JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME生物力学工程杂志—美国机械工程师学会汇刊
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME(英文缩写 J BIOMECH ENG-T ASME),ISSN 0148-0731,eISSN 1528-8951,中文译名:生物力学工程杂志—美国机械工程师学会汇刊 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-25 至 2026-09-25，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 1.899 | Q4 |
| 2022 | 1.700 | Q4 |
| 2023 | 1.700 | Q3 |
| 2024 | 1.700 | Q3 |
| 2025 | 1.600 | Q4 |
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME 最新收录文献
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1. Sex-Dependent Differences in Pulmonary Vascular Resistance, Impedance, and Distensibility Revealed by Impaired Shear Stress Mechanotransduction.
PMID:日期:2026-12-01Sex-dependent differences in pulmonary vascular mechanics have been reported in both healthy and diseased populations, yet the mechanisms contributing to these differences remain poorly defined. Differences in shear stress responsiveness by the pulmonary endothelial surface may contribute to these differences in mechanics. This study investigated sex differences in shear stress responsiveness by measuring pulmonary pressure-flow relationships in isolated perfused lungs from male and female C57BL/6J mice. Pressure-flow relationships were measured under steady and pulsatile flow conditions before and after treatment with heparinase I to impair shear stress mechanotransduction. Pulmonary vascular resistance (PVR), vascular impedance, wave reflectance (RW), and pulmonary vascular distensibility (α) were quantified from pressure-flow data. Prior to treatment, male and female lungs exhibited comparable pulmonary vascular mechanics. Following heparinase I treatment, female lungs demonstrated significantly greater increases in PVR, 0-Hz impedance (Z0), and RW than male lungs. In contrast, characteristic impedance (ZC) remained unchanged in both sexes post-treatment compared to pretreatment, indicating preservation of proximal conduit arterial mechanics. Female lungs also exhibited lower post-treatment distensibility than males, suggesting reduced pulmonary vascular adaptation to increasing flow. Collectively, these findings indicate that impaired shear stress mechanotransduction had a greater impact in females than males and predominantly affected distal pulmonary vascular function while preserving proximal arterial properties. Our findings reveal significant sex differences in pulmonary vascular function with impaired shear stress mechanotransduction. These findings highlight the importance of considering sex as a biological variable in studies of pulmonary vascular biomechanics and vascular adaptation to flow.
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2. Do Endothelial Cells Have "Comfort Zones" for a Range of Hemodynamic Stresses That Lead to Different Triggers of Atherosclerosis at Different Arterial Sites?
PMID:日期:2026-12-01The patchy distribution of atherosclerosis within arteries implies the existence of local risk factors that control its development. Many hypotheses suggest a role for hemodynamic wall shear stress (WSS), but there is disagreement about which particular characteristics of WSS correlate spatially with the prevalence of lesions. This review considers why such confusion persists despite much research over many decades. Possibilities include the large changes in lesion prevalence that occur over short distances, the inadequate spatial resolution of methods for measuring near-wall flow, the computational demands of including all relevant factors into numerical simulations of flow, the difficulty of obtaining maps of lesion occurrence and WSS metrics in the same artery, the simplistic ways in which WSS metrics have been defined, and failure to consider mechanical factors other than WSS. A particular focus is the fundamental underlying assumption that a single hemodynamic factor triggers the disease. It may instead be the case that endothelial cells have a comfort zone for many different mechanical stresses and express an atherogenic phenotype when exposed to any values of a wide range of metrics that are outside this zone. Preliminary evidence that different arterial regions have different mechanical triggers is presented, underlying reasons that can account for such variability are discussed, implications for endothelial mechanotransduction and downstream events such as increased permeability are outlined, and recommendations are made for how future studies might confirm or refute the comfort zone concept.
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3. Structural and Mechanical Changes to the Extracellular Matrix in Human Umbilical Arteries in Pregnancies Complicated by Gestational Diabetes.
