RESPIRATORY MEDICINE呼吸医学
RESPIRATORY MEDICINE(英文缩写 RESP MED),ISSN 0954-6111,eISSN 1532-3064,中文译名:呼吸医学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-28 至 2026-09-28，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.582 | Q2 |
| 2022 | 4.300 | Q2 |
| 2023 | 3.500 | Q2 |
| 2024 | 3.100 | Q2 |
| 2025 | 3.300 | Q2 |
RESPIRATORY MEDICINE 最新收录文献
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2. Differential diagnosis of asthma and COPD: Established and emerging biomarkers and technologies.
2. 哮喘和慢性阻塞性肺病的鉴别诊断：已建立和新兴的生物标志物和技术PMID:日期:2026-10-01Asthma and chronic obstructive pulmonary disease (COPD) represent the two most prevalent chronic respiratory conditions worldwide, affecting hundreds of millions of individuals and imposing substantial morbidity and mortality. Despite their distinct biological mechanisms, these diseases frequently exhibit overlapping clinical features-including dyspnea, cough, and wheezing-that complicate differential diagnosis, particularly in smoking adults, older patients, and those with mild or fluctuating airflow obstruction. Spirometry remains the cornerstone of diagnostic evaluation, yet its limitations, including dependence on patient effort, reduced sensitivity for early disease, and inability to fully capture small airways involvement, contribute to persistent underdiagnosis and overdiagnosis in clinical practice. This review examines current diagnostic approaches for asthma and COPD, their inherent limitations, and the emerging biomarkers and functional technologies that may improve diagnostic precision. Established biomarkers, including blood eosinophils, fractional exhaled nitric oxide (FeNO), and induced sputum analysis, provide complementary information that refines clinical characterization but lack sufficient disease specificity for standalone use. Novel approaches, including lipidomics, metabolomics, and extracellular vesicle profiling, demonstrate potential for identifying disease-specific molecular signatures and biologically distinct phenotypes, particularly in asthma-COPD overlap. Concurrently, new functional tools-including novel spirometric indices such as Parameter D or FEV3/FEV6, respiratory oscillometry, and artificial intelligence-driven tidal breathing analysis-are enabling more sensitive, effort-independent, and multidimensional assessment of airway disease. The integration of these clinical, functional, inflammatory, and molecular approaches supports a transition toward multimodal diagnostic frameworks that may substantially improve the recognition and differential diagnosis of asthma and COPD, particularly in challenging clinical scenarios and early disease states.
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3. Evaluation of radiological lung pattern and disease progression in patients with asbestosis compared to patients with idiopathic pulmonary fibrosis.
PMID:日期:2026-10-01This study aimed to compare lung patterns and disease progression in asbestosis and idiopathic pulmonary fibrosis (IPF) using qualitative and quantitative high-resolution computed tomography (HRCT) analysis. HRCT scans were obtained at baseline (T0) and follow-up (T1) in 17 patients with asbestosis and 17 with IPF, after a median follow-up of 35 months (IQR = 3) and 35 months (IQR = 13), respectively. Lung parenchyma was segmented using CALIPER software, which quantifies reticulations (RET), ground-glass opacities (GGO), and honeycombing (HC), providing an interstitial lung disease (ILD) score based on the percentage of affected lung volume. Disease progression was defined as the change in ILD score from T0 to T1, normalized per year (DeltaILD/year). A comparative analysis was performed between the groups. Additionally, qualitative HRCT features at T0 were reviewed to identify distinguishing radiological signs. Patients with asbestosis showed significantly slower disease progression (median DeltaILD/year = 0.70%/month; IQR = 1.27) compared to IPF (median = 2.06%/month; IQR = 4.80) (p = 0.024). Subpleural lines (both <5 mm and >5 mm from pleura), pleural plaques, and pleural thickening were more common in asbestosis, whereas hypertrophic mediastinal fat and honeycombing predominated in IPF. Quantitative HRCT analysis with CALIPER effectively demonstrated slower progression in asbestosis compared to IPF. Specific imaging features, including subpleural lines and pleural involvement, distinguished asbestosis, while honeycombing and mediastinal fat hypertrophy were typical of IPF.
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4. Adherence to inhaled treatment is associated with better disease control and quality of life in mild-to-moderate asthma.
