JOURNAL OF PSYCHIATRIC RESEARCH精神病学研究杂志
JOURNAL OF PSYCHIATRIC RESEARCH(英文缩写 J PSYCHIATR RES),ISSN 0022-3956,eISSN 1879-1379,中文译名:精神病学研究杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.250 | Q2 |
| 2022 | 4.800 | Q2 |
| 2023 | 3.700 | Q1 |
| 2024 | 3.200 | Q2 |
| 2025 | 3.600 | Q2 |
JOURNAL OF PSYCHIATRIC RESEARCH 最新收录文献
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1. Cognitive emotion regulation strategies as differential predictors of anxiety and depression, quality of life, and functioning in primary care patients with emotional disorders.
PMID:日期:2026-11-01Emotional disorders (ED) such as depression and anxiety are the most prevalent worldwide and are often addressed in primary care (PC). Stressful events can cause people to activate adaptive or maladaptive cognitive emotion regulation strategies (CERS). The type of CERS used by an individual with an ED may influence clinical outcomes, quality of life (QoL), and functioning, although the precise effects are not well-understood. The aim of this study was to determine whether CERS are significant predictors of clinical symptoms, QoL, and functioning in PC patients with EDs. This study included 685 patients referred for psychological therapy within the PsicAP-CV clinical trial. All data were obtained from self-report measures. Correlation analyses and hierarchical multiple linear regression models were performed, with sociodemographic variables entered in the first step and CERS in the second step. Sociodemographic variables explained 4% to 20% of variance. The addition of CERS increased the explained variance to 13%-40%, indicating that CERS is a significant predictor of clinical symptoms, QoL, and functioning in these patients. The use of adaptive CERS was associated with fewer clinical symptoms and better QoL and functioning. By contrast, maladaptive CERS were associated with higher levels of anxiety and depression and poorer QoL and functioning. Emotion regulation could be a relevant transdiagnostic construct to be considered in the therapeutic context, both in the prevention and treatment of anxiety and depression.
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2. Functional dysconnectivity of the long-axis hippocampal parcels at rest and during memory tasks in schizophrenia and bipolar disorder.
PMID:日期:2026-11-01Schizophrenia (SZ) and bipolar disorder (BD) are major psychiatric conditions that show both overlapping and distinct clinical features. The hippocampus, a structure central to multiple cognitive functions including episodic memory, is altered in both disorders. Rather than functioning as a single unit, the hippocampus contains subregions with distinct connectivity patterns that may help clarify similarities and differences between these disorders. The present study directly compared hippocampal functional connectivity in SZ and BD using six well-validated hippocampal seeds (bilateral anterior, mid, and posterior segments) across two experimental contexts: resting state and memory tasks and examined associations with clinical and cognitive measures. Relative to healthy controls, both clinical groups showed significant connectivity alterations. The right posterior hippocampal parcel exhibited hyperconnectivity with the right inferior temporal gyrus in SZ only. The right mid hippocampal parcel showed hypoconnectivity with the left middle temporal gyrus and right superior temporal gyrus, a pattern shared by both clinical groups. Finally, the right anterior hippocampal parcel demonstrated hypoconnectivity with the left middle temporal gyrus that was specific to SZ at rest but shared by both disorders during the memory condition. Overall, these findings reveal both shared and disorder-specific patterns of hippocampal dysconnectivity, with two connectivity clusters showing significant associations with mnemonic performance.
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3. Examination of the intersection of bipolar I disorder status and cannabis use disorder severity in relation to health-related quality-of-life and lifetime suicide attempts.
PMID:日期:2026-11-01Among people with bipolar I disorder (BD), cannabis use disorder (CUD) is highly comorbid and correlated with poorer clinical outcomes, including increased suicidal behaviors and decreased quality-of-life (QoL). However, research on different levels of CUD severity and their links to suicidal behaviors and QoL are underexplored. Using data from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III), this study examined the relationships between DSM-5 CUD severity and lifetime suicide attempts or health-related QoL in participants with and without lifetime bipolar I disorder (ns = 753 and 35,556, respectively). A logistic regression model, adjusted for sex, age, and race/ethnicity, indicated the rate of lifetime suicide attempts was 16.65% (95% CI [13.17, 20.83]) in people without BD and with severe CUD compared to 33.71% (95% CI [21.64, 48.36]) in people with BD and severe CUD. Additionally, an adjusted linear regression model showed that mental health QoL significantly declined in individuals without BD from those with no CUD symptoms (M = 51.49, 95% CI [51.33, 51.65]) to severe CUD (M = 45.28, 95% CI [44.35, 46.21]), whereas the mental health QoL for individuals with BD did not significantly vary across CUD severity. Physical health QoL was not significantly different across BD status nor CUD severity. Overall, these findings suggest that CUD severity is significantly associated with altered outcomes on lifetime suicide attempts and mental health QoL depending on lifetime BD status; however, BD may still play a more prominent role in mental health outcomes, regardless of CUD severity.
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4. Network structure and mental health correlates of the Mount Sinai Resilience Scale.