PMID:日期:2026-11-01The umbilical cord serves as a critical lifeline, connecting the fetus to the pregnant individual. Stillbirth, fetal death at or beyond 20 weeks' gestation, can occur due to developmental anomalies or complications of the umbilical cord. Gestational diabetes (GDM), which affects 8% of pregnancies in the United States, is associated with vascular abnormalities of the placenta and umbilical cord. While cellular and microstructural changes in the umbilical vasculature have been observed in pregnancies complicated by gestational diabetes, it is unknown if these influence the macroscale mechanical properties. Human umbilical arteries and veins from healthy pregnancies (n = 10) and from pregnancies with gestational diabetes requiring insulin for glucose management (n = 5) underwent quantitative histological analysis and circumferential ring testing to characterize the intact tissue and decellularized matrix. Collagen birefringence showed healthy umbilical arteries had a higher ratio of thick to thin collagen fibers than GDM. A two-way analysis of variance showed the viscoelastic behavior of the decellularized umbilical arteries was significantly affected by disease (p = 0.01) and pin strain (p = 0.02). GDM-decellularized umbilical arteries had a significantly (p = 0.04) lower first Piola-Kirchhoff stress than healthy at maximum pin strain. However, these differences did not persist within intact umbilical arteries. Additionally, there were no significant differences in the extracellular matrix content or mechanical properties between healthy and GDM umbilical veins. The results indicate umbilical arteries from pregnancies complicated by GDM have altered mechanical properties of the extracellular matrix, possibly due to decreased collagen fiber size.
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4. Computational Analysis of Unsteady Airway Flow Physics During Airway Pressure Release Ventilation.
PMID:日期:2026-11-01Airway pressure release ventilation (APRV) using the time-controlled adaptive ventilation (TCAV) method is seen to enhance proximal mucus movement relative to conventional volume-controlled ventilation (VCV), yet the airway-scale flow physics responsible for this behavior remain poorly understood. This study uses unsteady Reynolds-averaged Navier-Stokes simulations to examine how ventilator waveform timing and endotracheal tube (ETT) cuff geometry modify flow structures in an intubated tracheobronchial airway. Simulations were conducted in an idealized, asymmetric, three-dimensional Weibel airway model using three ventilation modes: assisted VCV, TCAV, and a modified high-duty-cycle VCV waveform designed to reproduce observed expiratory-biased flow conditions. Two ETT cuff geometries, representing Microcuff™ and TaperGuard™ styles, were analyzed under identical ventilator settings to isolate cuff-induced effects. Results show that assisted VCV generates a persistent high-momentum core and large-scale recirculatory structures, producing heterogeneous shear and strong jet-wall interactions. In contrast, TCAV suppresses large-scale recirculation and promotes more organized, wall-bounded shear layers, which is associated with reduced inspiratory shear exposure and more coherent expiratory flow structures. Cuff geometry strongly modulates these dynamics: the Microcuff sustains greater vortical persistence within the bronchi, whereas the TaperGuard produces a more ordered but less dynamically mixed flow field. Together, these results indicate that ventilator timing and cuff geometry govern airway flow organization, shear distribution, and unsteady transport characteristics. These airflow features are consistent with conditions that may be associated with secretion mobilization, although secretion transport is not directly resolved in the present simulations.
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5. Optimizing Marker Implantation for Three-Dimensional Kinematic Tracking in X-Ray Videos.
PMID:日期:2026-11-01For a detailed analysis of complex movements, such as disturbed locomotion, a combination of common approaches is helpful (calculation of 3D kinematics, measurements of myoelectrical activities, and ground reaction forces). The use of internal markers increased the accuracy of motion capturing and allowed the calculation of kinematics in 3D space, even long-axis rotation. Two implantation methods were designed and compared concerning their accuracy. Therefore, a double set of tantalum beads was implanted into the right forelimb of rats (test method versus glued reference). Our results showed that injecting the beads (1) via needle was the fastest method but caused considerable relative movements to the bones, which affected the angular 3D calculation (Ø root-mean-square (RMS) 3.4-31.6 deg), especially in the humerus. However, (2) embedding the internal markers into the muscles close to the periosteum enabled comparable results to the glued reference (Ø RMS 1.3-7.5 deg), while the surgery became easier and faster.
