PEDIATRIC NEUROLOGY小儿神经病学
PEDIATRIC NEUROLOGY(英文缩写 PEDIATR NEUROL),ISSN 0887-8994,eISSN 1873-5150,中文译名:小儿神经病学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.210 | Q1 |
| 2022 | 3.800 | Q1 |
| 2023 | 3.200 | Q1 |
| 2024 | 2.100 | Q2 |
| 2025 | 2.000 | Q2 |
PEDIATRIC NEUROLOGY 最新收录文献
-
2. Risk Factors for Postoperative New Brain Injury in Infants and Young Children With Congenital Heart Disease.
PMID:日期:2026-09-21Postoperative brain injury in congenital heart disease (CHD) impairs neurodevelopment. We aimed to identify risk factors for postoperative brain injury in infants and young children with CHD and explore age- and cyanosis-related patterns. Infants and young children undergoing open-heart surgery with preoperative and postoperative brain magnetic resonance imaging were retrospectively enrolled. Postoperative new brain injury (intracranial hemorrhage, white matter injury, stroke, venous thrombosis) was assessed. Demographic, intraoperative, intensive care, hematological, and echocardiographic data were collected. Participants were classified according to the presence or absence of new postoperative brain injury. Differences between groups were assessed using independent t test, Mann-Whitney U, and chi-square testing, as appropriate. Multivariable logistic regression (exclusion criteria P > 0.1) was used to identify risk factors for new postoperative brain injury, supplemented by stratification analyses based on age categories and cyanotic status. Among 172 infants and young children (35.5% with new brain injury), independent risk factors included older age (odds ratio [OR] = 1.049), longer cardiopulmonary bypass (CPB) time (OR = 1.029), smaller main pulmonary artery diameter (OR = 0.800), lower postoperative mean corpuscular hemoglobin concentration (OR = 0.779), and lower platelet count (OR = 0.993). Stratified analyses revealed age-cyanosis interactions: in noncyanotic children ≤365 days, younger age, lower platelets and mean corpuscular hemoglobin concentration increased risk; in noncyanotic children >365 days, prolonged CPB was dominant; cyanotic subgroups showed borderline age and sex effects. Postoperative brain injury risk in children with CHD follows age-dependent and cyanosis-stratified patterns. Modifiable predictors include CPB duration and perioperative hematological parameters, enabling tailored neuroprotective strategies.
-
3. When Does Infantile Nystagmus Predict Optic Pathway Glioma?
PMID:日期:2026-09-17Optic pathway glioma (OPG) is an uncommon tumor of infancy and childhood. Early recognition is critical to enable timely neuroimaging and treatment; however, this can be challenging. In children presenting symptoms can vary and assessments may be limited. In some, nystagmus may be the main, or occasionally, only presenting clinical sign. We review the clinical characteristics of the nystagmus in these cases and highlight the key elements that should alert the physician to the possibility of OPG and prompt early neuroimaging investigations. A retrospective study of all patients under 3 years of age, presenting with nystagmus who were subsequently diagnosed with OPG at a tertiary neuro-ophthalmology clinic over a 10-year period. Clinical characteristics of the nystagmus, associated ophthalmic and systemic findings, and magnetic resonance imaging features were reviewed. One hundred forty pediatric patients were diagnosed with OPG over a 10-year period. Of these 30 patients presented primarily with nystagmus, 27 of them with complete records and were included. In all cases, the OPG involved the optic chiasm. The most consistent diagnostic feature was delayed onset of nystagmus at or after 3 months of age. Additional characteristics included asymmetric or uniocular predominance, dysconjugate nystagmus, multiplanar directionality, and progression or evolution of eye movement patterns over time. Classical localizing patterns such as see-saw nystagmus were less frequent. Infantile nystagmus with onset beyond 3 months, particularly when accompanied by atypical movement characteristics, should prompt early neuroimaging to exclude OPG. Recognition of these features enables earlier diagnosis in the absence of other clinical signs.
-
4. Reply to "Prediction, Not Propensity: Methodologic Considerations in Cerebral Palsy Risk Modeling".
PMID:日期:2026-09-17该文献暂无摘要。
-
5. Noninvasive Intracranial Pressure Estimation Using Transcranial Doppler to Rule Out Intracranial Hypertension in Children Undergoing Lumbar Puncture: A Feasibility Study.
