TRENDS IN BIOTECHNOLOGY生物技术趋势
TRENDS IN BIOTECHNOLOGY(英文缩写 TRENDS BIOTECHNOL),ISSN 0167-7799,eISSN 1879-3096,中文译名:生物技术趋势 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 21.942 | Q1 |
| 2022 | 17.300 | Q1 |
| 2023 | 14.300 | Q1 |
| 2024 | 14.900 | Q1 |
| 2025 | 16.600 | Q1 |
TRENDS IN BIOTECHNOLOGY 最新收录文献
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1. Toward adaptive cyborg tissues.
1. 迈向自适应半机械组织PMID:日期:2026-10-01Organoids and engineered tissues have emerged as powerful models of human biology, yet their development and function are often characterized through endpoint measurements that provide only static snapshots of dynamic biological processes. Recent advances in stretchable mesh electronics, developmental biointegration, and organoid engineering have enabled the creation of cyborg tissues with embedded sensing, stimulation, and computational capabilities. This review highlights recent progress in developmental bioelectronic integration, multifunctional tissue mapping, biological state reconstruction, and artificial intelligence (AI)-enabled cyborg systems. We discuss how embedded bioelectronics can be combined with molecular and spatial profiling technologies to characterize tissue function, developmental trajectories, and biological states. These advances establish cyborg tissues as biologically integrated platforms for regenerative medicine, disease modeling, drug discovery, and adaptive biotechnology.
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2. Biotechnology as a platform for hair cosmetic science.
2. 生物技术作为毛发化妆品科学的平台PMID:日期:2026-10-01Hair cosmetics are undergoing a transition from conventional formulations based on passive surface deposition toward biotechnology-driven systems designed to interact with hair and scalp at the molecular level. Recent advances in proteins, peptides, biobased polymers, and responsive delivery platforms are enabling targeted repair of keratin damage, controlled reshaping, durable protection, and modulation of follicular activity. These technologies exploit biological specificity, renewable feedstocks, and programmable material properties to address limitations associated with traditional petrochemical ingredients. In this review, we examine how biotechnology is emerging as a unifying platform for hair cosmetic science, integrating biomolecular engineering, smart materials, computational design, and artificial intelligence to create more effective, sustainable, and biologically inspired hair-care solutions.
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3. Synonymous sequence design controls the folding, processing, and activity of the therapeutic protein ADAMTS13.
3. 同义序列设计控制治疗性蛋白ADAMTS13的折叠、加工和活性PMID:日期:2026-10-01Synonymous recoding is widely used to enhance therapeutic protein expression, yet its broader effects on biogenesis and function remain unclear. We systematically examined how synonymous recoding shapes protein structure, processing, and activity using plasma protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) and its truncated MDTCS (metalloprotease, disintegrin-like, thrombospondin type 1, cysteine-rich, and spacer) variant across cell-free expression, transient transfection, lentiviral delivery, and targeted genomic integration. Wild-type, codon-optimized, and codon-pair-optimized constructs displayed pronounced, system-dependent differences in intracellular proteolysis, secretion, enzymatic performance, and post-translational modifications. Targeted genomic integration produced the highest protein fidelity, whereas transient and lentiviral systems yielded lower extracellular protein levels, particularly for codon-pair-optimized variants. Glycoproteomic analyses revealed distinct glycosylation patterns among synonymous constructs, indicating altered maturation, while Ankyron-based assays detected differences in molecular surface properties of recoding variants. Optimized MDTCS exhibited increased catalytic activity but reduced substrate affinity. These findings demonstrate that synonymous recoding can reshape proteostasis and activity, emphasizing the need for comprehensive evaluation of engineered therapeutic genes beyond yield.
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4. Unnatural amino acids program thermoresponsive protein-polymer diblocks into shape-shifting nanostructures.
PMID:日期:2026-09-29Control over the morphology and function of self-assembling polymers remains a central challenge in engineering adaptive biomaterials and synthetic biological systems. Here, we establish that recombinant elastin-like polypeptide-resilin-like polypeptide diblocks can be programmed through incorporation of unnatural amino acids (uAAs) to undergo multistep, temperature-dependent phase transitions that generate shape-shifting nanostructures, including micelles, vesicles, and higher-order assemblies not typically accessible in conventional protein materials, thereby expanding their structural and functional design space. Incorporation of only six uAAs (<1.5% of residues) is sufficient to program phase behavior and assembly pathways, with uAA hydrophobicity and sequence position governing morphology and structural transitions. Photo-switchable uAAs further enable reversible, light-driven control over nanostructure morphology, modulating substrate encapsulation and enzymatic activity. Together, these findings define a genetically encoded design framework for adaptive protein materials and expand opportunities for their use in biotechnology, including synthetic organelle-like systems, dynamic biomolecular assemblies, responsive biocatalysis, and drug delivery.
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5. Metabolic engineering of Saccharomyces cerevisiae for the biosynthesis of indole-derived compounds.
