Annual Review of Microbiology微生物学年度综述
Annual Review of Microbiology(英文缩写 ANNU REV MICROBIOL),ISSN 0066-4227,eISSN 1545-3251,中文译名:微生物学年度综述 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 16.232 | Q1 |
| 2022 | 10.500 | Q1 |
| 2023 | 8.500 | Q1 |
| 2024 | 9.900 | Q1 |
| 2025 | 12.200 | Q1 |
Annual Review of Microbiology 最新收录文献
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1. {"_":"Syphilis Pathogenesis: Host Interactions, Immune Evasion, and Persistence of .","i":["Treponema pallidum"]}
1. 梅毒发病机制：宿主相互作用、免疫逃逸及梅毒螺旋体的持续存在PMID:日期:2026-09-01subsp. is the causative agent of syphilis, a chronic and potentially devastating infection that is resurging globally. The bacterium is highly invasive, disseminates rapidly, and establishes decades-long latency that may progress to severe tissue destruction and death. 's reduced genome contributes to its dependence on the host. Its impressive TprK antigenic variation, scarce outer membrane proteins, and periplasmic flagella provide for immune evasion, enabling persistence and reinfection. Our understanding of syphilis pathogenesis derives largely from experimental infection in rabbits and from historical studies in humans, though recent advances in continuous cultivation, genetic manipulation, hybrid-capture genome sequencing, and multi-omic approaches have opened new avenues for dissecting host-pathogen interactions and disease pathogenesis. This review highlights mechanisms of syphilis pathogenesis, the central role of the immune response in disease causation and progression, and the role of new technologies in answering long-standing questions and informing vaccine development.
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2. 25 Years Since the First Microsporidian Genome Assembly, Insights on How Genomics Has Shaped Our Understanding of Parasites with the Smallest Eukaryotic Genomes.
2. 自首个微孢子虫基因组组装以来的25年：基因组学如何塑造我们对拥有最小真核基因组的寄生虫的理解PMID:日期:2026-08-25Microsporidia are fungal intracellular parasites of animals and are a threat to human health and food security. In 2001, they became the first eukaryotic parasites to have their genome fully sequenced. Analysis revealed they possessed the smallest eukaryotic genomes, having undergone extreme genomic reduction. In this article, we review how genomic technologies have been applied to these parasites since this seminal discovery. We demonstrate how additional microsporidian genomes have enabled the examination of genome structure, gene conservation, population genetics, and diversity. We describe how transcriptomics has revealed parasite gene regulation across different life stages and host responses to infection. We discuss how proteomic and structural techniques have advanced our understanding of microsporidian biology and how various approaches have elucidated microsporidian protein function. Finally, we explore future directions for applying genomic technologies to accelerate our understanding of these fascinating parasites.
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3. Decoding Bistability and Drivers of Phenotypic Variation in Bacteria.
3. 解码细菌的表型变异的双稳态与驱动因素PMID:日期:2026-08-19In a process known as phenotypic heterogeneity or phenotypic variation, bacteria can produce distinct phenotypes within an isogenic population in response to shifting environmental conditions. Noise in gene expression, asymmetric cell division, phase variation, and quorum sensing are some of the mechanisms that contribute to this variability, which is maintained by gene regulatory networks (usually involving feedback loops). Bistability in gene regulatory networks generates subpopulations exhibiting specific traits that can contribute to more complex adaptive strategies, promoting the fitness of the bacterial community as a whole. This review explores recent examples of phenotypic heterogeneity and its functional importance in bacterial collective behaviors. We focus on how synthetic biology can be used to better understand bacterial gene regulatory networks and the mechanisms underlying antibiotic resilience and persistence, and we discuss the bistability of integrative and conjugative elements.
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4. Intraperiplasmic Predatory Bacteria: Diversity, Mechanisms, and Application as Alternatives to Antibiotics.
