AMERICAN JOURNAL OF OTOLARYNGOLOGY美国耳鼻咽喉科杂志
AMERICAN JOURNAL OF OTOLARYNGOLOGY(英文缩写 AM J OTOLARYNG),ISSN 0196-0709,eISSN 1532-818X,中文译名:美国耳鼻咽喉科杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 2.873 | Q2 |
| 2022 | 2.500 | Q2 |
| 2023 | 1.800 | Q2 |
| 2024 | 1.700 | Q2 |
| 2025 | 1.800 | Q2 |
AMERICAN JOURNAL OF OTOLARYNGOLOGY 最新收录文献
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2. The association between reduced bone mineral density and hearing impairment in postmenopausal women.
PMID:日期:2026-09-19To assess the association between bone mineral density (BMD) and auditory function in postmenopausal women and to assess the degree of hearing impairment across normal BMD, osteopenia, and osteoporosis. In this analytical cross-sectional study, 220 postmenopausal women aged 50-75 years were enrolled. All participants underwent dual-energy X-ray absorptiometry (DXA) of the lumbar spine and hip, followed by pure-tone audiometry and tympanometric assessment. Women using bone-modifying medications, those with metal implants or musculoskeletal conditions interfering with DXA, and those unable to maintain required positioning were excluded. Additional audiological exclusions covered otologic, neurologic, oncologic, inflammatory, and hereditary causes of secondary hearing loss. Hearing loss severity was graded from the better-ear air conduction pure-tone average. Thresholds and tympanometric parameters were compared across BMD groups with non-parametric tests, the severity distribution with exact categorical methods, and the BMD-hearing associations with multivariate logistic regression adjusted for age, body mass index (BMI) and duration of menopause. Decreasing BMD was associated with a stepwise worsening of auditory function. Women with osteoporosis demonstrated significantly higher pure-tone average and bone conduction thresholds, more negative tympanometric peak pressures, lower static admittance, and higher resonance frequencies compared with those with osteopenia and normal BMD (all p < 0.001). Moderate-or-worse hearing loss was most prevalent in the osteoporosis group (72.2%), compared with 41.2% in osteopenia and 22.4% in normal BMD. All pairwise differences were statistically significant. After adjustment for age, BMI and duration of menopause, the odds of moderate-or-worse hearing loss were about nine-fold higher in osteoporosis (adjusted OR = 8.97, 95%CI 3.81-21.1) and about 2.6 -fold higher in osteopenia (adjusted OR = 2.55, 95%CI 1.31-4.98) compared with normal BMD. None of these covariates was independently associated with the outcome. Reduced bone mineral density is significantly associated with impaired auditory function in postmenopausal women, with hearing thresholds worsening progressively from normal BMD to osteopenia and reaching its greatest severity in osteoporosis, independently of age, BMI and duration of menopause. Although causal inference cannot be drawn from this cross-sectional study, these findings are consistent with the systemic nature of osteoporosis and a possible involvement of the otic capsule and inner ear structures. Prospective, longitudinal studies are warranted to further clarify this association.
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3. Impact of kidney and liver transplant immunosuppression regimens on sinonasal disease.
PMID:日期:2026-09-18To compare differences in the rate of chronic rhinosinusitis with or without nasal polyposis (CRSwNP, CRSsNP), allergic rhinitis (AR), and acute invasive fungal sinusitis (IFS) among kidney and liver transplant patients following different immunosuppression regimens. This is a multicenter, retrospective cohort study utilizing data from the TriNetX database from January 1, 2010 to July 31, 2025. Data are derived from 106 healthcare organizations in the United States. Adult kidney and liver transplant recipients were identified and stratified by induction and maintenance immunosuppression. Induction therapy compared anti-thymocyte globulin (ATG) with basiliximab, and maintenance therapy compared a tacrolimus-based regimen with a cyclosporine-based regimen. Outcomes and rates of functional endoscopic sinus surgery were assessed. Treatment with basiliximab was associated with a higher rate of AR, CRSwNP, and acute IFS following induction treatment compared to ATG (RR: 0.89 [0.82-0.96]; 0.62 [0.41-0.93]; 0.43 [0.26-0.71]). The rates of FESS to address CRSsNP, CRSwNP, and acute IFS were also higher in group treated with basiliximab (RR: 0.60 [0.43-0.84]; 0.70 [0.50-0.96]; 0.62 [0.38-0.98]). Maintenance therapy with tacrolimus was associated with higher rates of AR and acute IFS compared to cyclosporine (RR: 1.29 [1.10-1.51]; 1.73 [1.17-2.54]). The rates of surgery for CRSsNP, CRSwNP, and acute IFS following maintenance therapy were similar between those treated tacrolimus and cyclosporine (RR: 1.11 [0.60-2.05]; 0.89 [0.45-1.71]; 1.13 [0.57-2.20]). When comparing common immunosuppression for kidney and liver transplant, basiliximab was associated with a higher rate of sinonasal disease and AR compared to ATG. For maintenance immunosuppression, treatment with tacrolimus-based regimens was associated with a higher rate of AR and acute IFS. Level 3.
