RADIOTHERAPY AND ONCOLOGY放射治疗与肿瘤学
RADIOTHERAPY AND ONCOLOGY(英文缩写 RADIOTHER ONCOL),ISSN 0167-8140,eISSN 1879-0887,中文译名:放射治疗与肿瘤学 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 6.901 | Q1 |
| 2022 | 5.700 | Q1 |
| 2023 | 4.900 | Q1 |
| 2024 | 5.300 | Q1 |
| 2025 | 5.800 | Q1 |
RADIOTHERAPY AND ONCOLOGY 最新收录文献
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3. GTV clinical scenario: protons vs photons in a patient with a second primary lung cancer and co-existing interstitial lung disease (ILD).
PMID:期刊:日期:2026-10-01该文献暂无摘要。
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4. Accuracy is a quantity, not a quality: Reflections on required and achievable accuracy in external-beam photon and particle therapy.
PMID:期刊:日期:2026-10-01This review provides a succinct up-to-date discussion of required and achievable accuracy in MV photon beam and particle therapy, focusing on technology and techniques reflecting today's general clinical practice for radical radiotherapy. The major advances in recent decades have enabled a new degree of geometric and dosimetric precision to be achieved. These are related to dosimetry standards, imaging for treatment planning, dose calculation algorithms and approaches, fluence-modulated techniques facilitating conformality optimisation, image guidance (IG), IG-enabled adaptive and motion management methods and volume-based dose prescription concepts. In addition, evolving quality assurance methodologies have contributed substantially to improve the dosimetric accuracy. Consequently, in state-of-the-art radiotherapy the emphasis has shifted from accuracy of reference (prescription) dose delivery to accuracy of spatial dose distribution delivery, with greater focus on geometric uncertainties. The relationship between delivered dose and the resulting biological effect is examined, to consider the clinical impact of radiotherapy accuracy. Developments in required and achievable accuracy for photon beams are discussed, including insights from audits and patient specific quality assurance. Based on the steeper dose-response relations, the dosimetric accuracy requirements are still similar to those in the late 1980's, but the geometric accuracy demands have become significantly more stringent. In optimal conditions, radiotherapy practice can achieve these standards, but this necessitates a continued strong focus on treatment precision and quality. Robust quality assurance programmes, evolving in step with conceptual and methodological radiotherapy developments, remain essential to meet the accuracy requirements. As regards particle therapy, there are some significant uncertainty differences to photon therapy, but the models and clinical data are not yet sufficiently detailed to confidently predict differences in accuracy requirements compared to photon beam therapy.
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5. Induction TPF versus adjuvant PF after CCRT in locally advanced nasopharyngeal carcinoma: A multicenter, randomized controlled phase III clinical trial.
5. 局部晚期鼻咽癌CCRT后诱导TPF与辅助PF：一项多中心、随机对照的III期临床试验PMID:期刊:日期:2026-10-01The efficacy and safety of TPF-induced chemotherapy(IC) combined with concurrent chemoradiotherapy(CCRT) compared to CCRT and sequential PF-adjuvant chemotherapy(AC) lack phase III randomized controlled clinical trials for evaluation, so the comparative efficacy and safety between the two approaches remain unclear. This randomized clinical phase III trial recruited patients from May 2018 to July 2021,at 4 institutions in China(NCT03574324), 266 patients were enrolled and randomly assigned to either the IC or AC groups. The IC group received TPF followed by CCRT, while the AC group received CCRT followed by PF. We are reporting on the primary outcome of progression-free survival (PFS) and secondary endpoints of overall survival(OS), locoregional relapse-free survival(LRFS), distant metastasis-free survival(DMFS), and toxicity profile. The 3-year PFS was similar between the two groups, with 79 % for the IC group and 74.5 % for the AC group (P = 0.454) at a median follow-up of 39 months. Similar findings were observed, with no significant disparities in OS, LRFS, and DMFS between the two treatment cohorts. Both groups had similar compliance rates for radiotherapy and chemotherapy. However, the IC group experienced fewer grade toxic effects during CCRT, such as nausea/vomiting, swallowing, and dryness (101[77.10 %] vs. 114[89.06 %] patients,40 [30.53 %]vs56 [43.75 %] patients and 58 [44.27 %]vs86 [67.19 %] patients, respectively). However,3-4 grade leukopenia and neutrophilia patients were increased(58 [44.27 %]vs28 [21.88 %] patients and 78 [59.54 %]vs24 [18.75 %]) in the IC group. In this randomized clinical trial, IC did not improve 3-year PFS for LA-NPC patients and increased hematological toxicity. Still, the advantage of it is that it did reduce the incidence rates of nausea/vomiting, swallowing, and dry mouth during radiotherapy.
