PERIODONTOLOGY 2000牙周病学2000
PERIODONTOLOGY 2000(英文缩写 PERIODONTOL 2000),ISSN 0906-6713,eISSN 1600-0757,中文译名:牙周病学2000 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 12.239 | Q1 |
| 2022 | 18.600 | Q1 |
| 2023 | 17.500 | Q1 |
| 2024 | 15.700 | Q1 |
| 2025 | 17.800 | Q1 |
PERIODONTOLOGY 2000 最新收录文献
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1. Potential impact of persistent hyperglycemia on platelet-rich fibrin mediated regeneration of periodontal and peri-implant tissues: Biological mechanisms and clinical implications.
PMID:日期:2026-09-26Platelet-rich fibrin (PRF) has emerged as a widely utilized autologous biomaterial in periodontal and peri-implant regenerative therapy owing to its ability to provide a three-dimensional fibrin scaffold enriched with platelets, leukocytes, growth factors, and cytokines. However, persistent hyperglycemia (as observed in patients with poorly controlled diabetes mellitus) induces oxidative stress in oral and systemic tissues and impairs angiogenesis and extracellular matrix remodeling. To provide an overview of the potential impact of persistent hyperglycemia on PRF-mediated regeneration of periodontal and peri-implant tissues, and to gain an in-depth understanding of the underlying biological mechanisms and their clinical implications. The research question was "Does a state of persistent hyperglycemia affect PRF-mediated periodontal and peri-implant tissue regeneration?" Indexed databases and Google Scholar were searched without time and language barriers up to and including August 2026. The pattern of the present study was customized to summarize the pertinent studies. Evidence evaluating the impact of persistent hyperglycemia on PRF remains limited and is largely confined to ex vivo, in vitro, and observational studies. Nevertheless, the available data consistently suggest that poorly controlled diabetes mellitus is associated with alterations in PRF architecture, including increased porosity, reduced clot dimensions, diminished PRF yield, and a less organized fibrin meshwork. Limited evidence also indicates that although growth factor release from PRF may be preserved under hyperglycemic conditions, PRF obtained from individuals with well-controlled diabetes mellitus shows structural and biological characteristics that closely resemble those observed in systemically healthy individuals. This suggests that regenerative capacity may be preserved when glycemic levels are adequately controlled. This supports the idea that the regenerative capacity of PRF may be preserved when glycemic levels are adequately maintained. Glycemic control appears to be a key determinant of PRF quality and regenerative outcomes. Nevertheless, the lack of prospective clinical studies evaluating direct regenerative outcomes highlights the need for well-designed clinical trials to clarify the influence of persistent hyperglycemia on PRF-mediated periodontal and peri-implant regeneration. Persistent hyperglycemia may compromise the regenerative potential of PRF primarily through alterations in fibrin architecture, which may further lead to faster clot breakdown and impairment of biological responsiveness within a chronically inflammatory environment. However, limited data to date suggest that effective glycemic control and patient education may help preserve PRF characteristics favorable for periodontal and peri-implant tissue regeneration.
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2. Antiresorptive therapy influence on peri-implant diseases: Clinical implications and osteoimmunological perspectives.
