CURRENT OPINION IN CELL BIOLOGY细胞生物学新见
CURRENT OPINION IN CELL BIOLOGY(英文缩写 CURR OPIN CELL BIOL),ISSN 0955-0674,eISSN 1879-0410,中文译名:细胞生物学新见 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 8.386 | Q1 |
| 2022 | 7.500 | Q1 |
| 2023 | 6.000 | Q1 |
| 2024 | 4.300 | Q2 |
| 2025 | 6.200 | Q2 |
CURRENT OPINION IN CELL BIOLOGY 最新收录文献
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1. Mechanisms of spatiotemporal regulation of transmembrane receptor turnover during directed cell migration.
1. 定向细胞迁移过程中跨膜受体周转的时空调控机制PMID:日期:2026-10-01Dynamic regulation of cellular and tissue response to cell-intrinsic and cell-extrinsic signal fluctuations is essential for ensuring that migrating cells end up in the right place at the right time. One way to achieve this is through adaptive spatiotemporal control of the turnover of cell surface transmembrane receptors, which stand between the internal and external environments to transmit crucial information. The underlying control mechanisms would allow both individual cells and cell groups to adapt their behaviours to their intracellular and extracellular needs, preventing unwanted halts in cell migration or cells making a wrong turn. Recent advancements in reporter tools and imaging technologies have allowed improved tracking of receptor turnover in both in vitro and in vivo systems to uncover the adaptation mechanisms that receptors use during change to give rise to physiologically reliable migratory outcomes. This review explores the overarching principles of spatiotemporal control mechanisms underlying adaptive receptor turnover during cell migration.
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2. Advances in bioelectrical sensing and signal transduction.
PMID:日期:2026-09-24During tissue morphogenesis, cellular rearrangements lead to the emergence of biophysical and biochemical scenarios that cells themselves can sense and translate into a number of responses, including cell division, migration, and differentiation. In this review, we highlight recent advances in the emergence, sensing, and transduction of bioelectrical signals and their contribution to cellular dynamics in embryogenesis and regeneration. We provide an overview of how non-neural cells generate electrical currents and how tissue-level interplay can translate these currents into spatial patterns resembling electric fields. We also discuss recent discoveries of mechanisms by which cells specifically sense and transduce these endogenous bioelectrical landscapes into directed cell migration, tissue growth, and differentiation. Finally, we discuss the relevance of integrating bioelectrical signals into formal cellular, molecular, and mechanical frameworks of directed cell migration and tissue morphogenesis. We emphasize that integrating bioelectrical signaling is both timely and relevant, as current models may remain incomplete if we continue to ignore this otherwise underexplored source of cellular signaling.
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3. Bioelectric regulation of stem cell fate: From the plasma membrane to organelles.
3. 干细胞命运的的生物电调控：从质膜到细胞器PMID:日期:2026-09-18Stem cell identity has traditionally been viewed through the lens of transcriptional and metabolic programs. Recent work has revealed an additional layer of complexity: the plasma membrane and intracellular organelles maintain compartment-specific membrane potentials, pH gradients, and ion dynamics that can influence stemness and fate. In this review, we synthesize recent advances identified across diverse stem cell populations to highlight convergent and divergent bioelectric mechanisms driving cell fate decisions. We explore how plasma membrane mechanosensors convert physical cues into internal ionic signals. We next examine the influence of lysosomal pH on metabolic programming to support cell transitions. We then discuss how differences in mitochondrial membrane potentials (MMPs) and inheritance, endoplasmic reticulum (ER)-calcium handling, and ER-mitochondrial coupling influence lineage commitment. Finally, we consider how nuclear ionic and mechano-osmotic conditions may shape chromatin organization and transcriptional competence. Collectively, these studies position the plasma membrane and organelles as coupled nodes within an integrated bioelectric network. This emerging framework identifies new questions about how compartment-specific ionic states are coordinated and suggests potential strategies for therapeutically redirecting cell fate.
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4. Modulation of host actin dynamics in pathogenic infections: An emergent perspective.
PMID:日期:2026-08-24Modulation of host actin dynamics by pathogens to enter and survive inside cells is a central theme of many pathogenic infections. Decades of research have given us deep insights into the role of individual pathogenic factors in regulating host actin dynamics. However, the combinatorial effects of pathogenic factors and their complex interplay in generating the wide plethora of actin structures are just beginning to be unraveled. This review aims to provide an emergent perspective on the modulation of host actin dynamics by pathogens. We begin with a discussion of pathogen-generated actin structures, provide insights into molecular mimicry mechanisms used by pathogenic factors to regulate actin remodeling, and conclude by examining the effect of pathogenic infections on modulation of host actin dynamics.
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5. Rabs in the driving seat: Coordinating vesicular traffic and membrane contact site dynamics.