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6. Quantifying Porosity-Linked Mechanical Behavior of Renal Tubular Epithelial Cells by Poroviscoelastic Modeling and Atomic Force Microscopy Nanoindentation.
PMID:日期:2026-10-01Understanding the permeability characteristics of renal tubular epithelial cells is essential for exploring the mechanobiological regulation of solute and fluid transport in kidney physiology. In this study, we investigated the depth-dependent mechanical properties of renal tubular epithelial cells using atomic force microscopy (AFM)-based nanoindentation in combination with finite element analysis (FEA). Two material models-viscoelastic (VE) and poroviscoelastic (PVE)-were applied to fit the force-relaxation response at various indentation depths. The PVE model demonstrated better fitting performance in capturing time- and depth-dependent behavior within the tested indentation range, by incorporating the effects of fluid redistribution within the cytoplasm. Furthermore, we assessed the impact of cytochalasin D on the mechanical response of cells. Drug treatment led to a significant reduction in elastic modulus and an increase in hydraulic permeability, indicating a softening effect and enhanced fluid mobility associated with cytoskeletal disruption. These findings have important implications for renal reabsorption and secretion, where fine regulation of water and solute movement is vital. This work provides new insights into how mechanical cues modulate epithelial barrier function, contributing to a better understanding of renal physiology and potential dysfunction in renal disease.
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7. Machine Learning Methods to Predict Unmeasured Muscle Activation in Upper Limb Reaching Task for Assessing Population-Level Cross-Subject Generalizability.
PMID:日期:2026-10-01Accurately estimating muscle activation remains a major challenge in neuromuscular modeling, particularly when direct measurements are limited by sensor placement, noise, and accessibility constraints. Traditional approaches such as inverse dynamics and static optimization require high-quality kinematic and kinetic data, while surface electromyography (sEMG) signals are often complex, nonlinear, and difficult to interpret directly. This study evaluated whether deep learning models can learn generalizable intermuscular activation relationships using sEMG alone. Measured muscle activations were treated as prediction targets during a standardized forward-reaching task performed by 30 participants. Three architectures, convolutional neural networks (CNN), long short-term memory (LSTM) networks, and hybrid CNN-LSTM models, were compared across different numbers of predicted muscles, training dataset sizes, and leave-one-muscle-out conditions. No single architecture consistently outperformed the others across all target muscles and prediction configurations. CNN-LSTM achieved favorable performance in selected cases, whereas CNN and LSTM produced comparable or better results in others. Compared with a population-mean baseline, the machine learning (ML) models did not consistently produce lower RMSE or higher correlation, suggesting that the standardized reaching task contained shared population-level activation structure captured reasonably well by a simple average profile. Prediction performance depended strongly on target muscle, prediction configuration, and subject-level variability, with the biceps showing consistently lower predictability. Increasing the number of training participants improved performance, but gains plateaued beyond 20 subjects. Overall, these results support the feasibility of sEMG-based deep learning for simultaneous muscle activation prediction, while indicating that its advantage over simpler baselines is configuration-dependent rather than systematic.
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8. Expanded Stoichiometric Model of Chondrocyte Metabolism: Response to Cyclical Shear and Compressive Loading.
PMID:日期:2026-10-01Cartilage deterioration is a hallmark of osteoarthritis, and there is substantial interest in developing strategies for cartilage repair. Cyclical mechanical stimulation has been known for decades to drive synthesis of cartilage matrix proteins. Matrix synthesis requires activation of central metabolism for producing precursors to nonessential amino acids required for protein translation. However, there are gaps in knowledge regarding how mechanical stimuli affect chondrocyte central metabolism. Here, we find that cyclical shear and compression drive differences in chondrocyte central metabolism in a sex-dependent manner. Based on established biochemistry, we developed and tested a stoichiometric model containing 139 metabolites and 172 reactions from central metabolism that includes production of key cartilage matrix proteins. We then used experimental metabolomics data from shear and compressive stimulation of osteoarthritic chondrocytes to constrain this model and ran multiple simulations examining the potential for producing matrix proteins and ATP. Our results show that both shear and compression can stimulate osteoarthritic chondrocyte metabolism in a manner consistent with production of cartilage matrix proteins, with notable differences between male and female chondrocytes. Additionally, and importantly, our simulation results suggest that nitrogen availability is a key limitation to chondrocyte synthesis of matrix proteins. These results are a starting point for using central metabolism of chondrocytes to optimize synthesis of matrix proteins for cartilage repair. For example, increasing glutamine levels in the presence of cyclical compression has potential to increase production of both types II and VI collagen. These strategies have potential for improving cartilage tissue engineering and repair.