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6. Advanced dose accumulation methods: A comparative study in online adaptive radiotherapy for abdominal-pelvic lymph node oligometastases.
PMID:期刊:日期:2026-10-01To investigate whether advanced registration methods for dose accumulation lead to meaningful differences in online adaptive radiotherapy (OART) to aid in-treatment dose adaptation (ITDA). In ITDA, fraction dose is adjusted when anatomy is favorable to shorten treatment or increase target dose. Twenty-five patients with abdominal-pelvic lymph node oligometastases were retrospectively included. 5 x 9 Gy OART was simulated. Gastrointestinal organ (GIO) segments were propagated and doses accumulated using five techniques: DVH summation, rigid registration, image-based and hybrid deformable registration, and Thin Plate Spline Robust Point Matching (TPS-RPM). Metrics included: Dice, Hausdorff distance (HD-99%), mean surface distance (MSD), and accumulated GIO V20Gy, D, and D, and respective robustness. The most accurate method was compared to DVH summation for ITDA. Geometric accuracy increased significantly with registration complexity. TPS-RPM achieved the highest accuracy (median Dice 0.98, HD-99% 1.4 mm, MSD 0.25 mm) with lowest variability, and yielded significantly lower accumulated GIO doses compared to DVH summation (D 25.5 Gy vs 26.9 Gy and V20Gy 5.4 cc vs 5.9 cc). Nonetheless, ITDA outcomes were identical or similar between the approaches. Fractions were reduced by 17%. PTV V and PTV D increased significantly. Only PTV D differed. Although advanced registration methods improve geometric accuracy and predict lower accumulated GIO doses, differences in fraction reduction or target dose were absent or minimal with ITDA compared to DVH summation. DVH summation therefore remains practical and efficient for this application, avoiding unnecessary complexity without compromising outcomes.
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7. Preoperative stereotactic body radiotherapy for early-stage luminal breast cancer: a systematic review and meta-analysis (PRELUMEN).
PMID:期刊:日期:2026-10-01Preoperative stereotactic body radiotherapy (SBRT) has emerged as a precision locoregional strategy for early luminal breast cancer, yet no quantitative meta-analysis exists in this subtype. We aimed to estimate the pooled pathological complete response (pCR) rate, identify its predictors through meta-regression, and characterise safety and cosmetic outcomes. A systematic review and meta-analysis of prospective trials of preoperative SBRT in patients with clinical stage T1-T2 N0-N1 luminal (ER-positive, HER2-negative) breast cancer was conducted following PRISMA 2020 guidelines. Random-effects models with REML estimation were fitted on logit-transformed proportions. Univariable meta-regression analyses examined absorbed dose (BED_4), irradiation-to-surgery interval, fractionation, technique, and biological tumor characteristics as covariates. Eleven prospective studies (428 patients) were included. Eight trials (N = 277) reported pCR data, yielding a pooled pCR rate of 21.4 % (95 % CI: 12.1-35.1 %; I = 77.0 %). The irradiation-to-surgery interval was the sole statistically significant predictor of pCR (β = +0.045 per week; p < 0.001; R = 98.9 %), whilst BED_4, fractionation, and technique showed no independent association. Pooled late grade ≥ 3 toxicity was 5.9 % (95 % CI: 3.7-9.1 %) and excellent or good cosmesis was achieved in 88.3 % of patients (95 % CI: 79.4-93.6 %). Preoperative SBRT achieves a clinically meaningful pCR rate in early luminal breast cancer, with acceptable toxicity and preserved cosmesis. The irradiation-to-surgery interval is the dominant modifiable predictor of pathological response. Randomized trials prospectively optimizing this interval in the luminal subtype are warranted.
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8. Radon inhalation reduces LPS-induced pneumonia symptoms in mice and promotes immunosuppression in the lung.
PMID:期刊:日期:2026-10-01Radon, a naturally occurring radioactive noble gas, remains an established component of European balneological medicine in the management of inflammatory diseases. Similarly, X-ray-based radiotherapy, known as low-dose radiation therapy (LDRT), is used. However, the use of both radon therapy and LDRT, remains controversial, even though it was used in some countries to treat patients during the COVID-19 pandemic. This raises the question of the effectiveness of LDRT, especially against inflammatory lung diseases. Previously, we could show in mice that X-ray LDRT has anti-inflammatory and immunosuppressive effects in the management of pneumonia. Our study presented here aimed to assess the effect of radon inhalation on murine pneumonia induced by intratracheal administration of lipopolysaccharide (LPS). Mice were treated with either radon or dexamethasone, the latter being the standard of care for inflammatory diseases. Both treatments improved clinical signs, general health condition and lung architecture in mice with LPS-induced pneumonia. Mechanistically, both treatments downregulated inflammatory pathways and promoted those related to tissue repair and integrity. In both treatment groups, the Th1-pro-inflammatory response was suppressed and a Th2-anti-inflammatory one was promoted. Interestingly, radon inhalation promoted the anti-inflammatory 'alternative' activation profile of lung macrophages. Furthermore, the assessment of the potential of radon to induce oncogene expression and thereby to increase the risk of cancer development following exposure, showed significant downregulation of oncogenes. In sum, our data provide indications for the effective use of radon in treatment of pneumonia as an alternative for patients who are refractory to dexamethasone treatment or unable to receive corticosteroids due to contraindications.
