BIOSCIENCE REPORTS生物科学报告
BIOSCIENCE REPORTS(英文缩写 BIOSCIENCE REP),ISSN 0144-8463,eISSN 1573-4935,中文译名:生物科学报告 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.977 | Q3 |
| 2022 | 4.000 | Q2 |
| 2023 | 3.800 | Q2 |
| 2024 | 4.700 | Q1 |
| 2025 | 4.500 | Q2 |
BIOSCIENCE REPORTS 最新收录文献
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1. A Thermally Processed Cafeteria Diet Reproducibly Mimics Early Metabolic Syndrome Through Obesogenic, Inflammatory, and Adipose Dysfunctions in Wistar Rats.
PMID:日期:2026-10-02The obesogenic nutrient composition and processing characteristics of ultra-processed foods may contribute to metabolic dysfunction. This study evaluated a standardized cafeteria diet, alone or combined with low-dose streptozotocin (STZ), in male Wistar rats. Animals (n = 32) were allocated to Healthy Control, STZ (35 mg/kg), Cafeteria Diet (CAF), and CAF+STZ groups. The diet contained standard chow, condensed milk, refined sugar, hydrogenated fat, soybean oil, and chocolate-filled biscuits, homogenized and thermally processed at 180 °C. After 102 days, anthropometric, metabolic, inflammatory, gene expression, microbiota, and histopathological parameters were assessed. CAF induced a marked obesogenic phenotype, with increased body weight (+172.3%) and abdominal circumference (+38.7%; p < 0.01). CAF showed hyperglycemia (median glucose, 403 mg/dL) and higher HOMA-IR than Healthy Control (p < 0.01); CAF+STZ also showed increased HOMA-IR (p < 0.05). CAF increased IL-1β and IL-6 (p < 0.05), triglycerides, adipocyte hypertrophy (p < 0.01), and adipose Leptin expression (p < 0.05), while reducing muscle Slc2a4/GLUT4 expression (p < 0.01). Liver, kidney, and pancreatic histopathological scores did not differ significantly. Gut microbiota showed marked compositional imbalance and low taxonomic evenness, with Firmicutes (99.83%), Ligilactobacillus (99.36%), and Lactobacillaceae (99.52%) predominating, while Enterobacteriaceae represented 0.14%. Despite no reduction in Shannon or Simpson indices, extreme Ligilactobacillus dominance indicated a restricted and uneven community. Overall, the cafeteria diet reproduced obesity-associated metabolic dysfunction, characterized by hyperglycemia, insulin resistance, inflammation, adipocyte hypertrophy, altered glucose and leptin expression, and substantial microbiota restructuring.
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2. MUC17 and the intestinal glycocalyx: structure, regulation, and barrier function in health and disease.
2. MUC17与肠道糖萼：在健康与疾病中的结构、调控及屏障功能PMID:日期:2026-10-01The intestinal epithelial surface is protected by a multilayered barrier system that includes secreted mucus and a membrane-bound glycocalyx. While gel-forming mucins have been extensively studied, the transmembrane mucins that form the enterocyte glycocalyx remain less well understood. MUC17 has emerged as a dominant and functionally important transmembrane mucin of the small intestinal brush border, where its large, extensively O-glycosylated extracellular domain forms a dense, hydrated barrier between luminal microbes and the epithelial membrane. This review summarizes current knowledge of MUC17 biology, from genomic organization and protein architecture to glycosylation, trafficking, developmental regulation, and barrier function. Particular emphasis is placed on how MUC17 contributes to size-selective exclusion, bacterial segregation, and host-microbe homeostasis. This review further discusses the developmental establishment of the MUC17-rich enterocyte glycocalyx during the suckling-weaning transition and covers the mechanisms that regulate MUC17 localization and dynamics in epithelial cells, including apical targeting, membrane retention, recycling, turnover, and responses to inflammatory cues. Finally, the review examines the consequences of altered MUC17 expression or function, with particular emphasis on glycocalyx barrier defects, host-microbe interactions, bacterial access to the epithelium, and the relevance of MUC17 dysfunction to Crohn's disease and experimental models of intestinal infection. Together, the review positions MUC17 as a central structural and functional component of the intestinal glycocalyx and an underexplored therapeutic axis for restoring epithelial barrier integrity in intestinal disease.