PMID:日期:2026-11-01The Mount Sinai Resilience Scale (MSRS) assesses cognitive, behavioral, and emotional resilience processes, yet the interrelationships among these processes, including which are most central and most strongly associated with mental health outcomes, remain poorly characterized. This study used network analysis to characterize the structure of MSRS-assessed resilience processes and their associations with clinical outcomes in a population-based sample of U.S. adults (N = 1794) enriched for elevated perceived stress and trauma exposure. Participants completed the MSRS and validated measures of depressive, anxiety, and posttraumatic stress disorder (PTSD) symptoms and well-being. Regularized Gaussian graphical models were estimated to characterize network structure and centrality, with clinical outcomes incorporated as nodes to identify unique associations with individual MSRS items. The network demonstrated moderate density (157 of 276 possible edges), reflecting widespread conditional associations among resilience processes. Engagement in meaningful activities, perceived positive impact of spirituality, and active emotional recovery demonstrated the highest centrality, while emotional awareness and directly facing fears also showed high expected influence. Staying hopeful about the future, directly facing fears, and engaging in meaningful activities were consistently associated with lower depressive, anxiety, and PTSD symptoms and higher well-being. Forgiveness was positively associated with PTSD symptoms, suggesting a more complex role in trauma-related adaptation. Overall, MSRS resilience processes were organized around interconnected domains of meaning, spirituality, and emotional regulation. Hope, behavioral approach to feared experiences, and engagement in meaningful activities emerged as resilience processes with consistent associations across multiple mental health outcomes, highlighting their potential relevance for resilience-focused interventions.
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5. Characterization of local tolerability of TV-46000, a long-acting subcutaneous formulation of risperidone for the treatment of schizophrenia.
PMID:日期:2026-11-01TV-46000 is a long-acting injectable antipsychotic (LAI) approved for the treatment of adults with schizophrenia and bipolar I disorder. LAIs like TV-46000 can improve adherence and reduce relapse in patients with schizophrenia; however, injection site reactions (ISRs) can contribute to LAI discontinuation. ISRs with TV-46000 treatment were characterized using data from two phase 3 trials of patients with schizophrenia (RISE [NCT03503318], SHINE [NCT03893825]) and a phase 1 study of patients with schizophrenia or schizoaffective disorder. Patients in the pooled safety population (aged 16-67 years) from RISE and SHINE (n = 525 TV-46000, n = 179 placebo) received 4554 TV-46000 injections and 2721 placebo injections. ISRs were reported in 19 % (n = 102) of patients who received TV-46000, corresponding to an exposure-adjusted event rate (EAER)/100 patient-years of 48.67. ISRs led to 9 (1.7 %) treatment discontinuations of TV-46000. The most frequently reported ISR adverse events were injection site pain (EAER, 15.38, n = 36 [7 %]) and injection site nodule (EAER, 12.01, n = 35 [7 %]). ISR frequency and pain and nodule adverse event frequency decreased after the first injection. In the phase 1 study (n = 99), mean injection site pain scores were highest immediately after injection, showed a notable decrease within 10 min of injection, and further decreased within 1 h after injection. In conclusion, for >4500 injections evaluated, ISR rates with TV-46000 were modest. Most ISRs were mild or moderate and rarely led to treatment discontinuation. Results support the favorable tolerability of TV-46000 as a treatment for schizophrenia in adults.
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6. Effect of cognitive enhancement therapy for early course schizophrenia on gray matter volume: A confirmatory multisite randomized clinical trial.
PMID:日期:2026-11-01Cognitive Enhancement Therapy (CET) is an evidence-based cognitive remediation intervention for early course schizophrenia with established benefits for cognition. CET may protect against broad temporolimbic gray matter volume loss associated with cognitive improvement, but this finding has yet to be replicated. This research reexamined if CET protects against temporolimbic gray matter volume loss in an independent and larger multisite early course sample, and if this neuroprotective effect predicts cognitive and social adjustment improvement. Ninety-nine participants with early course schizophrenia completed MRI, cognitive, and social adjustment assessments at baseline, 9 (mid-treatment), and 18 (end of treatment) months. Linear mixed-effects models examined the differential impact of CET (n = 56) compared to Enriched Supportive Therapy (n = 43) on temporolimbic gray matter volume in regions-of-interest (ROIs) that previously demonstrated CET-related neuroprotection (primary ROIs), as well as frontotemporal ROIs outlined in the first trial (secondary ROIs). The right rostral anterior cingulate was the only primary ROI to demonstrate a significant group × time interaction, but was unrelated to cognitive and social adjustment change. No secondary ROIs exhibited a differential treatment effect. This confirmatory trial did not recapitulate the observed broad pattern of CET-related temporolimbic gray matter volume neuroprotection. Consistent with the larger literature demonstrating limited evidence of cognitive remediation effects on the brain in schizophrenia, these findings underscore the need for continued investigation of CET-related changes with other neuroimaging modalities, especially given its established cognitive benefits. Such information is critical for cognitive remediation optimization based on validated therapeutic mechanisms.
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7. Family support is important for mitigating the mental health consequences of loneliness among Black Americans at midlife: Results from a longitudinal mediation analysis.
