TRENDS IN NEUROSCIENCES神经科学趋势
TRENDS IN NEUROSCIENCES(英文缩写 TRENDS NEUROSCI),ISSN 0166-2236,eISSN 1878-108X,中文译名:神经科学趋势 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 16.978 | Q1 |
| 2022 | 15.900 | Q1 |
| 2023 | 14.600 | Q1 |
| 2024 | 15.100 | Q1 |
| 2025 | 15.700 | Q1 |
TRENDS IN NEUROSCIENCES 最新收录文献
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1. When minds become data: brain-computer interfaces and the future of mental privacy.
1. 当心智成为数据：脑机接口与心理隐私的未来PMID:日期:2026-09-22The rapid advancement of brain-computer interfaces (BCIs), particularly adaptive closed-loop systems, presents unprecedented opportunities for medical intervention and human augmentation. At the same time, the growing adoption of applications outside clinical settings also poses significant risks to mental privacy. In this article, we review the current state of neural decoding advancements and their projected trajectory to assess what current and foreseeable technologies can reveal about mental states and the implications for mental privacy. Drawing on a neuroscientific perspective, we clarify the scope and limits of emerging mental privacy risks and argue for a shift in responsibility from reactive regulation to proactive, privacy-embedded design.
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2. The dynamics of functional connectivity-based language lateralization across timescales.
PMID:日期:2026-09-15In most individuals, language is predominantly left-lateralized, a prominent feature of human brain organization. Recent research increasingly views language lateralization as a property of distributed and interacting functional networks. In this article, we review evidence that the lateralization of functional connectivity within the language system varies in both degree and direction across multiple timescales. We propose that this connectivity-based lateralization undergoes long-term developmental, experience-dependent, and perturbation-induced reorganization, while also exhibiting short-term context-driven and spontaneous fluctuations within apparently stable patterns. Furthermore, we discuss neurobiological mechanisms that may support and constrain these dynamics. Together, these findings provide a multiscale framework for understanding how the human brain balances functional flexibility with relative stability in shaping the lateralized organization of language.
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3. Temporal astrocytic metabolic reprogramming gates pain chronification.
PMID:日期:2026-09-10Most experimental models of chronic pain emphasize the gradual emergence of sensory hypersensitivity, yet pain chronification can also be conceptualized as a metabolically regulated state transition. In this review, we synthesize evidence mainly from mouse and rat spinal cord and anterior cingulate cortex studies indicating that astrocytes temporally coordinate neuronal excitability, inflammatory signaling, and metabolic coupling. We propose that chronification proceeds through temporally organized astrocytic metabolic remodeling: GPCR-linked lactate-coupled signaling during acute induction, sustained glycolytic gene expression and glycogen remodeling during consolidation, and stabilization of pain-permissive astrocyte states through lactylation-linked inflammatory and chromatin regulation. By integrating these mechanisms along a temporal axis, this framework distinguishes processes that initiate chronicity from those that maintain established pain and suggests stage-specific logic for future interventions.
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4. Do rodent social hierarchy assays measure social dominance or task performance?
PMID:日期:2026-09-07Social hierarchy is a critical variable in rodent models of stress psychopathology and is often assessed using simplified competitive paradigms. These tasks frequently lack sufficient construct validity for social dominance, limiting interpretations of the neural mechanisms underlying social behavior. Advances in behavioral tracking now permit more ethologically grounded assessments of social dominance and provide a superior alternative to study social dominance.
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5. Beyond breathing: multimodal pathways connecting olfaction to autonomic nervous system modulation.
PMID:日期:2026-09-07The interaction between olfaction and respiration has recently emerged as a central aspect of brain-body interactions. To date, most studies in this context, both in rodents and humans, have focused on how respiratory airflow rhythmically drives brain activity. In this review, we shift the focus to the modulatory effects of odorant molecules, which engage chemical, affective, and trigeminal pathways to elicit integrated sensory experiences and robust autonomic responses. We synthesize recent findings showing that the olfactory system, through its unique connectivity with limbic and autonomic networks, operates at the interface between exteroception and interoception. By modulating respiratory dynamics, and more generally autonomic nervous system activity, odors emerge as a multimodal signal capable of influencing brain-body interactions and supporting well-being.