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3. Characterization of the Mos10 (Vps60) ESCRT-III complex.
PMID:日期:2026-09-28The endosomal sorting complex required for transport (ESCRT)-III protein Mos10 (also known as Vps60) forms an alternative ESCRT-III complex in yeast. Here, we explored the relationship between the Mos10 complex and the classical Snf7-based complex. Both proteins could in principle form completely independent complexes or mixed complexes. To address the present issue, we examined the composition of ESCRT-III in different mutants of the endosomal protein sorting pathway by co-immunoprecipitation. We found that the formation of the Mos10 complex was dependent on the activity of the AAA+ ATPase Vps4. At the same time, loss of Vps4 activity led to an accumulation of the canonical ESCRT-III proteins Snf7, Vps2, and Vps24. In none of the mutants tested could a complex be detected that contains only Mos10 and no Snf7. We therefore favor the view that Snf7 and Mos10 form mixed complexes, which could play a role in the disassembly of ESCRT-III. To further dissect the interactions among the ESCRT-III subunits, Mos10 mutants were isolated. The L49P mutation in helix α1 altered Mos10 localization, while the L150P mutation in helix α4 abolished membrane association. A potential explanation for the effect of the L49P mutation on Mos10 function is suggested by AlphaFold modeling.
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4. High-resolution cryoEM of nucleosomes in nuclear extracts of mammalian cells.
PMID:日期:2026-09-24Frontier Structural Biology methods are transitioning from analysis of reconstituted macromolecular complexes in vitro to imaging of macromolecular assemblies within the physiological confines of the cell. Preparation of samples for in situ cryoEM analysis requires FIB milling or ultramicrotome sectioning, laborious and technically challenging procedures that are low-throughput and require a high degree of technical skills. We have devised a simple approach for cryoEM of nuclear macromolecular complexes that preserves to a high degree their physiological environment while removing the need for thin sectioning of the sample. The method requires only the preparation of nuclear extracts without additional purification or enrichment steps. We applied the method to obtain a 2.3 Å cryoEM structure of nucleosomes visualised directly in the nuclear lysate of human cells.
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5. The convergent roles of metabolic dysfunction, alcohol, and iron in steatotic liver disease: a review.
PMID:日期:2026-09-24Steatotic liver disease (SLD) encompasses a broad spectrum of disorders influenced by metabolic dysfunction, alcohol use, and other cofactors. The updated classification of metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease (ALD), along with the recognition of the overlapping entity MetALD, allows for better identification of patients at increased risk of progressive liver injury. While iron dysregulation is known to worsen both MASLD and ALD, its role within MetALD remains poorly defined. Understanding how iron contributes to this combined phenotype may provide new insight into why these patients experience more severe disease outcomes. This review synthesises current evidence linking iron to MASLD, ALD, and their intersection in MetALD. It introduces the concept of Fe-MetALD, a "triple-hit" phenotype where metabolic dysfunction, alcohol, and iron overload act together to accelerate liver injury. Mechanistically, these insults share common pathways involving oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, and hepatic stellate cell activation, collectively promoting fibrosis progression and potentially increasing the risk of cirrhosis and hepatocellular carcinoma. Experimental studies suggest that the combination of these insults produces more severe liver injury than any individual factor alone. Emerging therapies that target iron pathways, including hepcidin mimetics, ferroportin inhibitors, and iron-reduction strategies like venesection or chelation, may offer therapeutic potential, although current evidence remains largely preclinical. Recognising Fe-MetALD as a high-risk phenotype supports incorporating iron markers into diagnosis and developing therapies targeting metabolic, alcohol-related, and iron-mediated injury. Understanding this triple-hit interaction may improve risk stratification and guide future therapies for SLD.