PMID:日期:2026-10-01Asthma is a common chronic disease worldwide, with most patients presenting with mild to moderate forms. Poor adherence to inhaled therapy is a recognized determinant of worse outcomes in chronic respiratory diseases. The aim of this study was to evaluate adherence to inhaled medications in a large cohort of adults with mild to moderate asthma and identify factors associated with suboptimal adherence. This cross-sectional real-world study analyzed data from the Mild-Moderate Asthma Network of Italy (MANI) database. Adult patients (≥18 years) with a confirmed diagnosis of asthma according to Global Initiative for Asthma (GINA) criteria were eligible. Data from the first visit in which the Test of Adherence to Inhalers (TAI) questionnaire was available were extracted. Patient-reported outcomes included the Asthma Control Test (ACT), the Asthma Quality of Life Questionnaire (AQLQ), and TAI adherence categories. Patients were classified into three classes according to TAI score as follows: adherents (score ≥50), intermediate adherents (score 46-49), and non-adherents (score <46). A total of 832 patients were included. Adherent patients were older than intermediate and non-adherent subjects (p < 0.001). Current smoking was less frequent among adherent patients (11% vs 16%). Type 2 diabetes and anxiety were more prevalent among non-adherent individuals (5.3% vs 0.8% and 1.8%, p = 0.014; 10.7% vs 7.1% and 3.8%, p = 0.003, respectively). Higher adherence levels were associated with better asthma control (χ (2) = 47.706, p < 0.001) and quality of life (χ (2) = 42.068, p < 0.001). In adults with mild to moderate asthma, better adherence to inhaled therapy is associated with improved disease control and quality of life. Demographic factors, smoking status, and comorbidities may influence adherence behaviors. Routine assessment of adherence and targeted interventions addressing modifiable barriers may improve outcomes in this large asthma population.
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5. Prognostic value of the lactate-to-albumin ratio in adult sepsis: An updated systematic review of prognostic evidence.
5. 乳酸与白蛋白比值在成人败血症中的预后价值：预后证据的最新系统综述PMID:日期:2026-10-01The lactate-to-albumin ratio (LAR) has emerged as a potential prognostic biomarker in sepsis. This systematic review evaluated the prognostic value of LAR for mortality in adults with sepsis or septic shock. PubMed/MEDLINE, Embase, Web of Science, Scopus, and the Cochrane Library were searched from inception through March 2026. Studies evaluating mortality-related prognostic performance of LAR in adults with sepsis or septic shock were included. Risk of bias was assessed using the Quality In Prognosis Studies (QUIPS) tool. Adjusted odds ratios (ORs) and hazard ratios (HRs) were evaluated separately because of methodological heterogeneity. Discrimination was assessed using study-specific area under the curve (AUC), sensitivity, specificity, and LAR thresholds. Fourteen primary studies were included. Higher LAR was consistently associated with increased mortality across emergency department and intensive care populations. AUC values generally ranged from approximately 0.65 to 0.87, although one smaller cohort reported an AUC of 0.976. Several multivariable analyses demonstrated associations between higher LAR and mortality after adjustment for clinical covariates. Adjusted ORs and HRs were not pooled because of differences in LAR scaling, thresholds, mortality endpoints, and adjustment strategies. Considerable variability was observed in reported cut-offs and diagnostic performance. Higher LAR is associated with mortality in adult sepsis and may provide complementary prognostic information. However, clinical and methodological heterogeneity precludes a universal cut-off or single pooled adjusted effect. Standardized prospective multicenter studies are required before routine clinical implementation.
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6. Prolonged smoking duration is independently associated with mortality in former smokers with COPD regardless of pack-years.