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4. Noninvasive vagus nerve stimulation in otolaryngology: A scoping review and evidence map.
PMID:日期:2026-09-17Noninvasive vagus nerve stimulation (nVNS) may influence brainstem nuclei and ascending networks via vagal afferent pathways and has been investigated as an additional treatment for otolaryngological problems. Nonetheless, the evidence base is fragmented and methodologically diverse. To conduct a comprehensive review with evidence mapping to map and synthesize reported human clinical evidence on nVNS in otolaryngology and identify gaps for future studies. A scoping review guided by PRISMA-ScR was conducted in the PubMed, Embase, Web of Science, and Scopus databases from inception to December 20, 2025. Eligible designs included randomized and nonrandomized interventional trials, cohort and mechanistic analyses, and case series. Data were organized using a predefined otolaryngology outcome-domain framework and presented as an evidence map. Of 4974 records, 2690 unique records were screened, and 20 studies were included. Seven indication categories were represented: pharyngeal dysesthesia (n = 1), laryngopharyngeal reflux-related disorders (n = 1), MD (n = 2), olfactory dysfunction (n = 2), dysphagia (n = 3), vestibular disorders/vestibular rehabilitation (n = 3), and tinnitus (n = 8). Outcomes were primarily patient-reported, with selected objective functional and mechanistic measures. Common limitations included small samples, variable comparators and blinding strategies, non-harmonized stimulation parameters and treatment-course definitions, short follow-up, and heterogeneous reporting of harms. Current evidence on otolaryngologic nVNS is largely exploratory and should not be interpreted as establishing clinical effectiveness. Tinnitus constitutes the largest evidence cluster, whereas vestibular rehabilitation and dysphagia studies more often incorporate operationalizable functional endpoints. Future confirmatory trials should harmonize stimulation and reporting, strengthen sham-controlled blinding, prespecify phenotype and mechanistic anchors, and extend follow-up to assess durability and maintenance.
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6. Global and regional burden, trends, and future projections of laryngeal cancer (1990-2041).
PMID:日期:2026-09-16Laryngeal cancer remains a significant global health challenge, with notable disparities across regions, socioeconomic strata, age groups, and genders. Using Global Burden of Disease data (1990-2021), we evaluated prevalence, incidence, mortality, and disability-adjusted life years across 204 countries and 21 regions stratified by the Socio-demographic Index. Through estimated annual percentage change analyses and the autoregressive integrated moving average modeling, we projected trends to 2041. Globally, age-standardized prevalence and incidence rates declined, with sharper mortality and disability-adjusted life years reductions, reflecting tobacco control and treatment advances. High Socio-demographic Index regions showed highest prevalence but significant decreases, while middle Socio-demographic Index regions exhibited rising trends. Central Europe, Caribbean, and South Asia had heaviest burdens, correlating with tobacco/alcohol/occupational exposures. Males aged 65-74 showed highest incidence. Projections indicate continued declines in both incidence and mortality (especially among males), while prevalence is expected to remain stable. These projections underscore the need for region-specific strategies targeting smoking cessation, occupational safety, and healthcare equity to mitigate remaining disparities. Future research should refine models and enhance surveillance in resource-limited settings.
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7. Ten-year institutional trends in syphilis: The first-contact role of otolaryngology and diagnostic pitfalls.
