GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY格雷弗临床与实验眼科学文献
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY(英文缩写 GRAEF ARCH CLIN EXP),ISSN 0721-832X,eISSN 1435-702X,中文译名:格雷弗临床与实验眼科学文献 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-10-01 至 2026-09-30，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.535 | Q2 |
| 2022 | 2.700 | Q2 |
| 2023 | 2.400 | Q2 |
| 2024 | 2.300 | Q2 |
| 2025 | 2.800 | Q2 |
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 最新收录文献
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1. Avoidable adverse events in cataract surgery: a national 11-year study of error types, care process patterns, and patient harm.
PMID:期刊:日期:2026-10-02This study aimed to systematically classify and analyse avoidable adverse events following cataract surgery in Sweden, with a focus on identifying the most frequent error types, their patterns across the care process, and areas for targeted patient safety improvement. In a retrospective cohort study 371 avoidable adverse events related to cataract surgery (1 January 2010-31 December 2020) were analysed using data from Löf, Sweden's national patient insurance company, together with patients' medical records. All events were confirmed as preventable through expert medical review. The most frequent adverse events were endophthalmitis (24%, n = 90), incorrect intraocular lens (IOL) power selection (10%, n = 37), inadequate cortex or lens removal (8%, n = 29), and iatrogenic corneal injury (7%, n = 26). Endophthalmitis, failure in postoperative monitoring, and inadequate preoperative evaluation, were associated with higher levels of permanent medical impairment, with ≥ 16% medical invalidity in 20-23% of affected patients. In contrast, deviations such as incorrect IOL power selection and IOL misplacement were more often linked to short-term outcomes or mild medical impairment. Endophthalmitis was the most common adverse event and was associated with the highest levels of permanent medical impairment. However, avoidable adverse events following cataract surgery extend beyond intraoperative technical errors and occur throughout the entire care process. Failures in preoperative evaluation and postoperative monitoring were most strongly associated with lasting visual harm. The mechanisms of avoidable harm identified are highly relevant across all healthcare settings performing high-volume cataract surgery.
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2. A four-year retrospective surgical case series examining postoperative complications following Removal of Silicone Oil (ROSO) scored using the Complications of Retinal Detachment Surgery (CORDS) severity classification tool.
PMID:期刊:日期:2026-10-02Silicone oil (SO) tamponade and the removal of silicone oil (ROSO) in the management of complex retinal detachments carry well-defined postoperative complications. Our objective was to classify and grade complications following ROSO using the Complications of Retinal Detachment Surgery (CORDS) Severity Classification and to propose a unifying proof-of-concept complication score. A single-centre retrospective case series of eyes undergoing ROSO was performed between 2018 and 2022. All patient data were collected with 12-month follow-up. Best recorded visual acuity (BRVA, LogMAR), intraocular pressure (IOP, mmHg) and complications were recorded from electronic patient records (EPR). Complications were scored using the CORDS Severity Classification. A Modified Global Complication Score (MGCS) was calculated for our study cohort. SO was removed from 46 eyes with a mean (SD) tamponade duration of 8.2 (6.61) months. A total of 88 de-duplicated CORDS items were recorded over the 12-month follow-up. Serious complications included anterior displacement of SO (12.5%), retinal re-detachment (5.68%), raised IOP requiring treatment (14.8%), severe loss of vision (18.9%), corneal decompensation (5.68%) and phthisis (2.27%). There was a statistically significant effect of timepoint on mean complication scores (χ² [3] = 11.22, P = 0.011); the effect greatest between the 3-month and 6-month timepoints (P = 0.002). The MGCS was 9.66% for our cohort. Postoperative complications following ROSO are common with high severity complications, such as secondary glaucoma, corneal decompensation and phthisis, emerging at 3-6 months. Our study proposes the MGCS as an exploratory comparison measure between future studies, but requires further validation in larger prospective cohorts that apply the CORDS Severity Classification.
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3. Inter-eye comparison of corneal stiffness parameters in primary open-angle glaucoma patients with unilateral damage.