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6. Metataxonomic strategy to decipher gut bacteriome biomarkers of type 2 diabetes and obesity in Tunisian population.
PMID:日期:2026-09-23Metabolic disorders are multifactorial diseases and major global health concerns, with many individuals worldwide responding inadequately to treatments. The gut bacteriome regulates metabolism and offers therapeutic potential; however, research from North Africa remains scarce despite the growing prevalence of non-communicable diseases in the region. This study examines gut bacterial profiles of Tunisian type 2 diabetic (T2D), obese (OB), and non-diabetic (ND) individuals within the framework of personalized medicine. Ninety-five participants were enrolled (33 ND, 26 T2D, 26 T2D with obesity and cardiovascular complications (T2D_OBCV), and 10 OB). Bacterial 16S rDNA V3-V4 regions were sequenced on Illumina MiSeq and analyzed using the QIIME 2 pipeline. Obese subjects exhibited gut dysbiosis with lower Akkermansia (p = 0.02) and Ligilactobacillus (p = 0.04) levels, an enrichment of Bifidobacterium (p = 0.004), as well as Sutterella (p = 0.03) and Erysipelatoclostridium (p = 0.02). However, the gut bacteriome landscape of T2D patients reveals differences in the distribution of Shigella (p = 0.01) highly abundant in the intestine, and a depletion of Clostridia vadin BB 60 group (p = 0.02) and Oscillospiraceae UCG 005 (p = 0.01). Noting that the gut bacteriome of T2D_OBCV patients is characterized by a depletion of Asteroleplasma (p = 0.01), Oscillospiraceae UCG 005 ( p = 0.02), Eubacterium ruminantium group (p= 0,0007), and Romboutsia (p = 0.002) beside an enrichment of Fusicatenibacter (p = 0.02). Gut bacteriome alterations in Tunisian T2D and obese subjects may serve as metabolic biomarkers.
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8. Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.
PMID:日期:2026-09-22Despite our constant exposure to potential dangers, our ability to withstand infection and tissue damage relies on a network of coordinated cellular security systems. One of these security features is our innate immune system, which senses danger signals from invading pathogens as well as host-derived stress signals while remaining largely unresponsive to normal host molecules and the flora of the host microbiota. This intertwining network of cellular guardians expresses pattern recognition receptors to recognise specifically pathogen-associated molecular patterns and danger-associated molecular patterns and elicit an inflammatory response. Inflammation is an integral process to eliminate a pathogenic threat while simultaneously promoting tissue repair. However, a balance exists, and persistent or aberrant inflammation can instead drive tissue damage and disease. To douse inflammatory flames, the endocrine system releases endogenous glucocorticoids, which possess potent immunomodulatory actions. This review will explore the cross-talk between endogenous glucocorticoid signalling and innate immune signalling pathways.
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9. The membrane skeleton density of red blood cells in MYH9-related disease patients is decreased.
PMID:日期:2026-09-17MYH9-related disease (MYH9-RD) is a rare autosomal dominant disorder caused by mutations in MYH9 gene, which encodes the heavy chain of nonmuscle myosin IIA. Nearly all MYH9-RD patients present with macrothrombocytopenia, characterized by decreased platelet count and increased platelet size. In the present study, we collected blood samples from three MYH9-RD patients (R702S, D1424N, and R1464C) and unexpectedly found that the actin levels in the red blood cells (RBCs) from all three MYH9-RD patients are substantially lower than the healthy controls. We further revealed that the levels of two RBC membrane skeleton proteins, α-spectrin and tropomodulin, are also reduced in MYH9-RD RBCs. We showed that the membrane skeleton of MYH9-RD RBCs was more porous and that MYH9-RD RBCs produced more severe deformation under hyperosmotic pressure compared with healthy controls. We propose that defects in the membrane-skeleton network of RBCs may be an abnormal manifestation of MYH9-RD.
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10. Retraction: Time series expression pattern of key genes reveals the molecular process of esophageal cancer.
PMID:日期:2026-09-17该文献暂无摘要。