PMID:日期:2026-09-16Syphilis, often referred to as "The Great Imitator," can resemble malignant tumors in the head and neck region. Otolaryngologists (ENT) specialists frequently serve as the first point of evaluation for oropharyngeal lesions; however, quantitative data on ENT diagnostic patterns, predictive factors, and temporal trends remain limited. This study aimed to identify clinical predictors of ENT diagnosis and assess diagnostic time patterns and annual trends. We retrospectively analyzed 58 syphilis cases over an 11-year period (2014-2025) at a single academic center. Predictors of ENT diagnosis were identified using multivariable logistic regression with internal validation through bootstrap resampling (1000 iterations). Diagnostic time was evaluated using Cox proportional hazards regression, while annual trends and the impact of the COVID-19 pandemic were analyzed using Poisson regression and period-stratified analysis. Among the 58 cases, 23 (39.7%) were diagnosed in ENT. Multivariable analysis identified oropharyngeal symptoms (adjusted odd ratio [OR] 110.49, 95% confidence interval [CI] 7.30-1673.39, p = 0.0007) and cervical lymphadenopathy (adjusted OR 30.61, 95% CI 1.94-482.75, p = 0.0150) as independent predictors of ENT diagnosis. Bootstrap validation confirmed minimal overfitting (mean optimism 0.007; optimism-corrected AUC 0.900). No significant difference in diagnostic time was observed between ENT and other departments. The proportion of ENT diagnoses increased markedly from 17.9% (2014-2019) to 60.0% (2020-2025; p = 0.0013), representing a 3.4-fold rise after the onset of COVID-19. Oropharyngeal symptoms and cervical lymphadenopathy are strong predictors of ENT diagnosis, and their combination constitutes a characteristic pattern of syphilis. ENT diagnoses have increased substantially in the post-COVID-19 era. Implementing a "bundle testing" strategy-simultaneous tumor workup and syphilis testing-is crucial to prevent diagnostic delays in tumor-mimicking cases.
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8. Clinical and radiological predictors of retropharyngeal abscesses in deep neck infections.
PMID:日期:2026-09-16Retropharyngeal abscesses (RPAs) are severe deep neck infections that require rapid intervention to prevent life-threatening complications. This study aimed to evaluate the clinical, laboratory, and radiological risk factors that predict the need for intensive care unit (ICU) admission and surgical drainage in adult patients with RPAs. A retrospective review was conducted on patients treated for RPAs at our center between January 2013 and December 2023. Of the 64 initial cases, 57 adults were included in the final analysis after excluding pediatric patients and incomplete records. We analyzed the impact of demographics, diabetes mellitus (DM) status, admission laboratory markers (C-reactive protein [CRP], white blood cell [WBC] count), and radiological abscess size on the necessity for ICU admission and surgical intervention. Additionally, Receiver Operating Characteristic (ROC) curves were generated to assess the predictive value of these variables for ICU admission. The cohort's mean age was 37.7 ± 16.7 years, with 9 patients (15.8%) requiring ICU care. Multivariate logistic regression identified DM (OR = 3.61, 95% CI: 1.31-9.92, p = 0.01), admission CRP level (OR = 1.01, 95% CI: 1.00-1.02, p = 0.03), and maximum abscess diameter (OR = 1.09, 95% CI: 1.02-1.18, p = 0.02) as independent predictors of ICU admission. ROC analysis for CRP yielded an area under the curve (AUC) of 0.87; a 200 mg/L cut-off achieved 100% sensitivity and 80.9% specificity. Maximum abscess diameter demonstrated an AUC of 0.81, with a 30 mm cut-off providing 88.9% sensitivity and 71.4% specificity. None of the evaluated parameters significantly correlated with the need for surgical drainage. Comorbid DM, elevated CRP levels, and larger abscess dimensions independently predict the need for intensive care in adults with RPAs. The strong discriminative capacity of admission CRP and radiological abscess size highlights their critical utility in early clinical risk stratification and guiding targeted treatment strategies.
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9. Septorhinoplasty and its relevance to health outcomes: A prospective cohort study of functional and psychosocial outcomes.
