual interpretations, and step-by-step derivations of the results, ensuring transparency and usability. The Sample Size Calculator is a validated and helpful resource for researchers seeking to optimize study design. The calculator can be accessed at the following website: https://biostats-shinyr.kumc.edu/PsychometricN/.
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9. Evaluating patient-reported outcome measurement in fibromyalgia clinical trials: a cross-sectional meta-research analysis of alignment with IMMPACT recommendations.
PMID:期刊:日期:2026-09-23Fibromyalgia diagnosis and treatment response depend mostly on patient report, making patient-reported outcomes central to trial evidence. The Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials provides recommendations for standardized outcome domains and endorsed patient-reported instruments in chronic pain trials. Whether fibromyalgia trials have converged on a common set of instruments remains unclear. We evaluated instrument standardization and IMMPACT alignment among registered fibromyalgia trials. We conducted a cross-sectional meta-research analysis of 916 interventional fibromyalgia trials registered on ClinicalTrials.gov. Outcomes were classified against an inductively built dictionary of patient-reported outcome instruments, with alignment defined as registration of at least one consensus-body-endorsed instrument. Completeness and alignment were assessed relative to the consensus body's 2005 publication, and cohort assembly and instrument detection were independently verified. Of 916 eligible trials, 778 (84.9%) named a patient-reported outcome instrument, rising from 47.4% in 2005 to a peak near 98% in 2021. Ninety-five distinct instruments were registered, but only 49.1% of these trials included one the consensus body endorses. The most common measure was the Fibromyalgia Impact Questionnaire, an unendorsed fibromyalgia-specific tool, and the non-endorsed Visual Analog Scale was registered nearly twice as often as the consensus-body-endorsed Numeric Rating Scale (348 vs. 192 trials). Fibromyalgia trials have largely resolved whether to measure patient-reported outcomes, but instrument selection remains fragmented despite two decades of guidance, limiting comparability across trials. Requiring a consensus-body-endorsed instrument alongside a disease-specific measure would close this gap without sacrificing disease-specific detail.
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10. Beyond observed changes: how differential item functioning and response shift alter health-related quality of life interpretation in preemptive versus non-preemptive kidney transplant patients.
PMID:期刊:日期:2026-09-21Experiencing dialysis and receiving a kidney transplant may induce differential item functioning (DIF) and response shift (RS), reflecting changes in how patients interpret and evaluate their health-related quality of life (HRQoL). This study investigates the impact of DIF and RS on HRQoL change estimation in preemptive (PKT) and non-preemptive (nPKT) kidney transplant patients before and after transplantation. In the prospective, multicentre, controlled PreKit-QoL study, HRQoL was assessed using the SF-36 every 6 months before transplantation, at hospital discharge, at 3 and 6 months, and annually until 5 years post-transplantation in PKT (n = 158) and nPKT (n = 226) patients. Changes in HRQoL and DIF and RS occurrence between the last visit before transplantation and 3 months post- transplantation, and between 3 and 6 months post-transplantation were investigated with an item-level DIF and RS detection algorithm, ROSALI. ROSALI estimates DIF and RS effects, and HRQoL changes accounting for these effects using Rasch models. Four SF-36 dimensions (Bodily Pain, Vitality, Social Functioning, Mental Health) were unaffected by DIF and RS, and showed general improvement shortly after transplantation, with only changes in Bodily Pain differing between groups. Two dimensions (Role Physical, General Health) exhibited DIF and RS shortly after transplantation. Ignoring these phenomena would have masked the deterioration in Role Physical for PKT patients and slightly underestimated the improvement in General Health. Investigating DIF and RS is essential for accurate PROM interpretation, revealing how patients' perception may evolve following transplantation. These insights inform both statistical analysis and understanding of patients' lived experience.