JOURNAL OF LIPOSOME RESEARCH脂质体研究杂志
JOURNAL OF LIPOSOME RESEARCH(英文缩写 J LIPOSOME RES),ISSN 0898-2104,eISSN 1532-2394,中文译名:脂质体研究杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.586 | Q1 |
| 2022 | 4.400 | Q2 |
| 2023 | 3.600 | Q2 |
| 2024 | 4.300 | Q1 |
| 2025 | 4.700 | Q1 |
JOURNAL OF LIPOSOME RESEARCH 最新收录文献
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1. Pharmacokinetic comparisons between liposome formulation and non-liposome formulation of omega-3 fatty acids: a randomized clinical study.
1. 脂质体配方与非脂质体配方ω-3脂肪酸的药代动力学比较：一项随机临床研究PMID:日期:2026-10-01This study was registered with the Clinical Research Information Service (KCT 0011550).
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2. Liposomal nanoparticle mediated gene modulation for the treatment of melanoma in murine models.
PMID:日期:2026-10-01Melanoma is a treatment-resistant and highly aggressive form of skin cancer. The aberrant activation of the Wnt/β-catenin pathway is a key driver of proliferation, tumor progression, and metastasis in many cancers, including melanoma. The active involvement in tumor growth and immune evasion makes the Wnt/β lipoplexes-catenin pathway a critical therapeutic target. Recent advancements in gene delivery systems, such as liposomal nanoparticles (LNPs), have opened new possibilities for targeted cancer therapies by efficiently delivering genetic material, including microRNA (miRNA), to cancer cells with minimal off-target effects. Among potential gene-based therapies, miR-124 has emerged as a promising candidate for targeting the Wnt/β-catenin pathway. However, a major challenge in miRNA-based therapeutics is the efficient delivery of miRNA to tumor cells. By using cationic liposomes to form lipoplexes with miR-124 plasmids, we aim to evaluate the efficiency of lipoplex-mediated delivery and transfection in both in vitro and in vivo melanoma models and observe their effects on WNT/β-catenin signaling and tumor growth. The application of lipoplexes in gene-based therapies represents a promising approach to improve treatment outcomes for melanoma patients.
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3. Optical assay interference and temporal redox retention in liposome-associated Trolox under mixed-metal stress.
3. 混合金属胁迫下脂质体相关Trolox的光学测定干扰与时间氧化还原保留PMID:日期:2026-09-19Absorbance-based antioxidant assays are widely used to characterize liposomal formulations, yet lipid vesicles scatter light and can contribute signal unrelated to redox activity. Using Trolox as a model antioxidant, we examined how liposome association alters the measured redox response over time, and how carrier-dependent optical interference affects its interpretation under a mixed-metal stress challenge. Free Trolox, empty liposomes and liposome-associated Trolox were followed over 0-48 h without and with a commercial 23-element metal mixture (10-1000 µg/L total), using dithiothreitol (DTT), Cupric Reducing Antioxidant Capacity (CUPRAC), Trolox Equivalent Antioxidant Capacity (TEAC) and Folin-Ciocalteu assays with parallel turbidity, plus a composition-matched physical mixture in an exploratory panel. Empty liposomes, containing no antioxidant, gave TEAC and Folin signals exceeding free Trolox and shared the same principal-component region as liposome-associated Trolox, so the combined axis reflects a redox-optical response rather than antioxidant capacity. DTT provided the clearest separation between the free-Trolox response and the empty-carrier background (free/empty ≈ 3.3), although it remained associated with turbidity. Without metal, the liposome-associated form declined more slowly on DTT (retention 0.89 versus 0.62). The metal mixture reduced the DTT response to near-background levels at every tested non-zero dose and exerted a dominant negative effect across the multichannel model. At 1000 µg/L, liposome-associated Trolox and the physical mixture were indistinguishable, showing no association-specific benefit. Empty-carrier, turbidity and composition-matched controls are essential to avoid overestimating liposomal antioxidant activity.
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4. Reduction-responsive cationic bolaamphiphile vesicles as a versatile platform for photodynamic and chemotherapeutic delivery.