PMID:日期:2026-09-16Intracranial pressure (ICP) monitoring is essential in pediatric neurocritical care, but current gold-standard methods are invasive, associated with relevant risks and necessity of sedation. Ultrasonographic methods, such as transcranial Doppler (TCD), would allow a noninvasive ICP estimation, permitting repeated samplings and serial monitoring. This study aimed to evaluate the feasibility and accuracy of TCD-derived ICP compared with cerebrospinal fluid opening pressure in children undergoing lumbar puncture. Prospective observational study at the University Hospital of Padua, Italy, including pediatric patients requiring diagnostic lumbar puncture. ICP was assessed invasively, measuring cerebrospinal fluid opening pressure and simultaneously estimated noninvasively using TCD-derived cerebral hemodynamic parameters: (i) pulsatility index derived methods (Bellner and Bellner-modified equation) and (ii) Czosnyka-equation. Accuracy and predictive capability of the best test were then tested. We included 60 children (median age 7.43 years). Among the tested methods, Czosnyka equation showed the best agreement with invasive ICP with mean difference of 3.78 mmHg [5.1 cmHO] and fair but significant correlation (Spearman rho = 0.29, P = 0.027). Accuracy was calculated for a threshold of 20 mmHg [27.2 cmHO] resulting in sensitivity 28.6%, specificity 91.3%, positive predictive value 50% and negative predictive value 80.8%, suggesting a good ability to exclude intracranial hypertension. Pulsatility index-based methods showed poor agreement. TCD-derived ICP estimation using Czosnyka equation may represent a useful noninvasive adjunct for ruling out intracranial hypertension in children. However, the limited sensitivity and accuracy preclude its use as a standalone diagnostic tool. Larger studies are needed to validate its role within multimodal monitoring strategies.
-
6. Parental Perspectives on Future Outcomes for Children Diagnosed With Fetal Neurological Conditions.
PMID:日期:2026-09-09Current literature on fetal neurological consultation contains limited input from families. We aimed to determine which potential future outcomes associated with prenatally diagnosed neurological conditions are the most important to parents. We performed a cross-sectional discrete choice experiment with parents who had undergone fetal neurological consultation at two children's hospitals. Parents ranked the relative importance of potential future outcomes associated with fetal neurological conditions. A hierarchal Bayesian application of multinomial logistic regression provided item-based relative importance scores (0-100). We used descriptive statistics to characterize importance score distribution by outcome. Fifty-six parents completed the survey, 54 (96%) of whom were mothers. All respondents had living children from the pregnancies for which they underwent fetal neurological consultation. Children were a median of 16 months old (interquartile range 8.5-30.5) at time of survey completion. Parents ranked the questions "Could my child's diagnosis shorten his or her life?" and "Will this diagnosis affect my child for the rest of his or her life?" as the most important. Seizures, vulnerability to other medical problems, trouble performing everyday activities, pain, difficulty eating and growing, and the child's happiness were also highly ranked. Importance scores for each outcome varied widely among parents. We characterize the relative importance of potential future outcomes to parents of children with prenatally diagnosed neurological conditions and find that outcomes ranked the most important pertain to lifespan, duration of impact, seizures, function, and vulnerability to other medical problems. Parents vary widely in their ranking of outcomes, supporting counseling tailored to individual priorities.
-
7. Clinical Utility of Structural Blood-Based Biomarkers in Pediatric Traumatic Brain Injury: A Focused Review of Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase L1, and S100 Calcium-Binding Protein B.
PMID:日期:2026-09-08Blood-based biomarkers are becoming increasingly relevant for the diagnosis of acute traumatic brain injury (TBI) in adults, but they remain underutilized in children. There exists the need for high-quality evidence to support their use in defined clinical contexts. This review synthesizes recent evidence on three structural biomarkers used clinically in adult TBI: glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase L1 (UCH-L1), and S100 calcium-binding protein B (S100 B) for diagnosis, management, and prognostication in pediatric TBI. Notably, plasma/serum biomarker levels in noninjured children were highest in infancy and inversely associated with age, and reference levels for GFAP and S100 B across pediatric age groups were higher than those of noninjured adults. Biomarker levels <24 hours postinjury showed acceptable diagnostic performance for clinically-important TBI (area under the receiver-operating characteristic curve (AUC): GFAP = 0.75, UCH-L1 = 0.76, S100 B = 0.77), and GFAP and UCH-L1 showed strong performance for traumatic intracranial lesions on computed tomography (overall AUC: GFAP = 0.85, UCH-L1 = 0.83, S100 B = 0.67; patients aged <5 years: GFAP = 1.00, UCH-L1 = 0.79, S100 B = 0.62). In European interventional studies, clinical management aided by S100 B was associated with relative reductions in computed tomography utilization exceeding 30% and hospitalizations by 45-55%, underscoring its utility for improving diagnostic efficacy and safety (i.e., decreasing ionizing radiation and time in-hospital). Structural biomarkers predicted death/severe functional disability at 12 months postinjury (AUC: GFAP = 1.00, UCH-L1 = 0.98, S100 B = 0.96). Blood-based biomarkers hold promise for improving pediatric TBI care. Prospective studies incorporating protocolized assessments are needed to validate their diagnostic and prognostic performance and support clinical qualification and implementation.