PMID:日期:2026-10-01Smoking exposure has been quantified using pack-years, which integrates smoking intensity and duration. However, pack-years may not fully capture the prognostic impact of prolonged exposure. We aimed to compare the prognostic value of smoking duration and cumulative smoking intensity for mortality risk stratification in patients with chronic obstructive pulmonary disease (COPD). We analyzed data from the Korea COPD Subtype Study, an ongoing prospective multicenter cohort (NCT02800499). Smoking exposure was categorized using thresholds of 40 pack-years and 40 years of smoking duration. The primary outcome was all-cause mortality and the secondary outcome was cause-specific mortality. Among 2166 patients with COPD, 210 deaths occurred over a median follow-up of 7 years. Smoking duration ≥40 years was associated with increased all-cause mortality risk regardless of cumulative smoking intensity. Compared with patients with <40 pack-years and smoking duration <40 years, those with <40 pack-years but smoking duration ≥40 years had higher all-cause mortality risk (adjusted hazard ratio [aHR] = 1.66; 95% confidence interval [CI] = 1.01-2.73). Similarly, patients with ≥40 pack-years and smoking duration ≥40 years had increased all-cause mortality risk (aHR = 1.58; 95% CI = 1.15-2.16). In contrast, ≥40 pack-years without prolonged smoking duration was not associated with all-cause mortality. In cause-specific mortality analyses, prolonged smoking duration was also associated with increased cardiovascular and cancer-related mortality. Smoking duration was more strongly associated with mortality risk than cumulative smoking intensity alone and may provide additional prognostic information beyond pack-years for mortality risk stratification in patients with COPD.
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7. Vital study: Real-world comparison of robotic and imaging-guided bronchoscopy: Impact of real-time imaging and tool-lesion alignment on diagnostic yield.
PMID:日期:2026-10-01Accurate bronchoscopic diagnosis of peripheral pulmonary lesions remains limited by navigation challenges and CT-to-body divergence. Integrated imaging techniques, including augmented fluoroscopy (AF) and C-arm-based tomography (CABT), have improved lesion localization across both robotic and non-robotic platforms. However, real-world comparative data in community settings remain limited. We conducted a retrospective, single-operator study comparing LungVision (LV) bronchoscopy (2022-2023, n = 75) and Galaxy robotic bronchoscopy (Galaxy RB) (2024-2025, n = 105) in a community hospital. Both platforms utilized integrated AF and CABT with a standard C-arm. Primary endpoints were strict diagnostic yield (DY) at index bronchoscopy (ATS/ACCP criteria) and diagnostic accuracy at 1.5 years. Secondary analyses evaluated determinants of diagnostic success and an exploratory randomized breath-hold subgroup. Strict DY was higher with Galaxy RB compared to LV (87.6% vs 74.7%; OR 2.40, 95% CI 1.10-5.24; p = 0.03). Diagnostic accuracy at 1.5 years was also greater (97.1% vs 92%). Non-diagnostic rates were lower with Galaxy RB (12.4% vs 25.3%), with all cases resolved on follow-up. Within the Galaxy RB cohort, diagnostic success was strongly associated with AF localization (OR 10.76, p <0.001), visual tool adjustment (OR 9.57, p <0.001), and tool-lesion alignment (TIL/TTL vs NTL; OR 16.55, p = 0.040). Breath-hold was not associated with improved yield (81.4% vs 86.5%; OR 0.68, p = 0.57). In a real-world community setting using integrated imaging, robotic bronchoscopy demonstrated higher diagnostic yield and accuracy compared to a non-robotic platform. However, diagnostic success was primarily driven by effective tool-lesion alignment and real-time imaging rather than platform type or breath-hold utilization.
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8. Integrating CBC-derived inflammatory biomarkers with machine learning for discriminating stable and exacerbated COPD.
PMID:日期:2026-10-01Chronic obstructive pulmonary disease (COPD) is a leading health burden and global cause of mortality. This study aimed to assess routine blood-derived biomarkers and integrate them with machine learning (ML) to improve detection and prognosis. We conducted a retrospective analysis of 75 patients with stable and acute exacerbation COPD (AECOPD). CRP, ESR, WBC count, NLR, PLR, and LMR were compared among stable and AECOPD groups. Statistical analysis, fold-change, effect sizes, ROC-AUC, sensitivity analyses and correlation patterns were assessed. Demographic parameters including age and sex were also included in classifying biomarkers for AECOPD. Multiple ML classifiers were trained to predict disease state from biomarker patterns. NLR showed the most substantial elevation (Cohen's d = 1.60) in AECOPD patients, followed by significant increases in CRP, PLR, and WBC. LMR significantly declined, while ESR's potential to discriminate AECOPD was non-significant. Feature importance analysis consistently ranked NLR, PLR, CRP and WBC as the top predictors, while ESR exhibited the least contribution. Integration of ML models with routine CBC-derived biomarkers, showed exploratory potential for distinguishing AECOPD from the stable state. Exacerbation remained the primary driver of inflammatory changes, irrespective of age and sex. Ensemble ML models outperformed traditional approaches.