PMID:期刊:日期:2026-09-29To investigate inter-eye differences in corneal biomechanical properties as assessed by Corvis ST among primary open-angle glaucoma (POAG) patients with unilateral damage. prospective cross-sectional study. This study included 240 eyes from 120 treatment-naïve patients with POAG, of which 60 were classified as normal-tension glaucoma (NTG) and 60 as high-tension glaucoma (HTG). Paired eyes were categorized into glaucomatous eyes and clinically unaffected fellow eyes according to ophthalmic examination. Ocular parameters, including corneal biomechanical properties, were compared between paired eyes within each group (POAG group, NTG and HTG subgroup). The generalized estimation equation (GEE) models with a binary logistic link were employed to examine the association between ocular parameters and the presence of glaucoma. Eyes with POAG had significantly higher biomechanically corrected intraocular pressure (bIOP; p = 0.007), more negative spherical equivalent (SE; p = 0.018), longer axial length (AL; p = 0.006), and thinner central corneal thickness (CCT; p = 0.007) than unaffected fellow eyes. Binocular comparison results differed across subgroups. NTG eyes had significantly thinner CCT (p = 0.015) and lower stiffness parameter at first applanation (SP-A1; p = 0.013) than unaffected fellow eyes. In contrast, HTG eyes showed significantly higher bIOP (p = 0.002), more negative SE (p = 0.047), and longer AL (p = 0.009) compared to controls. Multivariable GEE analysis demonstrated that higher baseline bIOP was significantly associated with the presence of both POAG (odds ratio, 1.111; p = 0.009) and HTG (odds ratio, 1.225; p = 0.002). In the NTG subgroup, lower SP-A1 was the only factor significantly correlated with the presence of glaucoma (odds ratio, 0.985; p = 0.035). Increased baseline bIOP was correlated with unilateral glaucomatous damage in patients with POAG and HTG. However, a lower corneal stiffness parameter was associated with glaucomatous eyes in NTG. This finding suggests that eyes with a more deformable cornea are vulnerable to glaucomatous damage, even when the IOP is within the normal range.
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4. Response to anti-VEGF injections for diabetic macular edema among patients on chronic exogenous insulin therapy.
PMID:期刊:日期:2026-09-29Diabetic macular edema (DME) is a leading cause of vision loss in diabetic patients worldwide. This study assessed whether there was a difference in functional and anatomic responsiveness to anti-VEGF therapy for DME among patients on chronic exogenous insulin therapy. This was a single-center retrospective cohort study of patients diagnosed with DME between 2014 and 2022. Patients were divided into two groups: those who were treated with exogenous insulin and those who were not. Treatment characteristics such as the type and total number of anti-VEGF injections, the use of intravitreal or periocular steroids, and length of follow-up were recorded from patient charts. Functional and anatomic ocular characteristics were measured at baseline and six-month intervals up to 24 months from the time of DME diagnosis. The main outcome measures were change in best corrected visual acuity (BCVA), central foveal thickness (CFT), and macular volume (MV). 101 patients (148 eyes) met the criteria for inclusion in this study. 82 patients (81.2%) used insulin while 19 patients (18.8%) did not. There were no significant differences in the stage of diabetic retinopathy, BCVA, CFT, or MV at baseline between the two groups. Patients in the no insulin group received more steroid injections in the first 12 months of treatment (0.8 vs. 0.2, p = 0.003); however, there were no significant differences in final BCVA, CFT, or MV between groups after 24 months (p > 0.05). The results of this study suggest that the chronic use of exogenous insulin may not influence the functional or anatomic response to anti-VEGF injections.
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5. Pupil size measurements with two multifunctional devices based on different technologies and an infrared based pupillometer.