4. 还原响应型阳离子双亲性bola型胶束囊泡作为光动力和化疗递送的多功能平台PMID:日期:2026-09-02A reduction-sensitive cationic bolaamphiphile bearing N-methylpyridinium terminal groups and a central disulfide bridge was synthesized and shown to self-assemble in water into stable vesicles with diameters of 200-250 nm. The vesicles undergo redox-triggered disassembly in the presence of tris(2-carboxyethyl)phosphine (TCEP), and analogous behavior was also observed using glutathione (GSH), supporting their responsiveness to reductive environments. Their potential as nanocarriers was evaluated using the photosensitizer Rose Bengal (RB) and the chemotherapeutic agents paclitaxel (PTX) and camptothecin (CPT) in A549, HT29, and MCF7 cancer cell lines. The vesicles significantly enhanced the cellular uptake of RB, as demonstrated by flow cytometry and confocal microscopy. Colocalization analysis with MitoTracker Green further supported preferential mitochondrial localization of RB fluorescence. This was accompanied by a pronounced increase in photodynamic activity upon light irradiation in A549 and MCF7 cells, where apoptosis was identified as the dominant cell-death pathway. In addition, vesicle-based formulations of PTX and CPT improved their cytotoxicity across all tested cell lines, with a particularly strong effect observed in HT29 cells under the experimental conditions employed. Overall, these pyridinium-based bolaamphiphilic vesicles represent a versatile redox-responsive delivery platform capable of enhancing intracellular delivery and therapeutic performance of both photosensitizers and poorly water-soluble anticancer drugs.
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5. Influence of polyglycerol versus polyethylene glycol coatings on the physicochemical properties and biological performance of liposomes.
PMID:日期:2026-08-28In recent years, polyglycerol (PG) has received much attention as an alternative to polyethylene glycol (PEG) with adequate biocompatibility and multifunctionality. However, systematic studies comparing the effects of PG- and PEG- coatings on liposomal properties are still lacking, which might provide more insights into their capacity for drug delivery. In this study, polyglycerol (10) stearate (PG-10-MS) was compared with polyethylene glycol (20) stearate (PEG-20-MS) in terms of how these two types of polymeric modifications influenced the physicochemical properties and biological functions of liposomes, with identical hydrophobic anchoring groups and comparable molecular weights for the polymeric moieties. The results demonstrated that both PEGylated and PGylated liposomes possessed excellent physical stability, reduced macrophage uptake , and prolonged circulation half-life . Although both polymers conferred hydrophilicity to the liposome surface, they exerted opposing effects on lipid membrane fluidity. On the other hand, PGylated liposomes exhibited superior erythrocyte compatibility, and cytotoxicity was relatively low. Following drug loading, both liposomal formulations showed comparable antitumor efficacy and . Collectively, these findings indicated that PGylation showed even superior blood compatibility and comparable drug delivery efficacy to PEGylation, underscoring the potential of PG-based polymers as viable alternatives to PEG.
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6. {"_":"Mitigating breast cancer with a transdermal formulation of letrozole-loaded transbilosomes: and studies.","i":["in vitro","in vivo"]}
6. {“_”：“用来曲唑经皮转运体制剂减轻癌症：和研究。”，“i”：[“体外”，“体内”]}PMID:日期:2026-08-19Letrozole (LTZ), an aromatase inhibitor, is commonly prescribed to patients with breast cancer (BC). LTZ can induce apoptosis and inhibit tumor angiogenesis. Despite its high efficacy, LTZ is hindered by significant side effects, low bioavailability, and poor solubility, all of which limit its overall effectiveness. The aim of this study was to develop a transdermal formulation of LTZ-loaded transbilosomes (LLT) for treatment of BC. This new formulation can lessen LTZ's toxicity while increasing its solubility, targeting, and efficacy. Multiple LLT formulations were created and tested using Design Expert software to select the optimal one. A DMBA rat model was used to evaluate the efficacy, targeting, and safety of the optimal LLT formulation. The optimal LLT formulation decreased drug release by 69.25%, compared to free LTZ. Compared to the disease group, the tumor volume in the transdermal LLT group decreased by 97.65%. The transdermal LLT formulation increased LTZ accumulation in the tumor by 4.7-fold. Histopathological and toxicity studies confirm the antiproliferative effects and safety of the transdermal LLT formulation. These findings support the potential of transdermal LLT formulation to be an effective and safe treatment for BC.
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7. Next-generation delivery systems for coenzyme Q10: trends in nanovesicles, penetration enhancers, and bioactivity optimization.
