ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES自然研究杂志C辑：生物科学
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES(英文缩写 Z NATURFORSCH C),ISSN 0939-5075,eISSN 1865-7125,中文译名:自然研究杂志C辑：生物科学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 1.885 | Q4 |
| 2022 | 2.000 | Q4 |
| 2023 | 1.800 | Q3 |
| 2024 | 2.100 | Q3 |
| 2025 | 2.100 | Q3 |
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES 最新收录文献
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1. Multitargeted drug strategies for Alzheimer's and Parkinson's diseases.
PMID:日期:2026-08-31Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are multifactorial diseases that are characterized by several interconnected pathological mechanisms, such as the aggregation of amyloid-beta (Aβ), hyperphosphorylation of tau, accumulation of α-synuclein, oxidative stress, mitochondrial dysfunction, neuroinflammation, and neurotransmitter imbalance. Conventional single-target therapies failed to produce significant clinical effects due to the fact that they target only individual disease pathways. Thus, the multitarget-directed ligand (MTDL) strategy has become an attractive therapeutic option, and MTDLs can act on several pathological targets simultaneously. Recent advances in multitarget drug development for AD and PD targeting compounds targeting Aβ, BACE1, MAO-B, cholinesterases, metal-ion dyshomeostasis, oxidative stress, and inflammatory pathways are reviewed. A few potential candidates, such as GV-971, Prasinezumab, Huperzine A, curcumin derivatives, and hybrids of MAO-B inhibitors, have shown neuroprotective and cognitive effects in preclinical and clinical studies. There are significant advances in the clinical pipeline, with over 180 clinical trials for AD and over 130 clinical trials for PD testing multitarget or disease-modifying strategies. The review also highlights the growing importance of computer-aided drug design (CADD), artificial intelligence (AI), and machine learning (ML) in speeding up the discovery of MTDL, optimizing their pharmacokinetic profiles, and predicting multitarget interactions. However, there are still major obstacles to be overcome, such as the ability to cross the blood-brain barrier, optimizing the pharmacokinetics, the difficulties of transferring from the animal to the human model, and the complexity of the regulatory process. New strategies based on nanomedicine, biomarker-driven trials, personalized medicine, and drug repurposing will enhance therapeutic precision and clinical success.
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2. {"_":"Phytochemical profiling, antimicrobial, cytotoxic and apoptotic effects of ethanolic extract.","i":["Glycyrrhiza glabra"]}
PMID:日期:2026-06-23L. is a medicinal plant rich in bioactive compounds, yet detailed studies on its antimicrobial, cytotoxic, and apoptotic properties remain limited. This research evaluated these effects using an ethanolic extract of . The extract was prepared via Soxhlet extraction, and its chemical constituents were identified using gas chromatography-mass spectrometry (GC-MS). antimicrobial activity was tested against various microorganisms through well diffusion and microdilution methods, while minimum bactericidal and fungicidal concentrations were determined using agar plate assays. Cytotoxicity on HepG2 human hepatocellular carcinoma cells was assessed with the MTT assay. Additionally, the expression of apoptosis-related genes (, , and ) was analyzed by quantitative real-time PCR. GC-MS results revealed a total of 28 compounds, with 2,8-dimethyl-7,8-dihydro-6H-cyclohepta (18.59 %) and thiophene (16.58 %) as the major constituents. The extract showed strong antimicrobial effects, especially against Gram-positive bacteria such as , , and . Among Gram-negative strains, was the most susceptible. Cytotoxic activity against HepG2 cells was observed, with an IC value of 206.8 µg/mL. This effect was associated with increased expression of and and decreased levels, indicating apoptosis. The ethanolic extract of shows strong antimicrobial and cytotoxic potential and may be explored as a potential chemopreventive agent.
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3. Rational design and biological evaluation of naturally inspired indole-oxadiazole derivatives as potent COX inhibitors.
PMID:日期:2026-06-09Indole-oxazole and indole-oxadiazole scaffolds, inspired by natural products, provide versatile platforms for the development of selective COX inhibitors. In this study, a novel series of indol-oxadiazole derivatives was rationally designed by incorporating N-alkyl-substituted indole moieties at the 5-position and optimizing aryl substitutions at the 2-position of the oxadiazole core. The synthesized compounds were systematically evaluated for COX-1 and COX-2 inhibition , revealing potent and selective activity. The compounds exhibited potent COX inhibition, with showing balanced dual activity against COX-1 (IC = 0.198 ± 0.022 µM) and COX-2 (IC = 0.158 ± 0.028 µM), and displaying strong COX-1 inhibition (IC = 0.175 ± 0.063 µM). Celecoxib served as the reference COX-2 inhibitor (IC = 0.119 ± 0.055 µM). Molecular docking and dynamics simulations provided insights into binding interactions and the stability of the COX complex within the COX active site. Selected derivatives were well tolerated in healthy cell lines, indicating favorable safety profiles. Structure-activity relationship analysis highlighted the critical role of the indole nucleus and strategic oxadiazole substitutions in modulating COX inhibitory potency and selectivity. These findings establish indole-oxadiazoles as a promising scaffold for selective COX inhibition and a foundation for future rational drug design.