PMID:日期:2026-09-16Septorhinoplasty is commonly performed to address functional nasal obstruction and aesthetic concerns. While functional outcomes are well established, the relationship between functional improvement and psychosocial well-being remains incompletely understood. A prospective observational cohort study was conducted including 150 consecutive eligible and consenting adult patients undergoing septorhinoplasty at a tertiary referral centre. Patient-reported outcomes were assessed preoperatively and at 6 months postoperatively using the Nasal Obstruction Symptom Evaluation (NOSE) scale, a stress assessment questionnaire, and the World Health Organization Quality of Life instrument (WHOQOL-BREF). Changes in scores were analysed using the Wilcoxon signed-rank test, and associations between functional and psychosocial outcomes were assessed using Spearman's rank correlation coefficient. All patients completed follow-up. The mean NOSE score improved significantly from 67.4 ± 18.2 to 21.6 ± 16.9 (p < 0.001), representing a mean reduction of 45.8 points that exceeded established thresholds for clinical relevance. Approximately 82% of patients achieved clinically meaningful improvement. Significant reductions in perceived stress were observed across most emotional and social domains (p < 0.05), while cognitive domains showed no significant change. WHOQOL-BREF analysis demonstrated significant improvements in the physical, psychological, and social domains (p < 0.001), with moderate-to-large effect sizes, whereas the environmental domain showed minimal change. A moderate association was observed between improvement in NOSE scores and psychological quality-of-life outcomes (r = 0.50, p < 0.05). Septorhinoplasty was associated with significant improvements in nasal obstruction and multiple psychosocial outcomes at 6 months. Functional improvement was moderately associated with enhanced psychological well-being. These findings should be interpreted as associations rather than causal effects, because the observational design could not fully control for potential confounders, including baseline psychosocial status, surgical indication, patient expectations, aesthetic satisfaction, and procedure-specific factors.
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10. Multilayer free-graft reconstruction with platelet-rich plasma augmentation for nasoseptal flap-sparing in endoscopic transsphenoidal surgery: A single-center prospective feasibility study.
PMID:日期:2026-09-15To prospectively evaluate the feasibility and safety of nasoseptal flap avoidance using a standardized multilayer free-graft reconstruction augmented with autologous platelet-rich plasma (PRP) in anatomically favorable transsphenoidal surgeries. This prospective single-center feasibility study included 42 consecutive patients undergoing endoscopic transsphenoidal surgery for Hardy grade A-C, Knosp grade 0-2 pituitary adenomas and comparable sellar lesions between January 2020 and March 2024. Skull base reconstruction employed a standardized multilayer technique consisting of intrasellar fat obliteration, inlay fascia lata graft, a PRP-augmented biological layer, onlay fascia lata graft, and absorbable gelatin sponge buttress. The primary outcome was the 30-day postoperative cerebrospinal fluid (CSF) leak rate. An exploratory analysis examined the association between suprasellar extension and postoperative CSF leak. Mean age was 51.1 ± 13.7 years. Pathologies included pituitary adenoma (n = 35, 83.3%), Rathke cleft cyst (n = 3), and other sellar lesions (n = 4). Intraoperative CSF communication was encountered in 23 cases (54.8%). Postoperative CSF leak occurred in 3 patients (7.1%; 95% CI: 1.5-19.5%). All observed postoperative CSF leaks were confined to patients with suprasellar extension ≥12 mm (3/13, 23.1%), whereas no leaks were observed in lesions with <12 mm extension (0/29, 0%; p = 0.025, Fisher's exact test). All leaks resolved with conservative management. No nasal complications such as septal perforation or major epistaxis were observed. Mean hospital stay was 4.3 ± 2.5 days, and no surgical reintervention was required during a mean follow-up of 19.2 ± 11.4 months. Detailed intraoperative findings and postoperative outcomes are summarized in Table 2. In this prospective feasibility study, multilayer free-graft reconstruction augmented with autologous PRP was feasible for nasoseptal flap avoidance in selected low-risk transsphenoidal cases, with a postoperative CSF leak rate comparable to published series. An exploratory association between suprasellar extension ≥12 mm and increased leak risk was observed, warranting further validation. This flap-sparing approach can be considered in carefully selected patients where nasal preservation is prioritized, though comparative studies are needed to define its role relative to vascularized flap reconstruction.