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6. Spatial navigation and the basal forebrain in Alzheimer's disease and other neurodegenerative diseases.
PMID:日期:2026-09-05Neurodegenerative diseases such as Alzheimer's disease (AD) and Lewy body disease (LBD) are frequently associated with spatial navigation impairments. However, these impairments are less pronounced in frontotemporal dementia and limbic-predominant age-related TDP-43 encephalopathy. While basal forebrain degeneration occurs in all of these diseases, disruption of cholinergic pathways and related cholinergic deficits has been primarily observed in AD and LBD, and in both of these conditions, basal forebrain degeneration appears to be associated with spatial navigation deficits. In this review, we discuss current understanding of spatial navigation impairments in neurodegenerative diseases, with a particular focus on disease-related changes in the basal forebrain and their associations with impaired spatial navigation abilities in humans.
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7. The nervous system as a systemic organizer of cancer-associated cachexia.
PMID:日期:2026-09-01Cancer-associated cachexia (CAC) is a progressive, multiorgan wasting syndrome that critically limits treatment response and survival. In CAC, the nervous system senses, amplifies, and coordinates responses to a broad range of tumor-induced perturbations, including both direct tumor-derived factors and the resulting systemic disturbances in inflammation, metabolism, and immunity. By dysregulating central neural circuits and remodeling peripheral innervation, tumor-hijacked neural coordination drives both anorexia and multiorgan wasting, forming a self-reinforcing cachexia loop. Additionally, treatment-associated neurotoxicity further augments dysfunction across the central and peripheral nervous systems. In this review, we synthesize evidence from patient studies and animal models to examine how tumors co-opt the nervous system to systemically organize cachexia, thereby providing a pathophysiological framework for studying early disease detection, biomarker development, and mechanism-based intervention for CAC.
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8. Amygdala excitability across development: mechanisms, environmental influences, and behavioral outcomes.
PMID:日期:2026-08-28Recent work in rodent models provides mechanistic insights into how the excitability of principal neurons is dynamically regulated to facilitate the encoding and retrieval of emotionally salient memories in the basolateral amygdala (BLA). In this review, we discuss the physiological mechanisms governing BLA excitability, emphasizing their impact on the recruitment of defined BLA ensembles encoding distinct behavioral states. In addition, we summarize the current understanding of how these mechanisms are established during development and suggest that this may follow distinct developmental phases. Lastly, we outline recent findings on how early-life adversity or genetic risk factors can acutely perturb developmental trajectories and may lead to enduring changes in BLA circuit function, with implications for neurodevelopmental disorders.
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9. The Microglia-Astrocyte-Neuron Lactate Shuttle model.
PMID:日期:2026-08-27In a recent study, Adler and colleagues demonstrated that microglia regulate blood glucose delivery to fuel the astrocyte-neuron lactate shuttle. As neuronal protein translation supported by this mechanism is essential for motor learning, these findings reveal how coordinated interactions among microglia, astrocytes, and neurons orchestrate neuroenergetics to support cognition.
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10. Beyond Bayesian integration: how meaning shapes placebo effects.
PMID:日期:2026-08-21Placebo effects illustrate how strongly expectations can shape symptom perception and treatment outcomes. Contemporary Bayesian accounts have provided valuable insights by formalising how expectations are integrated with sensory information. However, such accounts can struggle to explain why treatment expectations persist despite disconfirming evidence and why placebo responses vary widely across individuals. We argue that placebo effects arise from richer inferential processes in which the individual aims to make sense of their observations through inferred explanatory states that are shaped by their motivational preferences and guide the interpretation of treatment effects. Combining Bayesian principles with latent-state inference and higher-level beliefs provides a more comprehensive account of placebo effects and highlights new opportunities for neuroscience and clinical practice.