5. 酿酒酵母代谢工程用于吲哚衍生化合物的生物合成PMID:日期:2026-09-29Indole-3-acetonitrile (IAN) and its derivatives-indole-3-carboxaldehyde (I3A), indole-3-carboxylic acid (I3CA), and 3,3'-diindolylmethane (DIM)-are high-value indole-derived compounds widely used in the chemical, pharmaceutical, and nutraceutical industries. However, their de novo microbial production has not yet been achieved. In this study, we constructed a Saccharomyces cerevisiae platform for the de novo biosynthesis of IAN and its downstream derivatives. Reconstruction and optimization of the native plant pathway enabled production of 189.02 mg/l IAN from glucose, and the pathway was subsequently extended to I3A and I3CA, reaching titers of 65.85 and 13.95 mg/l, respectively. Furthermore, an artificial biosynthetic route to DIM was constructed by identifying a previously uncharacterized I3A reductase, enabling the microbial production of DIM from glucose. This work establishes a microbial platform for de novo biosynthesis of IAN and its derivatives and demonstrates a general strategy for producing natural and nonnatural indole derivatives.
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6. Engineering Pseudomonas putida KT2440 for open-loop upcycling of mixed plastics.
6. 工程化恶臭假单胞菌KT2440用于混合塑料的开环升级循环PMID:日期:2026-09-24Current recycling technologies address less than 10% of global plastic waste, necessitating alternative valorization routes. Biological upcycling via enzymatic depolymerization combined with microbial conversion of the resulting monomers offers a promising pathway to transform mixed-plastic waste into valuable alternatives. In this research article, we employed a single engineered Pseudomonas putida KT2440 for simultaneous co-utilization of five plastic monomers including ethylene glycol, terephthalate, adipate, 1,4-butanediol, and l-lactic acid, which can be derived from enzymatic hydrolysis of polyethylene terephthalate (PET), poly(butylene adipate-co-terephthalate) (PBAT), polyester polyurethanes (PUs), and polylactic acid. Continuous fermentation over 21 days with alternating mixed-monomer feeds achieved steady-state growth and complete substrate depletion, yielding adaptive mutations that informed iterative strain improvement. Further engineering enabled the biosynthesis of (R)-3-hydroxybutyrate (R-3HB), and 0.70 g l R-3HB was produced directly from enzymatic hydrolysates of blended PET, PBAT, and thermoplastic PU. These results establish a viable bio-based approach for upcycling realistic mixed plastics into value-added bioproducts.
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7. Plasmid copy number control offers a versatile tool in synthetic biology applications.
7. 质粒拷贝数控制为合成生物学应用提供了一种多功能的工具PMID:日期:2026-09-23Plasmids are typically regarded as static delivery vehicles for foreign DNA. Here, we expose the pivotal role that plasmid copy number (PCN) control can play in synthetic biology, not only in Escherichia coli but also in the next-generation bacterial workhorse Vibrio natriegens. We show that the antibiotic selection marker can impact PCN, thus affecting growth and protein production, and that cells can be cotransformed with multiple variants of the same plasmid, with their PCN controlled simultaneously and in unison. We reveal that plasmid loss can be mitigated via the integration of an additional origin of replication (ori) and that PCN control can be leveraged to modulate horizontal gene transfer, which we illustrate within the context of conjugation-based intercellular communication. Finally, we expand the MoClo modular cloning framework with inducible PCN control for rapid prototyping and to enhance the performance of complex biocircuits.
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8. Nanozymes and the restoration of immune tolerance in autoimmune diseases.
PMID:日期:2026-09-23Autoimmune diseases (ADs) are characterized by persistent immune dysregulation and oxidative imbalance, yet current therapies largely rely on broad immunosuppression that rarely restores durable immune homeostasis. Growing evidence indicates that reactive oxygen species (ROS) function as both inflammatory mediators and essential immune regulators, limiting the effectiveness of indiscriminate ROS scavenging. Here, we highlight nanozymes as emerging catalytic therapeutics for (ADs) and redefine their role as regulators of redox-guided immune homeostasis. We propose a catalytic redox set-point framework in which nanozymes restore a physiological redox window that supports immune regulation while constraining pathological inflammation. This perspective establishes a unifying mechanistic link between nanozyme catalysis and immune restoration, and outlines future opportunities for tolerance-oriented design and clinical translation.
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9. Asking pragmatic and RAD questions about organoid intelligence.
PMID:日期:2026-09-22Debates about whether organoid intelligence systems are conscious, or can suffer, often stall on the question of what these organoid entities and systems are. A reflexive, anticipatory, and deliberative approach, grounded in a moral principle of complexity, instead asks what they do and provides guidance on that basis. Unanswerable questions are transformed into more workable processes.
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10. Designing artificial cofactors and their enzymes together.
PMID:日期:2026-09-19When replacing expensive redox cofactors, making biomimetic cofactors with desirable thermostability and redox properties is only half of the equation; enzymes must also be able to use them. Ji and colleagues confront that trade-off by pairing the development of a thermostable carbocyclic cofactor with a dedicated regeneration enzyme for sustained biocatalysis.