PMID:日期:2026-11-01Social connectedness influences mental health, yet pathways through loneliness versus social isolation remain underexamined among Black Americans. This study examines these mediating pathways. We analyzed longitudinal data (between 2005-2006 and 2016-2017) among Black Americans (N = 592) in the Midlife in the United States (MIDUS), Milwaukee, WI. Social connectedness was measured across six dimensions: neighborhood social cohesion, social integration, support from family, support from friends, social contribution, and community contribution. Mediators included loneliness and social isolation (frequency of social contact). Outcomes were psychological distress (Kessler-6 Scale) and depression diagnosis (7-item binary measure assessing the presence of depressive symptoms over a two-week period). We used structural equation modeling with inverse probability weighting to examine both direct and indirect effects. Loneliness significantly predicted both psychological distress (β = 1.76, p < 0.001) and depression (aOR = 2.14, p = 0.010). Social isolation did not significantly predict either outcome. Support from family showed the strongest total protective effects on psychological distress (total β = -2.477, p < 0.05) and depression (total aOR = 0.208, p < 0.01), primarily driven by substantial indirect effects through reduced loneliness (psychological distress: β = -1.244, p < 0.01; depression: aOR = 0.538, p < 0.05). Support from family also showed a significant direct protective effect on depression (aOR = 0.301, p < 0.05), but not on psychological distress. Support from family reduced both psychological distress and depression primarily through its role in reducing loneliness, with an additional direct protective effect on depression. Programs and policies that strengthen family support are imperative to promote mental health in this population.
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9. Can fluoxetine's diminished efficacy in pediatric depression be explained by study sites, baseline severity, age, and psychological interventions? A secondary exploratory meta-regression.
PMID:日期:2026-11-01Fluoxetine's efficacy estimates in pediatric depression trials have declined to the range of placebo equivalence. We investigated whether changes in trial characteristics (number of study sites (NOSS), age, baseline severity, or added psychological interventions) could explain this trend. We conducted a secondary exploratory analysis based on our recent meta-analyses of pediatric fluoxetine depression trials. The outcome was symptom change on the Children's Depression Rating Scale Revised (CDRS-R). We used meta-regression to explore the association between NOSS, age, depression severity, and the addition of psychological interventions with efficacy and placebo response. NOSS increased over time and was not significantly associated with outcomes. When log-transformed, NOSS was associated with decreased efficacy (B = 1.57, 95% CI 0.24 to 2.90, p = 0.02) and greater placebo response (B = -1.90, 95% CI -3.41 to -0.40, p = 0.01). However, these associations were driven by an outlying single-center trial rated as high risk of bias and did not survive p-value adjustment. Age, baseline severity, and psychological interventions were not significantly associated with efficacy or placebo response. NOSS increased over time but the apparent associations with decreased efficacy or increased placebo response were driven by an outlying trial at risk of bias. Age of participants, baseline severity, or added psychological interventions also failed to explain fluoxetine's diminished efficacy. Limitations include the potential ecological fallacy in analysis of age and baseline severity. Overall, these findings do not support the assumption that fluoxetine's meta-analytic efficacy estimates are substantially influenced by these trial characteristics.
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10. Does impulsivity predict treatment outcomes in PTSD with borderline personality disorder features? Results from a randomized clinical trial.
PMID:日期:2026-11-01Trauma-focused psychotherapies are first-line treatments for posttraumatic stress disorder (PTSD). However, a substantial proportion of clients do not respond adequately or drop out of therapy prematurely. This has sparked interest in identifying individual-level predictors of treatment outcomes, including improvement in PTSD severity and dropout. Impulsivity may be a predictor because it may interfere with key therapeutic processes, such as cognitive restructuring and emotional processing. Consequently, we present a hypothesis-driven secondary analysis of a 15-month randomized clinical trial comparing Dialectical Behavior Therapy for PTSD (DBT-PTSD) and Cognitive Processing Therapy (CPT) in women with childhood abuse-related PTSD and borderline personality disorder features to test whether impulsivity, assessed at baseline, predicts PTSD improvement and dropout. We further explore whether the dimensions of impulsivity (non-planning, attentional impulsivity, and motor impulsivity) differentially affect the outcomes in DBT-PTSD vs. CPT. A total of 193 cis women with PTSD related to childhood abuse and borderline personality disorder features were assessed using the Clinician-Administered PTSD Scale (CAPS) and the Barratt Impulsiveness Scale (BIS-10). Separate probit models and general linear models were applied to predict dropout and pre-to-post changes in PTSD severity (ΔCAPS) from total impulsivity and subscale scores, i.e. non-planning, attentional and motor impulsivity. Overall, dropout rates were higher for participants with higher baseline impulsivity scores (p = 0.049), particularly for those with higher non-planning impulsivity (p = 0.012). In participants randomized to CPT improvement in PTSD symptom severity (ΔCAPS) was negatively related to baseline total impulsivity (p = 0.021). In participants randomized to DBT-PTSD this relation was not significant. The results suggest that impulsivity may predict treatment outcomes. Specifically, patients with elevated impulsivity may be less likely to respond adequately to CPT. If replicated, these findings have implications for personalization of treatment.