7. 辅酶Q10的下一代递送系统：纳米囊泡、渗透促进剂与生物活性优化的趋势PMID:日期:2026-08-18Coenzyme Q10 (CoQ10), a lipophilic benzoquinone essential for mitochondrial energy metabolism and intrinsic antioxidant defense, exhibits substantial therapeutic potential in cardiovascular, neurological, dermatological, and metabolic disorders. However, its pronounced hydrophobicity, high molecular weight (863.34 g/mol), thermolability, and extremely poor aqueous solubility significantly limit its oral and topical bioavailability, rendering conventional formulations insufficient for optimal therapeutic outcomes. This review provides a contemporary overview of advanced delivery strategies designed to overcome these limitations, with a primary focus on nano-vesicular drug delivery systems and bioavailability enhancement approaches. The physicochemical and biological characteristics of CoQ10 are discussed to clarify the major barriers restricting its effective administration. Particular emphasis is placed on nano-vesicular platforms, including niosomes, transfersomes, ethosomes, transethosomes, phytosomes, and cubosomes, highlighting their structural attributes, encapsulation efficiency, permeability enhancement, and reported preclinical and clinical outcomes. Additionally, complementary penetration-enhancing approaches, such as chemical permeation enhancers, microneedles, iontophoresis, and biomimetic or hybrid systems, are examined for their role in improving CoQ10 delivery. The relationship between formulation design and biological performance is critically evaluated to provide mechanistic insight into therapeutic enhancement. Available clinical evidence suggests improved systemic absorption and therapeutic efficacy of CoQ10 through lipid-based and nano-vesicular systems, particularly liposomal and phytosomal formulations. Finally, key translational challenges, including formulation stability, biological barriers, manufacturing scalability, and regulatory considerations, are discussed alongside emerging trends such as stimuli-responsive nanocarriers, mitochondria-targeted systems, and computationally guided formulation development. Collectively, these advances highlight the potential of nano-enabled delivery systems to overcome CoQ10 pharmacokinetic limitations and facilitate future clinical translation.
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8. Comparative evaluation of nephrotoxicity and antibacterial activity of free and liposomal gentamicin in rats: Biochemical, molecular and histopathological analysis.
8. 游离与脂质体庆大霉素大鼠肾毒性及抗菌活性的比较评价：生化、分子与组织病理学分析PMID:日期:2026-08-11[中文摘要] 庆大霉素是一种广泛使用的氨基糖苷类抗生素，但其临床应用受到剂量依赖性肾毒性的限制。脂质体药物递送系统可在保留抗菌疗效的同时降低毒性。本研究旨在在大鼠模型中比较评价游离庆大霉素与脂质体庆大霉素的肾毒性和抗菌作用。大鼠分为对照组、游离庆大霉素组（FGT；100 mg/kg）和脂质体庆大霉素组（LipGT；100 mg/kg），给药7天。分析肾功能参数、氧化应激生物标志物、促炎细胞因子、肾损伤标志物及基因表达水平。游离庆大霉素显著升高血清BUN和肌酐水平、氧化应激、炎性细胞因子及肾损伤生物标志物。脂质体庆大霉素减轻了这些改变，表现出保护作用。肌酐水平显示部分恢复正常，而BUN表现出不同的反应。脂质体治疗部分恢复了SIRT3表达，但未使PAX2恢复正常。组织病理学结果支持上述结果。抗菌分析显示，对大肠埃希菌的活性得以保留，但对金黄色葡萄球菌的效力降低。脂质体包封减轻了庆大霉素诱导的肾毒性，同时部分维持了抗菌活性，提示这是一种提高药物安全性的有前景的策略。
[英文摘要] Gentamicin is a widely used aminoglycoside antibiotic; however, its clinical use is limited by dose-dependent nephrotoxicity. Liposomal drug delivery systems may reduce toxicity while preserving antibacterial efficacy. This study aimed to comparatively evaluate the nephrotoxic and antimicrobial effects of free and liposomal gentamicin in a rat model. Rats were divided into control, free gentamicin (FGT; 100 mg/kg), and liposomal gentamicin (LipGT; 100 mg/kg) groups administered for 7 days. Renal function parameters, oxidative stress biomarkers, pro-inflammatory cytokines, renal injury markers, and gene expression levels were analyzed. Free gentamicin significantly increased serum BUN and creatinine levels, oxidative stress, inflammatory cytokines, and renal injury biomarkers. Liposomal gentamicin attenuated these alterations, demonstrating a protective effect. Creatinine levels showed partial normalization, whereas BUN exhibited a distinct response. Liposomal treatment partially restored SIRT3 expression but did not normalize PAX2. Histopathological findings supported these results. Antimicrobial analysis revealed preserved activity against Escherichia coli but reduced efficacy against Staphylococcus aureus. Liposomal encapsulation mitigates gentamicin-induced nephrotoxicity while partially maintaining antibacterial activity, suggesting a promising strategy to improve drug safety.