PMID:日期:2026-09-16Antiresorptive therapy represents a cornerstone in the management of osteoporosis and cancer-related bone disease through suppression of osteoclast-mediated bone resorption. As implant therapy becomes more common in aging populations, clinicians increasingly encounter patients receiving these medications, thus making their impact on peri-implant tissues clinically relevant. This narrative review critically examines clinical evidence on implant survival, peri-implant bone stability, peri-implantitis progression, and treatment considerations in patients receiving antiresorptive therapy, while integrating mechanistic insights. Evidence suggests that implant survival and marginal bone loss in osteoporotic patients are generally comparable to untreated individuals, indicating that suppression of bone resorption does not inherently compromise osseointegration. However, these outcomes may not fully reflect peri-implant tissue dynamics. Antiresorptives alter osteoclast functions and bone remodeling, potentially affecting the osteoimmune balance required to adapt to mechanical and oral microbial challenges. While these effects may remain subclinical under healthy conditions, they may become relevant during chronic peri-implant inflammation or repeated surgical interventions, where remodeling demands are increased. Altered remodeling may result in lesion persistence, impaired structural recovery, and late complications. Although medication-related osteonecrosis of the jaw remains rare, antiresorptives may modify osteoimmune interactions within inflamed tissues. Therefore, peri-implantitis may act as a contextual modifier influencing healing outcomes. Antiresorptive therapy should not be regarded as an absolute contraindication to implant therapy in appropriately selected patients, particularly those receiving osteoporosis-dose regimens. However, chronic peri-implant inflammation, repeated surgical intervention, and high-dose oncologic antiresorptive exposure may impair osteoimmune adaptation and increase susceptibility to delayed healing and MRONJ-related complications. Early control of peri-implant inflammation, individualized risk stratification, and strict supportive maintenance should be considered central components of clinical management in antiresorptive-exposed patients.
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3. From mouth to brain: Linking periodontal and peri-implant dysbiosis to systemic inflammation and neuropathology.
PMID:日期:2026-09-16Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases. A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was conducted to explore the associations among oral dysbiosis, including periodontitis and peri-implantitis, a low-grade inflammatory phenotype, and biological pathways that may contribute to the onset of neuroinflammation and neuropathologies. Periodontitis is a chronic inflammatory non-communicable disease driven by subgingival dysbiosis, increasingly linked not only to progressive bone and tooth loss but also to a broad range of systemic chronic non-communicable diseases. Indeed, the persistent burden of deregulated chronic inflammation not only exacerbates periodontal tissue destruction but also promotes a low-grade inflammatory phenotype that may predispose patients to a spectrum of degenerative diseases, such as neurodegenerative disorders. In contrast, evidence regarding peri-implantitis remains comparatively limited and indirect, although emerging data indicate potential systemic inflammatory and cognitive implications. Elucidating the intricate interactions between oral dysbiosis, periodontal diseases, chronic inflammation, and neurodegeneration is essential for understanding oral health's systemic implications for neurodegenerative and age-related diseases. Current evidence supports an association between oral dysbiosis, chronic oral inflammation, and pathways relevant to neurodegeneration, particularly for periodontitis. However, important knowledge gaps remain, especially concerning peri-implant diseases, where human data are limited. Effective management strategies targeting periodontal and peri-implant dysbiosis and restoring the immune imbalance may offer novel avenues for promoting healthy aging and preventing neuropathic morbidities.
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4. Efficacy and clinical indications of adjunctive chlorhexidine mouthrinses in nonsurgical and surgical periodontal therapy: A systematic review and meta-analysis.
PMID:日期:2026-09-15To evaluate the adjunctive effects of chlorhexidine (CHX) mouthrinses in nonsurgical and surgical periodontal therapy on periodontal parameters and postoperative wound healing, and to define their clinical indications. Two PICOS frameworks guided the inclusion of randomized controlled trials assessing CHX versus placebo/no rinse as an adjunct in nonsurgical and surgical periodontal therapy. A systematic search was conducted in Medline, EMBASE, Cochrane Library, Scopus, and Web of Science. Random-effects meta-analyses were performed for nonsurgical therapy; heterogeneity precluded quantitative synthesis for surgical outcomes. Risk of bias, sensitivity analyses, influence diagnostics, and GRADE assessments were applied. Twenty RCTs were included. In nonsurgical therapy, CHX produced statistically significant but clinically modest improvements in probing pocket depth (PPD) (MD -0.30 mm; 95% CI -0.50 to -0.09) and BOP (MD -9.35 percentage points; 95% CI -14.17 to -4.53), while no meaningful benefit was observed for CAL. Prediction intervals indicated limited reliability of PPD effects. In surgical therapy, CHX was associated with improved early postoperative inflammatory control, without evidence of superior long-term wound healing. Adjunctive CHX in nonsurgical periodontal therapy provides modest but outcome-specific benefits, mainly limited to inflammatory parameters, with no clear additional effect on attachment outcomes. In surgical therapy, the qualitative analysis seems to support early postoperative plaque control and inflammation control, while evidence for an effect on later healing remains limited.