5. Rab蛋白掌控全局：协调囊泡运输与膜接触位点动态变化PMID:日期:2026-07-30Rab GTPases are central regulators of intracellular membrane organization, ensuring the specificity and directionality of vesicular transport. Operating as 'molecular switches,' Rab GTPases cycle between an active GTP-bound and an inactive GDP-bound state, a process regulated by GEFs (guanine nucleotide exchange factors) and GAPs (GTPase-activating proteins). The dynamic switch-like behaviour and compartment-specific localization of Rab GTPases establish membrane identity and generate discrete membrane subdomains, providing spatiotemporal control over intracellular trafficking events. Rab GTPases also facilitate compartment maturation through coordinated Rab conversion, leading to transitions between different membrane identities. Membrane-localized Rab GTPases function as a recruitment platform for a cohort of effector proteins, which regulate the sequential steps of vesicular transport. The features discussed above also enable Rabs to participate in the formation of membrane contact sites, which facilitate direct transport of phospholipids and small molecules between compartments and regulate organelle motility and positioning. Here we review current insights into the mechanisms governing Rab GTPase regulation, including post translational modifications and interactions with effectors. We also discuss their roles in membrane domain formation, compartment maturation via Rab cascades, and non-vesicular communication pathways. These findings enhance our understanding of the multifaceted functions of Rab GTPases in compartmentalization and highlight emerging areas for future investigation.
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6. Mapping chemoattractant gradients in live tissues.
6. 在活体组织中绘制趋化因子梯度PMID:日期:2026-07-29Chemoattractant gradients guide cell migration in immunity, tissue repair, and development, yet their spatial and temporal distribution remains difficult to measure. In this review, we discuss how the field is moving beyond static source maps and indirect cellular proxies toward direct visualization of extracellular guidance cues. We outline the strengths and limitations of classical approaches for inferring chemoattractant gradients and highlight new strategies provided by genetically encoded chemoattractant indicators (GECHIs). Emerging PBP- and GPCR-based biosensors enable continuous visualization and localization of extracellular ligands in living tissues using fluorescence intensity- or lifetime-based readouts. Although the current toolbox is limited to a small number of chemoattractants, ongoing sensor development is likely to expand ligand coverage and enable multiplexed measurements with spectrally distinct sensors in the near future.
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7. Tribbles pseudokinases: Fine tuning of cell signaling with implications in metabolism, inflammation and cancer.
7. Tribbles伪激酶：细胞信号传导的精细调控及其在代谢、炎症和癌症中的意义PMID:日期:2026-07-23Within the family of protein kinases there is a subgroup of 'evolutionarily related members of the total human kinome' that are devoid (or have very limited) enzymatic activity. These proteins, so-called pseudokinases, play important functions thanks to their capacity to establish regulatory protein-protein interactions. Specifically, this opinion article focuses on a group of pseudokinases called Tribbles. Tribbles (Trbl) was originally discovered in Drosophila, followed by the subsequent identification of their orthologs in mammals (TRIB1, TRIB2, TRIB3, and STK40). Work over the last decades has shown how these proteins contribute to fine-tuning key signaling pathways involved in the regulation of proliferation, differentiation, inflammation and adaptation to nutritional changes. Accordingly, dysregulation of Tribbles proteins (TRIBs) contributes to the establishment and progression of insulin resistance, obesity, type II diabetes, atherosclerosis and cancer. Here, we will discuss some of the mechanisms by which Tribbles pseudokinases carry out their functions and the crucial importance of cell context in defining the precise role played by each of the TRIBs, with emphasis on TRIB1 and TRIB3, under different physiopathological situations.
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8. The orchestration of ciliary opus: Interplay of signalling molecules, GTPases, and trafficking machinery.
8. 纤毛杰作的编排：信号分子、GTP酶和运输机制的相互作用PMID:日期:2026-07-20Primary cilia are sensory organelles that host various signalling receptors and proteins to coordinate signalling pathways essential for tissue homeostasis. This review explores the molecular mechanisms by which intraflagellar transport (IFT) machinery, the BBSome coat complex, small GTPases, and various secondary messenger signalling molecules cooperate to establish and maintain ciliary composition. We discuss how IFT trains, guided by kinesin-2 and dynein-2 motors, traffic receptors and signalling components into and out of the cilium, and how the lipid composition within the cilium plays a regulatory function. We also described how secondary messengers such as cAMP and Ca coordinate ciliary signalling outputs, including hedgehog and insulin secretion. Finally, we have also discussed how the BBSome selects cargo for export and the role of small GTPases in its trafficking, together ensuring the compositional integrity and signalling fidelity of this organelle. A mechanistic understanding of these integrated trafficking and signalling systems provides a framework for elucidating the pathogenesis of ciliopathies and identifying potential therapeutic targets.
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9. Editorial overview: New directions and approaches in membrane trafficking.
9. 编辑概览：膜运输的新方向和方法PMID:日期:2026-07-17该文献暂无摘要。
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10. Directing traffic: MAPs, motors, and cellular logistics.
10. 指挥交通：MAPs、马达和细胞物流PMID:日期:2026-07-15Eukaryotic cells rely on long-range microtubule transport to accurately position mitochondria, and other organelles and vesicles with spatial and temporal precision. While kinesin and dynein motors drive directional movement, motor activity alone cannot explain the diversity and adaptability of organelle trafficking in vivo. Here, we synthesize recent evidence that non-motor microtubule-associated proteins (MAPs) convert microtubules into information-rich transport networks by decorating specific lattice subsets, modifying microtubule mechanics and controlling motor access and activation. Through steric filtering, modulation, or activation, MAPs impose motor-specific rules that shape transport efficiency and directionality. MAPs also couple trafficking to signaling by interacting with kinases, phosphatases, and receptors, and their dysregulation contributes to neurodegeneration and cancer, highlighting MAP-regulated transport as a therapeutic target.