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9. Dosimetric parameters of the axillary-lateral thoracic junction in predicting risk of breast cancer-related lymphedema.
PMID:期刊:日期:2026-10-01Regional nodal irradiation (RNI) is associated with breast cancer-related lymphedema (BCRL), yet varying definition of extensive RNI among radiation oncologists leads to the inconsistencies in risk assessment. Recently, the axillary-lateral thoracic junction (ALTJ) has been proposed as a potential organ-of-interest, but its role remains controversial. This study investigates the predictive role of ALTJ dose-volumetric parameters in BCRL development. We identified patients with breast cancer who underwent surgery and adjuvant radiotherapy (2018 - 2020). BCRL was defined as newly developed upper arm lymphedema after radiotherapy, with International Society of Lymphology stage ≥ 2. Following retrospective ALTJ contouring, multivariable Cox regression and Random Survival Forest models were developed using clinical factors and ALTJ dosimetric parameters. Model performance was evaluated via Harrell's C-index and 24-month landmark analysis. We investigated 722 patients with a median follow-up of 30 months. 283 (39.2%) underwent axillary lymph node dissection (ALND). In multivariate Cox regression, along with ALND, ALTJ V > 50% was associated with an increased risk BCRL (p = 0.003, HR 3.07), whereas binary RNI status wasn't (p = 0.363). When comparing multivariable prognostic frameworks, Model B (incorporating ALTJ V) demonstrated a more favorable statistical fit than Model A (incorporating RNI). While Model B yielded a numerically higher C-index (0.753 vs. 0.749), this gain was not statistically significant. This study highlights the significance of the ALTJ as an organ-of-interest in breast cancer patients who underwent radiotherapy. Incorporating ALTJ dosimetric parameters into predictive models enhances prognostic accuracy, addressing the limitations of variable RNI field definitions.
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10. Ultra-hypofractionated versus conventional chemoradiation for newly diagnosed glioblastoma: Survival and toxicity results of a multicenter randomized trial.
PMID:期刊:日期:2026-10-01In glioblastoma, standard first-line chemoradiation since the 2005 EORTC/NCIC trial is 30x2Gy with concurrent and adjuvant temozolomide. A phase II study suggested ultra-hypofractionation (6x6Gy) may offer comparable survival, with reduced treatment time and costs, potentially improving health-related quality of life (HRQoL). This phase III randomized trial (Netherlands Trial Registry, NL72953.041.20) evaluated non-inferiority of ultra-hypofractionated temozolomide chemoradiation in glioblastoma patients. Adults with newly diagnosed glioblastoma and a Karnofsky performance status ≥70 were randomized (1:1) to ultra-hypofractionated (6x6Gy in 2 weeks) or standard (30x2Gy in 6 weeks) radiotherapy, both with concurrent and 6 cycles of adjuvant temozolomide. The primary endpoint was 2-year overall survival (OS); the non-inferiority margin was a hazard ratio of 1.2. Secondary outcomes included progression-free survival (PFS) and toxicity. Enrollment stopped early, due to slow accrual (n=135/474 planned, 67 experimental, 68 standard). Median OS was shorter in the experimental arm: 13.0 months (95% CI 10.3-15.7) versus 21.0 months (95% CI not estimable). In a time-dependent analysis, survival was similar in the first 6 months (HR 0.99, 95% CI 0.39-2.50), but mortality was higher thereafter (HR 2.54, 95% CI 1.57-4.09, p < 0.001). Radiation necrosis or pseudoprogression was more frequent after ultra-hypofractionation (47.8% vs 16.2%; HR 5.20, 95% CI 2.56-10.58), with increased dexamethasone use at 6-12 months. No grade 4-5 toxicities were observed. Non-inferiority of the 6x6 Gy chemoradiation regimen could not be demonstrated. This ultra-hypofractionated regimen was associated with inferior survival and increased radiation necrosis, and therefore should not replace standard chemoradiation.