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9. Repurposed Axitinib delivered via lipid-extruded PEGylated liposomes: 2D/3D breast cancer cell evaluation and in-vivo pharmacokinetics.
9. 通过脂质挤出聚乙二醇化脂质体递送老药新用的阿昔替尼：二维/三维乳腺癌细胞评价及体内药代动力学研究PMID:日期:2026-08-06[中文摘要] 聚乙二醇化脂质体纳米载体已成为一种有前景的药物递送平台，可改善难溶性抗癌药物的药代动力学性能和全身循环。本研究制备了载阿昔替尼的聚乙二醇化脂质体（F11-PEGliposome），并评估其治疗乳腺癌的潜力。采用Box-Behnken设计优化制备脂质体，随后通过脂质挤出法进行挤出，获得囊泡粒径为158.6±2.4 nm、PDI为0.12±0.01、zeta电位为-1.2±0.5、包封率为79.9±1.8%。在二维细胞培养研究中，F11-PEGliposome显示出增强的抗癌活性，IC值分别比游离阿昔替尼低1.7倍和2.13倍。细胞摄取、ROS生成、JC-1线粒体膜电位和AO/EB染色实验显示其内化增强并诱导凋亡。在三维球体模型中，F11-PEGliposome表现出对肿瘤的深度穿透、显著的生长抑制、增加的ROS产生以及明显的凋亡性细胞死亡。药代动力学和生物分布研究显示其循环时间延长、生物利用度提高、半衰期延长。组织病理学评价及血清AST、ALT、肌酐和BUN水平降低表明肝毒性和肾毒性减轻。Western blot分析显示cleaved caspase-3和cleaved PARP1呈剂量依赖性增加，支持凋亡的结论。
[英文摘要] PEGylated liposomal nanocarriers have emerged as a promising drug delivery platform for improving the pharmacokinetic performance and systemic circulation of poorly water-soluble anticancer drugs. In this study, Axitinib-loaded PEGylated liposomes (F11-PEGliposome) were prepared and evaluated for the potential treatment of breast cancer. Liposomes were prepared by optimization with a Box-Behnken design and subsequently extruded using lipid extrusion to obtain a vesicle size of 158.6 ± 2.4 nm, PDI of 0.12 ± 0.01, zeta potential of -1.2 ± 0.5, and entrapment efficiency of 79.9 ± 1.8%. In 2D cell culture studies, F11-PEGliposome showed enhanced anticancer activity with IC values of 1.7- and 2.13-fold lower than free Axitinib. Cellular uptake, ROS generation, JC-1 mitochondrial membrane potential, and AO/EB staining assays exhibited enhanced internalization and apoptosis induction. In 3D spheroid models, F11-PEGliposome exhibited deep penetration in the tumor, significant growth inhibition, increased ROS production, and pronounced apoptotic cell death. pharmacokinetic and biodistribution studies showed extended circulation, enhanced bioavailability, and prolonged half-life. Reduced hepatic and renal toxicity was evident as shown by histopathological evaluation and decreased serum AST, ALT, creatinine, and BUN levels. Western blot analysis revealed dose-dependent increases of cleaved caspase-3 and cleaved PARP1, supporting the conclusion of apoptosis.
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10. A quality-by-design engineering strategy for hybrid lipid-random copolymer nanoparticles optimization: methotrexate loading and effectiveness studies.
10. 混合脂质-无规共聚物纳米粒子优化的质量源于设计工程策略：甲氨蝶呤负载及有效性研究PMID:日期:2026-07-21The quality by design approach supports the rational development of pharmaceutical formulations. This strategy is particularly valuable in the case of hybrid nanoparticles, where complex molecular interactions pose challenges to predictability, control, and therapeutic performance. In this study, based on preliminary findings, hybrid nanoparticles were developed and optimized using 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine and a statistical (random) copolymer, composed of oligo (ethylene glycol) methyl ether methacrylate and lauryl methacrylate incorporating a hydrophobic model drug-methotrexate. The effects of random copolymer concentration and drug content were investigated as critical formulation variables influencing key quality attributes. Additionally, nanoparticles stability under storage and biorelevant conditions was assessed. The most promising formulations were further evaluated for their anticancer efficacy using glioblastoma primary cells demonstrating encouraging results. It is anticipated that this research will shed light on the rational design of hybrid drug delivery systems combining well-established phospholipids and innovative random copolymers.