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5. Understanding exosomes: A history of EV-erything.
PMID:日期:2026-09-08Extracellular vesicles (EVs), including exosomes, have emerged as fundamental regulators of cell-to-cell communication and are increasingly recognized for their therapeutic and diagnostic promise. While EV research has expanded remarkably over the past two decades, the discipline is rooted in a much longer history of observations, conceptual progress, and technological innovations that gradually transformed the comprehension of these nanosized particles. This review offers a historical perspective on the evolution of EV biology, underscoring the pivotal discoveries, researchers, and community-mediated initiatives that have shaped the contemporary domain. A narrative review of the literature was conducted to assess major milestones in EV research, from the earlier descriptions of cell-free particulate material to modern progress in EV biology, standardization, and translational medicine. Particular emphasis was placed on landmark investigations that redefined the biological importance of EVs and on the development of international frameworks that enhanced reproducibility and methodological rigor. Early studies characterized EV-like particles as sedimentable plasma components or cellular waste, culminating in Peter Wolf's description of "platelet dust" in 1967. Subsequent research by Crawford, Johnstone, Stahl, Raposo, Ratajczak, and others established EVs as bioactive structures contributing to vesicle biogenesis, antigen presentation, and horizontal gene transfer of genetic information. Progress in particle characterization, molecular profiling, and imaging approaches further demonstrated EVs as intricate carriers of proteins, lipids, metabolites, and nucleic acids capable of mediating diverse physiological and pathological mechanisms. In parallel, the establishment of the International Society for Extracellular Vesicles (ISEV) and the successive MISEV guidelines offered a pivotal foundation for standardization, transparency, and reproducibility across the discipline. The history of EV research reflects a remarkable transition from observations of poorly understood extracellular particles to the recognition of EVs as key modulators of biological communication and potential therapeutic systems. As technological capabilities, standardization efforts, and translational applications continue to advance, EVs are poised to play an increasingly important role in the future of precision medicine.
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6. Dentifrice formulations for the treatment of dentin hypersensitivity: A systematic review and network meta-analysis.
PMID:日期:2026-08-31To update the evidence on the comparative effectiveness of self-applied dentifrices for the treatment of dentin hypersensitivity (DH) using systematic review and network meta-analysis methodology. Randomized controlled trials evaluating self-applied dentifrices in adults with a diagnosis of DH were identified through literature searching of OvidSP versions of Medline, EMBASE and the Cochrane Library from November 2022-July 2025, supplemented by records obtained in a previous review and manual citation searching. Outcomes were assessed using validated measures including evaporative cold, tactile and thermal cold stimuli. Random-effects frequentist network meta-analyses were conducted for outcomes measured at 2 weeks. Risk of bias was assessed using the RoB 2 and certainty of evidence evaluated using the CINeMA framework. Ninety-three studies (9548 participants) were included, with 47 studies (4636 participants) contributing to the network meta-analyses. In consolidating findings across different outcome measurements we found stannous fluoride and arginine-based dentifrices consistently demonstrated the most clinically meaningful reductions in DH symptoms compared with a benchmark fluoride dentifrice across evaporative cold (Stannous Schiff MD -0.85 (95% CI -1.08; -0.62), high confidence rating; Arginine MD -0.78 (95% CI -1.02, -0.54), low confidence rating) and tactile (Stannous Yeaple MD 14.87 (95% CI 10.24, 19.50), moderate confidence rating; Arginine MD 9.78 (95% CI 4.69, 14.86), low confidence rating) outcomes. High-certainty evidence supported stannous fluoride for evaporative cold outcomes, while arginine demonstrated comparable effect sizes with lower certainty. Other formulations showed small to moderate effects with generally low certainty when compared with a benchmark fluoride dentifrice at 2 weeks. Stannous fluoride and arginine dentifrices should be considered first-line self-care options for DH. Clinicians can recommend the use of stannous fluoride or arginine dentifrices as first-line treatment for DH, with choice guided by patient preference, tolerability and availability rather than expectation of superior efficacy.