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4. Cytotoxicity and antimicrobial activity of platinum(II) complexes based on the ligand precursor 2-phenyl-6-(1,2,3-triazol-4-yl)pyridine - influence of substituent and ancillary ligand on selectivity and activity.
PMID:日期:2026-06-01The development of metal-based anticancer agents has been a significant area of research since the discovery of cisplatin's cytostatic effects. In this study, we investigate the cytotoxicity of tridentate ligands derived from 2-phenyl-6-(1,2,3-triazol-4-yl)pyridine and their platinum(II) and palladium(II) complexes against various human cancer cell lines and normal fibroblasts. Several complexes exhibit high cytotoxicity, particularly against acute T-lymphoblastic leukemia cells (CCRF-CEM). Notably, a platinum(II) complex containing an acylpyrrolidine ligand demonstrates remarkable cancer cell selectivity with a sub-micromolar IC value of 0.17 μM. Cell cycle analysis revealed that these compounds induce apoptosis and affect DNA/RNA synthesis. Additionally, some complexes show significant antimicrobial activity against Gram-positive bacteria and yeast. Our findings highlight the potential of these metal complexes as selective anticancer agents and underscore the importance of further mechanistic studies.
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5. Structure activity relationship-guided scaffold hopping for identification of novel thiadiazole derivatives as potent SARS-CoV-2 Mpro inhibitors.
PMID:日期:2026-05-22The ongoing COVID-19 pandemic has presented enormous challenges to worldwide healthcare systems, and effective therapeutic strategies must accompany mass vaccination efforts. In this context, Mpro (the main protease of SARS-CoV-2) is arguably one of the most promising molecular targets for antiviral drug development because it is responsible for processing viral polyproteins and replicating the virus. In this study, a rational design approach was employed to develop a novel series of thiadiazole-based derivatives as potential Mpro inhibitors. A total of compounds (, , and ) were synthesized through three systematically organized synthetic schemes. Each stage of the design strategy incorporated progressive structural modifications to establish a clear structure activity relationship (SAR) and enhance inhibitory potency. The synthesized compounds were evaluated for their inhibitory activity against SARS-CoV-2 Mpro. Some derivatives like (IC = 44.63 ± 1.20 µM), (IC = 39.25 ± 1.60 μM), (IC = 41.93 ± 1.90 μM), showed good inhibitory activity as compared to reference drug Nirmatrelvir (IC = 58.4 ± 8.6 μM). Molecular docking analysis supported the experimental data by confirming stable binding of the synthesized compounds within the Mpro active site through key hydrogen-bonding and hydrophobic interactions.
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6. {"_":"Monoterpene-indole alkaloid from and antidiabetic potential of its hydrochloride.","i":["Rinorea yaundensis"]}
PMID:日期:2026-05-18Chromatographic resolutions of methanolic extract of the aerial parts of led to the isolation of a new monoterpene indole alkaloid yaundentine , along with its previously reported hydrochloride and sarpagine , respectively. Moreover, compound was screened to determine its possible antidiabetic properties oral administration to streptozotocin-induced diabetic rats for 14 days. Their subsequent treatment with compound significantly reduced the blood glucose levels in comparison with control glibenclamide. It could also be validated from the significant reduction in serum lipid profile markers and elevation in HDL-C, also signify the protective effect. The histopathological evaluation further revealed that the reduced number of islet cells were restored near to normal after treatment. This study revealed that compound possesses a potential antidiabetic activity and this effect could be due to the multitarget mode of action, which enables its utility as a complementary drug for diabetes and associated complications.
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7. {"_":"Calofrasolide A, a new pyranocoumarin from the stem bark of M.R.Hend. & Wyatt-Sm. and their antimicrobial and antibiofilm activities.","i":["Calophyllum fraseri"]}
PMID:日期:2026-05-12A new pyranocoumarin, Calofrasolide A (), was isolated from the stem bark of , together with the known constituents β-sitosterol, stigmasterol, friedelin, and lupeol. The structure of the new compound was established through comprehensive spectroscopic analyses and confirmed by comparison with reported data. Compound was evaluated for antimicrobial and antibiofilm activities using microdilution and crystal-violet assays. It exhibited notable antimicrobial activity, with MIC values of 62.5 μg/mL against and . In the antibiofilm assays, compound demonstrated pronounced inhibitory effects, suppressing biofilm formation by 30.25 ± 1.04 % and biofilms by 78.37 ± 0.22 %. Molecular docking studies supported the experimental findings, revealing favourable binding (LBE = -8.5 kcal/mol) within the active sites of ERG11 (5TZ1) and GtfB (8FK4). These findings highlight Calofrasolide A as a promising pyranocoumarin scaffold with potential antimicrobial and antibiofilm relevance, particularly against oral pathogenic infections.