4. peri胞内捕食性细菌：多样性、机制及作为抗生素替代品的应用PMID:日期:2026-08-19represents one of nature's most remarkable examples of obligate bacterial predation. This small, highly motile bacterium exhibits a biphasic life cycle alternating between a free-swimming attack phase and an intraperiplasmic growth phase within gram-negative prey bacteria. Recent advances have elucidated the molecular machinery coordinating prey recognition, invasion, and host manipulation, revealing sophisticated enzymatic arsenals and regulatory networks that orchestrate the predatory program. Transcriptomic studies demonstrate precise temporal control of lytic enzymes, nutrient acquisition systems, and developmental checkpoints throughout the life cycle. and related organisms occupy diverse niches, including soil, freshwater, and the mammalian gut, where they influence bacterial community composition through top-down predation. This ecological ubiquity, combined with inherent bactericidal activity, has generated considerable interest in therapeutic applications against multidrug-resistant pathogens, with encouraging results in animal infection models. In this article, we synthesize current understanding of predatory mechanisms, environmental roles, and biotechnological potential of while identifying key knowledge gaps: the regulatory logic governing life cycle transitions, molecular determinants of host range, and predator-prey population dynamics. Addressing these questions will advance both fundamental microbiology and antimicrobial innovation.
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5. Beyond the Bloodstream: The Impact of Malaria on Red Cell Development.
PMID:日期:2026-08-12Malaria, a life-threatening disease caused by eukaryotic intracellular parasites belonging to the genus , is classically characterized by the infection of circulating red blood cells. However, growing evidence reveals that these parasites also accumulate within the bone marrow, the primary site of red cell production. In this review, we detail the evidence for this cryptic reservoir of parasites, the associated implications for host erythropoiesis, and an array of complex host responses elicited by the parasites in this niche. The underlying bone marrow pathology stems from multiple factors, including direct parasite invasion of erythroid precursor cells and inflammatory effects of parasite-derived factors. By consolidating current evidence on this dynamic interaction, this review highlights critical questions for future research into the mechanisms of ineffective erythropoiesis and the development of host-protective therapeutic strategies.
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6. Structural Maintenance of Chromosomes Complexes in Bacteria.
6. 细菌中染色体的结构维持复合体PMID:日期:2026-08-07Structural maintenance of chromosomes (SMC) complexes are conserved ATP-driven machines that organize, compact, and segregate genomes in all domains of life. Despite variation in subunit composition and regulation, all SMC complexes share a core structure and mechanism of action. Bacteria possess two major classes of SMC complexes, SMC-ScpAB and MukBEF, which function in chromosome compaction and segregation. In addition, some bacteria contain other SMC complexes or SMC-like systems such as MksBEF, Wadjet, RecN, and SbcC, each with specialized functions. Bacterial SMC complexes coordinate genome maintenance, DNA replication, DNA repair, plasmid defense, and cell physiology. In this review, we discuss the structure and function of these bacterial SMC complexes, highlighting the shared characteristics and unique strategies employed by each.
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7. Adapting Architecture: Lipid Membrane Remodeling in Mycobacteria.
7. 适应结构：分枝杆菌中的脂质膜重塑PMID:日期:2026-08-04[中文摘要] 分枝杆菌细胞包膜是一道强大的屏障，被认为是生物界中化学和结构上最为复杂精细的构造之一。膜重塑，即膜脂组成响应应激因素而发生的变化，因其对通透性、抗生素敏感性、免疫原性和毒力的影响而成为广泛研究的主题。然而，由于膜重塑是一个由多条深度互联的细胞应答通路所调控的高度动态过程，其 underlying 机制和生物物理后果仍未完全阐明。在本综述中，我们综合了关于膜脂的组成和组织在生理相关条件下如何变化的现有知识，并审视了这些变化如何与关键应激应答通路相互交织。作为连接脂质组成、包膜结构和细胞功能的统一线索，我们总结了对分枝杆菌膜生物物理特性的认识，重点介绍了该领域的近期进展以及仍然存在的概念和方法学空白。
[英文摘要] The mycobacterial cell envelope is a formidable barrier, regarded as one of the most chemically and structurally elaborate architectures in the kingdom. Membrane remodeling, defined as changes in membrane lipid composition in response to stressors, has been a subject of broad investigation because of its implications for permeability, antibiotic susceptibility, immunogenicity, and virulence. However, because remodeling is a highly dynamic process governed by multiple, deeply interconnected cellular response pathways, its underlying mechanisms and biophysical consequences remain incompletely understood. In this review, we synthesize the current knowledge of how the composition and organization of membrane lipids shift under physiologically relevant conditions, and we examine how these changes intersect with key stress response pathways. As a unifying thread connecting lipid composition, envelope architecture, and cellular function, we summarize our understanding of mycobacterial membrane biophysical properties, highlighting recent advances as well as conceptual and methodological gaps that remain in the field.