PMID:期刊:日期:2026-09-29To compare inter- and intra-device agreement of pupil size (PS) measurements of an aberrometer/coherence interferometer/tomographer (Pentacam AXL Wave (OCULUS)), optical coherence tomographer/placido topographer (MS-39, (CSO/Schwind)) and an infrared based pupillometer (PupilX (Albomed)). In this prospective study, PS of healthy eyes was measured with Pentacam without (WO) and with glare (WG), PupilX in 0, 0.06, 0.12, 4 and 64 lx and MS-39 in 0.04, 4 and 50 lx three times each. Scotopic conditions were defined as WO and ≤ 0.12 lx, mesopic as 4 lx and photopic as WG, 50 and 64 lx. Measurements were compared per lighting condition. Thirty-seven eyes of 37 participants (mean age 30.8 years ± 9.1 years) were included. Pentacam WG and PupilX at 64 lx showed the lowest inter-device difference and had the only non-significant difference (p = 0.204). The second lowest mean difference was between Pentacam WO and PupilX at 0.06 lx where significance was also not met (p = 0.05). Pentacam WO and PupilX at 0 lx showed the highest inter-device difference (p < 0.001). The lowest intra-device difference (IDD) for scotopic conditions was 0.19 mm (standard deviation (SD): 0.17 mm) with PupilX at 0 lx. In mesopic conditions, the lowest IDD was 0.2 mm (SD: 0.15 mm) with MS-39, in photopic conditions 0.16 mm (SD: 0.11 mm) with PupilX. Pentacam showed close-to-acceptable agreement with PupilX in photopic conditions. In the other conditions significant differences were found, which applied for MS-39 and PupilX for all illumination levels. All three devices showed excellent intra-device repeatability for all illuminations levels.
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6. Association between human immunodeficiency virus infection and the risk of glaucoma: a real-world multicenter cohort study.
PMID:期刊:日期:2026-09-29To evaluate the association between human immunodeficiency virus (HIV) infection and the risk of developing glaucoma-related outcomes. We conducted a population-based retrospective cohort study using the TriNetX US Network, including adults aged ≥ 20 years with ophthalmology records between January 2003 and December 2022. Individuals with preexisting ocular conditions affecting intraocular pressure, optic nerve structure, or associated with ocular neovascularization were excluded. Eligible patients were categorized based on HIV infection status. Propensity score matching was performed to balance baseline characteristics. Primary outcomes included the incidence of open-angle glaucoma (OAG), preglaucoma, ocular hypertension (OHT), initiation of antiglaucoma medications, and glaucoma-related interventional therapies during the 3-year follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 20,336 patients with HIV infection (mean age: 49.1 ± 12.1 years) were matched to 20,336 individuals without HIV (mean age: 49.2 ± 14.4 years). HIV infection was associated with higher risks of OAG (HR:4.21, 95% CI:3.36-5.28), preglaucoma (HR:2.71, 95% CI:2.46-2.99), and OHT (HR:1.38, 95% CI:1.11-1.72). HIV infection was also associated with higher risks of antiglaucoma medication initiation (3.58% vs. 2.34%; HR, 1.50; 95% CI, 1.33-1.68) and interventional therapy (1.90% vs. 0.78%; HR, 2.37; 95% CI, 1.97-2.85). HIV infection was associated with increased risks of glaucoma-related diagnoses, as well as antiglaucoma medication initiation and interventional procedures. These findings support heightened clinical awareness and ophthalmic surveillance among patients with HIV.
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7. Impact of COVID-19 on refractive amblyopia risk factors in 5-years-old children: A nationwide cross sectional study.
PMID:期刊:日期:2026-09-26To assess the impact of COVID-19 on refractive amblyopia risk factors (rARFs), among 5-year-old children in Israel. We conducted a nationwide, community-based cross-sectional study to evaluate and compare trends in refractive amblyopia risk factors (rARFs) in more than 100,000 children aged 5 years, from urban kindergarten in Israel. The study was conducted from 2013 to 2023, using the PlusOptiX S12 autorefractor, a photo-screening device, to collect refractive measurements. The main outcome was the annual prevalence of rARFs across the ten-year study period. Overall, 101,626, 5 year-old children were included. The prevalence of rARFs declined from 11.4% (164/1445 children) in 2013 to 6.8% (476/6964 children) by 2023, with significant decrease observed during the post-COVID period. The prevalence of children with one rARF decreased from 9.0% to 5.6%, with corresponding reductions in those with two (1.6% to 1.0%) and three risk factors (0.8% to 0.2%). Analysis of each rARFs showed a shift in refractive patterns following COVID-19, with myopia increasing relative to the pre-COVID average, while anisometropia and astigmatism declined, and hyperopia showed a non-significant decrease. We observed a decrease in the prevalence of refractive amblyopia risk factors in an unscreened population of children in urban kindergartens over the past decade. Hyperopia, anisometropia, and astigmatism showed reductions during the post-COVID-19 period, while the myopia risk factor increased. These trends may reflect advances in diagnostic technology, greater public awareness, and the implementation of early vision screening, underscoring their importance.