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8. {"_":"Elucidating the biodegradation potential of Nudix hydrolase from via different approaches.","i":["Bacillus paranthracis"]}
PMID:日期:2026-04-07The Nudix hydrolase from MBBL1 was investigated using in silico approaches. Polyfluoroalkyl substances (PFAS) are persistent environmental contaminants associated with serious health and ecological risks because of their stable chemical nature and strong resistance to breakdown. The enzyme sequence was retrieved from NCBI (Accession No. MFQ6175622.1), and its secondary structure revealed 33 alpha-helices, 50 beta-strands, and 66 coil regions, suggesting a balanced structural conformation. Tertiary structure prediction using AlphaFold3 achieved a high-confidence model with 94.5 % residues in the most favored regions of the Ramachandran plot and an ERRAT quality score of 96.99 %, validating its stereochemical reliability. Physicochemical profiling indicated a molecular weight of 17 kDa, a theoretical pI of 4.86, and a GRAVY index of -0.245, confirming its hydrophilic and slightly acidic nature. Two active-sites were predicted by PrankWeb, with Pocket 1 showing a high binding score of 6.46. Molecular docking against twelve PFAS derivatives showed favorable binding affinities ranging from -6.4 to -9.5 kcal/mol. Perfluorodecanoic acid demonstrated the strongest interaction (-9.5 kcal/mol), followed by H-PFOS (-9.0 kcal/mol) and perfluorooctanesulfonic acid (-8.8 kcal/mol). Interaction analysis identified key residues such as ALA22, THR40, ASP42, and ASN133 forming multiple hydrogen, halogen, and electrostatic bonds. These findings suggest that Nudix hydrolase may have structural and functional attributes relevant to PFAS biodegradation. Acknowledging the computational nature of this study, experimental validation will be required to confirm biodegradation activity.
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9. {"_":"Synthesis and characterization of zinc oxide nanoparticles by the aerial part of extract and assessment of their biological activities.","i":["Artemisia roxburghiana"]}
PMID:日期:2026-03-13The zinc oxide nanoparticle (ZnONPs) used in this study were synthesized using extract (aerial part). The absorption peak at 353 nm in UV spectroscopy indicates the production of zinc oxide nanoparticles. The synthesis of ZnONPs using extracts of the aerial part of . is also supported by FTIR peaks around 622 cm. DLS analysis showed the synthesis of A-ZnONPs (zinc oxide nanoparticle synthesized by extracts of aerial part ) with a particle size of 6-10 nm. XRD pattern's detection of a hexagonal crystal structure of A-ZnONPs. HRTEM image confirming the preparation of irregularly shaped A-ZnONPs. The preparation, capping, and stabilization of A-ZnONPs are facilitated by bioactive compounds in the plant's aerial parts. This gives a plant with high total phenol content (TPC) of 93.4 ± 0.53 μg GAE/mg and total flavonoid content (TFC) of 23.22 ± 0.23 μg CE/mg, both of which are responsible for antioxidant activities. A-ZnONPs exhibited more significant antioxidant activity (IC50 = 147.4 μg/mL) and antibacterial activity against , , , and . A-ZnONPs exhibited improved inhibition as their concentration increased. A maximum inhibition zone of 23 mm is observed for , suggesting that it has antibacterial and antioxidant properties to combat illnesses.
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10. {"_":"Phytochemical and antibacterial studies of the ethanolic stem barks extract of planch, and the study of its secondary metabolites on two bacteria strains and .","i":["Anthocleista vogelii","in silico","Staphylococcus aureus","Salmonella typhi"]}
PMID:日期:2026-03-12This study investigates the phytochemical composition, antibacterial efficacy, and molecular interactions of stem barks extracts. Phytochemical screening revealed the presence of flavonoids, alkaloids, triterpenes, phenols, saponins, and other bioactive compounds in 95 % ethanol and hydro-ethanol extracts, while coumarins, steroids, and anthraquinones were absent in aqueous extracts. The 95 % ethanol extract demonstrated significant antibacterial activity against (MIC: 64 μg/mL) and (MIC: 8 μg/mL), with moderate effects against , , and Spp. (MIC: 512 μg/mL). Bactericidal activity (MBC/MIC ≤ 4) paralleled ciprofloxacin, particularly against Gram-positive pathogens. LC-MS analysis identified nine bioactive flavone derivatives, including fabiatrin, kaempferitrin, quercitrin, and naringin. Molecular docking revealed these compounds exhibited superior binding affinities (-6.6 to -11.7 kcal mol) to and targets compared to ciprofloxacin (-3.6 to -5.4 kcal mol), forming hydrogen bonds and -interactions critical for inhibition. ADMET predictions indicated poor gastrointestinal absorption and AMES toxicity risks but favorable plasma protein binding and cardiac safety. Frontier Molecular Orbital (FMO) analysis highlighted quercetin's high reactivity (ΔEgap: 3.70 eV) and naringin's stability. These findings position as a rich source of antimicrobial phytochemicals, though further optimization is needed to address pharmacokinetic limitations.