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7. Mapping the omics landscape for peri-implant diseases: A scoping review.
7. 绘制种植体周围疾病的组学图谱：一项范围综述PMID:日期:2026-08-31To map omics evidence across peri-implant health, peri-implant mucositis, and peri-implantitis, and to identify recurring molecular patterns and candidate biomarker signals relevant to diagnosis, monitoring, and treatment. This scoping review included human studies using genomics, DNA methylation-based epigenomics, bulk and single-cell transcriptomics, non-coding RNA analyses (including miRNA, lncRNA, and circRNA), proteomics, metabolomics, and microbiome profiling. Findings were organized by clinical state (health, mucositis, peri-implantitis) and interpreted within an implant-conditioned niche shaped by microbial, host, and biomaterial-related influences. Of 319 records identified, 78 studies were included. Most focused on genomics, transcriptomics, and the microbiome, with fewer studies in DNA methylation-based epigenomics, proteomics, and metabolomics. Peri-implant health was generally associated with oxygen-tolerant, biosynthetically active microbial communities and a regulated host-response baseline. Peri-implant mucositis appeared to be an intermediate plaque-induced state marked by expansion of bridge anaerobes and early innate inflammatory activation, but it was under-represented in transcriptomic, proteomic, and epigenomic datasets. Peri-implantitis was associated with stronger coupling between dysbiosis and host-destructive responses, including recurrent innate inflammatory hubs, chemokine-driven myeloid recruitment, protease activity, osteo-immune imbalance, and catabolic metabolomic profiles enriched in polyamines and short-chain fatty acids. DNA methylation studies linked disease status, and in limited cohorts, titanium particle burden, with altered methylation patterns. Non-coding RNA studies suggested additional regulatory networks related to inflammation and bone-associated signaling. Treatment studies indicated that decontamination may reduce bacterial biomass on rough titanium surfaces, but it does not consistently eliminate residual biofilm, suggesting biological improvements may reflect ecological shifts rather than complete surface decontamination. Current omics evidence suggests that peri-implant disease follows a staged, implant-conditioned biological trajectory rather than a simple binary healthy/diseased model.
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8. Understanding extracellular vesicles in antiaging.
PMID:日期:2026-08-31Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell-to-cell communication with potential roles in both enhancing and alleviating aging. This review aimed to synthesize existing literature on the mechanistic and therapeutic role of EVs in aging and age-associated disorders. A comprehensive narrative review was performed utilizing Web of Science, Scopus, and PubMed databases. Studies assessing EVs in aging, cellular senescence, regenerative biology, and age-related disorders were included. Both preclinical and clinical studies were qualitatively examined, emphasizing EV origin, molecular pathways, and treatment outcomes. EVs derived from young or stem cells show strong antiaging features across multiple systems, such as the immune, musculoskeletal, cardiovascular, and nervous systems. These impacts are regulated via mitigating cellular senescence, reestablishing mitochondrial activity, restoring mitophagic and autophagic signaling, regulating inflammatory signaling, and improving tissue regeneration. Contrarily, EVs from diseases or aged cells improve pro-aging phenotypes, such as inflammation, fibrosis, and metabolic dysregulation, underscoring their context-mediated duality. Preclinical evidence consistently supports EV-mediated therapies; nonetheless, clinical translation remains restricted owing to heterogeneity in EV subpopulations, lack of standardized isolation protocols, and variability in bioactive payload. EVs represent promising therapeutic agents and biomarkers in aging biology, with the potential to regulate multiple hallmarks of aging concurrently. Prospective research should prioritize standardization, targeted bioengineering, and rigorous clinical validation to allow successful antiaging interventions.