-
8. Factors Associated With Intensive Care Unit Length of Stay After Acute Arterial Ischemic Stroke in Children.
PMID:日期:2026-09-08Identifying features of children with acute arterial ischemic stroke (AIS) who require only a short intensive care unit (ICU) stay to assure stability allows for optimal use of health care resources. We aimed to understand characteristics of children who received ≤1 night of ICU care after AIS. This retrospective observational, cross-sectional single-center study identified children (age 29 days-18 years) with AIS confirmed via neurology evaluation and neuroimaging, 2012-2024, from an institutional pediatric "code stroke" quality improvement database. Per institutional practice, most children with acute stroke are admitted to the ICU to assure stability. Of 117 children with AIS, 33 (28%) were treated in the ICU for ≤1 night. The other 84 children required longer ICU stays, median 4.0 days (interquartile range: 2.0-8.0). Children with ≤1 ICU night were older, median age 14.0 vs 6.5 years, fewer had cardiac disease, 19% vs 46%, median Pediatric National Institutes of Health Stroke Scale (PedNIHSS) was lower: 4 vs 9. Acute stroke interventions, N = 20, were not associated with shorter ICU stay nor was smaller stroke size. In multivariable logistic regression analysis, older age (odds ratio 1.14 95% confidence interval: 1.05-1.25; P = 0.003) and lower PedNIHSS (odds ratio: 0.87, 95% confidence interval 0.76-0.99; P = 0.031) were significantly associated with requiring ≤1 ICU night. Among children with acute AIS, older age and lower PedNIHSS were associated with ≤1 ICU night. Identifying such children at the time of admission could result in a greater percentage of children with ≤1 ICU night, earlier intensive rehabilitation services, improved utilization of ICU beds, and cost-effective care.
-
9. Neurodevelopmental Outcomes of Prenatally Diagnosed Isolated Cerebellar Hemorrhage by Fetal Magnetic Resonance Imaging: Case Series and Review of Literature.
PMID:日期:2026-09-07The objective was to evaluate imaging and neurodevelopmental features in patients prenatally diagnosed with isolated cerebellar hemorrhage using fetal magnetic resonance imaging (MRI). This was a retrospective-cohort case series of patients with isolated cerebellar hemorrhage who underwent fetal MRI over a 9-year period. Existing literature in the field is also reviewed. Nine patients were identified; male predominance (n = 6) was noted. Injury patterns on fetal MRI included left cerebellar hemisphere only (n = 4), bilateral cerebellar hemispheres and vermis (n = 2), left cerebellar hemisphere and vermis (n = 1), right cerebellar hemisphere (n = 1), and right cerebellar hemisphere and vermis (n = 1). Overall, neurodevelopmental outcomes were favorable for 8 patients with available follow-up (range: 5 months-8 years). Eighty-seven point five percent had normal ambulation and all had normal speech. None required feeding or respiratory support. One patient had a diagnosis of Autism Spectrum Disorder. One patient had mild tremor with fine motor tasks. No patients had epilepsy. While studies of preterm infants with isolated cerebellar hemorrhage report high risk for severe developmental delay, outcome in prenatally diagnosed isolated cerebellar hemorrhage is overall favorable.
-
10. The Effects of Demographic Data on Age at First Seizure, Total Number of Seizures, and Seizure Type in Febrile Convulsion.
PMID:日期:2026-09-07Febrile convulsions (FCs) are common in early childhood, yet factors associated with seizure recurrence remain incompletely understood. This study aimed to evaluate demographic, clinical, and laboratory predictors of seizure recurrence and characteristics in children with FC. In this retrospective study, 137 children diagnosed with FC between January 2019 and January 2024 were included. Patients were identified using International Classification of Diseases, 10th Revision code R56.0. Demographic characteristics, feeding practices, family history, seizure features, and laboratory parameters including hemoglobin, mean corpuscular volume (MCV), ferritin, and vitamin D levels were analyzed. Associations between these variables and seizure recurrence were evaluated using appropriate statistical methods. No significant associations were found between sex, mode of delivery, feeding type, parental consanguinity, or family history of epilepsy and seizure characteristics. In univariable analyses, shorter breastfeeding duration, a positive family history of FC, lower MCV levels, lower ferritin levels, and vitamin D deficiency were associated with seizure recurrence. Low ferritin levels were also associated with a younger age at first seizure. However, after adjustment for potential confounding factors in a multivariable logistic regression model, only low MCV remained independently associated with seizure recurrence (odds ratio: 9.944, 95% confidence interval: 1.233-80.166, P = 0.031). Several demographic, familial, and nutritional factors were associated with seizure recurrence in univariable analyses. However, after adjustment for potential confounding factors, only low MCV remained independently associated with seizure recurrence. These findings suggest that iron status may play an important role in recurrent FCs and warrant further investigation in larger prospective studies.