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8. Structure-Based Insights into the Molecular Mechanisms of LuxR-Type Quorum Sensing Receptors.
PMID:日期:2026-08-03Quorum sensing (QS) enables bacteria to coordinate collective behaviors in response to population density. LuxI/R QS systems, common among gram-negative bacteria, consist of a LuxI-type synthase that produces an acyl L-homoserine lactone (AHL) signaling molecule and a LuxR-type receptor that senses the AHL. At threshold AHL concentrations, LuxR-type receptors undergo ligand-induced conformational changes that affect DNA binding and target gene transcription. Because of their role in regulating myriad collective behaviors, LuxI/R systems are targets for many applications, including antivirulence strategies and the engineering of beneficial microbiomes. Recent structural studies have led to substantial progress in understanding molecular mechanisms of LuxI/R systems. However, LuxR-type receptors fall into functionally diverse subfamilies for which structural bases remain incompletely understood. In this article, we summarize recent structural and mechanistic insights into LuxR-type receptor function, including interactions with small molecules, protein partners, and DNA. We identify critical knowledge gaps that highlight the need for additional structural and mechanistic information regarding LuxI/R QS.
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9. Structure and Function of the Type IX Secretion System for Protein Secretion and Cellular Motility.
PMID:日期:2026-08-03The type IX secretion system (T9SS) is a -specific multiprotein machine that supports a wide range of biological processes, from nutrient acquisition and surface modification to host interaction and gliding motility. T9SS effectors represent a structurally diverse repertoire of enzymes, adhesins, and surface proteins that all possess a C-terminal domain that addresses them to their final destination. Recent structural and mechanistic information has revealed the modular organization of the T9SS and molecular details governing effector selection, transport, processing, and sorting. In motile , the T9SS has been co-opted, evolved, and specialized for gliding motility. In this review, we summarize current knowledge on T9SS architecture and function, describe the embedded gliding machinery, and highlight conceptual advances and open questions regarding the mechanisms, dynamics, and ecological implications of this unique system.
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10. Ribosome Collisions Trigger Ribosome Rescue in Bacteria.
10. 核糖体碰撞触发细菌中的核糖体拯救PMID:日期:2026-07-23[中文摘要] 核糖体救援通路负责回收停滞核糖体上的亚基，并将中断的新生肽链靶向降解。在真核生物开创性研究的基础上，近期细菌中的研究表明，救援通路由核糖体碰撞触发。当上游核糖体追上停滞核糖体时，两者之间形成一个独特的界面，直接招募救援因子。例如，细菌中的核酸酶SmrB切割mRNA，使其靶向降解，并通过转移信使RNA（tmRNA）触发上游核糖体的救援。相比之下，MutS2/RqcU将停滞核糖体拆分为亚基，而不切割mRNA。最后，解旋酶HrpA通过不同机制将停滞核糖体拆分。本综述聚焦于这些因子的发现、它们在碰撞双核糖体上发挥作用的结构基础，以及拆分后滞留于50S亚基上的新生链如何被核糖体相关质量控制通路靶向降解。
[英文摘要] Ribosome rescue pathways recycle the subunits from stalled ribosomes and target the aborted nascent peptide for degradation. Building upon seminal studies in eukaryotes, recent work in bacteria shows that rescue pathways are triggered by ribosome collisions. When an upstream ribosome catches up to a stalled one, a unique interface that directly recruits rescue factors forms between them. The nuclease SmrB in , for example, cleaves mRNA, targeting it for decay and triggering the rescue of upstream ribosomes by transfer-messenger RNA (tmRNA). In contrast, MutS2/RqcU in splits stalled ribosomes into subunits without mRNA cleavage. Finally, the helicase HrpA splits stalled ribosomes in through a different mechanism. This review focuses on the discovery of these factors; the structural basis of their activities on collided disomes; and how, after splitting, the nascent chains trapped on 50S are targeted for degradation by the ribosome-associated quality control pathway.