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9. Flapless submucosal instrumentation treatment of peri-implantitis: Contemporary evidence and clinical protocol.
PMID:日期:2026-08-31Peri-implantitis is a plaque-associated disease characterized by inflammation of the peri-implant mucosa and progressive loss of supporting bone, representing a growing clinical and public health challenge. Conventional nonsurgical therapies often provide limited and unpredictable outcomes, while surgical approaches are associated with increased morbidity and variable long-term success. In this context, minimally invasive strategies, particularly flapless submucosal instrumentation, have emerged as a potential alternative or adjunct in the management of peri-implantitis. The aim of this narrative review is to critically appraise the contemporary evidence on flapless treatment approaches for peri-implantitis. This narrative review analyzes the available literature on flapless submucosal instrumentation for peri-implantitis, presented as a minimally invasive access approach performed without flap elevation that combines submarginal instrumentation with deliberate peri-implant degranulation/curettage to improve access to the defect and implant surface, and may be considered in treatable, selected peri-implantitis cases within a stepwise care pathway. The biological rationale for flapless therapy is discussed based on the histopathological characteristics of peri-implant lesions, emphasizing the role of inflamed peri-implant soft tissues as a persistent reservoir of infection. Current mechanical, chemical, and adjunctive modalities employed within flapless protocols are reviewed. Clinical, radiographic, systemic, and patient-reported outcomes associated with flapless treatment approaches are examined. In addition, indications, limitations, and prognostic factors-including defect morphology, implant surface characteristics, prosthetic design, and patient-related risk factors-are analyzed. Although the available evidence remains heterogeneous and is largely derived from nonrandomized studies, flapless submucosal instrumentation appears to be a biologically sound and minimally invasive option for selected peri-implantitis cases, which may be repeated when clinically indicated while acknowledging heterogeneous protocols and limited comparative evidence. Flapless submucosal instrumentation may reduce the need for more extensive surgical interventions. Practical clinical recommendations and step-by-step treatment algorithms are proposed to support evidence-based and patient-centered decision-making in the management of peri-implantitis.
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10. Individualized healing significantly improves pink esthetics around immediate single implants: A systematic review and meta-analysis.
PMID:日期:2026-08-31This systematic review and meta-analysis aimed to compare soft and hard tissue outcomes of applying anatomic healing abutments (AHA) and provisional restorations (PR) versus cylindrical healing abutments (CHA) on immediately placed single implants. Four databases (PubMed, Embase, Cochrane, and Web of Science) were searched on September 8, 2025, for two-armed studies comparing AHA/PR to CHA on immediate single-tooth implants. Outcomes included implant survival (IS), marginal bone loss (MBL), pink esthetic score (PES), patient satisfaction, as well as buccal bone and mucosal changes. Random-effects meta-analyses were performed. Twenty studies were included; 12 contributed to quantitative synthesis, showing no difference in IS (over 99% in all groups), MBL, or patient satisfaction. Pooled analysis of seven studies (340 implants) showed higher PES with AHA and PR than CHA group at 1 year (MD: 2.54; 95% CI: 1.12-3.96). Descriptive evidence suggested a trend toward improved horizontal tissue preservation with individualized healing. Within the limitations of this study, PR significantly improved PES without compromising IS or MBL. Their use may be beneficial, especially in the esthetic region, but further studies are needed to investigate their cost-effectiveness and long-term effect, especially on horizontal tissue changes. Anatomically shaped healing abutments and provisional restorations provide higher pink esthetics around immediately placed single implants, which is especially relevant for restorations in the anterior region.