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9. Blood urea nitrogen to serum albumin ratio (BAR) predicts mortality in septic cardiomyopathy: A retrospective cohort study with external validation.
PMID:日期:2026-10-01This study aimed to investigate the prognostic value of the blood urea nitrogen-to-albumin ratio (BAR) for predicting all-cause mortality (ACM) in patients septic cardiomyopathy (SCM). An external validation was conducted in SCM patients from the Affiliated Hospital of Chengde Medical University. The results demonstrated that a higher BAR was significantly related to an increased sequential organ failure assessment (SOFA) score, a greater number of comorbidities, and worse clinical outcomes. Multiple regression analysis revealed that each unit increase in BAR was associated with a 4.1% rise in short-term mortality (OR = 1.041, P = 0.04). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for BAR in predicting in-hospital mortality was < 0. 657, which was superior to that of blood urea nitrogen (BUN) alone or the SOFA score. In subgroup analyses, BAR remained stronger predictive ability in patients without any other comorbidities, such as renal insufficiency. In conclusion, BAR is an independent factor associated with short-term mortality in patients with SCM. As an easily accessible and broadly applicable marker reflecting both renal function and nutritional status, BAR may serve as a useful supplementary parameter for early risk stratification and medical treatment of patients with SCM. Receiver operating characteristic (ROC) analysis showed that BAR had modest discrimination for in-hospital mortality, with an AUC of 0.657 in the derivation cohort. Although this value was numerically higher than that of BUN alone and the SOFA score in the primary cohort, its overall discriminative ability remained limited. In the external validation cohort, BAR showed lower but still directionally consistent prognostic performance, with an AUC of 0.583. These findings suggest that BAR may serve as a simple and readily available supplementary marker for early risk stratification in patients with SCM, but it should not be interpreted as a stand-alone prognostic tool or a replacement for comprehensive clinical assessment. Multivariable regression analysis showed that each one-unit increase in BAR was associated with a higher risk of in-hospital mortality after full adjustment (OR = 1.041, 95% CI: 1.000-1.081, P = 0.04). However, the associations between BAR and 7-day, 30-day, and 365-day mortality after ICU discharge were attenuated and were no longer statistically significant in the fully adjusted model. These findings suggest that BAR is independently associated with in-hospital mortality in patients with SCM, whereas its relationship with post-ICU mortality should be interpreted as exploratory.
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10. Radiographic outcome and impact factors in children with bronchiectasis.
10. 儿童支气管扩张症的影像学结局及其影响因素PMID:日期:2026-10-01This study aims to investigate the radiological outcomes in children with bronchiectasis under current treatment strategies through a real-world prospective observational study, and to conduct a preliminary analysis of potential influencing factors. A total of 492 pediatric patients with bronchiectasis who underwent chest HRCT were enrolled from the Children's Hospital of Chongqing Medical University between January 2018 and December 2022, with follow-up extending until June 2024. Reversible imaging changes in bronchiectasis were determined by comparing changes in chest HRCT and modified Reiff scores (MRS). Univariable logistic regression models were used to preliminarily screen for factors related to imaging prognosis; variables with a significance level of P < 0.05 were subsequently included in multivariable logistic regression models for further analysis. Ultimately, 273 eligible pediatric patients were included in the final analysis, after excluding those lost to follow-up, those without follow-up chest HRCT, and those who underwent lobectomy. Reversible imaging changes were observed in 125 patients (45.8%), comprising 72 cases (26.4%) of complete radiological remission and 53 cases (19.4%) of improvement. Conversely, 148 patients (54.2%) exhibited stable or progressive disease. Multivariable logistic regression analysis revealed that localized radiological changes were significantly associated with radiological reversibility (OR = 1.82, 95% CI 1.11-3.00; P = 0.018). Bronchiectasis associated with a genetic condition and any acute exacerbation of respiratory symptoms during follow-up showed a significant negative association with radiological reversibility (OR = 0.48, 95% CI 0.25-0.91; P = 0.028 and OR = 0.58, 95% CI 0.35-0.97; P = 0.038, respectively). Pediatric bronchiectasis is partially reversible with appropriate treatment within a reasonable follow-up period. Patients with localized radiological changes are most likely to exhibit reversible imaging changes, whereas those with comorbid genetic diseases and recurrent infections are the least likely to do so.