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8. Novel semi-automated system for multi-dimensional analysis of macular neovascularization: quantitative biomarkers and rule-based morphological categorization across OCTA platforms.
PMID:期刊:日期:2026-09-26To develop and validate a novel semi-automated Python-based pipeline for multi-dimensional analysis of macular neovascularization (MNV) on optical coherence tomography angiography (OCTA) images. The system provides standardized biomarkers, rule-based morphological categorization, and morphology-derived interpretive labels. It also incorporates an automated morphological classification scheme to objectively distinguish active, mature quiescent, transitional, and arteriolarized states. We developed an advanced image-processing pipeline incorporating hybrid multiscale vessel enhancement using Frangi/tubeness and Laplacian of Gaussian filters, hybrid binarization (LoG-Otsu and tubeness-Sauvola with small-particle removal), dynamic region-of-interest refinement, and boundary-branch exclusion. The system generates a Standardized Vascular Complexity Score, a Standardized Caliber Uniformity Score, and a Standardized Maturity Index on a 0-100 scale, and performs rule-based classification into Medusa, Seafan, Glomerular, Tree in bud, and Dead tree patterns using predefined percentile and trunk-pattern thresholds. Morphology-derived interpretive categories - Active pattern, Maturequiescentpattern, Transitional-pattern, and Arteriolarized pattern - were assigned using quantitative thresholds and published morphological criteria. A total of 112 MNV lesions acquired on three OCTA platforms (Zeiss PlexElite 6 × 6 mm, Zeiss CIRRUS AngioPlex HD 3 × 3 mm, and Optovue Solix 6 × 6 mm) were analyzed. Masked expert-automated morphological agreement was assessed in a stratified subset (n = 54). Inter-observer reproducibility was evaluated with three operators in 46 lesions using ICC(2,1), and same-operator intra-observer test-retest reproducibility was assessed as a supplement (n = 46). Between-stratum score differences were summarized using Kruskal-Wallis tests and ε² effect sizes with bootstrap 95% confidence intervals. Raw topological metrics differed substantially by device, precluding direct numerical comparison. Device-specific standardization using principal component analysis and piecewise-linear normalization yielded convergent standardized Complexity, Caliber Uniformity, and Maturity scores on a common 0-100 reporting scale across devices, with median values of approximately 50. Under this standardized framework, Complexity Score, Caliber Uniformity Score, and Maturity Index did not differ significantly across strata (Kruskal-Wallis p = 0.425, 0.572, and 0.582, respectively; ε² ≈ 0). Automated morphological classification identified the full spectrum of MNV subtypes across all platforms. Agreement with masked expert grading was modest to moderate, with an overall agreement of 57.4% and a quadratic weighted κ of 0.507. Inter-observer ICC(2,1) was good for lesion area (0.859), Complexity Score (0.807), and Standardized Caliber Uniformity Score (0.770), and moderate for the Maturity Index derived from the Caliber score (0.593). This system provides a transparent and robust platform for quantification and rule-based morphological reporting of MNV architecture across OCTA platforms, establishing a common framework for comparative analysis. Future outcome-linked and multi-center evaluations will be required to establish clinical utility. By integrating morphological patterns with quantitative biomarkers and automated classification, the system enables objective differentiation of active angiogenesis from mature remodeling.
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9. The effect of fingolimod (FTY720) protecting the retina of rats from light-induced retinal degeneration (LIRD).