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9. Design and Evaluation of an Integrated Piezoelectric Force Sensing Total Knee Replacement.
PMID:日期:2026-10-01With patient dissatisfaction rates in total knee arthroplasty currently at 20%, smart knee technology seeks to provide an in vivo method for tracking postoperative joint forces, which could aid in early diagnosis of postoperative complications and provide key data to help improve implant designs and surgical procedures. This study investigates the design, simulation, and experimental evaluation of a piezoelectric force sensing system integrated into a commercially available knee implant that preserves the overall implant geometry. Finite element simulation and parametric analysis are used to identify the transducer arrangement with the lowest error in sensing compartmental joint contact forces. A prototype is then subjected to an axial load profile simulating walking using a joint motion simulator. Total and compartmental contact forces are evaluated, and accuracy of compartmental center of pressure localization is evaluated via ±3 mm and ±6 mm anterior-posterior translations. Results show the ability to track the axial force profile and demonstrate center of pressure deviations of ∼1 mm or better at 3-A and 3-P translations and ∼3-4 mm at 6-A and 6-P translations. Error of the order of ∼15% is observed in the total force measurement at maximum load. Suspected sources of error include plastic deformation of the tibial bearing insert and high stress levels in the piezoelectric transducers that suggest partial depolarization. Overall, our piezoelectric smart knee replacement shows promise for in vivo joint sensing, and this work marks a path for further development for integration into commercial knee replacement components.
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10. Multi-Objective Optimization Design of Synthetic Polymer Heart Valve Geometry.
PMID:日期:2026-10-01Aortic valve disease is a common valvular heart disorder that often progresses to heart failure. Aortic valve replacement with artificial heart valves is the standard treatment, making valve performance critical to patient outcomes and driving growing interest in optimized polymeric heart valves. Although prosthetic valve replacement is widely used, current artificial valves still face durability-hemodynamics tradeoffs. In this study, we sought to explore a computational design framework for improving the flow area, leakage, and stress distribution of a polyurethane-based synthetic polymer heart valve by simultaneously optimizing leaflet thickness and height through a data-driven workflow. A three-dimensional fluid-structure interaction model of a tri-leaflet valve made from siloxane-modified polyurethane was constructed and meshed. Twelve design points and three verification points covering the clinical design space were analyzed for effective orifice area (EOA), regurgitant fraction (RF), and peak von Mises stress. Response-surface surrogate models were fitted and interrogated using a multi-objective genetic algorithm. The leading Pareto solution was subsequently resimulated for half a cardiac cycle to evaluate its predicted performance. The surrogate prediction error was quantified as the absolute difference between surrogate and simulation results, and the ability to identify designs meeting ISO 5840-3 limits (EOA ≥ 125 mm2, RF ≤ 20%) was assessed. The optimized geometry (thickness 0.197 mm; height 15.49 mm) increased EOA from 140.5 mm2 to 164.5 mm2, reduced RF from 3.10% to 2.88%, and lowered peak stress from 1.88 MPa to 1.59 MPa. Surrogate predictions differed from the underlying simulation results by ≤5.3 mm2 for EOA, 0.59 percentage-point for RF, and 0.081 MPa for stress. Coupled optimization of leaflet thickness and height improved simulated hemodynamic and mechanical performance while satisfying ISO 5840-3 requirements. The presented workflow-combining fluid-structure interaction simulation, response-surface modeling, and multi-objective optimization-illustrates a computational methodology for exploring polymeric heart valve design spaces. Because the computational model has not yet been validated against independent experimental measurements, the reported performance improvements should be interpreted as preliminary computational findings pending future validation and comprehensive verification, validation, and uncertainty quantification (VVUQ).