9. 芬戈莫德（FTY720）对光诱导性视网膜变性（LIRD）大鼠视网膜的保护作用PMID:期刊:日期:2026-09-25Fingolimod (FTY720), an immunosuppressive agent, has previously shown protective effects against light-induced retinal injury in our prior work. In this study, we further explored whether 10 mg/kg FTY720 alleviates light-induced retinal degeneration (LIRD) in rats, and clarified its potential dual roles in suppressing retinal immune responses and inhibiting photoreceptor apoptosis during LIRD progression. Sprague-Dawley rats raised in cyclic dim light were exposed to 2700 lx white light for 6 h to establish LIRD animal models. FTY720 (10.0 mg/kg) or vehicle was administered intraperitoneally to rats 0.5 h before light exposure. Histology and F-ERG analyses were used to evaluate the structure and function of retina. TUNEL assay was performed to detect the apoptosis of retinal cells, and Immunofluorescence analysis was performed to evaluate both infiltrating T lymphocytes and activated microglia in light-damaged retinas. After light exposure, significantly reduced F‑ERG a‑ and b‑wave amplitudes, massive photoreceptor loss and thinning of the outer nuclear layer were observed in the vehicle‑treated group (VLD). No obvious structural and functional abnormalities were detected in the FTY720‑treated group (FTY), whose indicators were comparable to those of the non‑light‑damaged group (NLD). Pretreatment with FTY720 reduced light‑induced photoreceptor apoptosis and protected retinal structure and function against light damage. The number of CD3⁺CD4⁺ and CD3⁺CD8⁺ T lymphocytes was markedly elevated in the VLD group, whereas retinal T‑cell infiltration was remarkably restricted in FTY720‑pretreated rats. Additionally, light exposure triggered microglial activation, proliferation and migration in the outer retina, which was effectively suppressed by FTY720 pretreatment. FTY720 reduces photoreceptor apoptosis, decreases CD3⁺CD4⁺ and CD3⁺CD8⁺ T‑lymphocyte infiltration, and mitigates microglial activation in light‑injured rat retinas, conferring prominent photoreceptor‑protective effects. These findings deepen our understanding of the pathogenic mechanisms underlying LIRD and suggest that FTY720 may serve as a promising therapeutic agent for retinal degenerative disorders.
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10. Accuracy of intraocular lens power calculation in pediatric aphakia with the Artisan iris-claw lens.
PMID:期刊:日期:2026-09-25To compare the refractive accuracy of six intraocular lens (IOL) power calculation formulas in pediatric aphakia managed with anterior iris-claw (Artisan) IOL implantation. Children aged 18 years or younger with ectopia lentis or microspherophakia who underwent lensectomy and anterior Artisan Aphakia IOL implantation between 2013 and 2024 at the Hospital for Sick Children, Toronto, were reviewed retrospectively. Optical biometry was obtained using the IOLMaster (version 5.4). Predicted refraction was calculated using SRK/T, Holladay 1, Hoffer Q, T2, Barrett Universal II, and EVO 2.0 formulas, with lens constants iteratively optimised to zero mean prediction error. The primary analysis used first-operated eyes; cumulative data for all eyes are presented separately. Twenty-six first-operated eyes of 26 children were analysed. With manufacturer-supplied constants, SRK/T showed the least systematic bias (mean prediction error - 0.18 D), a mean absolute error (MAE) of 0.75 D, and the highest observed proportion of eyes within ± 0.50 D (61.5%). After lens-constant optimisation, SRK/T had the lowest observed MAE (0.76 D) and median absolute error (0.37 D), and 61.5% of eyes were within ± 0.50 D. T2 and EVO 2.0 showed comparable overall performance. Absolute prediction error did not differ significantly across the six formulas (Friedman test, p = 0.71). Although the proportion within ± 0.50 D differed across formulas overall (Cochran's Q, p = 0.03), no pairwise comparison remained statistically significant after Bonferroni adjustment. Differences at the ± 1.00 D and ± 2.00 D thresholds were not significant. The cumulative 44-eye analysis showed a similar overall pattern. In this cohort, SRK/T showed the least systematic bias with the manufacturer-supplied constant and the lowest observed absolute prediction errors after optimisation, with T2 and EVO 2.0 performing comparably. No individual formula demonstrated statistically significant superiority after correction for multiple comparisons. These findings require prospective validation in independent cohorts before informing routine formula selection.